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1. 发明申请

US20170233792A1 Fixation Method for Single Cell Analysis 审中-公开
公开(公告)号：US20170233792A1
公开(公告)日：2017-08-17
申请号：US15411025
申请日：2017-01-20
申请人： Chun-Liang Chen , Chun-Lin Lin , Joseph Liu , Tim Hui-Ming Huang , Aaron Mark Horning
发明人： Chun-Liang Chen , Chun-Lin Lin , Joseph Liu , Tim Hui-Ming Huang , Aaron Mark Horning
IPC分类号： C12Q1/68 , G01N1/30
CPC分类号： C12Q1/6806 , C12Q1/6841 , G01N1/30 , G01N2001/305 , C12Q2527/125
摘要： A novel fixation method is presented that will circumvent both biological and safety concerns with current fixation methods.

2. 发明授权

US09018203B2 Pharmaceutical composition of salicylanilide-derived small molecules and preparation and application thereof 有权
标题翻译：水杨酰苯胺衍生的小分子的药物组合物及其制备及应用
公开(公告)号：US09018203B2
公开(公告)日：2015-04-28
申请号：US13610489
申请日：2012-09-11
申请人： Deh-Ming Chang , Hsu-Shan Huang , Chun-Liang Chen , Chia-Chung Lee
发明人： Deh-Ming Chang , Hsu-Shan Huang , Chun-Liang Chen , Chia-Chung Lee
IPC分类号： C07D265/26 , A61K31/609 , A61K31/536 , C07C235/64
CPC分类号： A61K31/536 , A61K31/609 , C07C235/64 , C07D265/26
摘要： The present invention provides a pharmaceutical composition of salicylanilide-derived small molecules include: (a) a compound which structure is selected from formula I or formula II: (b) a pharmaceutically acceptable salt and excipient. The present invention also provides the synthesis method of the pharmaceutical composition and the application thereof.
摘要翻译：本发明提供了一种衍生自水杨酰苯胺的小分子的药物组合物，包括：（a）结构选自式I或式II的化合物：（b）药学上可接受的盐和赋形剂。本发明还提供了药物组合物的合成方法及其应用。

3. 发明授权

US07712345B1 Main beam fabrication procedure and system for making a main beam for warehouse framework 失效
标题翻译：主梁制造程序和系统，用于制造仓库框架的主梁
公开(公告)号：US07712345B1
公开(公告)日：2010-05-11
申请号：US11806078
申请日：2007-05-29
申请人： Chun-Liang Chen
发明人： Chun-Liang Chen
IPC分类号： B21B15/00 , B21F11/00 , B21B19/00
CPC分类号： B21D5/08 , B21D35/00
摘要： A main beam fabrication procedure and system for making main beams for warehouse framework through feeding, auto-forwarding and flattening, punching, roller shape-forming, cutting-off and finished product collection steps, in which the punching machine comprises an upper mold holder, four upper punching dies arranged in two longitudinal rows on the bottom side of the upper mold holder and adjustable to change the transverse pitch between the two longitudinal rows of upper punching dies, a bottom mold holder, and four bottom punching dies arranged in two longitudinal rows on the top side of the bottom mold holder and adjustable to change the transverse pitch between the two longitudinal rows of bottom punching dies.
摘要翻译：一种主梁制造程序和系统，用于通过进料，自动转换和压平，冲压，辊成型，切割和成品收集步骤制造仓库框架的主梁，其中冲孔机包括上模具架，四个上冲孔模具，其在上模具保持器的底侧上排列成两纵向排，并且可调节以改变上冲压模具的两个纵向排之间的横向间距，底模夹持器和四个底部冲孔模在底部模具支架的顶侧上并且可调节以改变两个纵向排的底部冲压模具之间的横向间距。

4. 发明授权

US5758958A Fog signal lamp 失效
标题翻译：雾信号灯
公开(公告)号：US5758958A
公开(公告)日：1998-06-02
申请号：US732857
申请日：1996-10-15
申请人： Chun-Liang Chen
发明人： Chun-Liang Chen
IPC分类号： B60Q1/20 , F21S8/10 , F21V17/00 , F21V17/14 , F21V7/00
CPC分类号： F21S48/1208 , B60Q1/20 , F21S48/1131 , F21S48/1216 , F21V17/14 , Y10S362/806
摘要： The present invention provides a fog signal lamp, which comprises a bulb set, a reflector, a shade holder, a decorative frame, an ornamental ring, a lampshade and an enclosing cover. Wherein, a colorful transparent ornamental ring can be fixed in the decorative frame, and the decorative frame is mounted on the front end of the reflector, therein the connection of the ornamental ring and the decorative frame is in bayonet joint. When the fog signal lamp is turned on, the beam emitting from the bulb shining the reflector is refracted and spotlighted with the lampshade as a common head-lamp, meanwhile the transparent ornamental ring absorbs refracted light to create a colorful ring light as a fog signal lamp.
摘要翻译：本发明提供一种雾信号灯，其包括灯泡组，反射器，遮光罩，装饰框架，装饰环，灯罩和封闭盖。其中，五颜六色的透明装饰环可以固定在装饰框架中，装饰框架安装在反光镜的前端，其中装饰环和装饰框架的连接处于卡口接头中。当雾灯信号灯亮起时，从发光反射镜的灯泡发射的光束被折射并用灯罩作为常见的头灯聚光，同时透明装饰环吸收折射光以产生作为雾信号的五颜六色的环形灯灯。

5. 发明申请

US20140154689A1 ANALYSIS OF CIRCULATING TUMOR CELLS AS DIAGNOSTIC AND PREDICTIVE BIOMARKERS FOR METASTATIC CANCERS 审中-公开
标题翻译：循环肿瘤细胞作为诊断和预测生物标志物的分析
公开(公告)号：US20140154689A1
公开(公告)日：2014-06-05
申请号：US14098112
申请日：2013-12-05
申请人： Tim Hui-Ming Huang , Chun-Liang Chen , Joseph Liu , Chiou-Miin Wang , Devalingam Mahalingam , Pawel Osmulski
发明人： Tim Hui-Ming Huang , Chun-Liang Chen , Joseph Liu , Chiou-Miin Wang , Devalingam Mahalingam , Pawel Osmulski
IPC分类号： G01N33/574
CPC分类号： G01N33/57492 , C12Q1/6806 , C12Q1/6886 , C12Q2600/158 , G01N2333/70589 , C12Q2523/308 , C12Q2563/131
摘要： A method of analyzing circulating tumor cells includes separating circulating tumor cells from a subject's blood sample by filtration; separating CD45-negative cells from any retained blood cells; and determining the EMT-related gene expression profiles, nanomechanical and/or nanochemical properties of the collected CD45-negative CTC cells. Analysis of the collected circulating tumor cells enables the investigators to make a quick and accurate assessment of the metastatic behavior of the subject's circulating tumor cells for early castration-resistance and metastasis prediction in a clinical setting.
摘要翻译：分析循环肿瘤细胞的方法包括通过过滤从受试者的血液样品中分离循环肿瘤细胞; 从任何保留的血细胞分离CD45阴性细胞; 并确定收集的CD45阴性CTC细胞的EMT相关基因表达谱，纳米机械和/或纳米化学性质。收集的循环肿瘤细胞的分析使得研究者能够对临床环境中早期去势抗性和转移预测对受试者的循环肿瘤细胞的转移行为进行快速和准确的评估。

6. 发明申请

US20120182704A1 ELECTRONIC DEVICE 有权
标题翻译：电子设备
公开(公告)号：US20120182704A1
公开(公告)日：2012-07-19
申请号：US13349333
申请日：2012-01-12
申请人： Chien-Yi Lee , Ching-Jen Wang , Yu-Ti Kuo , Chun-Liang Chen
发明人： Chien-Yi Lee , Ching-Jen Wang , Yu-Ti Kuo , Chun-Liang Chen
IPC分类号： H05K5/00
CPC分类号： H05K9/0067
摘要： An electronic device including a conductive element, a conductive layer, and a case is provided. The case has a surface, a first supporting member, and a second supporting member. The first supporting member and the second supporting member are disposed on the surface, and the first supporting member has a suspending arm. The case, the first supporting member and the second supporting member are integrally formed, and the conductive layer exists on the surface of the case, the first supporting member, and the second supporting member. The conductive element presses the first suspending arm to contact the second supporting member, such that a ground circuit is formed with the conductive element, the first suspending arm, the second supporting member, and the surface.
摘要翻译：提供了包括导电元件，导电层和外壳的电子设备。壳体具有表面，第一支撑构件和第二支撑构件。第一支撑构件和第二支撑构件设置在表面上，并且第一支撑构件具有悬挂臂。壳体，第一支撑构件和第二支撑构件一体地形成，并且导电层存在于壳体，第一支撑构件和第二支撑构件的表面上。导电元件按压第一悬臂以接触第二支撑构件，使得接地电路形成有导电元件，第一悬挂臂，第二支撑构件和表面。

7. 发明申请

US20120084594A1 USB DEVICE WITH A CLOCK CALIBRATION FUNCTION AND METHOD FOR CALIBRATING REFERENCE CLOCKS OF A USB DEVICE THEREOF 有权
标题翻译：具有时钟校准功能的USB设备和用于校准其USB设备的参考时钟的方法
公开(公告)号：US20120084594A1
公开(公告)日：2012-04-05
申请号：US13007663
申请日：2011-01-16
申请人： Chun-Liang Chen , Yi-Le Yang , Yu-Cheng Lo
发明人： Chun-Liang Chen , Yi-Le Yang , Yu-Cheng Lo
IPC分类号： G06F1/06
CPC分类号： G06F1/04 , G06F1/06
摘要： A USB device with a clock calibration function and a method for calibrating reference clocks of a USB device are provided. A USB 2.0 initial calibration is performed on the USB device in order to control an embedded oscillator (EMOSC) of the USB device to output a first reference clock compliance USB 2.0 specification and USB 3.0 specification during the initialization phase. After that, a USB 3.0 on-line calibration is performed on the USB device in order to control the EMOSC of the USB device to calibrate a second reference clock during a super-speed mode of USB 3.0 specification.
摘要翻译：提供了具有时钟校准功能的USB设备和用于校准USB设备的参考时钟的方法。在USB设备上执行USB 2.0初始校准，以便控制USB设备的嵌入式振荡器（EMOSC），以在初始化阶段输出第一个参考时钟符合性USB 2.0规范和USB 3.0规范。之后，在USB设备上执行USB 3.0在线校准，以便在USB 3.0规范的超速模式下控制USB设备的EMOSC校准第二个参考时钟。

8. 发明授权

US08076962B2 Frequency synthesis system with self-calibrated loop stability and bandwidth 有权
标题翻译：频率合成系统具有自校准的环路稳定性和带宽
公开(公告)号：US08076962B2
公开(公告)日：2011-12-13
申请号：US12923200
申请日：2010-09-09
申请人： Chun-Liang Chen , Hui-Chun Hsu
发明人： Chun-Liang Chen , Hui-Chun Hsu
IPC分类号： H03L7/06
CPC分类号： H03L7/0995 , H03L7/093 , H03L2207/04
摘要： In a frequency synthesis system with self-calibrated loop stability and bandwidth, a detector produces a detection signal based on a difference between an input signal and a feedback signal; a charge pump produces a control signal based on the detection signal; a filter produces a tuning signal and a source current based on the control signal; a bias circuit produces first and second bias signals; a controllable oscillator produces a differential output signal with a selected specific frequency; a differential-to-single converter produces an output signal with the selected specific frequency; a programmable frequency divider produces the feedback signal; a current mirror circuit receives the source current for producing a mirror current; a compensation circuit produces a compensation current based on the mirror current for compensating the variation of the damping factor and the bandwidth-to-reference frequency ratio.
摘要翻译：在具有自校准环路稳定性和带宽的频率合成系统中，检测器基于输入信号和反馈信号之间的差异产生检测信号; 电荷泵基于检测信号产生控制信号; 滤波器基于控制信号产生调谐信号和源电流; 偏置电路产生第一和第二偏置信号; 可控振荡器产生具有所选择的特定频率的差分输出信号; 差分到单个转换器产生具有所选择的特定频率的输出信号; 可编程分频器产生反馈信号; 电流镜电路接收源电流以产生镜电流; 补偿电路基于镜电流产生补偿电流，用于补偿阻尼因子和带宽与参考频率比的变化。

9. 发明授权

US08067988B2 Low jitter and wide-range frequency synthesizer for low voltage operation 有权
标题翻译：低抖动和宽频率频率合成器，用于低电压操作
公开(公告)号：US08067988B2
公开(公告)日：2011-11-29
申请号：US12656865
申请日：2010-02-18
申请人： Chun-Liang Chen , Hui-Chun Hsu
发明人： Chun-Liang Chen , Hui-Chun Hsu
IPC分类号： H03L7/00
CPC分类号： H03L7/183 , H03L7/0995
摘要： A low jitter and wide-range frequency synthesizer for low voltage operation includes a detector to generate a detection signal based on a logic level difference between an input signal and a feedback signal, a charge pump to generate a control signal based on the detection signal, a filter to generate a tuning signal based on the control signal, a bias circuit to generate a first bias signal and a second bias signal based on the tuning signal, a controllable oscillator to generate a differential output signal based on the first and the second bias signals, a differential to single ended converter to convert the differential output signal into an output signal, and a programmable frequency divider to generate the feedback signal based on the output signal.
摘要翻译：用于低电压操作的低抖动和宽范围频率合成器包括：检测器，用于基于输入信号和反馈信号之间的逻辑电平差产生检测信号;电荷泵，用于基于检测信号产生控制信号; 基于所述控制信号产生调谐信号的滤波器，基于所述调谐信号产生第一偏置信号和第二偏置信号的偏置电路，基于所述第一和第二偏置产生差分输出信号的可控振荡器信号，差分到单端转换器将差分输出信号转换成输出信号，以及可编程分频器，以基于输出信号产生反馈信号。

10. 发明授权

US07940097B2 All digital phase locked loop circuit 有权
标题翻译：全数字锁相环电路
公开(公告)号：US07940097B2
公开(公告)日：2011-05-10
申请号：US12575050
申请日：2009-10-07
申请人： Chun-Liang Chen
发明人： Chun-Liang Chen
IPC分类号： H03L7/06
CPC分类号： H03L7/18 , H03L7/07 , H03L7/0812 , H03L7/085 , H03L2207/50
摘要： An all digital phase locked loop circuit includes a reference frequency indicator for receiving a reference signal with a reference frequency and generating a frequency indicating value; a phase frequency detector for comparing the reference signal with a frequency divided signal and generating a phase difference pulse; a time-to-digital circuit for receiving the phase difference pulse and a plurality of output signals and generating a phase difference value; a digital controller for receiving the frequency indicating value and the phase difference value and generating a control value; a delta-sigma modulator for modulating the control value and generating a modulated control value; a DCO for receiving the modulated control value and generating an output oscillating signal with a digital controlled frequency; a frequency divider for dividing the digital controlled frequency to generate the frequency divided signal; and a multi-phase generator for receiving the output oscillating signal and generating the output signals.
摘要翻译：全数字锁相环电路包括用于接收具有参考频率的参考信号并产生频率指示值的参考频率指示器; 相位频率检测器，用于将参考信号与分频信号进行比较并产生相位差脉冲; 用于接收相位差脉冲的时间数字电路和多个输出信号并产生相位差值; 用于接收频率指示值和相位差值并产生控制值的数字控制器; 用于调制控制值并产生调制控制值的Δ-Σ调制器; 用于接收调制控制值并产生具有数字受控频率的输出振荡信号的DCO; 用于分割数字受控频率以产生分频信号的分频器; 以及用于接收输出振荡信号并产生输出信号的多相发生器。

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