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1. 发明申请

US20090198298A1 METHODS AND SYSTEMS FOR USE IN SELECTING CARDIAC PACING SITES 有权
标题翻译：用于选择心脏病网站的方法和系统
公开(公告)号：US20090198298A1
公开(公告)日：2009-08-06
申请号：US12421176
申请日：2009-04-09
申请人： Daniel R. Kaiser , Michael R. Neidert , Nicholas David Skadsberg , Kenneth C. Gardeski , Lawrence J. Mulligan , James F. Kelley , Michael B. Shelton , Trent M. Fischer
发明人： Daniel R. Kaiser , Michael R. Neidert , Nicholas David Skadsberg , Kenneth C. Gardeski , Lawrence J. Mulligan , James F. Kelley , Michael B. Shelton , Trent M. Fischer
IPC分类号： A61N1/365 , A61B5/05
CPC分类号： A61B5/1107 , A61B5/1104 , A61B5/686 , A61B5/6882 , A61B2562/0209 , A61N1/0573 , A61N1/3627 , A61N1/36578 , A61N1/368 , A61N1/3684 , A61N1/3686 , A61N2001/0585
摘要： A method and system for use in selecting a cardiac pacing site includes sensors for tracking wall motion (e.g., sensors coupled to the right and left ventricular heart wall). The wall motion of one or more non-paced cardiac cycles is compared to the wall motion of one or more paced cardiac cycles to determine the effectiveness of one or more pacing sites. For example, image data may be generated to notify the user as to the effectiveness of the one or more pacing sites.
摘要翻译：用于选择心脏起搏部位的方法和系统包括用于跟踪壁运动的传感器（例如耦合到右心室壁和左心室心壁的传感器）。将一个或多个非节奏心脏周期的壁运动与一个或多个节奏心动周期的壁运动进行比较，以确定一个或多个起搏部位的有效性。例如，可以生成图像数据以通知用户关于一个或多个起搏站点的有效性。

2. 发明授权

US08180428B2 Methods and systems for use in selecting cardiac pacing sites 有权
标题翻译：用于选择心脏起搏部位的方法和系统
公开(公告)号：US08180428B2
公开(公告)日：2012-05-15
申请号：US12421176
申请日：2009-04-09
申请人： Daniel R. Kaiser , Michael R. Neidert , Nicholas David Skadsberg , Kenneth C. Gardeski , Lawrence J. Mulligan , James F. Kelley , Michael B. Shelton , Trent M. Fischer
发明人： Daniel R. Kaiser , Michael R. Neidert , Nicholas David Skadsberg , Kenneth C. Gardeski , Lawrence J. Mulligan , James F. Kelley , Michael B. Shelton , Trent M. Fischer
IPC分类号： A61B5/00
CPC分类号： A61B5/1107 , A61B5/1104 , A61B5/686 , A61B5/6882 , A61B2562/0209 , A61N1/0573 , A61N1/3627 , A61N1/36578 , A61N1/368 , A61N1/3684 , A61N1/3686 , A61N2001/0585
摘要： A method and system for use in selecting a cardiac pacing site includes sensors for tracking wall motion (e.g., sensors coupled to the right and left ventricular heart wall). The wall motion of one or more non-paced cardiac cycles is compared to the wall motion of one or more paced cardiac cycles to determine the effectiveness of one or more pacing sites. For example, image data may be generated to notify the user as to the effectiveness of the one or more pacing sites.
摘要翻译：用于选择心脏起搏部位的方法和系统包括用于跟踪壁运动的传感器（例如耦合到右心室壁和左心室心壁的传感器）。将一个或多个非节奏心脏周期的壁运动与一个或多个节奏心动周期的壁运动进行比较，以确定一个或多个起搏部位的有效性。例如，可以生成图像数据以通知用户关于一个或多个起搏站点的有效性。

3. 发明申请

US20090125078A1 SELECTING CARDIAC PACING SITES 审中-公开
标题翻译：选择CARDIAC PACING SITES
公开(公告)号：US20090125078A1
公开(公告)日：2009-05-14
申请号：US12245570
申请日：2008-10-03
申请人： Daniel R. Kaiser , Michael R. Neidert , Nicholas D. Skadsberg , Kenneth G. Gardeski , Lawrence J. Mulligan , James F. Kelley , Michael B. Shelton , Trent M. Fischer
发明人： Daniel R. Kaiser , Michael R. Neidert , Nicholas D. Skadsberg , Kenneth G. Gardeski , Lawrence J. Mulligan , James F. Kelley , Michael B. Shelton , Trent M. Fischer
IPC分类号： A61N1/37
CPC分类号： A61N1/368 , A61B5/042 , A61B5/062 , A61B5/1104 , A61B5/1107 , A61B5/686 , A61B5/6882 , A61N1/0573 , A61N1/3627 , A61N1/36578 , A61N1/3684 , A61N1/3686
摘要： A method for selecting a cardiac pacing site includes steps of: securing first and second electromagnetic receiver coils at first and second positions, respectively, along a heart wall; collecting a set of non-paced heart wall motion data from each of the coils secured at the corresponding positions; applying cardiac pacing stimulation at at least one first pacing site; collecting a first set of paced heart wall motion data from each of the secured coils; comparing the non-paced heart wall motion data to the first set of paced heart wall motion data; and determining, based on the comparing, whether to maintain pacing at the at least one first cardiac pacing site or to apply pacing stimulation at a second pacing site for collection of a second set of paced heart wall motion data. The at least one first pacing site may include a right ventricular site and a left ventricular site.
摘要翻译：用于选择心脏起搏部位的方法包括以下步骤：分别沿心壁将第一和第二电磁接收线圈固定在第一和第二位置; 从固定在相应位置的每个线圈收集一组无节奏的心壁运动数据; 在至少一个第一起搏部位应用心脏起搏刺激; 从每个固定线圈收集第一组起搏心壁运动数据; 将不起搏的心脏壁运动数据与第一组起搏心脏壁运动数据进行比较; 以及基于所述比较确定是否在所述至少一个第一心脏起搏部位保持起搏，或者在第二起搏部位施加起搏刺激，以收集第二组起搏心脏壁运动数据。至少一个第一起搏部位可以包括右心室部位和左心室部位。

4. 发明申请

US20110029034A1 ALGORITHM TO MODULATE ATRIAL-VENTRICULAR DELAY AND RATE RESPONSE BASED ON AUTONOMIC FUNCTION 有权
标题翻译：基于自动功能调节心律延迟和速率响应的算法
公开(公告)号：US20110029034A1
公开(公告)日：2011-02-03
申请号：US12787058
申请日：2010-05-25
申请人： Trent M. Fischer , Douglas A. Hettrick , Todd J. Sheldon , Paul A. Belk , Thomas J. Mullen , John C. Rueter , Daniel R. Kaiser
发明人： Trent M. Fischer , Douglas A. Hettrick , Todd J. Sheldon , Paul A. Belk , Thomas J. Mullen , John C. Rueter , Daniel R. Kaiser
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0456 , A61N1/36514 , A61N1/36542 , A61N1/36557 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3688
摘要： An implantable medical device and associated method provide atrial pacing and measure an atrial ventricular (AV) delay. An autonomic function index is computed using the AV delay. The autonomic function index may be compiled in a medical report. In some embodiments, the autonomic function index is used to adjust atrial pacing control parameters.
摘要翻译：可植入医疗器械和相关方法提供心房起搏并测量心房（AV）延迟。使用AV延迟计算自主功能指数。自主功能指数可以在医疗报告中编制。在一些实施例中，自主功能指数用于调节心房起搏控制参数。

5. 发明授权

US09037237B2 Algorithm to modulate atrial-ventricular delay and rate response based on autonomic function 有权
标题翻译：基于自主功能调制心房延迟和速率反应的算法
公开(公告)号：US09037237B2
公开(公告)日：2015-05-19
申请号：US12787058
申请日：2010-05-25
申请人： Trent M. Fischer , Douglas A. Hettrick , Todd J. Sheldon , Paul A. Belk , Thomas J. Mullen , John C. Rueter , Daniel R. Kaiser
发明人： Trent M. Fischer , Douglas A. Hettrick , Todd J. Sheldon , Paul A. Belk , Thomas J. Mullen , John C. Rueter , Daniel R. Kaiser
IPC分类号： A61N1/368 , A61N1/362 , A61N1/365 , A61B5/0456
CPC分类号： A61N1/3627 , A61B5/0456 , A61N1/36514 , A61N1/36542 , A61N1/36557 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3688
摘要： An implantable medical device and associated method provide atrial pacing and measure an atrial ventricular (AV) delay. An autonomic function index is computed using the AV delay. The autonomic function index may be compiled in a medical report. In some embodiments, the autonomic function index is used to adjust atrial pacing control parameters.
摘要翻译：可植入医疗器械和相关方法提供心房起搏并测量心房（AV）延迟。使用AV延迟计算自主功能指数。自主功能指数可以在医疗报告中编制。在一些实施例中，自主功能指数用于调节心房起搏控制参数。

6. 发明授权

US09386927B2 Implantable blood pressure monitor 有权
标题翻译：可植入血压计
公开(公告)号：US09386927B2
公开(公告)日：2016-07-12
申请号：US12510370
申请日：2009-07-28
申请人： Daniel R. Kaiser
发明人： Daniel R. Kaiser
IPC分类号： A61B5/08 , A61B5/0215 , A61B5/04 , A61N1/36 , A61B5/00 , A61N1/365
CPC分类号： A61B5/0215 , A61B5/0031 , A61B5/04001 , A61B5/6846 , A61B5/7405 , A61B5/7455 , A61N1/36114 , A61N1/36117 , A61N1/36135 , A61N1/36564 , G06F19/00
摘要： A method for monitoring blood pressure includes sensing and storing sympathetic nerve activity data of a patient via a recording lead of an implantable medical device. Changes in sympathetic nerve activity from the nerve activity data are determined. Corresponding changes in blood pressure are determined from the changes in sympathetic nerve activity. An alert signal and/or modification of therapy can be provided.
摘要翻译：用于监测血压的方法包括通过可植入医疗装置的记录引线感测和存储患者的交感神经活动数据。确定神经活动数据中交感神经活动的变化。相应的血压变化由交感神经活动的变化决定。可以提供警报信号和/或治疗的修改。

7. 发明授权

US08755881B2 Pacing therapy adjustment based on ventriculo-atrial delay 有权
标题翻译：基于心房 - 心房延迟的起搏治疗调整
公开(公告)号：US08755881B2
公开(公告)日：2014-06-17
申请号：US12363439
申请日：2009-01-30
申请人： Daniel R. Kaiser , Nicholas D. Skadsberg , Steven R. Hornberger , Thomas J. Mullen
发明人： Daniel R. Kaiser , Nicholas D. Skadsberg , Steven R. Hornberger , Thomas J. Mullen
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3682
摘要： Techniques for adjusting pacing therapy based on ventriculo-atrial delay are described herein. These techniques may be used to control ventricular filling times during the delivery of pacing therapy. In some examples, a device or system delivers pre-excitation fusion pacing therapy to a ventricular chamber, determines a ventriculo-atrial delay interval for the ventricular chamber for at least one cardiac cycle, and adjusts the pacing therapy delivered by the implantable medical device to compensate for decreased ventricular filling time when the ventriculo-atrial delay interval is less than a threshold. In some examples, the device or system may adjust the pacing therapy by decreasing a pacing rate of the implantable medical device, increasing a pre-excitation interval for pacing of the ventricular chamber, and/or switching from a fusion pacing mode to a biventricular pacing mode.
摘要翻译：本文描述了基于心房 - 心房延迟来调节起搏治疗的技术。这些技术可用于控制起搏治疗期间的心室充盈时间。在一些示例中，装置或系统将预激发融合起搏治疗递送至心室，确定心室至少一个心动周期的心房 - 心房延迟间隔，并调整由可植入医疗装置递送的起搏疗法补偿当心室 - 心房延迟间隔小于阈值时心室充盈时间减少。在一些示例中，装置或系统可以通过降低可植入医疗装置的起搏速率，增加心室的起搏间隔和/或从融合起搏模式切换到双心室起搏来调节起搏治疗模式。

8. 发明授权

US08423141B2 Pre-excitation stimulus timing based on mechanical event 有权
标题翻译：基于机械事件的预激励刺激时序
公开(公告)号：US08423141B2
公开(公告)日：2013-04-16
申请号：US12363147
申请日：2009-01-30
申请人： Daniel R. Kaiser
发明人： Daniel R. Kaiser
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36564 , A61N1/36578 , A61N1/3682
摘要： Techniques for determining when to deliver a pre-excitation signal to damaged cardiac tissue, e.g., infarct tissue, of a ventricle during cardiac pacing are described. A medical device detects an intrinsic or paced atrial depolarization, and then detects a subsequent mechanical event, e.g., contraction, in a ventricle. As examples, the mechanical event may be detected by measuring ventricular movement, or changes in intracardiac or systemic blood pressure. The medical device determines an interval between the atrial depolarization and the ventricular mechanical event, which may be referred to as an A-Vm interval. By subtracting a pre-excitation interval (PEI) from the A-Vm, the medical device determines an A-V interval between an atrial depolarization and delivery of the pre-excitation signal.
摘要翻译：描述了用于在心脏起搏期间确定何时向心脏组织（例如心肌组织）传递预激发信号的技术。医疗装置检测内在或节奏的心房去极化，然后检测心室中随后的机械事件，例如收缩。作为示例，机械事件可以通过测量心室移动或心脏内或全身血压的变化来检测。医疗设备确定心房去极化和心室机械事件之间的间隔，其可被称为A-Vm间隔。通过从A-Vm中减去预激励间隔（PEI），医疗设备确定心房去极化和预激励信号传递之间的A-V间隔。

9. 发明授权

US07697985B2 System and method for providing alternative pacing modality selection 有权
标题翻译：提供替代起搏模式选择的系统和方法
公开(公告)号：US07697985B2
公开(公告)日：2010-04-13
申请号：US11189488
申请日：2005-07-26
申请人： Daniel R. Kaiser , John E. Burnes , Thomas J. Mullen
发明人： Daniel R. Kaiser , John E. Burnes , Thomas J. Mullen
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684 , A61N1/371 , A61N2001/083
摘要： An implantable medical device (IMD) identifies lead performance issues and provides alternative lead configurations to continue with the programmed therapy. In the absence of an appropriate alternatively lead configuration, the IMD determines alternative mechanisms to provide a similar therapy or to determine a secondary therapy.
摘要翻译：可植入医疗器械（IMD）可以识别铅的性能问题，并提供替代的导线配置来继续编程治疗。在没有适当的替代引导配置的情况下，IMD确定提供类似疗法或确定次级治疗的替代机制。

10. 发明申请

US20100198294A1 PRE-EXCITATION STIMULUS TIMING BASED ON MECHANICAL EVENT 有权
标题翻译：基于机械事件的预激励时序
公开(公告)号：US20100198294A1
公开(公告)日：2010-08-05
申请号：US12363147
申请日：2009-01-30
申请人： Daniel R. Kaiser
发明人： Daniel R. Kaiser
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36564 , A61N1/36578 , A61N1/3682
摘要： Techniques for determining when to deliver a pre-excitation signal to damaged cardiac tissue, e.g., infarct tissue, of a ventricle during cardiac pacing are described. A medical device detects an intrinsic or paced atrial depolarization, and then detects a subsequent mechanical event, e.g., contraction, in a ventricle. As examples, the mechanical event may be detected by measuring ventricular movement, or changes in intracardiac or systemic blood pressure. The medical device determines an interval between the atrial depolarization and the ventricular mechanical event, which may be referred to as an A-Vm interval. By subtracting a pre-excitation interval (PEI) from the A-Vm, the medical device determines an A-V interval between an atrial depolarization and delivery of the pre-excitation signal.
摘要翻译：描述了用于在心脏起搏期间确定何时向心脏组织（例如心肌组织）传递预激发信号的技术。医疗装置检测内在或节奏的心房去极化，然后检测心室中随后的机械事件，例如收缩。作为示例，机械事件可以通过测量心室移动或心脏内或全身血压的变化来检测。医疗设备确定心房去极化和心室机械事件之间的间隔，其可被称为A-Vm间隔。通过从A-Vm中减去预激励间隔（PEI），医疗设备确定心房去极化和预激励信号传递之间的A-V间隔。

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