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1. 发明授权

US08273900B2 Organic compounds 有权
标题翻译：有机化合物
公开(公告)号：US08273900B2
公开(公告)日：2012-09-25
申请号：US12462318
申请日：2009-07-31
申请人： David Beattie , Anny-Odile Colson , Andrew James Culshaw , Lisa Sharp , Emily Stanley , Lilya Sviridenko
发明人： David Beattie , Anny-Odile Colson , Andrew James Culshaw , Lisa Sharp , Emily Stanley , Lilya Sviridenko
IPC分类号： C07D231/00
CPC分类号： A61K31/5377 , A61K31/166 , A61K31/415 , A61K31/426 , A61K31/44 , A61K31/4406 , A61K45/06 , C07C233/79 , C07C255/58 , C07C311/39 , C07C317/28 , C07C2601/14 , C07D209/08 , C07D213/74 , C07D213/82 , C07D213/84 , C07D215/38 , C07D231/12 , C07D231/16 , C07D231/38 , C07D231/56 , C07D233/61 , C07D233/64 , C07D239/42 , C07D249/12 , C07D249/14 , C07D257/04 , C07D257/06 , C07D261/14 , C07D277/04 , C07D277/42 , C07D295/135 , C07D401/04 , C07D401/12 , C07D403/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： There are described cyclohexyl amide derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists.
摘要翻译：描述了可用作促肾上腺皮质激素释放因子（CRF1）受体拮抗剂的环己基酰胺衍生物。

2. 发明申请

US20100035898A1 Organic compounds 有权
标题翻译：有机化合物
公开(公告)号：US20100035898A1
公开(公告)日：2010-02-11
申请号：US12462318
申请日：2009-07-31
申请人： David Beattie , Anny-Odile Colson , Andrew James Culshaw , Lisa Sharp , Emily Stanley , Lilya Sviridenko
发明人： David Beattie , Anny-Odile Colson , Andrew James Culshaw , Lisa Sharp , Emily Stanley , Lilya Sviridenko
IPC分类号： A61K31/519 , A61K31/437 , A61K31/44 , A61K31/425 , C07D487/00 , C07D471/02 , C07D401/12 , C07D277/04
CPC分类号： A61K31/5377 , A61K31/166 , A61K31/415 , A61K31/426 , A61K31/44 , A61K31/4406 , A61K45/06 , C07C233/79 , C07C255/58 , C07C311/39 , C07C317/28 , C07C2601/14 , C07D209/08 , C07D213/74 , C07D213/82 , C07D213/84 , C07D215/38 , C07D231/12 , C07D231/16 , C07D231/38 , C07D231/56 , C07D233/61 , C07D233/64 , C07D239/42 , C07D249/12 , C07D249/14 , C07D257/04 , C07D257/06 , C07D261/14 , C07D277/04 , C07D277/42 , C07D295/135 , C07D401/04 , C07D401/12 , C07D403/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： There are described cyclohexyl amide derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists.
摘要翻译：描述了可用作促肾上腺皮质激素释放因子（CRF1）受体拮抗剂的环己基酰胺衍生物。

3. 发明申请

US20110152261A1 Organic compounds 有权
标题翻译：有机化合物
公开(公告)号：US20110152261A1
公开(公告)日：2011-06-23
申请号：US13057015
申请日：2009-08-05
申请人： David Beattie , Anny-Odile Colson , Andrew James Culshaw , Lisa Rooney , Emily Stanley , Lilya Sviridenko
发明人： David Beattie , Anny-Odile Colson , Andrew James Culshaw , Lisa Rooney , Emily Stanley , Lilya Sviridenko
IPC分类号： A61K31/5377 , C07C233/79 , A61P1/00 , A61P1/12 , A61P1/04 , A61K31/166 , C07D213/74 , A61K31/4406 , C07D413/04 , C07D231/38 , A61K31/415 , C07D277/42 , A61K31/426 , C07D277/82 , A61K31/428 , A61K31/4184 , C07D235/30 , C07D241/20 , A61K31/4965
CPC分类号： A61K31/5377 , A61K31/166 , A61K31/415 , A61K31/426 , A61K31/44 , A61K31/4406 , A61K45/06 , C07C233/79 , C07C255/58 , C07C311/39 , C07C317/28 , C07C2601/14 , C07D209/08 , C07D213/74 , C07D213/82 , C07D213/84 , C07D215/38 , C07D231/12 , C07D231/16 , C07D231/38 , C07D231/56 , C07D233/61 , C07D233/64 , C07D239/42 , C07D249/12 , C07D249/14 , C07D257/04 , C07D257/06 , C07D261/14 , C07D277/04 , C07D277/42 , C07D295/135 , C07D401/04 , C07D401/12 , C07D403/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： There are described cyclohexyl amide derivatives useful as corticotropin releasing (CRF1) receptor antagonists.
摘要翻译：描述了可用作促肾上腺皮质激素释放（CRF1）受体拮抗剂的环己基酰胺衍生物。

4. 发明授权

US08835444B2 Cyclohexyl amide derivatives as CRF receptor antagonists 有权
标题翻译：环己基酰胺衍生物作为CRF受体拮抗剂
公开(公告)号：US08835444B2
公开(公告)日：2014-09-16
申请号：US13576040
申请日：2011-01-31
申请人： David Beattie , Ian Bruce , Anny-Odile Colson , Andrew James Culshaw , Thomas Sharp
发明人： David Beattie , Ian Bruce , Anny-Odile Colson , Andrew James Culshaw , Thomas Sharp
IPC分类号： C07C233/79 , C07D213/82 , C07D231/12 , C07D231/38 , C07D249/08 , C07D401/12 , C07D231/16 , C07D473/00 , C07D231/54 , C07D231/14 , C07D405/04 , C07D491/052 , C07D231/20 , C07D231/56 , C07D401/04 , C07D471/04 , C07D401/14
CPC分类号： C07D213/82 , C07C233/79 , C07C2601/14 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/20 , C07D231/38 , C07D231/54 , C07D231/56 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D471/04 , C07D473/00 , C07D491/052
摘要： There are described cyclohexyl amide derivatives useful as corticotropin releasing factor (CRF) receptor antagonists Formula (I).
摘要翻译：描述了可用作促肾上腺皮质激素释放因子（CRF）受体拮抗剂式（I）的环己基酰胺衍生物。

5. 发明申请

US20120316185A1 Cyclohexyl Amide Derivatives as CRF Receptor Antagonists 有权
标题翻译：环己基酰胺衍生物作为CRF受体拮抗剂
公开(公告)号：US20120316185A1
公开(公告)日：2012-12-13
申请号：US13576040
申请日：2011-01-31
申请人： David Beattie , Ian Bruce , Anny-Odile Colson , Andrew James Culshaw , Thomas Sharp
发明人： David Beattie , Ian Bruce , Anny-Odile Colson , Andrew James Culshaw , Thomas Sharp
IPC分类号： A61K31/4439 , C07D471/04 , A61K31/437 , A61P5/04 , A61K31/519 , C07D473/00 , A61K31/52 , C07D401/12 , C07D487/04
CPC分类号： C07D213/82 , C07C233/79 , C07C2601/14 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/20 , C07D231/38 , C07D231/54 , C07D231/56 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D471/04 , C07D473/00 , C07D491/052
摘要： There are described cyclohexyl amide derivatives useful as corticotropin releasing factor (CRF) receptor antagonists Formula (I).
摘要翻译：描述了可用作促肾上腺皮质激素释放因子（CRF）受体拮抗剂式（I）的环己基酰胺衍生物。

6. 发明申请

US20050010031A1 Melanocortin receptor ligands 失效
标题翻译：黑皮质素受体配体
公开(公告)号：US20050010031A1
公开(公告)日：2005-01-13
申请号：US10689022
申请日：2003-10-20
申请人： Frank Ebetino , Xinrong Tian , Wieslaw Mazur , Anny-Odile Colson
发明人： Frank Ebetino , Xinrong Tian , Wieslaw Mazur , Anny-Odile Colson
IPC分类号： C07D241/04 , C07D241/08 , C07D401/12 , C07D403/12 , C07K14/72
CPC分类号： C07D401/12 , C07D241/04 , C07D241/08 , C07D403/12
摘要： The present invention relates to compounds which comprise a nitrogen-containing ring scaffold substituted by an R1 alkyl units selected from the group consisting of C1-C12 linear or branched alkyl, C3-C8 cyclic alkyl, C2-C12 linear or branched alkenyl, or haloalkyl, for example, the 2-keto-3-alkylpiperazines having the formula: wherein R is selected from the group consisting of phenyl, 3-fluorophenyl, 4-fluorophenyl, 3,5-difluorophenyl, and 4-chlorophenyl; R1 is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, cyclopropyl, cyclopropylmethyl, cyclopentyl, cyclopentylmethyl, cyclohexyl, cyclohexylmethyl, benzyl, allyl, 1-methylallyl, 2-methylallyl, but-2-enyl, and propargyll; R7a is selected from the group consisting of hydrogen, —CO2H, —CONH2, —CONHCH3, and —CON(CH3)2; R8 is benzyl, substituted benzyl, or naphthalen-2-ylmethyl.
摘要翻译：本发明涉及包含由选自C 1 -C 12直链或支链烷基，C 3 -C 8环烷基，C 2 -C 12直链或支链烯基的C 1 -C 12烷基单元取代的含氮环支架的化合物或卤代烷基，例如具有下式的2-酮-3-烷基哌嗪：其中R选自苯基，3-氟苯基，4-氟苯基，3,5-二氟苯基和4-氯苯基; R 1选自甲基，乙基，丙基，异丙基，丁基，异丁基，仲丁基，叔丁基，环丙基，环丙基甲基，环戊基，环戊基甲基，环己基，环己基甲基，苄基，烯丙基，1-甲基烯丙基，2-甲基烯丙基，丁-2-烯基和炔丙基; R 7a选自氢，-CO 2 H，-CONH 2，-CONHCH 3和-CON（CH 3）2; R 8是苄基，取代的苄基或萘-2-基甲基。

7. 发明申请

US20100048633A1 Piperidine-4-acrylamides 审中-公开
标题翻译：哌啶-4-丙烯酰胺
公开(公告)号：US20100048633A1
公开(公告)日：2010-02-25
申请号：US12523130
申请日：2008-01-29
申请人： Philipp Lehr , Klaus Weigand , Anny-Odile Colson
发明人： Philipp Lehr , Klaus Weigand , Anny-Odile Colson
IPC分类号： A61K31/445 , C07D211/34 , C07D401/12 , A61K31/454 , A61P29/00
CPC分类号： C07D211/70 , C07D401/12
摘要： A compound of formula (I), wherein substituents are as given above, useful in the treatment of a disease mediated by the action of CCR3.
摘要翻译：式（I）化合物，其中取代基如上所述，可用于治疗由CCR3的作用介导的疾病。

8. 发明申请

US20060247224A1 Melanocortin receptor ligands 审中-公开
公开(公告)号：US20060247224A1
公开(公告)日：2006-11-02
申请号：US11473972
申请日：2006-06-23
申请人： Frank Ebetino , Xinrong Tian , Wieslaw Mazur , Anny-Odile Colson
发明人： Frank Ebetino , Xinrong Tian , Wieslaw Mazur , Anny-Odile Colson
IPC分类号： A61K31/496 , C07D409/02 , C07D405/02 , C07D403/02
CPC分类号： C07D401/12 , C07D241/04 , C07D241/08 , C07D403/12
摘要： The present invention relates to compounds which comprise a nitrogen-containing ring scaffold substituted by an R1 alkyl units selected from the group consisting of C1-C12 linear or branched alkyl, C3-C8 cyclic alkyl, C2-C12 linear or branched alkenyl, or haloalkyl, for example, the 2-keto-3-alkylpiperazines having the formula: wherein R is selected from the group consisting of phenyl, 3-fluorophenyl, 4-fluorophenyl, 3,5-difluorophenyl, and 4-chlorophenyl; R1 is selected from the group consisting of methyl, ethyl, propyl, iso-propyl, butyl, iso-butyl, sec-butyl, tert-butyl, cyclopropyl, cyclopropylmethyl, cyclopentyl, cyclopentylmethyl, cyclohexyl, cyclohexylmethyl, benzyl, allyl, 1-methylallyl, 2-methylallyl, but-2-enyl, and propargyll; R7a is selected from the group consisting of hydrogen, —CO2H, —CONH2, —CONHCH3, and —CON(CH3)2; R8 is benzyl, substituted benzyl, or naphthalen-2-ylmethyl.

9. 发明申请

US20050170433A1 Three dimensional coordinates of melanin-concentrating hormone receptors 审中-公开
标题翻译：黑色素浓缩激素受体的三维坐标
公开(公告)号：US20050170433A1
公开(公告)日：2005-08-04
申请号：US10414522
申请日：2003-04-15
申请人： Glen Mieling , Katherine Mieling , Rodney Bush , Anny-Odile Colson
发明人： Glen Mieling , Katherine Mieling , Rodney Bush , Anny-Odile Colson
IPC分类号： G01N33/48 , G01N33/50 , G01N33/53 , G01N33/567 , G01N33/68 , G06F19/00
CPC分类号： G01N33/6803 , C07K2299/00 , G01N2333/726 , G01N2500/04
摘要： Three-dimensional coordinates of melanin-concentrating hormone receptors are useful in computer aided drug design.
摘要翻译：黑色素浓缩激素受体的三维坐标可用于计算机辅助药物设计。

10. 发明授权

US07132539B2 Melanocortin receptor ligands 失效
标题翻译：黑皮质素受体配体
公开(公告)号：US07132539B2
公开(公告)日：2006-11-07
申请号：US10689022
申请日：2003-10-20
申请人： Frank Hallock Ebetino , Xinrong Tian , Wieslaw Adam Mazur , Anny-Odile Colson
发明人： Frank Hallock Ebetino , Xinrong Tian , Wieslaw Adam Mazur , Anny-Odile Colson
IPC分类号： C07D403/12 , C07D241/04 , A61K31/495 , A61K31/496
CPC分类号： C07D401/12 , C07D241/04 , C07D241/08 , C07D403/12
摘要： The present invention relates to compounds which comprise a nitrogen-containing ring scaffold substituted by an R1 alkyl units selected from the group consisting of C1–C12 linear or branched alkyl, C3–C8 cyclic alkyl, C2–C12 linear or branched alkenyl, or haloalkyl, for example, the 2-keto-3-alkylpiperazines having the formula: wherein R is selected from the group consisting of phenyl, 3-fluorophenyl, 4-fluorophenyl, 3,5-difluorophenyl, and 4-chlorophenyl; R1 is selected from the group consisting of methyl, ethyl, propyl, iso-propyl, butyl, iso-butyl, sec-butyl, tert-butyl, cyclopropyl, cyclopropylmethyl, cyclopentyl, cyclopentylmethyl, cyclohexyl, cyclohexylmethyl, benzyl, allyl, 1-methylallyl, 2-methylallyl, but-2-enyl, and propargyll; R7a is selected from the group consisting of hydrogen, —CO2H, —CONH2, —CONHCH3, and —CON(CH3)2; R8 is benzyl, substituted benzyl, or naphthalen-2-ylmethyl.
摘要翻译：本发明涉及包含由选自C 1 -C 12烷基的R 1烷基单元取代的含氮环支架的化合物，直链或支链烷基，C 3 -C 8环烷基，C 2 -C 12直链状或支链烯基或卤代烷基，例如具有下式的2-酮-3-烷基哌嗪：其中R选自苯基，3-氟苯基，4-氟苯基，3,5-二氟苯基和4-氟苯基，氯苯基; R 1选自甲基，乙基，丙基，异丙基，丁基，异丁基，仲丁基，叔丁基，环丙基，环丙基甲基，环戊基，环戊基甲基，环己基，环己基甲基，苄基，烯丙基，1-甲基烯丙基，2-甲基烯丙基，丁-2-烯基和炔丙基; R 7a选自氢，-CO 2 H，-CONH 2，-CONHCH 3，/ SUB >和-CON（CH 3 3）2。 R 8是苄基，取代的苄基或萘-2-基甲基。

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