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1. 发明申请

US20120226329A1 System for Seeking for an Optimal Configuration of a Bi-, Tri- or Multi-ventricular Cardiac Resynchronization Implanted Device 有权
标题翻译：用于寻求双，三心室或多心室心脏再同步植入装置的最佳配置的系统
公开(公告)号：US20120226329A1
公开(公告)日：2012-09-06
申请号：US13411412
申请日：2012-03-02
申请人： Fabrizio Renesto , Lionel Giorgis
发明人： Fabrizio Renesto , Lionel Giorgis
IPC分类号： A61N1/37
CPC分类号： A61N1/36578 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3686 , A61N1/3706
摘要： An apparatus and a system for seeking for an optimal configuration of a bi-, tri- or multi-ventricular cardiac resynchronization implantable medical device. This system includes ventricular pacing, a signal representative of an endocardial acceleration (EA) of a patient's heart, and isolating and pre-processing the EA signal to obtain an EA1 component and an EA2 component. The effectiveness of the current pacing configuration is evaluated by one or more composite indexes that combine at least two of the following parameters: peak-to-peak amplitude (PEA1) of the EA1 component; time occurrence (TstEA1) of the beginning of the EA1 component; time interval (LargEA1) between the beginning of the EA1 component and the moment of the energy peak of the EA1 component; and duration of systole (Syst), represented by the time interval between the beginning (TstEA1) of the EA1 component and the beginning (TstEA2) of the EA2 component.
摘要翻译：用于寻求双心室，三心室或多心室再同步植入式医疗装置的最佳配置的装置和系统。该系统包括心室起搏，代表患者心脏的心内加速度（EA）的信号，以及分离和预处理EA信号以获得EA1分量和EA2分量。目前的起搏配置的有效性由一个或多个组合索引来评估，所述复合索引组合以下参数中的至少两个：EA1分量的峰 - 峰幅度（PEA1）; 时间发生（TstEA1）开始的EA1组件; EA1分量开始时间间隔（LargEA1）与EA1分量能量峰值时刻间隔（LargEA1）; 和持续时间（Syst），由EA1组分的起始点（TstEA1）与EA2组分的起始点（TstEA2）之间的时间间隔表示。

2. 发明授权

US08712526B2 System for seeking for an optimal configuration of a bi-, tri- or multi-ventricular cardiac resynchronization implanted device 有权
标题翻译：用于寻求双，三心室或多心室心脏再同步植入装置的最佳配置的系统
公开(公告)号：US08712526B2
公开(公告)日：2014-04-29
申请号：US13411412
申请日：2012-03-02
申请人： Fabrizio Renesto , Lionel Giorgis
发明人： Fabrizio Renesto , Lionel Giorgis
IPC分类号： A61N1/00
CPC分类号： A61N1/36578 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3686 , A61N1/3706
摘要： An apparatus and a system for seeking for an optimal configuration of a bi-, tri- or multi-ventricular cardiac resynchronization implantable medical device. This system includes ventricular pacing, a signal representative of an endocardial acceleration (EA) of a patient's heart, and isolating and pre-processing the EA signal to obtain an EA1 component and an EA2 component. The effectiveness of the current pacing configuration is evaluated by one or more composite indexes that combine at least two of the following parameters: peak-to-peak amplitude (PEA1) of the EA1 component; time occurrence (TstEA1) of the beginning of the EA1 component; time interval (LargEA1) between the beginning of the EA1 component and the moment of the energy peak of the EA1 component; and duration of systole (Syst), represented by the time interval between the beginning (TstEA1) of the EA1 component and the beginning (TstEA2) of the EA2 component.
摘要翻译：用于寻求双心室，三心室或多心室再同步植入式医疗装置的最佳配置的装置和系统。该系统包括心室起搏，代表患者心脏的心内加速度（EA）的信号，以及分离和预处理EA信号以获得EA1分量和EA2分量。目前的起搏配置的有效性由一个或多个组合索引来评估，所述复合索引组合以下参数中的至少两个：EA1分量的峰 - 峰幅度（PEA1）; 时间发生（TstEA1）开始的EA1组件; EA1分量开始时间间隔（LargEA1）与EA1分量能量峰值时刻间隔（LargEA1）; 和持续时间（Syst），由EA1组分的起始点（TstEA1）与EA2组分的起始点（TstEA2）之间的时间间隔表示。

3. 发明授权

US08874209B2 Device for characterizing the cardiac status of a patient equipped with a biventricular pacing active implant 有权
标题翻译：用于表征装备有双心室起搏活性植入物的患者的心脏状态的装置
公开(公告)号：US08874209B2
公开(公告)日：2014-10-28
申请号：US12331286
申请日：2008-12-09
申请人： Fabrizio Renesto , Filippo Ziglio
发明人： Fabrizio Renesto , Filippo Ziglio
IPC分类号： A61N1/00 , A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/36542 , A61N1/36578 , A61N1/3682 , A61N1/3684
摘要： A medical device for characterizing the cardiac status of a patient equipped with a bi-ventricular pacing active implant device. The implant collects an endocardiac acceleration signal and searches for an optimal pacing configuration. This latter tests a plurality of different pacing configurations and delivers for each tested configuration parameters derived from the endocardiac acceleration peak (PEA). The device derives a patient clinical status from those parameters, the indication being representative of the patient's response to the cardiac resynchronization therapy. Those parameters include: the possibility to automatically get or not a valid optimal AV Delay among all the biventricular pacing configurations; a factor indicating the character sigmoid of the PEA/AVD characteristic; the average value of the PEA for the various configurations; and the PEA signal/noise ratio. The active implantable medical device includes control software and processes for executing the characterizing functionality described.
摘要翻译：用于表征装备有双心室起搏活动植入装置的患者的心脏状态的医疗装置。植入物收集心内加速度信号并搜索最佳的起搏配置。后者测试多个不同的起搏配置，并为从心内膜加速峰（PEA）得到的每个测试配置参数递送。该装置从这些参数中导出患者临床状态，该指征代表患者对心脏再同步治疗的反应。这些参数包括：在所有双心室起搏配置中自动获得有效的最佳AV延迟的可能性; 表示PEA / AVD特征的字符Sig的一个因子; 各种配置的PEA的平均值; 和PEA信号/噪声比。主动植入式医疗装置包括用于执行描述的特征功能的控制软件和处理。

4. 发明授权

US07664547B2 Active implantable medical device with biventricular pacing and automatic optimization of pacing configuration 有权
标题翻译：具有双心室起搏和自动优化起搏配置的主动植入式医疗设备
公开(公告)号：US07664547B2
公开(公告)日：2010-02-16
申请号：US11425668
申请日：2006-06-21
申请人： Gianni Plicchi , Emanuela Marcelli , Fabrizio Renesto
发明人： Gianni Plicchi , Emanuela Marcelli , Fabrizio Renesto
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36185 , A61N1/36542 , A61N1/36578 , A61N1/368 , A61N1/3682 , A61N1/3684 , A61N1/3686 , A61N1/3688
摘要： An active implantable medical device with biventricular pacing and automatic optimization of pacing configuration. The device collects and analyzes an endocardial acceleration signal (EA), and searches for an optimal pacing configuration based upon a performance index derived from at least one value relating to one and/or the other of the two endocardial acceleration peaks (PEA I, PEA II) over a given heart cycle. Optimization search operates through a scanning of a parameter, e.g., atrio-ventricular delay, and calculation of the surface area underneath the characteristic of the peak amplitude as a function of the scanned parameter (atrioventricular delay).
摘要翻译：具有双心室起搏和自动优化起搏配置的主动植入式医疗设备。该装置收集和分析心内加速度信号（EA），并且基于从与两个心内加速度峰值（PEA I，PEA中的一个和/或另一个）相关的至少一个值导出的性能指数来搜索最佳起搏配置 II）在给定的心脏周期。优化搜索通过扫描参数，例如心房延迟，以及作为扫描参数（房室延迟）的函数的峰值幅度的特征下的表面积的计算来进行操作。

5. 发明授权

US08219193B2 Active implantable medical device for cardiac resynchronization with automatic optimization of atrioventricular and interventricular delays 有权
标题翻译：用于心脏再同步的主动植入式医疗装置，具有房室和室间延迟的自动优化
公开(公告)号：US08219193B2
公开(公告)日：2012-07-10
申请号：US12906844
申请日：2010-10-18
申请人： Fabrizio Renesto , Cyrille Casset
发明人： Fabrizio Renesto , Cyrille Casset
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61B5/0468 , A61B5/1107 , A61B5/6869 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/37264
摘要： An active implantable medical device for cardiac resynchronization with automatic optimization of atrioventricular and interventricular delays is disclosed. The device collects an endocardial acceleration signal EA and calculates the atrioventricular delay AVD and the interventricular delay VVD. The device isolate in the EA signal a component EA4 corresponding to the fourth EA peak and measure a temporal parameter related to a time interval between the detection of an atrial event (P/A) and the occurrence of the EA4 component. The device isolates an EA1 component corresponding to the first EA peak and measures a non-temporal parameter (APEA1) related to the peak amplitude or a signal energy of the EA1 component. The optimal AVD (AVDO) is determined by the temporal parameter related to the EA4 component, and is calculated for a plurality of different values of VVD to obtain a plurality of pairs of optimal values {AVDO, VVD}. The device selects one of these pairs of values based on the non-temporal parameter related to the EA1 component.
摘要翻译：公开了一种用于心脏再同步的主动植入式医疗装置，其具有房室和室间延迟的自动优化。该装置收集心内加速度信号EA并计算房室延迟AVD和室间延迟VVD。 EA中的器件分离出与第四EA峰对应的分量EA4，并测量与心房事件（P / A）的检测与EA4分量的发生之间的时间间隔相关的时间参数。该装置隔离对应于第一EA峰值的EA1分量，并测量与峰值振幅或EA1分量的信号能量相关的非时间参数（APEA1）。通过与EA4分量相关的时间参数确定最佳AVD（AVDO），并且针对多个不同的VVD值计算以获得多对最优值{AVDO，VVD}。该设备基于与EA1组件相关的非时间参数来选择这些值对之一。

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