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1. 发明授权

US07835559B1 Method and apparatus for quantitative and comparative analysis of image intensities in radiographs 有权
标题翻译：用于定量和比较分析影像强度的方法和装置
公开(公告)号：US07835559B1
公开(公告)日：2010-11-16
申请号：US11741657
申请日：2007-04-27
申请人： David J. Schurman , Robert Lane Smith
发明人： David J. Schurman , Robert Lane Smith
IPC分类号： G06K9/00 , G01N23/05
CPC分类号： G01N23/04 , G01N2223/302 , G01N2223/6123 , G06T7/0014 , G06T2207/10116 , G06T2207/30008
摘要： A system for determining image intensity of a radiograph includes an illuminator for providing lighting to the radiograph, an image reference standard having a predetermined color, a digital imaging device for obtaining a digital image of the radiograph and the image reference standard, a computer for receiving and storing the digital image and for executing programs, and an image analysis program being executed on the computer for providing a first image intensity value of a target area in the radiograph and a second image intensity value of the image reference standard and for computing a normalized image intensity value of the target area using the first and second image intensity values. In one embodiment, the image reference standard is an image reference standard of a black color or a white color.
摘要翻译：一种用于确定X射线照片的图像强度的系统包括：用于向射线照片提供照明的照明器，具有预定颜色的图像参考标准，用于获得射线照片的数字图像的数字成像装置和图像参考标准;用于接收的计算机以及存储数字图像和用于执行程序的图像分析程序，以及在计算机上执行的图像分析程序，用于提供放射照相中的目标区域的第一图像强度值和图像参考标准的第二图像强度值，并且用于计算标准化使用第一和第二图像强度值的目标区域的图像强度值。在一个实施例中，图像参考标准是黑色或白色的图像参考标准。

2. 发明授权

US07892799B2 Method for in vivo, ex vivo and in vitro repair and regeneration of cartilage 有权
标题翻译：体内，体外和体外修复和再生软骨的方法
公开(公告)号：US07892799B2
公开(公告)日：2011-02-22
申请号：US11897911
申请日：2007-08-30
申请人： Robert Lane Smith , Dennis R. Carter , David J. Schurman
发明人： Robert Lane Smith , Dennis R. Carter , David J. Schurman
IPC分类号： C12N5/00
CPC分类号： C12N5/0655 , A61F2/08 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2240/001 , A61F2310/00365 , A61K35/12 , A61K35/32 , C12N2500/02 , C12N2521/00
摘要： A method for in vivo, ex vivo and in vitro regeneration of cartilage, collagen and bone remodeling by intermittently applied hydrostatic pressure consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The intermittent hydrostatic pressure is applied at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene expression of growth factors that are inhibitory to type II collagen expression.
摘要翻译：一种通过间歇性施加的静水压力的体内，体外和体外再生软骨，胶原和骨重建的方法，所述静态压力由重复的施加的静水压力周期组成，并在恢复期后中断。间歇静水压力以生理水平5-10MPA施用，间隔4小时，随后的恢复时间长达约20小时。间隔负荷导致基质降解酶，促炎细胞因子和趋化因子的选择性抑制，其吸引炎症细胞进入关节腔，并选择性降低抑制II型胶原表达的生长因子的基因表达。

3. 发明申请

US20090176304A1 Method for in vivo, ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling 审中-公开
标题翻译：体内，体外和体外修复和再生软骨和胶原蛋白和骨重塑的方法
公开(公告)号：US20090176304A1
公开(公告)日：2009-07-09
申请号：US11980967
申请日：2008-07-11
申请人： R. Lane Smith , Dennis R. Carter , David J. Schurman
发明人： R. Lane Smith , Dennis R. Carter , David J. Schurman
IPC分类号： C12N5/08 , C12N5/06
CPC分类号： C12N5/0655 , A61F2/08 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2240/001 , A61F2310/00365 , A61K35/12 , A61K35/32 , C12N2500/02 , C12N2521/00
摘要： A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene expression of growth factors that are inhibitory to type II collagen expression.
摘要翻译：一种体内，体外和体外再生软骨和胶原蛋白的方法。通过间歇施加的静水压力，体内，离体和体外再生和从头形成关节软骨和胶原。外部间隔负荷的应用由反复施加的静水压力组成，随后由复原期间中断。在生理水平5-10MPA下间歇4小时的间歇静水压力的应用，随后的恢复期直到约20小时，所述压力在体外施加于软骨细胞，体外离体外植体和体内至软体在关节关节的关节间隙内保持完整的软骨。间隔负荷导致基质降解酶，促炎细胞因子和趋化因子的选择性抑制，其吸引炎症细胞进入关节腔，并选择性降低抑制II型胶原表达的生长因子的基因表达。

4. 发明授权

US06528052B1 Method for in vivo ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling 有权
标题翻译：体外离体和体外修复和再生软骨和胶原和骨重塑的方法
公开(公告)号：US06528052B1
公开(公告)日：2003-03-04
申请号：US09677109
申请日：2000-09-29
申请人： R. Lane Smith , Dennis R. Carter , David J. Schurman
发明人： R. Lane Smith , Dennis R. Carter , David J. Schurman
IPC分类号： C12N500
CPC分类号： C12N5/0655 , A61F2/08 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2240/001 , A61F2310/00365 , A61K35/12 , A61K35/32 , C12N2500/02 , C12N2521/00
摘要： A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene, expression of growth factors that are inhibitory to type II collagen expression.
摘要翻译：一种体内，体外和体外再生软骨和胶原蛋白的方法。通过间歇施加的静水压力，体内，离体和体外再生和从头形成关节软骨和胶原。外部间隔负荷的应用由反复施加的静水压力组成，随后由复原期间中断。在生理水平5-10MPA下间歇4小时的间歇静水压力的应用，随后的恢复期直到约20小时，所述压力在体外施加于软骨细胞，体外离体外植体和体内至软体在关节关节的关节间隙内保持完整的软骨。间隔负荷导致基质降解酶，促炎细胞因子和趋化因子的选择性抑制，其吸引炎症细胞进入关节腔，并选择性降低基因，抑制II型胶原表达的生长因子的表达。

5. 发明授权

US4358859A Articulated prosthetic knee and method for implanting same 失效
标题翻译：铰接假肢膝盖及其植入方法
公开(公告)号：US4358859A
公开(公告)日：1982-11-16
申请号：US81713
申请日：1979-10-04
申请人： David J. Schurman , Robert L. Piziali
发明人： David J. Schurman , Robert L. Piziali
IPC分类号： A61F2/38 , A61F1/03
CPC分类号： A61F2/3845
摘要： An articulated knee prosthesis in which a femoral implant has a condyle section and a femoral stem that is cemented into the femur. A tibial implant carries a tibial plateau section on which is mounted a stop plate for engaging the condyle section and arresting movement of the knee beyond its fully extended position. The tibial implant includes a tibial stem that is cemented into the tibia. A pivotal connection between the two implants is positioned posteriorly of the implant and at an elevation above a lowermost point of the condyle section (when the implants are fully extended). The pivot axis of the connection and the stems are positioned with respect to each other so that upon the implantation of the implant, the patient's tibia is moved in an anterior direction as compared to the normal anatomical position of the tibia relative to the femur. At least a portion of the hinged connection, which frequently includes the pivot axis, is located posteriorly of portions of the femur proximate the knee joint to maximize the arc through which the knee can be flexed.
摘要翻译：一种关节膝关节假体，其中股骨植入物具有骨髁部分和股骨柄，该股骨柄被胶合到股骨中。胫骨植入物携带胫骨平台部分，其上安装有止动板用于接合髁部分并阻止膝盖移动到其完全伸出位置。胫骨植入物包括胫骨柄，其被固定到胫骨中。两个植入物之间的枢转连接位于植入物的后方并且位于髁部分的最低点之上（当植入物完全延伸时）的高度。连接件和杆的枢转轴线相对于彼此定位，使得在植入物植入时，与胫骨相对于股骨的正常解剖位置相比，患者的胫骨在前方向上移动。经常包括枢转轴线的铰链连接的至少一部分位于靠近膝盖关节的股骨部分的后方，以最大限度地使得膝盖能弯曲的电弧最大化。

6. 发明授权

US06383226B1 Prostheses having curvilinear collars 失效
标题翻译：假肢有曲线领
公开(公告)号：US06383226B1
公开(公告)日：2002-05-07
申请号：US09094230
申请日：1998-06-09
申请人： Dennis R. Carter , Jay A. Mandell , Gary S. Beaupré , David J. Schurman
发明人： Dennis R. Carter , Jay A. Mandell , Gary S. Beaupré , David J. Schurman
IPC分类号： A61F236
CPC分类号： A61F2/3609 , A61F2/0095 , A61F2/30767 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/40 , A61F2/4014 , A61F2/4059 , A61F2002/30004 , A61F2002/30112 , A61F2002/3021 , A61F2002/30604 , A61F2002/30616 , A61F2002/307 , A61F2002/3071 , A61F2002/30729 , A61F2002/3611 , A61F2002/3625 , A61F2002/3631 , A61F2002/4018 , A61F2002/4029 , A61F2002/4033 , A61F2002/4631 , A61F2230/0004 , A61F2230/0067 , A61F2250/0014 , A61F2250/0064 , A61F2250/0081 , A61F2250/0085 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179 , A61F2310/00796
摘要： Novel prostheses, particularly femoral prostheses, are provided. The subject devices are characterized by the presence of a curvilinear collar. Also provided are methods of implanting a prosthesis in a manner sufficient to provide for a pressure profile at the collar interface in which the pressure increases from the endosteal to the periosteal surface of the bone.
摘要翻译：提供新型假体，特别是股骨假体。主题装置的特征在于存在曲线领。还提供了以足够的方式植入假体的方法，所述方式足以提供在颈部界面处的压力分布，其中压力从骨的内膜到骨膜表面增加。

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