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1. 发明授权

US08816058B2 Polynucleotides encoding anti-CD100 antibodies or antigen-binding fragments thereof 有权
标题翻译：编码抗CD100抗体的多核苷酸或其抗原结合片段
公开(公告)号：US08816058B2
公开(公告)日：2014-08-26
申请号：US13517807
申请日：2012-06-14
申请人： Ernest S. Smith , Terrence Lee Fisher
发明人： Ernest S. Smith , Terrence Lee Fisher
IPC分类号： C07H21/04 , C12N1/20
CPC分类号： C07K16/2803 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/2896 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Isolated polynucleotides are provided which encode antibody VH and VL polypeptides, and anti-CD100 antibodies and antigen-binding fragments thereof. In another aspect, the invention provides a vector comprising a polynucleotide of the invention. In another aspect, the invention provides a host cell comprising the vector of the invention. In another aspect, the invention provides a method of producing an antibody of the invention, e.g., for treating diseases associated with CD100, including certain autoimmune diseases, inflammatory diseases, and cancers.
摘要翻译：提供了分离的多核苷酸，其编码抗体VH和VL多肽，以及编码抗CD100抗体及其抗原结合片段。另一方面，本发明提供了包含本发明多核苷酸的载体。另一方面，本发明提供了包含本发明载体的宿主细胞。另一方面，本发明提供了制备本发明抗体的方法，例如用于治疗与CD100相关的疾病，包括某些自身免疫疾病，炎性疾病和癌症。

2. 发明授权

US08496938B2 Anti-CD100 neutralizing neutralizing antibodies and methods of using the same 有权
标题翻译：抗CD100中和抗体及其使用方法
公开(公告)号：US08496938B2
公开(公告)日：2013-07-30
申请号：US12776187
申请日：2010-05-07
申请人： Ernest S. Smith , Terrence Lee Fisher
发明人： Ernest S. Smith , Terrence Lee Fisher
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/2803 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/2896 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Compositions and methods are provided for treating diseases associated with CD100, including certain autoimmune diseases, inflammatory diseases, and cancers. In particular, anti-CD100 monoclonal antibodies have been developed to neutralize CD100.
摘要翻译：提供组合物和方法用于治疗与CD100相关的疾病，包括某些自身免疫疾病，炎性疾病和癌症。特别地，已经开发了抗CD100单克隆抗体来中和CD100。

3. 发明申请

US20120270268A1 Anti-CD100 Neutralizing Antibodies and Methods of Using the Same 有权
标题翻译：抗CD100中和抗体及其使用方法
公开(公告)号：US20120270268A1
公开(公告)日：2012-10-25
申请号：US13517807
申请日：2012-06-14
申请人： Ernest S. SMITH , Terrence Lee Fisher
发明人： Ernest S. SMITH , Terrence Lee Fisher
IPC分类号： C12N15/13 , C12N5/10 , C12N1/21 , C12N1/19 , C12P21/02 , C12N15/63
CPC分类号： C07K16/2803 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/2896 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Compositions and methods are provided for treating diseases associated with CD100, including certain autoimmune diseases, inflammatory diseases, and cancers. In particular, anti-CD100 monoclonal antibodies have been developed to neutralize CD100.
摘要翻译：提供组合物和方法用于治疗与CD100相关的疾病，包括某些自身免疫疾病，炎性疾病和癌症。特别地，已经开发了抗CD100单克隆抗体来中和CD100。

4. 发明申请

US20080219971A1 HUMAN ANTI-CD100 ANTIBODIES 有权
标题翻译：人抗CD100抗体
公开(公告)号：US20080219971A1
公开(公告)日：2008-09-11
申请号：US12030356
申请日：2008-02-13
申请人： Ernest S. Smith , Terrence Lee Fisher , Maurice Zauderer
发明人： Ernest S. Smith , Terrence Lee Fisher , Maurice Zauderer
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/00 , C12N5/00 , C12P21/04
CPC分类号： C07K16/2803 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods are provided for treating diseases associated with CD100, including certain types of cancers, autoimmune diseases, inflammatory diseases including central nervous system (CNS) and peripheral nervous system (PNS) inflammatory diseases, transplant rejections, and invasive angiogenesis. Compositions include anti-CD100 antibodies capable of binding to a soluble human CD100 antigen or a CD100 antigen located on the surface of a human CD100-expressing cell, wherein the antibody has CD100 blocking activity that is achieved by having at least one optimized CDR or FWR engineered within the variable region of the antibody. Compositions also include antigen-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-CD100 antibodies of the invention, or antigen-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier, and methods of use of these anti-CD100 antibodies.
摘要翻译：提供用于治疗与CD100相关的疾病的组合物和方法，包括某些类型的癌症，自身免疫疾病，包括中枢神经系统（CNS）和周围神经系统（PNS）炎性疾病，移植排斥和侵袭性血管发生的炎性疾病。组合物包括能够结合位于人CD100表达细胞表面的可溶性人CD100抗原或CD100抗原的抗CD100抗体，其中所述抗体具有CD100阻断活性，其通过具有至少一种优化的CDR或FWR 在抗体的可变区内工程化。组合物还包括单克隆抗体的抗原结合片段，变体和衍生物，产生这些抗体组合物的细胞系和编码抗体氨基酸序列的分离的核酸分子。本发明还包括药物组合物，其包含本发明的抗CD100抗体或其药学上可接受的载体中的抗原结合片段，变体或衍生物，以及这些抗CD100抗体的使用方法。

5. 发明申请

US20100285036A1 Anti-CD100 Neutralizing Antibodies and Methods of Using the Same 有权
标题翻译：抗CD100中和抗体及其使用方法
公开(公告)号：US20100285036A1
公开(公告)日：2010-11-11
申请号：US12776187
申请日：2010-05-07
申请人： Ernest S. Smith , Terrence Lee Fisher
发明人： Ernest S. Smith , Terrence Lee Fisher
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , C12N15/63 , C12N5/07 , C12P21/00 , A61P29/00 , A61P37/02 , A61P19/02 , A61P35/00
CPC分类号： C07K16/2803 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/2896 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Compositions and methods are provided for treating diseases associated with CD100, including certain autoimmune diseases, inflammatory diseases, and cancers. In particular, anti-CD100 monoclonal antibodies have been developed to neutralize CD100.
摘要翻译：提供组合物和方法用于治疗与CD100相关的疾病，包括某些自身免疫疾病，炎性疾病和癌症。特别地，已经开发了抗CD100单克隆抗体来中和CD100。

6. 发明授权

US5841460A Thermal printer which recirculates receiver sheet between successive printing passes 失效
标题翻译：热敏打印机使接收片在连续的打印通道之间再循环
公开(公告)号：US5841460A
公开(公告)日：1998-11-24
申请号：US641250
申请日：1996-04-30
申请人： Daniel Charles Maslanka , Terrence Lee Fisher , Vlade Josif Kordovich
发明人： Daniel Charles Maslanka , Terrence Lee Fisher , Vlade Josif Kordovich
IPC分类号： B41J2/32 , B41J13/00 , B41J13/10
CPC分类号： B41J13/0045 , B41J13/10 , B41J2/32
摘要： A thermal printer (10) is useful for printing onto a receiver sheet (22, 24, 26) having a leading edge and a trailing edge and includes an elongated rotatable platen (34); an elongated thermal print head (30) positioned parallel to the platen; a closed loop pathway (12, 14, 16) for recirculating the receiver sheet in a printing direction from the platen and back to the platen, the platen being positioned for rotation in the printing direction with at least a portion of the platen in the pathway to engage the receiver sheet or a dye donor web (31); a supply roll (28) of dye donor web positioned upstream of the print head; a mechanism (76-112, 132-142) for moving the print head into the pathway opposite the platen to press the print head into engagement with the dye donor web, the dye donor web into engagement with the receiver sheet, and the receiver sheet into engagement with the platen; a mechanism (180-188) for rotating the platen in the printing direction to move either the dye donor web or both the dye donor web and the receiver sheet between the print head and the platen; and a mechanism (18, 166-174) for recirculating the receiver sheet through the closed loop pathway in the printing direction for successive thermal transfers of different dyes from the dye donor web. A method of thermal printing also is taught.
摘要翻译：热敏打印机（10）可用于打印到具有前缘和后缘的接收片（22,24,26）上并且包括细长的可旋转压板（34）; 与压板平行设置的细长热敏打印头（30）; 用于使接收片在打印方向上从压板再循环回到压板的闭环路径（12,14,16），所述压板被定位成在打印方向上旋转，所述压板的至少一部分在所述通路接合接收片或染料供体片（31）; 位于打印头上游的染料供体幅材的供应辊（28）; 用于将打印头移动到与压板相对的通道中的机构（76-112,132-142），以将打印头推压成与染色供体幅面接合，染料供体幅材与接收片接合，以及接收片与压板接合; 用于在打印方向上旋转所述压板以将所述染料供体幅材或所述染料供体幅材和所述接收片材两者移动在所述打印头和所述压板之间的机构（180-188）以及用于使接收片材在打印方向上循环通过闭环路径的机构（18,166-174），用于不同染料从染料供体幅片的连续热传递。还教导了热敏打印的方法。

7. 发明授权

US5798783A Thermal printer with sensor for leading edge of receiver sheet 失效
标题翻译：带传感器的热敏打印机，用于接收片的前缘
公开(公告)号：US5798783A
公开(公告)日：1998-08-25
申请号：US641127
申请日：1996-04-30
申请人： Daniel Charles Maslanka , Terrence Lee Fisher
发明人： Daniel Charles Maslanka , Terrence Lee Fisher
IPC分类号： B41J2/32 , B41J13/00 , B41J13/10 , B41J33/52
CPC分类号： B41J13/0045 , B41J13/10 , B41J2/32
摘要： A thermal printer (10) is useful for printing onto a receiver sheet (22, 24, 26) having a leading edge and a trailing edge and includes an elongated rotatable platen (34); an elongated thermal print head (30) positioned parallel to the platen; a pathway (12, 14, 16) for receiving a receiver sheet in a printing direction from the platen, the platen being positioned for rotation in the printing direction with at least a portion of the platen in the pathway to engage a receiver sheet or a dye donor web (31); a supply roll (28) of dye donor web positioned upstream of the print head; a mechanism (76-112, 132-142) for moving the print head into the pathway opposite the portion of the platen to press the print head into engagement with the dye donor web, the dye donor web into engagement with the receiver sheet, and the receiver sheet into engagement with the platen; a mechanism (180-188) for rotating the platen in the printing direction to move either the dye donor web or both the dye donor web and the receiver sheet between the print head and the platen; a mechanism (36-42) for sensing when the leading edge of the receiver sheet has reached a predetermined location downstream of the print head and for producing a signal; a controller (212), responsive to the signal, for activating the print head to cause dye transfer between the dye donor web and the receiver sheet; and a mechanism (18 , 166-174) for moving the receiver sheet in the pathway for successive thermal transfers of different dyes from the dye donor web.
摘要翻译：热敏打印机（10）可用于打印到具有前缘和后缘的接收片（22,24,26）上并且包括细长的可旋转压板（34）; 与压板平行设置的细长热敏打印头（30）; 用于沿打印方向从压板接收接收片的通路（12,14,16），所述压板被定位成在打印方向上旋转，所述压板在所述通路中的至少一部分与接收片接合染料供体网（31）; 位于打印头上游的染料供体幅材的供应辊（28）; 用于将打印头移动到与压板的部分相对的通道中的机构（76-112,132-142），以将打印头推压成与染料供体幅面接合，染料供体幅材与接收片接合，以及接收片与压板接合; 用于在打印方向上旋转所述压板以将所述染料供体幅材或所述染料供体幅材和所述接收片材两者移动在所述打印头和所述压板之间的机构（180-188）用于感测接收片的前缘何时到达打印头下游的预定位置并产生信号的机构（36-42）控制器（212），响应所述信号，用于启动所述打印头以在所述染料供体幅和所述接收片之间引起染料转移; 以及用于在所述路径中移动所述接收片的机构（18,166-174），用于不同染料从所述染料供体幅的连续热传递。

8. 发明授权

US5838357A Thermal printer which uses platen to transport dye donor web between successive printing passes 失效
标题翻译：热敏打印机，使用压板在连续印刷通道之间输送染料供体纤维网
公开(公告)号：US5838357A
公开(公告)日：1998-11-17
申请号：US641128
申请日：1996-04-30
申请人： Daniel Charles Maslanka , Vlade Josif Kordovich , Terrence Lee Fisher
发明人： Daniel Charles Maslanka , Vlade Josif Kordovich , Terrence Lee Fisher
IPC分类号： B41J2/32 , B41J13/00 , B41J13/10
CPC分类号： B41J13/10 , B41J13/0045 , B41J2/32
摘要： A thermal printer (10) is useful for printing onto a receiver sheet (22, 24, 26) and includes an elongated rotatable platen (34); an elongated thermal print head (30) positioned parallel to the platen; a supply roll (28) of dye donor web (31) positioned upstream of the print head; a mechanism (76-112, 132-142) for pressing the print head into engagement with the dye donor web and, in an absence of a receiver sheet, for pressing the dye donor web into engagement with the platen; and a mechanism (180-188) for rotating the platen, while the print head is pressing the dye donor web against the platen, to move the dye donor web between the print head and the platen.
摘要翻译：热敏打印机（10）可用于在接收片（22,24,26）上打印并且包括细长的可旋转压板（34）; 与压板平行设置的细长热敏打印头（30）; 位于打印头上游的染料供体卷筒纸（31）的供应辊（28）用于将印刷头按压与染料供体纤维网接合的机构（76-112,132-142），以及在不存在接收片材的情况下，用于将染料供体片材压制成与压板接合; 以及用于旋转压板的机构（180-188），同时打印头将染料供体薄片压靠在压板上，以使染料供体薄片在打印头和压板之间移动。

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