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1. 发明申请

US20230065295A1 MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS 有权
公开(公告)号：US20230065295A1
公开(公告)日：2023-03-02
申请号：US17369871
申请日：2021-07-07
申请人： Genomatica, Inc.
发明人： Priti Pharkya , Anthony P. Burgard , Stephen J. Van Dien , Robin E. Osterhout , Mark J. Burk , John D. Trawick , Michael P. Kuchinskas , Brian Steer
IPC分类号： C12N1/20 , C12P7/18 , C12N9/18 , C12N15/52 , C12P7/42 , C12N1/14 , C12N1/16 , C12N15/63 , C07C31/20 , C07C59/01 , C08G18/28 , C08G18/32 , C08G63/06 , C08G63/16 , C08G63/181 , C08G69/02
摘要： The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate or related products using the microbial organisms.

2. 发明授权

US11525149B2 Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate 有权
公开(公告)号：US11525149B2
公开(公告)日：2022-12-13
申请号：US15600479
申请日：2017-05-19
申请人： Genomatica, Inc.
发明人： Mark J. Burk , Anthony P. Burgard , Priti Pharkya
IPC分类号： C12P7/46 , C12N15/00 , C12N9/00 , C12P7/04 , C12P7/40 , C12N9/88
摘要： A non-naturally occurring eukaryotic or prokaryotic organism includes one or more gene disruptions occurring in genes encoding enzymes imparting increased fumarate, malate or acrylate production in the organism when the gene disruption reduces an activity of the enzyme. The one or more gene disruptions confers increased production of acrylate onto the organism. Organisms that produce acrylate have an acrylate pathway that at least one exogenous nucleic acid encoding an acrylate pathway enzyme expressed in a sufficient amount to produce acrylate, the acrylate pathway comprising a decarboxylase. Methods of producing fumarate, malate or acrylate include culturing these organisms.

3. 发明申请

US20220333143A1 MICROORGANISMS AND METHODS FOR PRODUCTION OF SPECIFIC LENGTH FATTY ALCOHOLS AND RELATED COMPOUNDS 有权
公开(公告)号：US20220333143A1
公开(公告)日：2022-10-20
申请号：US17526632
申请日：2021-11-15
申请人： Genomatica, Inc.
发明人： Robin E. Osterhout , Anthony P. Burgard
IPC分类号： C12P7/64 , C12P7/6409 , C12P7/04 , C12P7/24 , C12N15/52 , C07C31/20 , C12N9/04 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/88 , C12N9/00
摘要： The invention provides non-naturally occurring microbial organisms containing a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms selectively produce a fatty alcohol, fatty aldehyde or fatty acid of a specified length. Also provided are non-naturally occurring microbial organisms having a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms further include an acetyl-CoA pathway. In some aspects, the microbial organisms of the invention have select gene disruptions or enzyme attenuations that increase production of fatty alcohols, fatty aldehydes or fatty acids. The invention additionally provides methods of using the above microbial organisms to produce a fatty alcohol, a fatty aldehyde or a fatty acid.

4. 发明授权

US11371063B2 Microorganisms and methods for the production of butadiene using acetyl-coA 有权
公开(公告)号：US11371063B2
公开(公告)日：2022-06-28
申请号：US16664549
申请日：2019-10-25
申请人： Genomatica, Inc.
发明人： Priti Pharkya , Anthony P. Burgard , Mark J. Burk
IPC分类号： C12P5/02 , C12N15/52 , C12P3/00 , C12P7/40 , C01B3/00 , C08F36/06 , C08F36/14 , C12N9/04 , C12N9/02 , C12N9/10 , C12N9/12
摘要： The invention provides non-naturally occurring microbial organisms containing butadiene or 2,4-pentadienoate pathways comprising at least one exogenous nucleic acid encoding a butadiene or 2,4-pentadienoate pathway enzyme expressed in a sufficient amount to produce butadiene or 2,4-pentadienoate. The organism can further contain a hydrogen synthesis pathway. The invention additionally provides methods of using such microbial organisms to produce butadiene or 2,4-pentadienoate by culturing a non-naturally occurring microbial organism containing butadiene or 2,4-pentadienoate pathways as described herein under conditions and for a sufficient period of time to produce butadiene or 2,4-pentadienoate. Hydrogen can be produced together with the production of butadiene or 2,4-pentadienoate.

5. 发明授权

US11371046B2 Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors 有权
公开(公告)号：US11371046B2
公开(公告)日：2022-06-28
申请号：US15270578
申请日：2016-09-20
申请人： Genomatica, Inc.
发明人： Mark J. Burk , Stephen J. Van Dien , Anthony P. Burgard , Wei Niu
IPC分类号： C12N15/52 , C12P7/18 , C12P7/42 , C12N9/04 , C12N9/02 , C12N9/88 , C12N9/00 , C12P7/52 , C12P17/04 , B01D3/00 , C12N15/70 , C12N15/81
摘要： The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce monomeric 4-hydroxybutanoic acid (4-HB). Also provided is a non-naturally occurring microbial biocatalyst including a microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (BDO) biosynthetic pathways, the pathways include at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, 4-hydroxybutyrate:CoA transferase, 4-butyrate kinase, phosphotransbutyrylase, α-ketoglutarate decarboxylase, aldehyde dehydrogenase, alcohol dehydrogenase or an aldehyde/alcohol dehydrogenase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce 1,4-butanediol (BDO). Additionally provided are methods for the production of 4-HB and BDO.

6. 发明授权

US11293026B2 Microorganisms for the production of adipic acid and other compounds 有权
公开(公告)号：US11293026B2
公开(公告)日：2022-04-05
申请号：US16550010
申请日：2019-08-23
申请人： Genomatica, Inc.
发明人： Anthony P. Burgard , Priti Pharkya , Robin E. Osterhout
IPC分类号： C12N1/21 , C12P7/44 , C12N9/04 , C12N9/12 , C12N9/10 , C12N9/88 , C12N9/02 , C12N9/16 , C12N15/52 , C12P13/00 , C12P13/02 , C12P17/10 , C12N9/80 , C12P7/46 , C12P7/62
摘要： The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or caprolactam. The method can include culturing an adipate, 6-aminocaproic acid or caprolactam producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an adipate, 6-aminocaproic acid or caprolactam pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid or caprolactam.

7. 发明授权

US11180780B2 Organisms for the production of 1,3-butanediol 有权
公开(公告)号：US11180780B2
公开(公告)日：2021-11-23
申请号：US15616841
申请日：2017-06-07
申请人： Genomatica, Inc.
发明人： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya
IPC分类号： C12N9/88 , C12N9/90 , C12P7/16 , C12N15/00 , C12P7/18 , C12N15/52 , C12N9/04 , C07C29/80 , C12N9/02 , C12N9/10
摘要： A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4-hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2-one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA-dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl-CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.

8. 发明申请

US20210332393A1 MICROORGANISMS AND METHODS FOR IMPROVING PRODUCT YIELDS ON METHANOL USING ACETYL-COA SYNTHESIS 有权
公开(公告)号：US20210332393A1
公开(公告)日：2021-10-28
申请号：US17064404
申请日：2020-10-06
申请人： Genomatica, Inc.
发明人： Robin E. Osterhout , Anthony P. Burgard , Priti Pharkya , Stefan Andrae
IPC分类号： C12P5/02 , C12P7/18 , C12N1/14 , C12N1/20 , C12P7/42 , C12P7/02 , C12P7/40 , C12N15/70 , C12N15/81 , C12P7/04 , C12P7/44 , C12P13/00 , C12P17/10
摘要： The invention provides non-naturally occurring microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA. In some embodiments, the microbial organisms of the invention having such pathways also include pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation. The enhanced carbon flux through acetyl-CoA, in combination with pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation can, in some embodiments, be used for production of a bioderived compound. Accordingly, in some embodiments, the microbial organisms of the invention can include a pathway capable of producing a bioderived compound of the invention. The invention still further provides a bioderived compound produced by a microbial organism of the invention, culture medium having the bioderived compound of the invention, compositions having the bioderived compound of the invention, a biobased product comprising the bioderived compound of the invention, and a process for producing a bioderived compound of the invention.

9. 发明申请

US20210147881A1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF BUTADIENE 有权
公开(公告)号：US20210147881A1
公开(公告)日：2021-05-20
申请号：US16912409
申请日：2020-06-25
申请人： Genomatica, Inc.
发明人： Mark J. Burk , Anthony P. Burgard , Jun Sun , Robin E. Osterhout , Priti Pharkya
IPC分类号： C12P5/02 , C12P7/04 , C07C1/24 , C12N15/52
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.

10. 发明申请

US20210123078A1 MICROORGANISMS FOR PRODUCING 1,3-BUTANEDIOL AND METHODS RELATED THERETO 有权
公开(公告)号：US20210123078A1
公开(公告)日：2021-04-29
申请号：US16894600
申请日：2020-06-05
申请人： Genomatica, Inc.
发明人： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Jun Sun , Priti Pharkya
IPC分类号： C12P7/18 , C12N15/52
摘要： Provided herein is a non-naturally occurring microbial organism having a 1,3-butanediol (1,3-BDO) pathway and comprising at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. In some embodiments, the pathway includes reducing equivalents from CO or hydrogen. In certain embodiments, a 1,3-BDO pathway proceeds by way of central metabolites pyruvate, succinate or alpha-ketoglutarate. Also provided herein is a method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.

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