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1. 发明授权

US07974736B2 Robot deployed weapon system and safing method 有权
标题翻译：机器人部署的武器系统和安全方法
公开(公告)号：US07974736B2
公开(公告)日：2011-07-05
申请号：US11732875
申请日：2007-04-05
申请人： Gary R. Morin , Daniel R. Deguire , Kurt Bruck , James Chung , David Platt
发明人： Gary R. Morin , Daniel R. Deguire , Kurt Bruck , James Chung , David Platt
IPC分类号： B25J9/00
CPC分类号： F42D5/04 , F41A23/34 , F41H7/005
摘要： This subject invention features a robot deployed weapon system. A remotely controlled mobile robot has a weapon mounted to the robot. There is a firing circuit for the weapon and a weapon interrupt module on board the robot. An operator control unit is for remotely operating the robot and the weapon. The operating control unit preferably includes a stop switch. Also, a separate operator module is in communication with the weapon interrupt module. Preferably, the operator module includes a kill switch. There are two communication links. The first communication link is between the operator control unit and the robot. This communication link is configured to safe the weapon if the stop switch is activated and/or the first communication link degrades. The second communication link is between the operator module and the weapon interrupt module. The communication link is configured to safe the weapon if the kill switch is activated and/or the second communication link degrades.
摘要翻译：本发明的特征在于机器人部署的武器系统。远程控制的移动机器人具有安装在机器人上的武器。机器人上有武器和武器中断模块的发射电路。操作员控制单元用于远程操作机器人和武器。操作控制单元优选地包括停止开关。另外，单独的操作员模块与武器中断模块通信。优选地，操作者模块包括杀死开关。有两个通信链接。第一通信链路位于操作员控制单元和机器人之间。如果停止开关被激活和/或第一通信链路降级，则该通信链路被配置为安全地使用武器。第二个通信链接在操作员模块和武器中断模块之间。通信链路被配置为如果杀死开关被激活和/或第二通信链路劣化就安全地使用武器。

2. 发明申请

US20080286251A1 Compositions and Methods for the Enhancement of Chemotherapy with Microbial Cytotoxins 审中-公开
标题翻译：用微生物细胞毒素增强化疗的组合物和方法
公开(公告)号：US20080286251A1
公开(公告)日：2008-11-20
申请号：US11659170
申请日：2005-08-02
申请人： David Platt , Eliezer Zomer
发明人： David Platt , Eliezer Zomer
IPC分类号： A61K35/74 , A61P35/00
CPC分类号： A61K31/5575 , A61K31/559 , A61K35/74 , A61K38/00 , A61K45/06 , A61K2300/00
摘要： Described herein is a microbial composition used to enhance anti-cancer drugs. Specifically, microbial compositions that comprise a part of or an entire microorganism having surface lectins specific to carbohydrate moieties on tumor surface combined with an oncolytic agent.
摘要翻译：本文描述了用于增强抗癌药物的微生物组合物。具体地说，包含一部分或整个微生物的微生物组合物，其具有与肿瘤表面上的碳水化合物部分特异的表面凝集素结合于一种溶瘤剂。

3. 发明授权

US07216235B1 Drive/host locking system 有权
标题翻译：驱动/主机锁定系统
公开(公告)号：US07216235B1
公开(公告)日：2007-05-08
申请号：US09642617
申请日：2000-08-17
申请人： David Platt
发明人： David Platt
IPC分类号： H04L9/00
CPC分类号： H04L9/3271 , G06F21/80 , G06F2221/2103 , H04L9/3239
摘要： An authentication system for securing information within a disk drive to be read and written to only by a specific host computer such that it is difficult or impossible to access the drive by any system other than a designated host is disclosed. While the invention is similar in intent to a password scheme, it significantly more secure. The invention thus provides a secure environment for important information stored within a disk drive. The information can only be accessed by a host if the host can respond to random challenges asked by the disk drive. The host's responses are generated using a cryptography chip processing a specific algorithm. This technique allows the disk drive and the host to communicate using a coded security system where attempts to break the code and choose the correct password take longer to learn than the useful life of the disk drive itself.
摘要翻译：公开了一种用于保护磁盘驱动器内的信息以仅由特定主机计算机读取和写入的认证系统，从而难以或不可能通过除指定主机之外的任何系统访问驱动器。虽然本发明的意图与密码方案相似，但其显着更加安全。因此，本发明为存储在磁盘驱动器内的重要信息提供了安全的环境。如果主机可以响应磁盘驱动器提出的随机问题，信息只能由主机访问。使用加密芯片处理特定算法来生成主机的响应。这种技术允许磁盘驱动器和主机使用编码安全系统进行通信，其中尝试打破代码并选择正确的密码需要更长的时间来学习磁盘驱动器本身的使用寿命。

4. 发明申请

US20060190379A1 Price grabber 审中-公开
标题翻译：价格抓住
公开(公告)号：US20060190379A1
公开(公告)日：2006-08-24
申请号：US11361514
申请日：2006-02-23
申请人： Eric Maas , David Platt , Jalali Hartman
发明人： Eric Maas , David Platt , Jalali Hartman
IPC分类号： G06Q40/00
CPC分类号： G06Q30/0603 , G06Q40/00
摘要： Systems and methods for automatic price monitoring of an online marketplace. The online marketplace is a virtual store (e.g., web-based) for buyers and sellers to exchange goods or products. A system includes a price monitoring module coupled to a market server, and buyer and seller devices. The price monitoring module retains a position garnered by a seller with the lowest price by periodically adjusting a subscribing seller's listing price to beat competing seller prices. The price monitoring module can be configured according to price parameters which gauge how much sellers are willing to concede. The price parameters can include, for example, a default listing price for a product, a decrement amount, a minimum listing price, and the like.
摘要翻译：在线市场自动价格监控的系统和方法。在线市场是一个虚拟商店（例如，基于网络的），供买卖双方交换商品或产品。系统包括耦合到市场服务器的价格监控模块以及买卖双方的设备。价格监控模块通过定期调整订阅卖家的上市价格以抵消竞争的卖家价格，保留卖方以最低价格获得的头寸。价格监控模块可以根据价格参数进行配置，从而衡量卖家愿意承认的价格。价格参数可以包括例如产品的默认上市价格，减量金额，最低上市价格等。

5. 发明授权

US06914055B2 Delivery of a therapeutic agent in a formulation for reduced toxicity 有权
标题翻译：在制剂中递送治疗剂以降低毒性
公开(公告)号：US06914055B2
公开(公告)日：2005-07-05
申请号：US10649130
申请日：2003-08-27
申请人： Anatole Klyosov , David Platt
发明人： Anatole Klyosov , David Platt
IPC分类号： A61K47/36 , A01N43/04 , A61K20060101 , A61K9/08 , A61K9/14 , A61K31/505 , A61K31/513 , A61K31/704 , A61K31/715 , A61K31/736 , A61K45/00 , A61K45/06 , A61P35/00 , A61K31/70
CPC分类号： A61K45/06 , A61K31/505 , A61K31/513 , A61K31/704 , A61K31/715 , A61K31/736 , Y10S514/974 , A61K2300/00
摘要： Methods and compositions for reducing toxicity of a toxic agent are provided in which a polysaccharide, galactomannan is coadministered with a therapeutic agent in a liquid formulation to a subject to reduce toxicity of the agent for the subject.
摘要翻译：提供了用于降低毒性毒性毒性的方法和组合物，其中将多糖，半乳甘露聚糖与液体制剂中的治疗剂共同施用于受试者以降低该药物对受试者的毒性。

6. 发明申请

US20050080577A1 Portable calibration unit for test equipment 失效
标题翻译：用于测试设备的便携式校准单元
公开(公告)号：US20050080577A1
公开(公告)日：2005-04-14
申请号：US10675103
申请日：2003-09-30
申请人： Fred Ives , David Platt
发明人： Fred Ives , David Platt
IPC分类号： G01R35/00 , G06F19/00
CPC分类号： G01R35/00
摘要： A portable calibration unit for calibrating test equipment is disclosed that may incorporate a communication interface for connecting to a computer embedded within the test equipment, a variable signal source for producing a test signal, a processor in communication with the computer for controlling the variable signal source, and a test interface for communicating the test signal to the test equipment.
摘要翻译：公开了一种用于校准测试设备的便携式校准单元，其可以包括用于连接到嵌入在测试设备内的计算机的通信接口，用于产生测试信号的可变信号源，与计算机通信的处理器，用于控制可变信号源以及用于将测试信号传送到测试设备的测试接口。

7. 发明申请

US20050043272A1 Compositions and methods for hydrophobic drug delivery 审中-公开
标题翻译：疏水药物递送的组合物和方法
公开(公告)号：US20050043272A1
公开(公告)日：2005-02-24
申请号：US10889555
申请日：2004-07-12
申请人： David Platt , Eliezer Zomer , Anatole Klyosov
发明人： David Platt , Eliezer Zomer , Anatole Klyosov
IPC分类号： A61K20060101 , A61K9/00 , A61K31/715
CPC分类号： A61K9/5161 , A61K9/0019 , A61K9/1075
摘要： Disclosed herein are compositions and methods for the delivery and targeting of therapeutics using nanometer sized polysaccharide structures. The methods and compositions described herein afford improved efficacy for pharmaceuticals such as anti-tumor drugs on metastatic tumor. The methods described herein are applicable to all chemotherapeutic agents and are especially useful for poorly soluble (hydrophobic) drugs which when formulated with the present compositions render them deliverable in physiological fluids. The methods and compositions described herein also improve the efficacy of pharmaceutical agents by targeting carbohydrate receptors specific to tumors that mediate endocytosis or enhance delivery of the drug to the ultimate site of action.
摘要翻译：本文公开了使用纳米尺寸多糖结构递送和靶向治疗剂的组合物和方法。本文所述的方法和组合物提供药物（例如抗肿瘤药物）对转移性肿瘤的功效。本文描述的方法适用于所有化学治疗剂，并且特别适用于当与本发明组合物配制使其能够在生理流体中递送时的难溶性（疏水性）药物。本文所述的方法和组合物还通过靶向调节内吞作用的肿瘤特异性的碳水化合物受体或增强药物到最终作用位点而提高药剂的功效。

8. 发明授权

US5527770A Immunotherapeutic agent derived from bacteria 失效
标题翻译：来自细菌的免疫治疗剂
公开(公告)号：US5527770A
公开(公告)日：1996-06-18
申请号：US299145
申请日：1994-08-31
申请人： David Platt
发明人： David Platt
IPC分类号： A61K35/74 , A61K38/00 , A61K39/00 , A61K39/39 , C07K5/08 , C07K14/35 , C12N1/00 , A23J1/00
CPC分类号： C07K5/08 , A61K35/74 , A61K39/39 , C07K14/35 , A61K2039/55516 , A61K38/00 , Y10S435/849 , Y10S435/863 , Y10S514/885
摘要： An immunotherapeutic agent is prepared from cells of E. coli or members of the genus Mycobacterium. The material is effective as an anti-tumor agent, an immunostimulant, and an adjuvant. Also disclosed is a method of evoking an immunostimulatory response through the activation of the RAS gene.
摘要翻译：免疫治疗剂由大肠杆菌的细胞或分枝杆菌属的成员制备。该物质作为抗肿瘤剂，免疫刺激剂和佐剂是有效的。还公开了通过激活RAS基因来诱发免疫刺激反应的方法。

9. 发明申请

US20130302471A1 COMPOSITION OF PURIFIED SOLUBLE MANNANS FOR DIETARY SUPPLEMENTS AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于膳食补充品的纯化可溶性肉豆蔻的组合物及其使用方法
公开(公告)号：US20130302471A1
公开(公告)日：2013-11-14
申请号：US13938409
申请日：2013-07-10
申请人： David Platt
发明人： David Platt
IPC分类号： A23L1/308
摘要： A composition of chemically purified soluble mannans from legumes' seeds (e.g. Ceratonia siliqua, Caesalpinia spinosa Trigonelle foenum-graecum, and Cyamopsis tetragonolobus) and their use in the assembly of palatable dietary supplements is disclosed herein. The fractionation process provides high-quality physiologically soluble, chemically modified and purified homogeneous size polysaccharide fibers, devoid of natural impurities, for example proteins, alkaloids, glycoalkaloids, and/or environmental impurities including heavy metals, agricultural residues and microbial toxins. This process provides hypoallergenic dietary fibers devoid of any potential allergens, cytotoxins, and gastrointestinal toxins. A sequential process for assembly of the soluble fibers with plurality of molecular weights to create a time controlled dissolution of the functional high and low molecular weight fibers for improving solubility and palatability with improved dietary performance in the oral and gastro-intestinal system is also disclosed herein.
摘要翻译：本文公开了一种来自豆科植物种子（例如Ceratonia siliqua，Caesalpinia spinosa Trigonelle foenum-graecum和Cyamopsis tetragonolobus）的化学纯化的可溶性甘露聚糖的组合物及其在可口的膳食补充剂的组装中的用途。分馏方法提供了高质量的生理上可溶性，化学修饰和纯化的均匀大小的多糖纤维，其中没有天然杂质，例如蛋白质，生物碱，糖生物碱和/或环境杂质，包括重金属，农业残留物和微生物毒素。该过程提供低过敏性膳食纤维，没有任何潜在的过敏原，细胞毒素和胃肠道毒素。用于组装具有多种分子量的可溶性纤维的顺序方法，以产生功能性高分子量和低分子量纤维的时间控制溶解，以改善口腔和胃肠系统中改善的膳食表现的溶解度和适口性，此外还公开。

10. 发明申请

US20120157407A1 GALACTOSE-PRONGED POLYSACCHARIDES IN A FORMULATION FOR ANTIFIBROTIC THERAPIES 有权
公开(公告)号：US20120157407A1
公开(公告)日：2012-06-21
申请号：US13333497
申请日：2011-12-21
申请人： David Platt , Eliezer Zomer , Anatole Klyosov
发明人： David Platt , Eliezer Zomer , Anatole Klyosov
IPC分类号： A61K31/736 , A61P9/12 , A61P25/00 , A61P1/16
CPC分类号： A61K31/732 , A61K31/715 , A61K39/395 , A61K45/06 , C08B37/0045 , C08B37/006 , A61K2300/00
摘要： Methods and compositions for reducing fibrosis and cirrhosis are provided in which an effective dose of an admixture of a polysaccharide compound and, for example, a compound selected from the group consisting of antibodies specific to intracellular or cell-surface: (i) beta-PDGF receptors; (ii) synaptophysin; (iii) zvegf3; (iv) CCR1 receptors; (v) connective tissue growth factor; (vi) alpha 1-smooth muscle actin; (vii) matrix metalloproteinases MMP 2 and MMP9; (viii) matrix metalloproteinase inhibitors TIMP1 and TMP2; (ix) integrins; (x) TFG-β1; (xi) endothelin receptor antagonists; and (xii) collagen synthesis and degradation modulating compounds; (xiii) actin synthesis and degradation modulating compounds; and (xiv) tyrosine kinases is administered to an animal in order to treat fibrosis.

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