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1. 发明授权

US10167463B2 Modified chymosin polypeptides 有权
公开(公告)号：US10167463B2
公开(公告)日：2019-01-01
申请号：US14397865
申请日：2013-05-03
申请人： DSM IP ASSETS B.V.
发明人： Petrus Jacobus Theodorus Dekker , Rene Marcel De Jong , Michael Dennis Tabeling , Cornelis Marinus Muijlwijk
IPC分类号： C12N9/64 , A23C19/032 , A23C19/068 , A23C19/072
摘要： The invention relates to a polypeptide having chymosin activity which: a. is capable of hydrolyzing bovine alpha s1-casein at position F23F24 so as to form αs1-I CN (f24-199) more rapidly than camel chymosin; and b. has a C/P ratio higher than the C/P ratio of bovine chymosin.

2. 发明申请

US20180030427A1 CHYMOSINE ENZYME VARIANTS 审中-公开
公开(公告)号：US20180030427A1
公开(公告)日：2018-02-01
申请号：US15782528
申请日：2017-10-12
申请人： DSM IP ASSETS B.V.
发明人： Petrus Jacobus Theodorus DEKKER , Rene Marcel De Jong , Cornelis Marinus Muijlwijk
IPC分类号： C12N9/64 , A23C19/072 , A23C19/032 , A23C19/068
CPC分类号： C12N9/6483 , A23C19/032 , A23C19/0326 , A23C19/0684 , A23C19/072 , A23C2220/202 , A23C2250/15 , C12Y304/23004
摘要： A variant polypeptide having chymosin activity, wherein the variant has an amino acid sequence which, when aligned with the chymosin comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 2, 22, 40, 48, 50, 51, 53, 61, 62, 76, 88, 98, 99, 109, 112, 117, 125, 126, 135, 144, 160, 161, 163, 187, 189, 194, 200, 201, 202, 203, 221, 223, 240, 242, 244, 254, 267, 271, 273, 278, 280, 284, 289, 292, 294 or 295 said positions being defined with reference to SEQ ID NO: 2 and wherein the variant has one or more altered properties as compared with a reference polypeptide having chymosin activity. Such a variant polypeptide may be used in the preparation of a cheese.

3. 发明授权

US10655115B2 Carbohydrate degrading polypeptide and uses thereof 有权
公开(公告)号：US10655115B2
公开(公告)日：2020-05-19
申请号：US16250860
申请日：2019-01-17
申请人： DSM IP ASSETS B.V.
发明人： Alrik Pieter Los , Rene Marcel De Jong , Maaike Appeldoorn
IPC分类号： C12N9/24 , C12P19/02 , C12P19/12 , C12P19/14
摘要： The invention relates to a polypeptide having hemicellulase activity which comprises the amino acid sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, 6, 11, 16, 21, 26, 31, 36, 41, 46, 51, 56, 61, 66 or 71, SEQ ID NO: 4, 9, 14, 19, 24, 29, 34, 39, 44, 49, 54, 59, 64, 69 or 74, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 75% sequence identity with the sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72 or the variant polynucleotide encodes a polypeptide that has at least 75% sequence identity with the sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional protein and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.

4. 发明授权

US10000537B2 Polypeptides with permease activity 有权
公开(公告)号：US10000537B2
公开(公告)日：2018-06-19
申请号：US14895742
申请日：2014-06-04
申请人： DSM IP ASSETS B.V.
发明人： Paul Klaassen , Paulus Petrus De Waal , Rene Marcel De Jong , Arnold Jacob Mattieu Driessen , Jeroen Gerben Nijland , Hyun Yong Shin
IPC分类号： C12P21/06 , C12P19/34 , C12N15/00 , C12N1/00 , C07H21/04 , C07K1/00 , C07K14/395 , C12P19/02
CPC分类号： C07K14/395 , C12P19/02
摘要： The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS). In an embodiment, the substitution is at position corresponding to 376 and wherein the amino acid at that position is replaced by an amino acid that has a van der Waals volume of 80 to 138 Å3 and a side chain hydrophobicity of 10 to 100 ΔtR.

5. 发明授权

US09822352B2 Chymosine enzyme variants 有权
公开(公告)号：US09822352B2
公开(公告)日：2017-11-21
申请号：US14397866
申请日：2013-05-03
申请人： DSM IP ASSETS B.V.
发明人： Petrus Jacobus Theodorus Dekker , Rene Marcel De Jong , Cornelis Marinus Muijlwijk
IPC分类号： C12N9/64 , A23C19/032 , A23C19/068 , A23C19/072
CPC分类号： C12N9/6483 , A23C19/032 , A23C19/0326 , A23C19/0684 , A23C19/072 , A23C2220/202 , A23C2250/15 , C12Y304/23004
摘要： A variant polypeptide having chymosin activity, wherein the variant has an amino acid sequence which, when aligned with the chymosin comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 2, 22, 40, 48, 50, 51, 53, 61, 62, 76, 88, 98, 99, 109, 112, 117, 125, 126, 135, 144, 160, 161, 163, 187, 189, 194, 200, 201, 202, 203, 221, 223, 240, 242, 244, 254, 267, 271, 273, 278, 280, 284, 289, 292, 294 or 295 said positions being defined with reference to SEQ ID NO: 2 and wherein the variant has one or more altered properties as compared with a reference polypeptide having chymosin activity. Such a variant polypeptide may be used in the preparation of a cheese.

6. 发明授权

US10889807B2 Lipolytic enzyme variants 有权
公开(公告)号：US10889807B2
公开(公告)日：2021-01-12
申请号：US16471121
申请日：2017-12-19
申请人： DSM IP Assets B.V.
发明人： Rene Marcel De Jong , Chantal Christis , Neil Carr
IPC分类号： C12N15/00 , C12N9/16 , C12N9/18 , A21D8/04 , C12N9/20
摘要： The present disclosure describes a variant polypeptide having lipolytic activity, wherein the variant has an amino acid sequence which, when aligned with the amino acid sequence as set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue at a position corresponding to any of the positions 113, 122, 138, 141, 179, 282, 284, 286, 295,
said positions being defined with reference to SEQ ID NO: 2, and wherein said variant has at least 70% identity with the mature polypeptide having lipolytic activity as set out in SEQ ID NO: 2.
Such a variant polypeptide may be used in the preparation of a baked product.

7. 发明申请

US20190136213A1 CARBOHYDRATE DEGRADING POLYPEPTIDE AND USES THEREOF 审中-公开
公开(公告)号：US20190136213A1
公开(公告)日：2019-05-09
申请号：US16250860
申请日：2019-01-17
申请人： DSM IP ASSETS B.V.
发明人： Alrik Pieter LOS , Rene Marcel De Jong , Maaike Appeldoorn
IPC分类号： C12N9/24 , C12P19/14 , C12P19/02 , C12P19/12
摘要： The invention relates to a polypeptide having hemicellulase activity which comprises the amino acid sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, 6, 11, 16, 21, 26, 31, 36, 41, 46, 51, 56, 61, 66 or 71, SEQ ID NO: 4, 9, 14, 19, 24, 29, 34, 39, 44, 49, 54, 59, 64, 69 or 74, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 75% sequence identity with the sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72 or the variant polynucleotide encodes a polypeptide that has at least 75% sequence identity with the sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional protein and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.

8. 发明申请

US20170268012A1 PENTOSE SUGAR FERMENTING CELL 审中-公开
公开(公告)号：US20170268012A1
公开(公告)日：2017-09-21
申请号：US15612728
申请日：2017-06-02
申请人： DSM IP ASSETS B.V.
发明人： Paul KLAASSEN , Gijsberdina Pieternella Van Suylekom , Rene Marcel De Jong
IPC分类号： C12N15/81 , C12P5/02 , C12P7/10 , C12P7/56 , C12P7/54 , C12P7/48 , C12P7/46 , C12P7/42 , C12P35/00 , C12P7/20 , C12P7/18 , C12P7/16 , C12P7/06 , C12P7/40 , C12N9/92
CPC分类号： C12N15/81 , C12N9/92 , C12N15/815 , C12P5/026 , C12P7/06 , C12P7/10 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P35/00 , C12Y503/01005 , Y02E50/16 , Y02E50/17
摘要： The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least 75% sequence identity to the amino acid sequence set out in SEQ ID NO: 2 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.

9. 发明授权

US11447759B2 Carbohydrate degrading polypeptide and uses thereof 有权
公开(公告)号：US11447759B2
公开(公告)日：2022-09-20
申请号：US16788868
申请日：2020-02-12
申请人： DSM IP ASSETS B.V.
发明人： Alrik Pieter Los , Rene Marcel De Jong , Maaike Appeldoorn
IPC分类号： C12N9/24 , C12P19/02 , C12P19/12 , C12P19/14
摘要： The invention relates to a polypeptide having hemicellulase activity which comprises the amino acid sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, 6, 11, 16, 21, 26, 31, 36, 41, 46, 51, 56, 61, 66 or 71, SEQ ID NO: 4, 9, 14, 19, 24, 29, 34, 39, 44, 49, 54, 59, 64, 69 or 74, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 75% sequence identity with the sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72 or the variant polynucleotide encodes a polypeptide that has at least 75% sequence identity with the sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional protein and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.

10. 发明授权

US10829748B2 Mutant lipase and use thereof 有权
公开(公告)号：US10829748B2
公开(公告)日：2020-11-10
申请号：US16305348
申请日：2017-06-08
申请人： DSM IP Assets B.V.
发明人： Rene Marcel De Jong , Willem Bijleveld , Evert Tjeerd Van Rij
IPC分类号： C12N9/20 , C12N1/20 , C12N1/14 , C12N15/52 , C12N15/63 , A23C13/16 , A23C15/12 , A23C19/06 , A23C19/082
摘要： The present invention relates to a polypeptide having lipase activity wherein the polypeptide, which, when aligned with a polypeptide according to SEQ ID NO: 1, comprises at least one amino acid substitution resulting in Ser (S), Ala (A) or Leu (L) at position 246, Trp (W) at position 307, Leu (L) at position 345, Ile (I) at position 365, and/or Phe (F) at position 534, wherein the position is defined with reference to SEQ ID NO: 1, wherein Ala(A) at position 1 in SEQ ID NO: 1 is counted as number 1 and a method for preparing the polypeptide.The present invention further relates to a process for preparing a food product wherein a polypeptide according to the present invention is used.

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