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1. 发明申请

US20130041331A1 Modular Drug Delivery System for Minimizing Trauma During and After Insertion of a Cochlear Lead 审中-公开
标题翻译：模块化药物输送系统，用于在耳蜗插入期间和之后最小化创伤
公开(公告)号：US20130041331A1
公开(公告)日：2013-02-14
申请号：US13588837
申请日：2012-08-17
申请人： Edward H. Overstreet , Jian Xie , Michael S. Colvin , Michael A. Faltys
发明人： Edward H. Overstreet , Jian Xie , Michael S. Colvin , Michael A. Faltys
IPC分类号： A61M5/00
CPC分类号： A61K9/0024 , A61K9/0046 , A61K31/573 , A61K45/06 , A61N1/0541 , A61K2300/00
摘要： A system for delivering a therapeutic agent to biological tissue includes a surgically implantable lead to be inserted into the biological tissue. The surgically implantable lead includes a preformed cavity. A modular capsule is configured to be retained within the preformed cavity. The modular capsule includes a first therapeutic agent and a second therapeutic agent, wherein the first therapeutic agent elutes rapidly into the biological tissue and the second therapeutic agent elutes more slowly into the biological tissue.
摘要翻译：用于将治疗剂递送到生物组织的系统包括插入到生物组织中的可手术植入的引线。手术可植入引线包括预成型腔。模块化胶囊被构造成保持在预成型腔内。模块化胶囊包括第一治疗剂和第二治疗剂，其中第一治疗剂快速洗脱到生物组织中，第二治疗剂更缓慢地洗脱到生物组织中。

2. 发明授权

US08271101B2 Modular drug delivery system for minimizing trauma during and after insertion of a cochlear lead 有权
标题翻译：用于在耳蜗引线插入期间和之后最小化创伤的模块化药物递送系统
公开(公告)号：US08271101B2
公开(公告)日：2012-09-18
申请号：US12533963
申请日：2009-07-31
申请人： Edward H. Overstreet , Jian Xie , Michael S. Colvin , Michael A. Faltys
发明人： Edward H. Overstreet , Jian Xie , Michael S. Colvin , Michael A. Faltys
IPC分类号： A61N1/05
CPC分类号： A61K9/0024 , A61K9/0046 , A61K31/573 , A61K45/06 , A61N1/0541 , A61K2300/00
摘要： A system for delivering therapeutic agents to biological tissue includes a surgically implantable lead configured to be inserted into the biological tissue, the surgically implantable lead including a preformed cavity; and a modular capsule containing a therapeutic agent which includes dexamethasone base; the modular capsule being secured within the preformed cavity; the modular capsule releasing the therapeutic agent into the biological tissue. A method of delivering therapeutic agents to biological tissue includes obtaining a surgically implantable lead with a preformed cavity; obtaining a modular capsule containing a therapeutic agent comprising dexamethasone base and securing it within the preformed cavity; and inserting the surgically implantable lead into the biological tissue.
摘要翻译：用于将治疗剂递送到生物组织的系统包括构造成插入到生物组织中的手术可植入引线，所述手术可植入引线包括预成型腔; 和含有治疗剂的模块化胶囊，其包括地塞米松碱; 模块化胶囊固定在预成型腔内; 模块化胶囊将治疗剂释放到生物组织中。将治疗剂递送到生物组织的方法包括获得具有预成型腔的手术可植入的引线; 获得含有治疗剂的模块化胶囊，所述治疗剂包含地塞米松碱并将其固定在预成型腔内; 并将手术可植入的铅插入生物组织。

3. 发明授权

US08190271B2 Minimizing trauma during and after insertion of a cochlear lead 有权
标题翻译：在耳蜗引线插入期间和之后最小化创伤
公开(公告)号：US08190271B2
公开(公告)日：2012-05-29
申请号：US12202134
申请日：2008-08-29
申请人： Edward H. Overstreet , Michael A. Faltys , Jian Xie , Michael S. Colvin
发明人： Edward H. Overstreet , Michael A. Faltys , Jian Xie , Michael S. Colvin
IPC分类号： A61N1/05
CPC分类号： A61N1/0541 , A61K9/0024 , A61K9/0046 , A61K31/495
摘要： A method for delivering dexamethasone base (DXMb) via an implantable electrode includes coupling DXMb to the implantable electrode and inserting the implantable electrode into animal tissue, the DXMb eluting into the animal tissue. An implantable nerve stimulating device includes an elongated member having a distal end bearing at least one electrode; and DXMb coupled to the elongated member, the DXMb being eluted into tissue surrounding the elongated member.
摘要翻译：通过可植入电极递送地塞米松碱（DXMb）的方法包括将DXMb连接到可植入电极并将可植入电极插入动物组织中，DXMb洗脱到动物组织中。植入式神经刺激装置包括具有至少一个电极的远端的细长构件; 和DXMb耦合到细长构件，DXMb被洗脱到围绕细长构件的组织中。

4. 发明申请

US20090292237A1 Modular Drug Delivery System for Minimizing Trauma During and After Insertion of a Cochlear Lead 有权
标题翻译：模块化药物输送系统，用于在耳蜗插入期间和之后最小化创伤
公开(公告)号：US20090292237A1
公开(公告)日：2009-11-26
申请号：US12533963
申请日：2009-07-31
申请人： Edward H. Overstreet , Jian Xie , Michael S. Colvin , Michael A. Faltys
发明人： Edward H. Overstreet , Jian Xie , Michael S. Colvin , Michael A. Faltys
IPC分类号： A61K9/22 , A61N1/36 , A61K9/52
CPC分类号： A61K9/0024 , A61K9/0046 , A61K31/573 , A61K45/06 , A61N1/0541 , A61K2300/00
摘要： A system for delivering therapeutic agents to biological tissue includes a surgically implantable lead configured to be inserted into the biological tissue, the surgically implantable lead including a preformed cavity; and a modular capsule containing a therapeutic agent which includes dexamethasone base; the modular capsule being secured within the preformed cavity; the modular capsule releasing the therapeutic agent into the biological tissue. A method of delivering therapeutic agents to biological tissue includes obtaining a surgically implantable lead with a preformed cavity; obtaining a modular capsule containing a therapeutic agent comprising dexamethasone base and securing it within the preformed cavity; and inserting the surgically implantable lead into the biological tissue.
摘要翻译：用于将治疗剂递送到生物组织的系统包括构造成插入到生物组织中的手术可植入引线，所述手术可植入引线包括预成型腔; 和含有治疗剂的模块化胶囊，其包括地塞米松碱; 模块化胶囊固定在预成型腔内; 模块化胶囊将治疗剂释放到生物组织中。将治疗剂递送到生物组织的方法包括获得具有预成型腔的手术可植入的引线; 获得含有治疗剂的模块化胶囊，所述治疗剂包含地塞米松碱并将其固定在预成型腔内; 并将手术可植入的铅插入生物组织。

5. 发明申请

US20090062896A1 Minimizing Trauma During and After Insertion of a Cochlear Lead 有权
标题翻译：最小化耳蜗插入期间和之后的创伤
公开(公告)号：US20090062896A1
公开(公告)日：2009-03-05
申请号：US12202134
申请日：2008-08-29
申请人： Edward H. Overstreet , Michael A. Faltys , Jian Xie , Michael S. Colvin
发明人： Edward H. Overstreet , Michael A. Faltys , Jian Xie , Michael S. Colvin
IPC分类号： A61F11/00 , A61N1/05
CPC分类号： A61N1/0541 , A61K9/0024 , A61K9/0046 , A61K31/495
摘要： A method for delivering dexamethasone base (DXMb) via an implantable electrode includes coupling DXMb to the implantable electrode and inserting the implantable electrode into animal tissue, the DXMb eluting into the animal tissue. An implantable nerve stimulating device includes an elongated member having a distal end bearing at least one electrode; and DXMb coupled to the elongated member, the DXMb being eluted into tissue surrounding the elongated member.
摘要翻译：通过可植入电极递送地塞米松碱（DXMb）的方法包括将DXMb连接到可植入电极并将可植入电极插入动物组织中，DXMb洗脱到动物组织中。植入式神经刺激装置包括具有至少一个电极的远端的细长构件; 和DXMb耦合到细长构件，DXMb被洗脱到围绕细长构件的组织中。

6. 发明授权

US09339643B1 Acutely stiff implantable electrodes 有权
标题翻译：急性植入式电极
公开(公告)号：US09339643B1
公开(公告)日：2016-05-17
申请号：US11694769
申请日：2007-03-30
申请人： Michael A. Moffitt , Michael S. Colvin , Michael Onuscheck
发明人： Michael A. Moffitt , Michael S. Colvin , Michael Onuscheck
IPC分类号： A61N1/00 , A61N1/05 , A61N1/375 , A61N1/04
CPC分类号： A61N1/0553 , A61N1/0476 , A61N1/05 , A61N1/375
摘要： An implantable device for stimulating body tissue that includes an electrode lead body and at least one stimulating electrode contact disposed on the electrode lead body. The electrode lead body may be a percutaneous electrode lead or an electrode paddle that is configured and arranged to be substantially stiff outside the patient's body and during insertion into the patient's body and then becomes non-stiff within the patient's body. The stiffness may be modified using, for example, resorbable materials, temperature sensitive materials, or a lumen within the lead body for introducing a pressurized gas or liquid to modify a stiffness of the lead body. In one embodiment, the lead body may have different acute and/or chronic shapes.
摘要翻译：一种用于刺激身体组织的可植入装置，包括电极引线体和设置在电极引线体上的至少一个刺激电极触点。电极引线体可以是经皮电极引线或电极焊盘，其被构造和布置成在插入到患者体内并且然后在患者身体内变得非刚性时基本上刚性地在患者身体外部僵硬。可以使用例如可吸收材料，温度敏感材料或引线体内的管腔来引入加压气体或液体以改变引线体的刚度来改变刚度。在一个实施例中，引线体可具有不同的急性和/或慢性形状。

7. 发明申请

US20130013044A1 NEURAL STIMULATION LEAD FIXATION 失效
标题翻译：神经刺激引线固定
公开(公告)号：US20130013044A1
公开(公告)日：2013-01-10
申请号：US13620138
申请日：2012-09-14
申请人： James R. Thacker , Michael S. Colvin , David K.L. Peterson , James P. McGivern
发明人： James R. Thacker , Michael S. Colvin , David K.L. Peterson , James P. McGivern
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61M25/1002 , A61M25/1011
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译：具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。一个实施方案涉及脊髓刺激（SCS）引线。将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。气球充满空气，液体或柔顺材料。当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。

8. 发明授权

US06934572B2 Implantable enzyme-based monitoring system having improved longevity due to improved exterior surfaces 有权
标题翻译：基于植入式酶的监测系统由于改进的外表面而具有改善的寿命
公开(公告)号：US06934572B2
公开(公告)日：2005-08-23
申请号：US10286174
申请日：2002-10-31
申请人： Joseph H. Schulman , Charles L. Byers , Gerald E. Adomian , Michael S. Colvin
发明人： Joseph H. Schulman , Charles L. Byers , Gerald E. Adomian , Michael S. Colvin
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532
摘要： An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.
摘要翻译：提供了一种适用于长期体内使用的可植入酶的监测系统，用于测量规定物质如葡萄糖的浓度。在一个实施方案中，可植入酶基监测系统包括至少一个传感器组件，围绕传感器组件的外部膜并且在其中具有窗口，以及固定到外部膜并覆盖窗户的聚合物窗口盖。优选地，监测系统的外膜是硅树脂，窗罩是甲基丙烯酸2-羟乙酯（HEMA），甲基丙烯酸N，N，N-二甲基氨基乙酯（DMAEMA）和甲基丙烯酸（MA）的聚合物。本文还提供了一种植入式酶基监测系统，其具有至少一个传感器组件，围绕传感器组件的外膜和固定到外膜外表面的涂层，其中该涂层抗凝血和蛋白质结合到外部外膜表面。优选地，涂层是80:20摩尔比的聚乙二醇（PEG）和肝素。最后，本文提供了一种涂覆可植入酶基监测系统的外膜的外表面的方法，包括以下步骤：通过等离子体蚀刻在硅氧烷表面上形成羟基; 使硅氧烷表面与氨基官能化硅烷反应，从而在硅氧烷表面上形成氨基; 同时将聚乙二醇（PEG）和肝素共价结合到氨基上; 并将肝素离子结合到监测系统表面。

9. 发明授权

US08554342B2 Neural stimulation lead fixation 失效
标题翻译：神经刺激铅固定
公开(公告)号：US08554342B2
公开(公告)日：2013-10-08
申请号：US13620138
申请日：2012-09-14
申请人： James R. Thacker , Michael S. Colvin , David K. L. Peterson , James P. McGivern
发明人： James R. Thacker , Michael S. Colvin , David K. L. Peterson , James P. McGivern
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61M25/1002 , A61M25/1011
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译：具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。一个实施方案涉及脊髓刺激（SCS）引线。将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。气球充满空气，液体或柔顺材料。当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。

10. 发明授权

US07722913B2 Implantable enzyme-based monitoring system having improved longevity due to improved exterior surfaces 有权
标题翻译：基于植入式酶的监测系统由于改进的外表面而具有改善的寿命
公开(公告)号：US07722913B2
公开(公告)日：2010-05-25
申请号：US11096818
申请日：2005-03-31
申请人： Joseph H. Schulman , Charles L. Byers , Gerald E. Adomian , Michael S. Colvin
发明人： Joseph H. Schulman , Charles L. Byers , Gerald E. Adomian , Michael S. Colvin
IPC分类号： A61L33/00
CPC分类号： A61B5/14865 , A61B5/14532
摘要： An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.
摘要翻译：提供了一种适用于长期体内使用的可植入酶的监测系统，用于测量规定物质如葡萄糖的浓度。在一个实施方案中，可植入酶基监测系统包括至少一个传感器组件，围绕传感器组件的外部膜并且在其中具有窗口，以及固定到外部膜并覆盖窗户的聚合物窗口盖。优选地，监测系统的外膜是硅树脂，窗罩是甲基丙烯酸2-羟乙酯（HEMA），甲基丙烯酸N，N，N-二甲基氨基乙酯（DMAEMA）和甲基丙烯酸（MA）的聚合物。本文还提供了一种植入式酶基监测系统，其具有至少一个传感器组件，围绕传感器组件的外膜和固定到外膜外表面的涂层，其中该涂层抗凝血和蛋白质结合到外部外膜表面。优选地，涂层是80:20摩尔比的聚乙二醇（PEG）和肝素。最后，本文提供了一种涂覆可植入酶基监测系统的外膜的外表面的方法，包括以下步骤：通过等离子体蚀刻在硅氧烷表面上形成羟基; 使硅氧烷表面与氨基官能化硅烷反应，从而在硅氧烷表面上形成氨基; 同时将聚乙二醇（PEG）和肝素共价结合到氨基上; 并将肝素离子结合到监测系统表面。

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