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1. 发明授权

US08986733B2 Materials and methods for nerve repair 有权
公开(公告)号：US08986733B2
公开(公告)日：2015-03-24
申请号：US12966540
申请日：2010-12-13
申请人： David F. Muir
发明人： David F. Muir
IPC分类号： A61K38/51 , A61K35/30 , A61L27/22 , A61L27/36 , A61L27/38 , A61L31/04
CPC分类号： A61L27/3687 , A61K35/30 , A61K38/51 , A61L27/227 , A61L27/3604 , A61L27/3675 , A61L27/3683 , A61L27/383 , A61L27/3878 , A61L31/047 , A61L2430/32 , A61K2300/00
摘要： The subject invention pertains to compositions and methods for promoting repair of damaged nerve tissue. The compositions and methods of the subject invention can be employed to restore the continuity of nerve interrupted by disease, traumatic events or surgical procedures. Compositions of the subject invention comprise one or more chondroitin sulfate proteoglycan (CSPG)-degrading enzymes that promote axonal penetration into damaged nerve tissue. The invention also concerns methods for promoting repair of damaged nerve tissue using the present compositions and nerve tissue treated according to such methods. The invention also pertains to kits for nerve repair.

2. 发明授权

US09386990B2 Nerve repair with a hydrogel and adhesive 有权
标题翻译：神经修复与水凝胶和粘合剂
公开(公告)号：US09386990B2
公开(公告)日：2016-07-12
申请号：US12922725
申请日：2009-03-19
申请人： David F. Muir , James B. Graham , Debbie Neubauer
发明人： David F. Muir , James B. Graham , Debbie Neubauer
IPC分类号： A61B17/11 , A61L24/00 , A61L24/04 , A61L24/10 , A61L27/18 , A61L27/52 , A61L31/14
CPC分类号： A61B17/1128 , A61L24/00 , A61L24/0031 , A61L24/046 , A61L24/106 , A61L27/18 , A61L27/52 , A61L31/145 , A61L2430/32 , C08L71/02
摘要： The subject invention provides materials and methods for effective nerve repair. In a preferred embodiment, the subject invention provides nerve repair methods comprising the steps of applying a fibrin glue between severed nerve stumps, coapting the nerve stumps, and applying a polyethylene glycol (PEG) hydrogel to encase the coapted nerve stumps.
摘要翻译：本发明提供了有效神经修复的材料和方法。在一个优选的实施方案中，本发明提供了神经修复方法，其包括以下步骤：在切断的神经树桩之间施加纤维蛋白胶，使神经残片发生凹凸，并施加聚乙二醇（PEG）水凝胶以包住被覆的神经残片。

3. 发明授权

US07851447B2 Methods for nerve repair 有权
标题翻译：神经修复方法
公开(公告)号：US07851447B2
公开(公告)日：2010-12-14
申请号：US10218316
申请日：2002-08-13
申请人： David F. Muir
发明人： David F. Muir
IPC分类号： A61K38/51 , A61K38/30
CPC分类号： A61L27/3687 , A61K35/30 , A61K38/51 , A61L27/227 , A61L27/3604 , A61L27/3675 , A61L27/3683 , A61L27/383 , A61L27/3878 , A61L31/047 , A61L2430/32 , A61K2300/00
摘要： The subject invention pertains to compositions and methods for promoting repair of damaged nerve tissue. The compositions and methods of the subject invention can be employed to restore the continuity of nerve interrupted by disease, traumatic events or surgical procedures. Compositions of the subject invention comprise one or more chondroitin sulfate proteoglycan (CSPG)-degrading enzymes that promote axonal penetration into damaged nerve tissue. The invention also concerns methods for promoting repair of damaged nerve tissue using the present compositions and nerve tissue treated according to such methods. The invention also pertains to kits for nerve repair.
摘要翻译：本发明涉及用于促进受损神经组织修复的组合物和方法。本发明的组合物和方法可以用于恢复由疾病，外伤事件或外科手术中断的神经的连续性。本发明的组合物包含一种或多种促进轴突渗透入受损神经组织的硫酸软骨素蛋白聚糖（CSPG）降解酶。本发明还涉及使用本发明组合物和根据这些方法治疗的神经组织促进受损神经组织修复的方法。本发明还涉及用于神经修复的试剂盒。

4. 发明申请

US20080299536A1 Material and Methods for Nerve Grafting 审中-公开
标题翻译：神经移植的材料和方法
公开(公告)号：US20080299536A1
公开(公告)日：2008-12-04
申请号：US12190359
申请日：2008-08-12
申请人： David F. Muir
发明人： David F. Muir
IPC分类号： A01N1/02
CPC分类号： A61L27/3687 , A61K35/30 , A61K38/51 , A61L27/227 , A61L27/3604 , A61L27/3675 , A61L27/3683 , A61L27/383 , A61L27/3878 , A61L31/047 , A61L2430/32 , A61K2300/00
摘要： The subject invention pertains to compositions and methods for promoting repair of damaged nerve tissue using nerve grafts and preparation of nerve grafts. The compositions and methods of the subject invention can be employed to restore the continuity of nerve interrupted by disease, traumatic events or surgical procedures. Compositions of the subject invention comprise one or more chondroitin sulfate proteoglycan (CSPG)-degrading enzymes that promote axonal penetration into damaged nerve tissue and nerve graft. The invention also concerns methods for promoting repair of damaged nerve tissue using the present compositions and nerve tissue treated according to such methods. The invention also includes storage solutions for nerve tissue.
摘要翻译：本发明涉及使用神经移植物促进修复损伤的神经组织并制备神经移植物的组合物和方法。本发明的组合物和方法可以用于恢复由疾病，外伤事件或外科手术中断的神经的连续性。本发明的组合物包含一种或多种硫酸软骨素蛋白聚糖（CSPG）降解酶，其促进轴突穿透进入损伤的神经组织和神经移植物。本发明还涉及使用本发明组合物和根据这些方法治疗的神经组织促进受损神经组织修复的方法。本发明还包括神经组织的储存解决方案。

5. 发明申请

US20110137328A1 Nerve Repair with a Hydrogel and Optional Adhesive 有权
标题翻译：神经修复与水凝胶和可选粘合剂
公开(公告)号：US20110137328A1
公开(公告)日：2011-06-09
申请号：US12922725
申请日：2009-03-19
申请人： David F. Muir , James B. Graham , Debbie Neubauer
发明人： David F. Muir , James B. Graham , Debbie Neubauer
IPC分类号： A61B17/11
CPC分类号： A61B17/1128 , A61L24/00 , A61L24/0031 , A61L24/046 , A61L24/106 , A61L27/18 , A61L27/52 , A61L31/145 , A61L2430/32 , C08L71/02
摘要： The subject invention provides materials and methods for effective nerve repair. In a preferred embodiment, the subject invention provides nerve repair methods comprising the use of a fibrin glue and a polyethylene glycol (PEG) hydrogel to coapt severed nerve stumps or nerve grafts.
摘要翻译：本发明提供了有效神经修复的材料和方法。在一个优选的实施方案中，本发明提供了神经修复方法，其包括使用纤维蛋白胶和聚乙二醇（PEG）水凝胶来切割切断的神经根或神经移植物。

6. 发明授权

US06972168B2 Materials and methods for nerve grafting, selection of nerve grafts, and in vitro nerve tissue culture 有权
标题翻译：神经移植的材料和方法，神经移植物的选择和体外神经组织培养
公开(公告)号：US06972168B2
公开(公告)日：2005-12-06
申请号：US10218864
申请日：2002-08-13
申请人： David F. Muir
发明人： David F. Muir
IPC分类号： C12N5/06 , A61K35/12 , A61K35/16 , A61K35/30 , A61K38/00 , A61K38/22 , A61K38/27 , A61K38/51 , A61K45/00 , A61K47/30 , A61K48/00 , A61L27/00 , A61L27/22 , A61L27/36 , A61L27/38 , A61L31/04 , A61P25/00 , A61P25/02 , A61P43/00 , C12N5/08 , A01N1/00 , A01N1/02
CPC分类号： A61L27/3687 , A61K35/30 , A61K38/51 , A61L27/227 , A61L27/3604 , A61L27/3675 , A61L27/3683 , A61L27/383 , A61L27/3878 , A61L31/047 , A61L2430/32 , A61K2300/00
摘要： The subject invention pertains to compositions and methods for culturing nerve tissue in vitro and nerve grafts produced using such methods. The compositions and methods of the subject invention can be employed to restore the continuity of nerve interrupted by disease, traumatic events or surgical procedures. The invention also concerns methods for promoting repair of damaged nerve tissue using the present compositions and nerve tissue treated according to such methods.
摘要翻译：本发明涉及用于在体外培养神经组织的组合物和方法以及使用这些方法产生的神经移植物。本发明的组合物和方法可以用于恢复由疾病，外伤事件或外科手术中断的神经的连续性。本发明还涉及使用本发明组合物和根据这些方法治疗的神经组织促进受损神经组织修复的方法。

7. 发明申请

US20110082482A1 Materials and Methods for Nerve Repair 有权
标题翻译：神经修复的材料和方法
公开(公告)号：US20110082482A1
公开(公告)日：2011-04-07
申请号：US12966540
申请日：2010-12-13
申请人： David F. Muir
发明人： David F. Muir
IPC分类号： A61B17/00 , A61K38/43 , A61K38/46 , A61K9/00 , A61K38/51 , A61P25/00 , A61P43/00
CPC分类号： A61L27/3687 , A61K35/30 , A61K38/51 , A61L27/227 , A61L27/3604 , A61L27/3675 , A61L27/3683 , A61L27/383 , A61L27/3878 , A61L31/047 , A61L2430/32 , A61K2300/00
摘要： The subject invention pertains to compositions and methods for promoting repair of damaged nerve tissue. The compositions and methods of the subject invention can be employed to restore the continuity of nerve interrupted by disease, traumatic events or surgical procedures. Compositions of the subject invention comprise one or more chondroitin sulfate proteoglycan (CSPG)-degrading enzymes that promote axonal penetration into damaged nerve tissue. The invention also concerns methods for promoting repair of damaged nerve tissue using the present compositions and nerve tissue treated according to such methods. The invention also pertains to kits for nerve repair.
摘要翻译：本发明涉及用于促进受损神经组织修复的组合物和方法。本发明的组合物和方法可以用于恢复由疾病，外伤事件或外科手术中断的神经的连续性。本发明的组合物包含一种或多种促进轴突渗透入受损神经组织的硫酸软骨素蛋白聚糖（CSPG）降解酶。本发明还涉及使用本发明组合物和根据这些方法治疗的神经组织促进受损神经组织修复的方法。本发明还涉及用于神经修复的试剂盒。

8. 发明授权

US07732200B2 Materials and methods for nerve grafting, selection of nerve grafts, and in vitro nerve tissue culture 有权
标题翻译：神经移植的材料和方法，神经移植物的选择和体外神经组织培养
公开(公告)号：US07732200B2
公开(公告)日：2010-06-08
申请号：US10812776
申请日：2004-03-29
申请人： David F. Muir
发明人： David F. Muir
IPC分类号： C12N5/071 , C12N5/079 , A01N1/02
CPC分类号： A61L27/3687 , A61K35/30 , A61K38/51 , A61L27/227 , A61L27/3604 , A61L27/3675 , A61L27/3683 , A61L27/383 , A61L27/3878 , A61L31/047 , A61L2430/32 , A61K2300/00
摘要： The subject invention pertains to compositions and methods for culturing nerve tissue in vitro and nerve grafts produced using such methods. The compositions and methods of the subject invention can be employed to restore the continuity of nerve interrupted by disease, traumatic events or surgical procedures. The invention also concerns methods for promoting repair of damaged nerve tissue using the present compositions and nerve tissue treated according to such methods.
摘要翻译：本发明涉及用于在体外培养神经组织的组合物和方法以及使用这些方法产生的神经移植物。本发明的组合物和方法可以用于恢复由疾病，外伤事件或外科手术中断的神经的连续性。本发明还涉及使用本发明组合物和根据这些方法治疗的神经组织促进受损神经组织修复的方法。

9. 发明授权

US06182730B2 Label cutting apparatus 失效
标题翻译：标签切割装置
公开(公告)号：US06182730B2
公开(公告)日：2001-02-06
申请号：US09057318
申请日：1998-04-09
申请人： David F. Muir
发明人： David F. Muir
IPC分类号： B65C918
CPC分类号： B65C9/1826 , Y10T156/1322 , Y10T156/1339 , Y10T156/1744 , Y10T156/1768
摘要： A label application apparatus comprising a main housing and a printer and an applicator mounted to the main housing for applying a label to an object. A supply reel is rotatably mounted to the main housing and has a continuous web of label material thereon. A feed mechanism is also provided for feeding the continuous web of label material from the supply reel to the printer and applicator. A cutting mechanism is associated with the applicator to cut labels from the continuous web of label material between the printer and the applicator whereby the applicator then places the severed label onto the object.
摘要翻译：一种标签施加装置，包括主壳体和打印机以及安装到主壳体上的施加装置，用于向物体施加标签。供应卷轴可旋转地安装到主壳体上，并且在其上具有连续的标签材料幅材。还提供了一种进给机构，用于将标签材料的连续卷材从供应卷轴供给到打印机和涂布器。切割机构与施加器相关联，以从打印机和施加器之间的标签材料的连续卷材切割标签，由此施加器然后将切断的标签放置在物体上。

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