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1. 发明申请

US20130041331A1 Modular Drug Delivery System for Minimizing Trauma During and After Insertion of a Cochlear Lead 审中-公开
标题翻译：模块化药物输送系统，用于在耳蜗插入期间和之后最小化创伤
公开(公告)号：US20130041331A1
公开(公告)日：2013-02-14
申请号：US13588837
申请日：2012-08-17
申请人： Edward H. Overstreet , Jian Xie , Michael S. Colvin , Michael A. Faltys
发明人： Edward H. Overstreet , Jian Xie , Michael S. Colvin , Michael A. Faltys
IPC分类号： A61M5/00
CPC分类号： A61K9/0024 , A61K9/0046 , A61K31/573 , A61K45/06 , A61N1/0541 , A61K2300/00
摘要： A system for delivering a therapeutic agent to biological tissue includes a surgically implantable lead to be inserted into the biological tissue. The surgically implantable lead includes a preformed cavity. A modular capsule is configured to be retained within the preformed cavity. The modular capsule includes a first therapeutic agent and a second therapeutic agent, wherein the first therapeutic agent elutes rapidly into the biological tissue and the second therapeutic agent elutes more slowly into the biological tissue.
摘要翻译：用于将治疗剂递送到生物组织的系统包括插入到生物组织中的可手术植入的引线。手术可植入引线包括预成型腔。模块化胶囊被构造成保持在预成型腔内。模块化胶囊包括第一治疗剂和第二治疗剂，其中第一治疗剂快速洗脱到生物组织中，第二治疗剂更缓慢地洗脱到生物组织中。

2. 发明授权

US08271101B2 Modular drug delivery system for minimizing trauma during and after insertion of a cochlear lead 有权
标题翻译：用于在耳蜗引线插入期间和之后最小化创伤的模块化药物递送系统
公开(公告)号：US08271101B2
公开(公告)日：2012-09-18
申请号：US12533963
申请日：2009-07-31
申请人： Edward H. Overstreet , Jian Xie , Michael S. Colvin , Michael A. Faltys
发明人： Edward H. Overstreet , Jian Xie , Michael S. Colvin , Michael A. Faltys
IPC分类号： A61N1/05
CPC分类号： A61K9/0024 , A61K9/0046 , A61K31/573 , A61K45/06 , A61N1/0541 , A61K2300/00
摘要： A system for delivering therapeutic agents to biological tissue includes a surgically implantable lead configured to be inserted into the biological tissue, the surgically implantable lead including a preformed cavity; and a modular capsule containing a therapeutic agent which includes dexamethasone base; the modular capsule being secured within the preformed cavity; the modular capsule releasing the therapeutic agent into the biological tissue. A method of delivering therapeutic agents to biological tissue includes obtaining a surgically implantable lead with a preformed cavity; obtaining a modular capsule containing a therapeutic agent comprising dexamethasone base and securing it within the preformed cavity; and inserting the surgically implantable lead into the biological tissue.
摘要翻译：用于将治疗剂递送到生物组织的系统包括构造成插入到生物组织中的手术可植入引线，所述手术可植入引线包括预成型腔; 和含有治疗剂的模块化胶囊，其包括地塞米松碱; 模块化胶囊固定在预成型腔内; 模块化胶囊将治疗剂释放到生物组织中。将治疗剂递送到生物组织的方法包括获得具有预成型腔的手术可植入的引线; 获得含有治疗剂的模块化胶囊，所述治疗剂包含地塞米松碱并将其固定在预成型腔内; 并将手术可植入的铅插入生物组织。

3. 发明授权

US08190271B2 Minimizing trauma during and after insertion of a cochlear lead 有权
标题翻译：在耳蜗引线插入期间和之后最小化创伤
公开(公告)号：US08190271B2
公开(公告)日：2012-05-29
申请号：US12202134
申请日：2008-08-29
申请人： Edward H. Overstreet , Michael A. Faltys , Jian Xie , Michael S. Colvin
发明人： Edward H. Overstreet , Michael A. Faltys , Jian Xie , Michael S. Colvin
IPC分类号： A61N1/05
CPC分类号： A61N1/0541 , A61K9/0024 , A61K9/0046 , A61K31/495
摘要： A method for delivering dexamethasone base (DXMb) via an implantable electrode includes coupling DXMb to the implantable electrode and inserting the implantable electrode into animal tissue, the DXMb eluting into the animal tissue. An implantable nerve stimulating device includes an elongated member having a distal end bearing at least one electrode; and DXMb coupled to the elongated member, the DXMb being eluted into tissue surrounding the elongated member.
摘要翻译：通过可植入电极递送地塞米松碱（DXMb）的方法包括将DXMb连接到可植入电极并将可植入电极插入动物组织中，DXMb洗脱到动物组织中。植入式神经刺激装置包括具有至少一个电极的远端的细长构件; 和DXMb耦合到细长构件，DXMb被洗脱到围绕细长构件的组织中。

4. 发明申请

US20090292237A1 Modular Drug Delivery System for Minimizing Trauma During and After Insertion of a Cochlear Lead 有权
标题翻译：模块化药物输送系统，用于在耳蜗插入期间和之后最小化创伤
公开(公告)号：US20090292237A1
公开(公告)日：2009-11-26
申请号：US12533963
申请日：2009-07-31
申请人： Edward H. Overstreet , Jian Xie , Michael S. Colvin , Michael A. Faltys
发明人： Edward H. Overstreet , Jian Xie , Michael S. Colvin , Michael A. Faltys
IPC分类号： A61K9/22 , A61N1/36 , A61K9/52
CPC分类号： A61K9/0024 , A61K9/0046 , A61K31/573 , A61K45/06 , A61N1/0541 , A61K2300/00
摘要： A system for delivering therapeutic agents to biological tissue includes a surgically implantable lead configured to be inserted into the biological tissue, the surgically implantable lead including a preformed cavity; and a modular capsule containing a therapeutic agent which includes dexamethasone base; the modular capsule being secured within the preformed cavity; the modular capsule releasing the therapeutic agent into the biological tissue. A method of delivering therapeutic agents to biological tissue includes obtaining a surgically implantable lead with a preformed cavity; obtaining a modular capsule containing a therapeutic agent comprising dexamethasone base and securing it within the preformed cavity; and inserting the surgically implantable lead into the biological tissue.
摘要翻译：用于将治疗剂递送到生物组织的系统包括构造成插入到生物组织中的手术可植入引线，所述手术可植入引线包括预成型腔; 和含有治疗剂的模块化胶囊，其包括地塞米松碱; 模块化胶囊固定在预成型腔内; 模块化胶囊将治疗剂释放到生物组织中。将治疗剂递送到生物组织的方法包括获得具有预成型腔的手术可植入的引线; 获得含有治疗剂的模块化胶囊，所述治疗剂包含地塞米松碱并将其固定在预成型腔内; 并将手术可植入的铅插入生物组织。

5. 发明申请

US20090062896A1 Minimizing Trauma During and After Insertion of a Cochlear Lead 有权
标题翻译：最小化耳蜗插入期间和之后的创伤
公开(公告)号：US20090062896A1
公开(公告)日：2009-03-05
申请号：US12202134
申请日：2008-08-29
申请人： Edward H. Overstreet , Michael A. Faltys , Jian Xie , Michael S. Colvin
发明人： Edward H. Overstreet , Michael A. Faltys , Jian Xie , Michael S. Colvin
IPC分类号： A61F11/00 , A61N1/05
CPC分类号： A61N1/0541 , A61K9/0024 , A61K9/0046 , A61K31/495
摘要： A method for delivering dexamethasone base (DXMb) via an implantable electrode includes coupling DXMb to the implantable electrode and inserting the implantable electrode into animal tissue, the DXMb eluting into the animal tissue. An implantable nerve stimulating device includes an elongated member having a distal end bearing at least one electrode; and DXMb coupled to the elongated member, the DXMb being eluted into tissue surrounding the elongated member.
摘要翻译：通过可植入电极递送地塞米松碱（DXMb）的方法包括将DXMb连接到可植入电极并将可植入电极插入动物组织中，DXMb洗脱到动物组织中。植入式神经刺激装置包括具有至少一个电极的远端的细长构件; 和DXMb耦合到细长构件，DXMb被洗脱到围绕细长构件的组织中。

6. 发明申请

US20090264962A1 Electric and Acoustic Stimulation Fitting Systems and Methods 有权
公开(公告)号：US20090264962A1
公开(公告)日：2009-10-22
申请号：US12495593
申请日：2009-06-30
申请人： Michael A. Faltys , Philip A. Segel , Edward H. Overstreet , William Vanbrooks Harrison
发明人： Michael A. Faltys , Philip A. Segel , Edward H. Overstreet , William Vanbrooks Harrison
IPC分类号： H04R25/00
CPC分类号： H04R25/70 , A61N1/36036
摘要： Methods and systems for modifying the parameters of at least one hearing device for a patient with residual hearing provide needed orchestration of acoustic and electric stimulation of patients wearing such devices.

7. 发明授权

US07561920B2 Electric and acoustic stimulation fitting systems and methods 有权
标题翻译：电声刺激配件系统和方法
公开(公告)号：US07561920B2
公开(公告)日：2009-07-14
申请号：US11097611
申请日：2005-03-31
申请人： Michael A. Faltys , Philip A. Segel , Edward H. Overstreet , William Vanbrooks Harrison
发明人： Michael A. Faltys , Philip A. Segel , Edward H. Overstreet , William Vanbrooks Harrison
IPC分类号： A61N1/18
CPC分类号： H04R25/70 , A61N1/36036
摘要： Methods and systems for modifying the parameters of at least one hearing device for a patient with residual hearing provide needed orchestration of acoustic and electric stimulation of patients wearing such devices.
摘要翻译：用于修改具有残留听力的患者的至少一个听力装置的参数的方法和系统为佩戴这种装置的患者提供对声学和电刺激的所需编排。

8. 发明申请

US20080221640A1 Multi-electrode stimulation to elicit electrically-evoked compound action potential 审中-公开
标题翻译：多电极刺激引发电诱发复合动作电位
公开(公告)号：US20080221640A1
公开(公告)日：2008-09-11
申请号：US10698097
申请日：2003-10-31
申请人： Edward H. Overstreet , Leonid M. Litvak , Michael A. Faltys
发明人： Edward H. Overstreet , Leonid M. Litvak , Michael A. Faltys
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61N1/36036
摘要： A multichannel neurostimulation device spatially spreads the excitation pattern in the target neural tissue by either: (1) rapid sequential stimulation of a small group of electrodes, or (2) simultaneously stimulating a small group of electrodes. Such multi-electrode stimulation stimulates a greater number of neurons in a synchronous manner, thereby increasing the amplitude of the extra-cellular voltage fluctuation and facilitating its recording. The electrical stimuli are applied simultaneously (or sequentially at a rapid rate) on selected small groups of electrodes while monitoring the evoked compound action potential (ECAP) on a nearby electrode. The presence of an observable ECAP not only validates operation of the implant device at a time when the patient may be unconscious or otherwise unable to provide subjective feedback, but also provides a way for the magnitude of the observed ECAP to be recorded as a function of the amplitude of the applied stimulus. From this data, a safe, efficacious and comfortable threshold level can be obtained which may be used thereafter as the initial setting of the stimulation parameters of the neurostimulation device, or to guide the setting of the stimulation parameters of the neurostimulation device.
摘要翻译：多通道神经刺激装置通过以下方式之一将目标神经组织中的激发图案空间扩展：（1）快速连续刺激小组电极，或（2）同时刺激小组电极。这种多电极刺激以同步方式刺激更多数量的神经元，从而增加细胞外电压波动的幅度并促进其记录。电刺激同时（或以快速顺序）施加在选定的小组电极上，同时监测附近电极上的诱发化合物动作电位（ECAP）。可观察到的ECAP的存在不仅在患者无意识或不能提供主观反馈的时候验证植入装置的操作，而且还提供了将所观察到的ECAP的大小记录为作为施加的刺激的幅度。从该数据可以获得安全，有效和舒适的阈值水平，其可以随后用作神经刺激装置的刺激参数的初始设置，或者指导神经刺激装置的刺激参数的设置。

9. 发明申请

US20090264963A1 Electric and Acoustic Stimulation Fitting Systems and Methods 有权
标题翻译：电声和声音刺激配件系统和方法
公开(公告)号：US20090264963A1
公开(公告)日：2009-10-22
申请号：US12495620
申请日：2009-06-30
申请人： Michael A. Faltys , Philip A. Segel , Edward H. Overstreet , William Vanbrooks Harrison
发明人： Michael A. Faltys , Philip A. Segel , Edward H. Overstreet , William Vanbrooks Harrison
IPC分类号： A61F11/04 , A61N1/36
CPC分类号： H04R25/70 , A61N1/36036
摘要： Methods and systems for modifying the parameters of at least one hearing device for a patient with residual hearing provide needed orchestration of acoustic and electric stimulation of patients wearing such devices.
摘要翻译：用于修改具有残留听力的患者的至少一个听力装置的参数的方法和系统为佩戴这种装置的患者提供对声学和电刺激的所需编排。

10. 发明授权

US07076308B1 Cochlear implant and simplified method of fitting same 有权
标题翻译：人工耳蜗植入和简化方法相似
公开(公告)号：US07076308B1
公开(公告)日：2006-07-11
申请号：US10218645
申请日：2002-08-13
申请人： Edward H. Overstreet , Michael A. Faltys
发明人： Edward H. Overstreet , Michael A. Faltys
IPC分类号： A61N1/36
CPC分类号： A61N1/36036 , A61N1/0541
摘要： A bionic ear cochlear stimulation system has the capability to stimulate fast enough to induce stochastic neural firing, thereby acting to restore “spontaneous” neural activity. Such neurostimulation involves the use of a high rate pulsitile stimulation signal that is amplitude modulated with sound information. Advantageously, by using such neurostimulation, a fitting system may be utilized that does not normally require T-level threshold measurements. T-level threshold measurements are not required in most instances because the high-rate pulsitile stimulation, even though at levels that would normally be a sub-threshold electrical stimulus, is able to modulate neural firing patterns in a perceptible way.
摘要翻译：仿生耳蜗耳刺激系统具有刺激足够快以诱导随机神经发射的能力，从而起到恢复“自发”神经活动的作用。这种神经刺激涉及使用用声音信息进行幅度调制的高速率脉动刺激信号。有利地，通过使用这种神经刺激，可以采用通常不需要T级阈值测量的拟合系统。在大多数情况下，不需要T级阈值测量，因为即使在通常为亚阈值电刺激的水平下，高速率脉动刺激能够以可察觉的方式调节神经发射模式。

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