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1. 发明授权

US07835559B1 Method and apparatus for quantitative and comparative analysis of image intensities in radiographs 有权
标题翻译：用于定量和比较分析影像强度的方法和装置
公开(公告)号：US07835559B1
公开(公告)日：2010-11-16
申请号：US11741657
申请日：2007-04-27
申请人： David J. Schurman , Robert Lane Smith
发明人： David J. Schurman , Robert Lane Smith
IPC分类号： G06K9/00 , G01N23/05
CPC分类号： G01N23/04 , G01N2223/302 , G01N2223/6123 , G06T7/0014 , G06T2207/10116 , G06T2207/30008
摘要： A system for determining image intensity of a radiograph includes an illuminator for providing lighting to the radiograph, an image reference standard having a predetermined color, a digital imaging device for obtaining a digital image of the radiograph and the image reference standard, a computer for receiving and storing the digital image and for executing programs, and an image analysis program being executed on the computer for providing a first image intensity value of a target area in the radiograph and a second image intensity value of the image reference standard and for computing a normalized image intensity value of the target area using the first and second image intensity values. In one embodiment, the image reference standard is an image reference standard of a black color or a white color.
摘要翻译：一种用于确定X射线照片的图像强度的系统包括：用于向射线照片提供照明的照明器，具有预定颜色的图像参考标准，用于获得射线照片的数字图像的数字成像装置和图像参考标准;用于接收的计算机以及存储数字图像和用于执行程序的图像分析程序，以及在计算机上执行的图像分析程序，用于提供放射照相中的目标区域的第一图像强度值和图像参考标准的第二图像强度值，并且用于计算标准化使用第一和第二图像强度值的目标区域的图像强度值。在一个实施例中，图像参考标准是黑色或白色的图像参考标准。

2. 发明授权

US07892799B2 Method for in vivo, ex vivo and in vitro repair and regeneration of cartilage 有权
标题翻译：体内，体外和体外修复和再生软骨的方法
公开(公告)号：US07892799B2
公开(公告)日：2011-02-22
申请号：US11897911
申请日：2007-08-30
申请人： Robert Lane Smith , Dennis R. Carter , David J. Schurman
发明人： Robert Lane Smith , Dennis R. Carter , David J. Schurman
IPC分类号： C12N5/00
CPC分类号： C12N5/0655 , A61F2/08 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2240/001 , A61F2310/00365 , A61K35/12 , A61K35/32 , C12N2500/02 , C12N2521/00
摘要： A method for in vivo, ex vivo and in vitro regeneration of cartilage, collagen and bone remodeling by intermittently applied hydrostatic pressure consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The intermittent hydrostatic pressure is applied at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene expression of growth factors that are inhibitory to type II collagen expression.
摘要翻译：一种通过间歇性施加的静水压力的体内，体外和体外再生软骨，胶原和骨重建的方法，所述静态压力由重复的施加的静水压力周期组成，并在恢复期后中断。间歇静水压力以生理水平5-10MPA施用，间隔4小时，随后的恢复时间长达约20小时。间隔负荷导致基质降解酶，促炎细胞因子和趋化因子的选择性抑制，其吸引炎症细胞进入关节腔，并选择性降低抑制II型胶原表达的生长因子的基因表达。

3. 发明授权

US08685107B2 Double-structured tissue implant and a method for preparation and use thereof 有权
标题翻译：双重结构的组织植入物及其制备和使用方法
公开(公告)号：US08685107B2
公开(公告)日：2014-04-01
申请号：US11894124
申请日：2007-08-20
申请人： Hans Peter Ingemar Claesson , Laurence J. B. Tarrant , Robert Lane Smith , Sonya Shortkroff
发明人： Hans Peter Ingemar Claesson , Laurence J. B. Tarrant , Robert Lane Smith , Sonya Shortkroff
IPC分类号： A61F2/02
CPC分类号： A61L27/48 , A61F2002/0086 , A61F2210/0076 , A61F2310/00371 , A61F2310/00982 , A61L27/24 , A61L27/3817 , A61L27/54 , A61L27/56 , A61L2400/18 , A61L2430/34 , C08L89/06
摘要： A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment.
摘要翻译：双组织组织植入物及其制备和使用方法，用于植入组织缺陷。双重结构的组织植入物包括主要支架和由可溶性胶原溶液组合的辅助支架，所述可溶性胶原溶液与产生并定位在主要支架内的非离子表面活性剂组合。独立的二次支架植入物或单位。制备双结构植入物或独立的第二支架的方法，其包括冻干和脱水热处理。

4. 发明授权

US07537780B2 Method for preparing and implanting a cartilage construct to treat cartilage lesions 有权
标题翻译：用于制备和植入软骨构造物以治疗软骨损伤的方法
公开(公告)号：US07537780B2
公开(公告)日：2009-05-26
申请号：US10626459
申请日：2003-07-22
申请人： Shuichi Mizuno , Akihiko Kusanagi , Laurence J. B. Tarrant , Toshimasa Tokuno , Robert Lane Smith
发明人： Shuichi Mizuno , Akihiko Kusanagi , Laurence J. B. Tarrant , Toshimasa Tokuno , Robert Lane Smith
IPC分类号： A61F2/00 , C12N11/02 , C12N11/08 , C12N5/06 , C12N5/08
CPC分类号： A61L27/24 , A61F2/28 , A61F2310/00365 , A61K35/12 , A61L27/3633 , A61L27/38 , A61L27/3817 , A61L27/3843 , A61L27/3852 , A61L27/3895 , A61L27/56 , A61L2430/06 , C12N5/0655
摘要： Neo-cartilage constructs for growth and surface coating for the de novo formation of a superficial cartilage layer. A method for generation of the neo-cartilage and the neo-cartilage construct. A method for repair and restoration of the injured, damaged, diseased or aged cartilage into its full functionality and for treatment of injured or diseased cartilage by implanting the neo-cartilage construct between two layers of biologically acceptable sealants.
摘要翻译：用于生长和表面涂层的新软骨构建体用于从头形成的软骨层。用于产生新软骨和新软骨构建体的方法。通过将新软骨构建体植入两层生物可接受的密封剂之间，将损伤的，损伤的，患病的或老化的软骨修复和恢复成其全部功能并用于治疗受损或患病的软骨的方法。

5. 发明申请

US20090012627A1 Double-structured tissue implant and a method for preparation and use thereof 有权
标题翻译：双重结构的组织植入物及其制备和使用方法
公开(公告)号：US20090012627A1
公开(公告)日：2009-01-08
申请号：US11894124
申请日：2007-08-20
申请人： Hans Peter Ingemar Claesson , Laurence J.B. Tarrant , Robert Lane Smith , Sonya Shortkroff
发明人： Hans Peter Ingemar Claesson , Laurence J.B. Tarrant , Robert Lane Smith , Sonya Shortkroff
IPC分类号： A61F2/02 , A01N1/00
CPC分类号： A61L27/48 , A61F2002/0086 , A61F2210/0076 , A61F2310/00371 , A61F2310/00982 , A61L27/24 , A61L27/3817 , A61L27/54 , A61L27/56 , A61L2400/18 , A61L2430/34 , C08L89/06
摘要： A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment.
摘要翻译：双组织组织植入物及其制备和使用方法，用于植入组织缺陷。双重结构的组织植入物包括主要支架和由可溶性胶原溶液组合的辅助支架，所述可溶性胶原溶液与产生并定位在主要支架内的非离子表面活性剂组合。独立的二次支架植入物或单位。制备双结构植入物或独立的第二支架的方法，其包括冻干和脱水热处理。

6. 发明授权

US08070827B2 Method for use of a double-structured tissue implant for treatment of tissue defects 有权
标题翻译：使用双组织植入物治疗组织缺陷的方法
公开(公告)号：US08070827B2
公开(公告)日：2011-12-06
申请号：US11982268
申请日：2007-10-31
申请人： Sonya Shortkroff , Laurence J. B. Tarrant , Eric J. Roos , Robert Lane Smith , Hans Peter Ingemar Claesson
发明人： Sonya Shortkroff , Laurence J. B. Tarrant , Eric J. Roos , Robert Lane Smith , Hans Peter Ingemar Claesson
IPC分类号： A61F2/02
CPC分类号： A61L27/48 , A61L27/38 , A61L27/54 , A61L27/56 , A61L2300/254 , A61L2300/258 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/428 , A61L2300/43 , A61L2300/802
摘要： A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit.
摘要翻译：用于双组织植入物或用于治疗组织缺陷的独立植入物的二次支架的方法。双重结构的组织植入物包括主要支架和由可溶性胶原溶液组合的辅助支架，所述可溶性胶原溶液与产生并定位在主要支架内的非离子表面活性剂组合。独立的二次支架植入物或单位。

7. 发明申请

US20090012628A1 Method for use of a double-structured tissue implant for treatment of tissue defects 有权
标题翻译：使用双组织植入物治疗组织缺陷的方法
公开(公告)号：US20090012628A1
公开(公告)日：2009-01-08
申请号：US11982268
申请日：2007-10-31
申请人： Sonya Shortkroff , Laurence J. B. Tarrant , Eric J. Roos , Robert Lane Smith , Hans Peter Claesson
发明人： Sonya Shortkroff , Laurence J. B. Tarrant , Eric J. Roos , Robert Lane Smith , Hans Peter Claesson
IPC分类号： A61F2/02
CPC分类号： A61L27/48 , A61L27/38 , A61L27/54 , A61L27/56 , A61L2300/254 , A61L2300/258 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/428 , A61L2300/43 , A61L2300/802
摘要： A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit.
摘要翻译：用于双组织植入物或用于治疗组织缺陷的独立植入物的二次支架的方法。双重结构的组织植入物包括主要支架和由可溶性胶原溶液组合的辅助支架，所述可溶性胶原溶液与产生并定位在主要支架内的非离子表面活性剂组合。独立的二次支架植入物或单位。

8. 发明申请

US20170312391A1 DOUBLE-STRUCTURED TISSUE IMPLANT AND A METHOD FOR PREPARATION AND USE THEREOF 审中-公开
公开(公告)号：US20170312391A1
公开(公告)日：2017-11-02
申请号：US15631699
申请日：2017-06-23
申请人： Hans Peter Ingemar Claesson , Laurence J.B. Tarrant , Robert Lane Smith , Sonya Shortkroff
发明人： Hans Peter Ingemar Claesson , Laurence J.B. Tarrant , Robert Lane Smith , Sonya Shortkroff
IPC分类号： A61L27/48 , A61L27/54 , A61L27/56 , A61L27/38 , A61L27/24 , A61F2/00
CPC分类号： A61L27/48 , A61F2002/0086 , A61F2210/0076 , A61F2310/00371 , A61F2310/00982 , A61L27/24 , A61L27/3817 , A61L27/54 , A61L27/56 , A61L2400/18 , A61L2430/34 , C08L89/06
摘要： A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment.

9. 发明申请

US20160206787A9 Method For Improvement Of Differentiation Of Mesenchymal Stem Cells Using A Double-Structured Tissue Implant 有权
公开(公告)号：US20160206787A9
公开(公告)日：2016-07-21
申请号：US12195255
申请日：2008-08-20
申请人： Sonya Shortkroff , Joseph Khoury , Laurence J.B. Tarrant , Hans P.I. Claesson , Robert Lane Smith
发明人： Sonya Shortkroff , Joseph Khoury , Laurence J.B. Tarrant , Hans P.I. Claesson , Robert Lane Smith
IPC分类号： A61F2/02 , A61L27/56 , A61F2/30 , A61L27/52 , A61L27/26 , A61L27/54 , A61L27/24 , A61B17/08 , A61L27/38
CPC分类号： A61F2/02 , A61F2/08 , A61F2/28 , A61F2/30756 , A61F2002/30766 , A61F2240/001 , A61L27/24 , A61L27/26 , A61L27/3804 , A61L27/3817 , A61L27/3834 , A61L27/3839 , A61L27/3847 , A61L27/3852 , A61L27/386 , A61L27/3873 , A61L27/3878 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2430/06 , A61L2430/20 , A61L2430/30 , A61L2430/32 , A61L2430/34
摘要： A double-structured tissue implant (DSTI) and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant for differentiation, growth and transformation of cells, stem cells, mesenchymal stem cells and bone marrow stem cells. DSTI comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold.

10. 发明授权

US07557051B2 3-D interconnected multi-layer microstructure of thermoplastic materials 失效
标题翻译： 3-D互连多层微结构的热塑性材料
公开(公告)号：US07557051B2
公开(公告)日：2009-07-07
申请号：US11078907
申请日：2005-03-11
申请人： WonHyoung Ryu , Seoung Jai Bai , Kyle Hammerick , Robert Lane Smith , Ralph S. Greco , Friedrich B. Prinz , Rainer J. Fasching
发明人： WonHyoung Ryu , Seoung Jai Bai , Kyle Hammerick , Robert Lane Smith , Ralph S. Greco , Friedrich B. Prinz , Rainer J. Fasching
IPC分类号： H01L21/00 , B29C45/00
CPC分类号： B29C43/021 , B01L3/5027 , B01L3/5085 , B29C33/0033 , B29C33/424 , B29C43/003 , B29C59/02 , B29C59/022 , B29C59/04 , B29C2043/025 , B29C2043/463 , B29C2043/5883 , B29C2059/023 , B29L2031/7532
摘要： Methods for compression molding through holes in polymer layers are provided, as are the resulting patterned polymer layers. Two key aspects of the invention are provision of a mold and substrate having different mechanical hardness, and provision of room for local flow of material. These aspects of the invention facilitate formation of through holes by compression molding that are not blocked or partially blocked by undesirable material. These polymer layers can be formed into three dimensional patterned structures by bonding patterned layers together. Since the layers include through holes, a three-dimensional polymer pattern can be formed. These patterned polymer layers and three dimensionally patterned polymer constructs have a wide variety of applications. For example, these constructs can be used for fabrication of micro-fluidic devices, and/or can be used for various medical and biological applications including drug delivery devices and tissue engineering devices.
摘要翻译：提供了聚合物层中的孔的压缩模塑方法，以及所形成的图案化聚合物层。本发明的两个关键方面是提供具有不同机械硬度的模具和基材，并提供用于局部流动材料的空间。本发明的这些方面有助于通过压缩成型形成未被不期望的材料阻挡或部分阻挡的通孔。这些聚合物层可以通过将图案化层结合在一起而形成三维图案化结构。由于层包括通孔，因此可以形成三维聚合物图案。这些图案化的聚合物层和三维图案化的聚合物构造物具有广泛的应用。例如，这些构建体可用于制造微流体装置，和/或可用于各种医疗和生物应用，包括药物递送装置和组织工程装置。

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