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1. 发明申请

US20200234936A1 Dynamic Equilibration Time Calculation to Improve MS/MS Dynamic Range 审中-公开
公开(公告)号：US20200234936A1
公开(公告)日：2020-07-23
申请号：US16639161
申请日：2018-08-31
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： Douglas Arnold Simmons , Nic G. Bloomfield
IPC分类号： H01J49/00 , H01J49/06 , H01J49/42
摘要： Dynamic skimmer pulsing and dynamic equilibration times are used for MS and MS/MS scans. A target percentage transmission of the ion beam is calculated based on a previous percentage transmission and a previous TIC or a previous highest intensity of a previous cycle time. An equilibration time is calculated based on the current percentage transmission and the target percentage transmission. A skimmer of a tandem mass spectrometer is controlled to attenuate the ion beam to the target percentage transmission to prevent saturation of a detector of the tandem mass spectrometer and to increase the dynamic range of the tandem mass spectrometer. The tandem mass spectrometer is controlled to perform an MS scan or an MS/MS scan after the calculated equilibration time to reduce the cycle time.

2. 发明申请

US20170250065A1 Grouping Amplitudes of TOF Extractions to Detect Convolution Due to Resolution Saturation 有权
公开(公告)号：US20170250065A1
公开(公告)日：2017-08-31
申请号：US15513267
申请日：2015-09-21
申请人： DH Technologies Development Pte. Ltd.
发明人： Nic G. Bloomfield
IPC分类号： H01J49/40 , H01J49/00 , H01J49/04 , H01J49/28 , G01N27/62 , H01J49/26
CPC分类号： H01J49/40 , G01N27/62 , H01J49/0036 , H01J49/04 , H01J49/26
摘要： Sample molecules are ionized producing a beam of ions using an ion source. A plurality of ion extractions are performed on the beam of ions using a TOF mass spectrometer. Electrical detections from each extraction are measured using an ADC, producing a mass sub-spectrum for each extraction. An ion m/z from the plurality of mass sub-spectra is selected. For each mass sub-spectrum, the amplitude and m/z of an ion within a m/z tolerance of the ion m/z is assigned to the corresponding amplitude band of a plurality of predetermined amplitude bands, producing a plurality of amplitude and m/z values for the each amplitude band. For each amplitude band of the plurality of predetermined amplitude bands, the plurality of amplitude and m/z values are combined into a peak, resulting in a plurality of peaks corresponding to the plurality of predetermined amplitude bands.

3. 发明申请

US20160148791A1 Intensity Correction for TOF Data Acquisition 审中-公开
标题翻译： TOF数据采集强度校正
公开(公告)号：US20160148791A1
公开(公告)日：2016-05-26
申请号：US15008385
申请日：2016-01-27
申请人： DH Technologies Development Pte. Ltd.
发明人： Nic G. Bloomfield , Alexandre V. Loboda
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/0009 , H01J49/0036 , H01J49/025 , H01J49/40
摘要： Systems and methods are provided for correcting uniform detector saturation of a mass analyzer using a calibration curve. In one method, a measured spectrum is received from a mass analyzer that includes a detector and an analog-to-digital converter (ADC) detector subsystem and that analyzes a beam of ions produced by an ion source that ionizes molecules of a sample using a processor. A total ion value of the measured spectrum is calculated by summing intensities of ions in the measured spectrum using the processor. A correction factor is determined by comparing the total ion value to a stored calibration curve that provides correction factors as a function of total ion values using the processor. Intensities of the measured spectrum are multiplied by the determined correction factor producing a corrected measured spectrum using the processor.
摘要翻译：提供了使用校准曲线校正质量分析器的均匀检测器饱和度的系统和方法。在一种方法中，从包括检测器和模拟 - 数字转换器（ADC）检测器子系统的质量分析器接收测量的光谱，并且分析由离子源产生的离子束，其使用离子源离子化样品的分子处理器。通过使用处理器对所测量的光谱中的离子的强度求和来计算测量光谱的总离子值。通过将总离子值与存储的校准曲线进行比较来确定校正因子，该校准曲线使用处理器提供作为总离子值的函数的校正因子。测量光谱的强度乘以确定的校正因子，使用处理器产生校正的测量光谱。

4. 发明申请

US20220199390A1 Improved TOF Qualitative Measures using a Multichannel Detector 有权
公开(公告)号：US20220199390A1
公开(公告)日：2022-06-23
申请号：US17310959
申请日：2020-04-15
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： David Michael Cox , Nic G. Bloomfield
IPC分类号： H01J49/40 , H01J49/02 , H01J49/00
摘要： The resolution of a TOF mass analyzer is maintained despite a loss of resolution in one or more channels of a multichannel ion detection system by selecting the highest resolution channels for qualitative analysis. Ion packets that impact a multichannel detector are converted into multiplied electrons and emitted from two or more segmented electrodes that correspond to impacts in different regions across a length of the detector. The electrons received by each electrode of the two or more segmented electrodes for each ion packet are converted into digital values in a channel of a multichannel digitizer, producing digital values for at least two or more channels Qualitative information about the ion packets is calculated using digital values of a predetermined subset of one or more channels of the at least two or more channels known to provide the highest resolution.

5. 发明授权

US10784098B2 Two-and-a-half channel detection system for time-of-flight (TOF) mass spectrometer 有权
公开(公告)号：US10784098B2
公开(公告)日：2020-09-22
申请号：US16490400
申请日：2018-03-01
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： Igor Chernushevich , Nic G. Bloomfield
IPC分类号： H01J49/40 , H01J49/02 , H01J49/00 , H01J49/06
摘要： Two-channel electrical and photo-electrical TOF ion detection systems are provided. These systems maintain the resolution and dynamic range advantages of four-channel systems but at a lower cost. Electrodes or light pipes are configured to direct electrons or photons produced by ion impacts into two separate channels. The first channel receives electrons or photons resulting from the inner or central part of the rectangular pattern of each ion impact. The second channel receives electrons or photons resulting from the two outer ends of the rectangular pattern of each ion impact. In a two-channel digitizer, the first channel and the second channel are independently calibrated to align the first digital value and the second digital value in time and account for the convex shape of the ion impacts of each ion packet and/or the curvature of a microchannel plate.

6. 发明授权

US09472387B2 Systems and methods for identifying precursor ions from product ions using arbitrary transmission windowing 有权
标题翻译：使用任意透射窗口从产物离子中鉴定前体离子的系统和方法
公开(公告)号：US09472387B2
公开(公告)日：2016-10-18
申请号：US15089529
申请日：2016-04-02
申请人： DH Technologies Development Pte. Ltd.
发明人： Nic G. Bloomfield , Frank Londry
IPC分类号： H01J49/00 , H01J49/06
CPC分类号： H01J49/0036 , H01J49/0027 , H01J49/004 , H01J49/061 , H01J49/40 , H01J49/4215 , H01J49/427
摘要： Ions are separated from a sample over time and filtered. The precursor ions produced at each step are fragmented. Resulting product ions are analyzed using a mass analyzer, producing a product ion spectrum for each step of the transmission window and a plurality of product ion spectra for the mass range for the each scan. The plurality of product ion spectra are received, producing a plurality of multi-scan product ion spectra. At least one product ion is selected from the plurality of multi-scan product ion spectra that is present at least two or more times in product ion spectra from each of two or more scans. A known separation profile of a precursor ion is fit to intensities from the at least one product ion in the plurality of multi-scan product ion spectra to reconstruct a separation profile of a precursor ion of the at least one product ion.
摘要翻译：离子与样品随时间分离并过滤。在每个步骤产生的前体离子是碎裂的。使用质量分析仪分析所得产物离子，产生用于传输窗口的每个步骤的产物离子谱和用于每次扫描的质量范围的多个产物离子光谱。接收多个产物离子光谱，产生多个多扫描产物离子光谱。从多个多扫描产物离子光谱中选择至少一个产物离子，所述离子谱在两次或更多次扫描中的每一次的产物离子谱中至少存在两次或更多次。前体离子的已知分离曲线适合于多个多扫描产物离子光谱中的至少一种产物离子的强度，以重建至少一种产物离子的前体离子的分离曲线。

7. 发明申请

US20220093377A1 Acquisition Strategy for Top-Down Analysis with Reduced Background and Peak Overlapping 有权
公开(公告)号：US20220093377A1
公开(公告)日：2022-03-24
申请号：US17423934
申请日：2020-01-31
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： Pavel Ryumin , Takashi Baba , Nic G. Bloomfield
IPC分类号： H01J49/00 , H01J49/02
摘要： Intensity measurements made by electron multiplier and image-charge detectors are proportional to charge state. These intensities are used to separate detected ions into different data sets and create mass spectra from the different data sets. Ion measurements are separated by charge state using (i) a single electron multiplier detector, (ii) a single image-charge detector, or (iii) multiple electron multiplier ADC detectors. Using (i), the intensity of a peak calculated from each measured pulse is compared to predetermined intensity ranges and each peak is stored in a corresponding data set. Using (ii), each measured transient time-domain signal is converted to frequency-domain peaks, the intensity of each frequency-domain peak is compared to predetermined intensity ranges, and each peak is stored in a corresponding data set. Using (iii), each detector is adapted to measure a predetermined intensity range and store calculated peaks from the measured pulses in corresponding data sets.

8. 发明授权

US09978575B2 Grouping amplitudes of TOF extractions to detect convolution due to resolution saturation 有权
公开(公告)号：US09978575B2
公开(公告)日：2018-05-22
申请号：US15513267
申请日：2015-09-21
申请人： DH Technologies Development Pte. Ltd.
发明人： Nic G. Bloomfield
IPC分类号： H01J49/40 , G01N27/62 , H01J49/26 , H01J49/00 , H01J49/04
CPC分类号： H01J49/40 , G01N27/62 , H01J49/0036 , H01J49/04 , H01J49/26
摘要： Sample molecules are ionized producing a beam of ions using an ion source. A plurality of ion extractions are performed on the beam of ions using a TOF mass spectrometer. Electrical detections from each extraction are measured using an ADC, producing a mass sub-spectrum for each extraction. An ion m/z from the plurality of mass sub-spectra is selected. For each mass sub-spectrum, the amplitude and m/z of an ion within a m/z tolerance of the ion m/z is assigned to the corresponding amplitude band of a plurality of predetermined amplitude bands, producing a plurality of amplitude and m/z values for the each amplitude band. For each amplitude band of the plurality of predetermined amplitude bands, the plurality of amplitude and m/z values are combined into a peak, resulting in a plurality of peaks corresponding to the plurality of predetermined amplitude bands.

9. 发明申请

US20160233077A1 Systems and Methods for Arbitrary Quadrupole Transmission Windowing 有权
标题翻译：用于任意四极传输窗口的系统和方法
公开(公告)号：US20160233077A1
公开(公告)日：2016-08-11
申请号：US15026236
申请日：2014-10-07
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： James Walter Hager , Frank Londry , Nic G. Bloomfield
IPC分类号： H01J49/42 , H01J49/04 , H01J49/00
CPC分类号： H01J49/4215 , H01J49/0027 , H01J49/004 , H01J49/04 , H01J49/427
摘要： Systems and methods are provided for shaping an effective transmission window used to select precursor ions for a precursor mass range of a sequential windowed acquisition experiment. For at least one precursor mass range, an ion transfer function is selected that is a function of mass using a processor. A quadrupole mass filter that transmits ions from a sample is instructed to produce two or more transmission windows over time using the processor. The two or more transmission windows are produced to cumulatively create an effective transmission window for the at least one precursor mass range with a shape described by the ion transfer function.
摘要翻译：提供了系统和方法，用于形成用于选择前体离子的有效传输窗口用于顺序窗口采集实验的前体质量范围。对于至少一个前体质量范围，选择使用处理器作为质量的函数的离子传递函数。指示从样品传输离子的四极质量过滤器使用处理器随时间产生两个或更多个传输窗口。产生两个或更多个传输窗口以累积地产生具有由离子传递函数描述的形状的至少一个前体质量范围的有效传播窗口。

10. 发明申请

US20160189943A1 Intensity Correction for TOF Data Acquisition 有权
标题翻译： TOF数据采集强度校正
公开(公告)号：US20160189943A1
公开(公告)日：2016-06-30
申请号：US14907447
申请日：2014-08-07
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： Nic G. Bloomfield , Alexandre V. Loboda
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/0009 , H01J49/0036 , H01J49/025 , H01J49/40
摘要： Systems and methods are provided for correcting uniform detector saturation. In one method, a mass analyzer analyzes N extractions of an ion beam. A nonzero amplitude from an ADC detector subsystem is counted as one ion, producing a count of one for each ion of each sub-spectrum. The ADC amplitudes and counts of the N sub-spectra are summed, producing a spectrum that includes a summed ADC amplitude and a total count for each ion of the spectrum. A probability that the total count arises from single ions hitting the detector is calculated. For each ion of the spectrum where the probability exceeds a threshold value, an amplitude response is calculated, producing amplitude responses for ions found to be single ions hitting the detector. Amplitude responses are combined, producing a combined amplitude response. The total count is dynamically corrected using the combined amplitude response and the summed ADC amplitude.
摘要翻译：提供了系统和方法来校正均匀的检测器饱和度。在一种方法中，质量分析器分析离子束的N次提取。来自ADC检测器子系统的非零幅度被计为一个离子，为每个子光谱的每个离子产生一个计数。将N个子光谱的ADC幅度和计数相加，产生包括每个光谱离子的ADC幅度和总计数的谱的频谱。计算总计数来自单个离子撞击检测器的概率。对于概率超过阈值的频谱的每个离子，计算振幅响应，产生发现是单个离子撞击检测器的离子的振幅响应。振幅响应被组合，产生组合振幅响应。使用组合幅度响应和总和的ADC幅度动态校正总计数。

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