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1. 发明授权

US09428508B2 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as FAK/Pyk2 inhibitors 有权
标题翻译： 2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物，为FAK / Pyk2抑制剂
公开(公告)号：US09428508B2
公开(公告)日：2016-08-30
申请号：US13978475
申请日：2012-01-07
申请人： Dengming Xiao , Liang Cheng , Xijie Liu , Yuandong Hu , Xinhe Xu , Zhihua Liu , Lipeng Zhang , Wei Wu , Shulong Wang , Yu Shen , Gen Li , Yin Wang , Sheng Zhao , Chonglong Li , Jia Tang , Honghao Yu
发明人： Dengming Xiao , Liang Cheng , Xijie Liu , Yuandong Hu , Xinhe Xu , Zhihua Liu , Lipeng Zhang , Wei Wu , Shulong Wang , Yu Shen , Gen Li , Yin Wang , Sheng Zhao , Chonglong Li , Jia Tang , Honghao Yu
IPC分类号： C07D487/04 , C07D413/12 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/4523 , A61P35/00 , C07D401/12 , C07D493/12 , C07D417/12
CPC分类号： C07D487/04 , A61K31/4523 , A61K31/519 , A61K31/5377 , A61K31/541 , C07D401/12 , C07D413/12 , C07D417/12 , C07D493/12
摘要： The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/or Pyk2 mediated disorder or disease.
摘要翻译：本发明涉及一种新型的作为FAK和/或Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物，其制备方法和组合物以及该化合物用于抑制FAK和/或Pyk2的方法和用于治疗FAK和/或Pyk2介导的病症或疾病的方法。

2. 发明申请

US20130281438A1 2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS 有权
标题翻译： 2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物，以FAK / Pyk2抑制剂
公开(公告)号：US20130281438A1
公开(公告)日：2013-10-24
申请号：US13978475
申请日：2012-01-07
申请人： Dengming Xiao , Liang Cheng , Xijie Liu , Yuandong Hu , Xinhe Xu , Zhihua Liu , Lipeng Zhang , Wei Wu , Shulong Wang , Yu Shen , Gen Li , Yin Wang , Sheng Zhao , Chonglong Li , Jia Tang , Honghao Yu
发明人： Dengming Xiao , Liang Cheng , Xijie Liu , Yuandong Hu , Xinhe Xu , Zhihua Liu , Lipeng Zhang , Wei Wu , Shulong Wang , Yu Shen , Gen Li , Yin Wang , Sheng Zhao , Chonglong Li , Jia Tang , Honghao Yu
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/4523 , A61K31/519 , A61K31/5377 , A61K31/541 , C07D401/12 , C07D413/12 , C07D417/12 , C07D493/12
摘要： The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/or Pyk2 mediated disorder or disease.
摘要翻译：本发明涉及一种新型的作为FAK和/或Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物，其制备方法和组合物以及该化合物用于抑制FAK和/或Pyk2的方法和用于治疗FAK和/或Pyk2介导的病症或疾病的方法。

3. 发明授权

US08947663B2 Dual-modulation faraday rotation spectroscopy 有权
标题翻译：双调制法拉第旋转光谱
公开(公告)号：US08947663B2
公开(公告)日：2015-02-03
申请号：US14215739
申请日：2014-03-17
申请人： Yin Wang , Gerard Wysocki
发明人： Yin Wang , Gerard Wysocki
IPC分类号： G01J4/00 , G01J4/04 , G01N21/21
CPC分类号： G01N21/21 , G01J3/447 , G01N21/1717 , G01N2021/1727
摘要： A dual-modulation Faraday rotation spectroscopic (FRS) system is disclosed. The FRS system uses an FRS sample cell configured to subject a sample to a low frequency modulated magnetic field. The system includes a polarized laser light source configured to generate a high frequency wavelength-modulated light beam incident on the sample, the high frequency wavelength-modulated light beam being modulated at a higher frequency than the low frequency modulated magnetic field. A polarizer is configured to receive from the sample a transmitted light beam having a modulated polarization having a polarization rotation and translate the modulated polarization of the transmitted light beam into an intensity modulated beam. A photodetector is configured to detect the intensity modulated beam and generate a photodetector signal. A dual demodulator is coupled to the photodetector and is configured to demodulate the photodetector signal.
摘要翻译：公开了一种双调制法拉第旋转光谱（FRS）系统。 FRS系统使用被配置为使样本进入低频调制磁场的FRS采样单元。该系统包括被配置为产生入射在样品上的高频波长调制光束的偏振激光光源，高频波长调制光束以比低频调制磁场更高的频率进行调制。偏振器被配置为从样本接收具有具有偏振旋转的调制偏振的透射光束，并将透射光束的调制偏振转换成强度调制光束。光电检测器被配置为检测强度调制光束并产生光电检测器信号。双重解调器耦合到光电检测器并且被配置为解调光电检测器信号。

4. 发明申请

US20140268148A1 Dual-Modulation Faraday Rotation Spectroscopy 有权
标题翻译：双调制法拉第旋转光谱
公开(公告)号：US20140268148A1
公开(公告)日：2014-09-18
申请号：US14215739
申请日：2014-03-17
申请人： Yin Wang , Gerard Wysocki
发明人： Yin Wang , Gerard Wysocki
IPC分类号： G01J4/04 , G01N21/21
CPC分类号： G01N21/21 , G01J3/447 , G01N21/1717 , G01N2021/1727
摘要： A dual-modulation Faraday rotation spectroscopic (FRS) system is disclosed. The FRS system uses an FRS sample cell configured to subject a sample to a low frequency modulated magnetic field. The system includes a polarized laser light source configured to generate a high frequency wavelength-modulated light beam incident on the sample, the high frequency wavelength-modulated light beam being modulated at a higher frequency than the low frequency modulated magnetic field. A polarizer is configured to receive from the sample a transmitted light beam having a modulated polarization having a polarization rotation and translate the modulated polarization of the transmitted light beam into an intensity modulated beam. A photodetector is configured to detect the intensity modulated beam and generate a photodetector signal. A dual demodulator is coupled to the photodetector and is configured to demodulate the photodetector signal.
摘要翻译：公开了一种双调制法拉第旋转光谱（FRS）系统。 FRS系统使用被配置为使样本进入低频调制磁场的FRS采样单元。该系统包括被配置为产生入射在样品上的高频波长调制光束的偏振激光光源，高频波长调制光束以比低频调制磁场更高的频率进行调制。偏振器被配置为从样本接收具有具有偏振旋转的调制偏振的透射光束，并将透射光束的调制偏振转换成强度调制光束。光电检测器被配置为检测强度调制光束并产生光电检测器信号。双重解调器耦合到光电检测器并且被配置为解调光电检测器信号。

5. 发明申请

US20120264697A1 USES OF HYPOXIA-INDUCIBLE FACTOR INHIBITORS 有权
标题翻译： HYPOXIA诱导因子抑制剂的使用
公开(公告)号：US20120264697A1
公开(公告)日：2012-10-18
申请号：US13513659
申请日：2010-06-25
申请人： Yang Liu , Yin Wang , Yan Liu , Sami N. Malek , Pan Zheng
发明人： Yang Liu , Yin Wang , Yan Liu , Sami N. Malek , Pan Zheng
IPC分类号： A61K38/12 , A61P35/00
CPC分类号： A61K38/07 , A61K31/00 , A61K31/395 , A61K31/4355 , A61K31/498 , A61K31/565 , A61K38/08 , A61K45/06 , A61K2300/00
摘要： The present invention relates to treating a hematologic cancer using a Hypoxia- Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIF inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIF inhibitor.
摘要翻译：本发明涉及使用缺氧诱导因子（HIF抑制剂）治疗血液癌症。本发明还涉及使用HIF抑制剂诱导急性骨髓性白血病缓解。本发明还涉及使用HIF抑制剂抑制癌症干细胞（CSC）的维持或存活功能。

6. 发明申请

US20110126219A1 Middleware for Extracting Aggregation Statistics to Enable Light-Weight Management Planners 失效
标题翻译：提取聚合统计数据以实现轻量级管理规划者的中间件
公开(公告)号：US20110126219A1
公开(公告)日：2011-05-26
申请号：US12622737
申请日：2009-11-20
申请人： Aameek Singh , Sandeep M. Uttamchandani , Yin Wang
发明人： Aameek Singh , Sandeep M. Uttamchandani , Yin Wang
IPC分类号： G06F9/46
CPC分类号： G06F9/50
摘要： Management of a planner through use of a middleware layer. A computer system is configured with the middleware layer in communication with both a planner and a data repository. One or more modules are provided in the middleware layer to support the functionality of the planner. Application program interface calls are employed to call the modules, thereby mitigating duplication of the functionality in separate planners.
摘要翻译：通过使用中间件层来管理计划者。计算机系统配置有与计划者和数据存储库通信的中间件层。在中间件层中提供一个或多个模块以支持计划者的功能。应用程序接口调用用于调用模块，从而减轻单独规划者中功能的重复。

7. 发明授权

US07823154B2 System and method for providing, by a plurality of schedulers, differentiated service to consumers of distributed resources 有权
标题翻译：由多个调度器向分散资源的消费者提供差分服务的系统和方法
公开(公告)号：US07823154B2
公开(公告)日：2010-10-26
申请号：US11228901
申请日：2005-09-16
申请人： Yin Wang , Arif Merchant
发明人： Yin Wang , Arif Merchant
IPC分类号： G06F9/46 , H04L12/28 , G06F15/173
CPC分类号： H04L47/623 , G06F3/0605 , G06F3/0656 , G06F3/0659 , G06F3/067 , H04L47/50 , H04L47/56
摘要： One embodiment of the present invention provides a method comprising assigning a first weight to a first consumer and a second weight to a second consumer. The method further comprises receiving at a first scheduler a request for service by a first resource to the first consumer; receiving at a second scheduler a request for service by a second resource to the first consumer; and receiving at the first scheduler a request for service by the first resource to the second consumer. The method further comprises scheduling, by the first and second schedulers, service from the first and second resources to the first and second consumers, wherein the scheduling maintains total service provided by the first and second resources to the first and second consumers in proportion to the respective weights of the first and second consumers without requiring the first and second schedulers to communicate with each other.
摘要翻译：本发明的一个实施例提供了一种方法，包括将第一权重分配给第一消费者，第二权重分配给第二消费者。该方法还包括在第一调度器处接收由第一资源向第一消费者服务的请求; 在第二调度器处接收第二资源到第一消费者的服务请求; 以及在所述第一调度器处接收所述第一资源到所述第二消费者的服务请求。该方法还包括由第一和第二调度器将从第一和第二资源到第一和第二消费者的服务进行调度，其中调度将由第一和第二资源提供的总服务按照第一和第二消费者的相应权重，而不需要第一和第二调度器彼此通信。

8. 发明申请

US20090325868A1 Materials And Methods For FOXP3 Tumor Suppression 有权
标题翻译： FOXP3肿瘤抑制的材料与方法
公开(公告)号：US20090325868A1
公开(公告)日：2009-12-31
申请号：US12119158
申请日：2008-05-12
申请人： Yang Liu , Pan Zheng , Xing Chang , Lizhong Wang , Runhua Liu , Yin Wang , Yan Liu , Tao Zuo
发明人： Yang Liu , Pan Zheng , Xing Chang , Lizhong Wang , Runhua Liu , Yin Wang , Yan Liu , Tao Zuo
IPC分类号： A61K38/16 , A61K31/7052 , A61K31/4375 , A61K31/40 , A61K31/7064 , C12N5/00 , C12Q1/02 , C12Q1/68 , A61P35/00
CPC分类号： G01N33/57415 , A61K31/7088 , A61K38/1709 , A61K45/06 , G01N33/57434 , A61K2300/00
摘要： Provided herein are methods of treating a cancer in a subject comprising administering a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Methods of altering a phenotype of a cancer cell or tumor cell, methods of inhibiting growth of such cells, and methods of inducing apoptosis of these cells are also provided herein. These methods comprise contacting the cell with a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Further provided herein are diagnostic methods, comprising comparing the expression or structure of a FOXP3 protein or FOXP3 gene in a test sample to that of a normal or prior sample. A method of screening a test compound for anti-cancer activity comprising administering to cells the test compound and measuring FOXP3 protein or FOXP3 gene expression is moreover provided herein.
摘要翻译：本文提供了治疗受试者中的癌症的方法，包括施用FOXP3蛋白，编码FOXP3蛋白的核酸或诱导FOXP3蛋白表达的诱导化合物。本文还提供了改变癌细胞或肿瘤细胞表型的方法，抑制细胞生长的方法和诱导细胞凋亡的方法。这些方法包括使细胞与FOXP3蛋白，编码FOXP3蛋白的核酸或诱导FOXP3蛋白表达的诱导化合物接触。本文进一步提供了诊断方法，其包括将测试样品中FOXP3蛋白或FOXP3基因的表达或结构与正常或先前样品的表达或结构进行比较。筛选测试化合物用于抗癌活性的方法，其中还提供了向细胞施用测试化合物并测量FOXP3蛋白或FOXP3基因表达。

9. 发明申请

US20090258656A1 Method for Exchanging Location-Relevant Information Using a Mobile Device with an Interactive Map Display 审中-公开
标题翻译：使用具有交互式地图显示的移动设备交换位置相关信息的方法
公开(公告)号：US20090258656A1
公开(公告)日：2009-10-15
申请号：US12101998
申请日：2008-04-13
申请人： Yin Wang , Tao Jin
发明人： Yin Wang , Tao Jin
IPC分类号： H04W4/02
CPC分类号： H04W4/029 , H04L67/18
摘要： A method is disclosed for wirelessly providing easily accessed and comprehended location-relevant information to a mobile device or web browser by displaying a map showing locations of interest. Simply by touching the map, a user can specify locations and regions used for queries and for uploading peer-to-peer information such as blogs, reviews, items for sale, etc. The device can request information, receive synchronously or asynchronously pushed responses, and display them with symbols that indicate category, age, etc. Location-aware devices can automatically specify their locations and provide location histories. Regions of interest can be adjusted according to visitation frequency, or region boundaries can simply be traced on the map. Limits can be placed on requested information and on distribution of uploaded information. Queries can use fuzzy logic, transactions can be completed using the devices, and requested information can be delivered when battery charge level and wireless link quality are appropriate.
摘要翻译：公开了一种用于通过显示示出感兴趣的位置的地图来向移动设备或网络浏览器无线地提供容易访问和理解的位置相关信息的方法。通过触摸地图，用户可以指定用于查询的位置和区域，以及用于上传诸如博客，评论，出售物品等对等信息。设备可以请求信息，同步或异步地推送响应，并使用指示类别，年龄等的符号显示它们。位置感知设备可以自动指定其位置并提供位置历史。感兴趣区域可以根据访问频率进行调整，也可以简单地在地图上追踪区域边界。限制可以放在所要求的信息和分发上传的信息上。查询可以使用模糊逻辑，可以使用设备完成事务，并且当电池电量级别和无线链路质量合适时，可以提供所请求的信息。

10. 发明申请

US20070082187A1 Celluosic products comprising substantially voc-free compositions 审中-公开
标题翻译：包含基本上无声组合物的Celluosic产品
公开(公告)号：US20070082187A1
公开(公告)日：2007-04-12
申请号：US11477096
申请日：2006-06-27
申请人： Yin Wang , Wenbo Jiang
发明人： Yin Wang , Wenbo Jiang
IPC分类号： C08L97/02 , C08L1/00
CPC分类号： C08L97/02 , B27K3/15 , B27K5/02 , B27K5/065 , C08L61/24 , Y10T428/249924
摘要： Embodiments of a composition useful for forming cellulosic products are disclosed, as well as products made using disclosed compositions. One disclosed composition comprises effective amount of dihydroxyethylene urea(s), dihydroxypropanol ureas, glycoluril(s), or combinations thereof. Such compositions can be cross linked, or not. The compositions can include other materials, such as methylol melamine; maltodextrin, where the DE of the maltodextrin can vary from about 4 to about 25, optional auxiliary additives, including a surfactant; a trialkanolamine, a preservative, a fire retardant; an aesthetic material, such as a dye that, in certain embodiments, substantially completely penetrates the cross section of the board product; a hardness enhancer; and any and all combinations of such materials. One embodiment of a disclosed method for making a cellulosic product comprises first providing a disclosed composition and applying it to cellulosic material, such as by substantially immersing cellulosic material in desired compositions in an autoclave.
摘要翻译：公开了用于形成纤维素产品的组合物的实施方案，以及使用所公开的组合物制备的产品。一种公开的组合物包含有效量的二羟基亚乙基脲，二羟基丙基脲，甘脲或其组合。这样的组合物可以是交联的或不交联的。组合物可以包括其它材料，例如羟甲基三聚氰胺; 麦芽糖糊精，其中麦芽糖糊精的DE可以在约4至约25之间变化，任选的辅助添加剂，包括表面活性剂; 三烷醇胺，防腐剂，阻燃剂; 美学材料，例如染料，其在某些实施方案中基本上完全渗透板产品的横截面; 硬度增强剂以及这些材料的任何和所有组合。公开的制造纤维素产品的方法的一个实施方案包括首先提供所公开的组合物并将其施加到纤维素材料上，例如通过将高分子化合物中的纤维素材料基本上浸入所需的组合物中。

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