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    • 4. 发明授权
    • Engine cooling system and thermostat with improved bypass control
    • 发动机冷却系统和恒温器,具有改进的旁路控制
    • US5967101A
    • 1999-10-19
    • US71245
    • 1998-05-01
    • David B. RothLarry S. Rogosin
    • David B. RothLarry S. Rogosin
    • F01P7/16G05D23/13F01P3/00
    • G05D23/1326F01P7/16G05D23/134F01P2037/02F01P2060/08
    • This liquid cooling system for internal combustion engines employs a double acting thermostat to prevent coolant temperature fluctuation over a large range of engine loads and speeds and to selectively block coolant flow through the bypass circuit so that the heater and defrost circuit at engine start up and idle will have optimal flow from the coolant pump through the engine for quick heat and defrost purposes. With increased engine speed for vehicle operation, the pump increases coolant flow and pressure, causing the thermostat to open the bypass circuit in parallel with the heater core circuit. This increases flow capacity of the system and eliminate pump cavitation to enhance pump efficiency and system service life. At predetermined higher coolant temperatures, a pellet in the thermostat expands to effect thermostat opening of the high capacity radiator circuit of the system and closing the bypass circuit so that efficiency is further increased and excessive heat energy is effectively dissipated from the coolant.
    • 用于内燃机的液体冷却系统采用双作用恒温器来防止在大范围的发动机负载和速度下的冷却剂温度波动,并且选择性地阻止通过旁路回路的冷却剂流动,使得发动机起动和空转时的加热器和除霜回路 将具有来自冷却剂泵通过发动机的最佳流量,用于快速加热和除霜目的。 随着车辆运行的发动机转速的增加,泵增加冷却剂流量和压力,导致恒温器与加热器核心电路并联打开旁路电路。 这增加了系统的流量并消除了泵气蚀,提高了泵的效率和系统使用寿命。 在预定的较高冷却剂温度下,恒温器中的颗粒膨胀以实现系统的高容量散热器电路的恒温开启并关闭旁路电路,从而进一步提高效率,并从冷却剂中有效地散发过多的热能。
    • 7. 发明授权
    • Compositions, kits, and methods for stimulation of homologous recombination
    • 用于刺激同源重组的组合物,试剂盒和方法
    • US07604995B2
    • 2009-10-20
    • US10887593
    • 2004-07-09
    • David B. RothGregory S. Lee
    • David B. RothGregory S. Lee
    • C12N15/87C12N15/00C12N15/64C12P19/34
    • C12N15/1082
    • A method of stimulating homologous recombination by creating at least one nick in a targeted polynucleotide sequence. Wherein nonhomologous recombination is suppressed resulting in increasing the ratio of targeted to nontargeted events. A method of increasing double strand break-initiated gene targeting by inducing a nick in a targeted polynucleotide sequence, wherein overall recombination levels are increased. A method of increasing homologous recombination employing a recombinase that releases the ends in living cells by stimulating homolgous recombination to higher levels than those attainable with standard nucleases. A composition for stimulating homologous recombination including a nicking mechanism for creating nicks in a polynucleotide, wherein the nicking mechanism stimulates homologous recombination. A composition for stimulating homologous recombination including a nicking endonucleases. Various kits for stimulating homologous recombination. A method for modulating and channeling site-specific DNA stand breaks by shepherding the DNA strand breaks to particular recombination pathways.
    • 通过在靶向多核苷酸序列中产生至少一个切口来刺激同源重组的方法。 其中非同源重组被抑制,导致增加靶向与非靶向事件的比例。 通过在靶向多核苷酸序列中诱导缺口来增加双链断裂启动的基因靶向的方法,其中总复合水平增加。 使用重组酶增加同源重组的方法,所述重组酶通过刺激同源重组达到比标准核酸酶可达到的水平更高的水平而释放活细胞中的末端。 用于刺激同源重组的组合物,其包括用于在多核苷酸中产生切口的切口机制,其中所述切口机制刺激同源重组。 用于刺激同源重组的组合物,包括切口内切核酸酶。 用于刺激同源重组的各种试剂盒。 通过将DNA链断裂转移到特定的重组途径来调节和引导位点特异性DNA的方法来破坏。
    • 8. 发明申请
    • ENGINE AIR BOOST SYSTEM
    • 发动机升压系统
    • US20090044788A1
    • 2009-02-19
    • US12132837
    • 2008-06-04
    • John ShuttyPhilip S. KellerThomas GrissomDavid WhiteDavid B. Roth
    • John ShuttyPhilip S. KellerThomas GrissomDavid WhiteDavid B. Roth
    • F02B33/00F02M37/04
    • F02B21/00F02B37/10Y02T10/144
    • One implementation of an air boost system for an engine includes a boost device and an accumulator adapted to store pressurized fluid and selectively provide pressurized fluid to the boost device. A pump may deliver fluid under pressure to one or both of the accumulator and the boost device in at least some operating conditions. A first control valve may be disposed between the pump and the accumulator to control fluid flow to the accumulator, and a bypass may be provided between the pump and the first control valve. The bypass may, in at least some operating conditions, permit at least some of the pressurized fluid from the pump to bypass the accumulator and be delivered to the boost device. In one form, the accumulator is carried by the boost device in a compact unit.
    • 用于发动机的空气增压系统的一个实施方式包括升压装置和蓄能器,其适于存储加压流体并且选择性地向加压装置提供加压流体。 在至少一些操作条件下,泵可以将压力下的液体输送到蓄能器和升压装置中的一个或两个。 第一控制阀可以设置在泵和蓄能器之间以控制流向蓄能器的流体流动,并且可以在泵和第一控制阀之间设置旁路。 在至少一些操作条件下,旁路可允许来自泵的至少一些加压流体绕过蓄能器并被输送到升压装置。 在一种形式中,蓄能器由升压装置以紧凑的单元承载。