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1. 发明授权

US09909150B2 Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,2-propanediol, n-propanol, 1,3-propanediol, or glycerol related thereto 有权
公开(公告)号：US09909150B2
公开(公告)日：2018-03-06
申请号：US14071318
申请日：2013-11-04
申请人： Genomatica, Inc.
发明人： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC分类号： C12P7/04 , C12P7/18 , C12P7/24 , C12N1/20 , C12N1/16 , C12N1/14 , C12P7/20 , C12N9/04 , C12N9/06 , C12N9/10 , C12N15/52
CPC分类号： C12P7/24 , C12N1/14 , C12N1/16 , C12N1/20 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N15/52 , C12P7/04 , C12P7/18 , C12P7/20 , C12Y101/01244 , C12Y105/0102
摘要： Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,2-propanediol, n-propanol, 1,3-propanediol or glycerol. Also provided herein are methods for using such an organism to produce 1,2-propanediol, n-propanol, 1,3-propanediol or glycerol.

2. 发明授权

US10808262B2 Microorganisms and methods for improving product yields on methanol using acetyl-CoA synthesis 有权
公开(公告)号：US10808262B2
公开(公告)日：2020-10-20
申请号：US15039221
申请日：2014-11-25
申请人： GENOMATICA, INC.
发明人： Robin E. Osterhout , Anthony P. Burgard , Priti Pharkya , Stefan Andrae
IPC分类号： C12N1/16 , C12N1/20 , C12P7/02 , C12P5/02 , C12P7/18 , C12N1/14 , C12P7/42 , C12P7/40 , C12N15/70 , C12N15/81 , C12P7/04 , C12P7/44 , C12P13/00 , C12P17/10
摘要： The invention provides non-naturally occurring microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA. In some embodiments, the microbial organisms having such pathways also include pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation. The enhanced carbon flux through acetyl-CoA, in combination with pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation can, in some embodiments, be used for production of a bioderived compound. Accordingly, in some embodiments, the microbial organisms of the invention can include a pathway capable of producing a bioderived compound of the invention. The invention still further provides a bioderived compound produced by a microbial organism of the invention, culture medium having the bioderived compound of the invention, compositions having the bioderived compound of the invention, a biobased product comprising the bioderived compound of the invention, and a process for producing a bioderived compound of the invention.

3. 发明申请

US20190032096A1 MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING SUCCINATE RELATED THERETO 审中-公开
公开(公告)号：US20190032096A1
公开(公告)日：2019-01-31
申请号：US15904198
申请日：2018-02-23
申请人： Genomatica, Inc.
发明人： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC分类号： C12P7/46 , C12N9/04 , C12N15/81 , C08G63/00 , C12N15/74 , C12N9/06 , C12N9/10 , C07C59/235 , C12P7/24 , C12N15/77 , C12N15/70 , C07C55/10
摘要： Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as succinate. Also provided herein are methods for using such an organism to produce succinate.

4. 发明申请

US20150203875A1 MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 1.4-BUTANEDIOL RELATED THERETO 审中-公开
标题翻译：用于提高甲醇存在下降低等效物质和生产与其相关的1,4-丁二醇的可行性的微生物和方法
公开(公告)号：US20150203875A1
公开(公告)日：2015-07-23
申请号：US14424404
申请日：2013-08-27
申请人： Genomatica, Inc.
发明人： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC分类号： C12P7/18 , C12P19/02 , C12N9/04 , C12N9/88 , C12N9/10 , C07D207/12 , C08G18/32 , C08G63/12 , C08G63/66 , C08G69/26 , C08G63/06 , C12P7/24 , C12N9/06
CPC分类号： C12P7/18 , C07D207/12 , C08G18/3206 , C08G63/06 , C08G63/12 , C08G63/66 , C08G69/26 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N9/88 , C12P7/24 , C12P19/02 , C12Y101/01224 , C12Y101/01244 , C12Y101/02007 , C12Y105/0102 , C12Y201/01 , C12Y201/0109 , C12Y402/01 , Y02P20/52
摘要： Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.
摘要翻译：本文提供了具有甲醇代谢途径（MMP）的非天然存在的微生物生物，其可以在甲醇存在下增强还原当量的可用性。这种还原当量可用于增加由微生物生物例如1,4-丁二醇（BDO）产生的有机化合物的产物产率。本文还提供了使用这种生物体产生BDO的方法。

5. 发明申请

US20140235815A1 MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING SUCCINATE RELATED THERETO 有权
标题翻译：用于提高甲醇存在下减少等效物的可行性的微生物和方法以及用于生产与其相关的成分
公开(公告)号：US20140235815A1
公开(公告)日：2014-08-21
申请号：US14059285
申请日：2013-10-21
申请人： Genomatica, Inc.
发明人： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC分类号： C12P7/46 , C08G63/00 , C07C55/10 , C12P7/24 , C12N15/70 , C12N15/81
CPC分类号： C12P7/46 , C07C55/10 , C07C59/235 , C08G63/00 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N15/70 , C12N15/74 , C12N15/77 , C12N15/81 , C12N15/815 , C12P7/24 , C12Y101/01244 , C12Y105/0102
摘要： Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as succinate. Also provided herein are methods for using such an organism to produce succinate.
摘要翻译：本文提供了具有甲醇代谢途径的非天然存在的微生物生物，其可以在甲醇存在下增强还原当量的可用性。这种还原当量可以用于增加由微生物生物如琥珀酸酯产生的有机化合物的产物产率。本文还提供了使用这种生物体来生产琥珀酸盐的方法。

6. 发明申请

US20210332393A1 MICROORGANISMS AND METHODS FOR IMPROVING PRODUCT YIELDS ON METHANOL USING ACETYL-COA SYNTHESIS 有权
公开(公告)号：US20210332393A1
公开(公告)日：2021-10-28
申请号：US17064404
申请日：2020-10-06
申请人： Genomatica, Inc.
发明人： Robin E. Osterhout , Anthony P. Burgard , Priti Pharkya , Stefan Andrae
IPC分类号： C12P5/02 , C12P7/18 , C12N1/14 , C12N1/20 , C12P7/42 , C12P7/02 , C12P7/40 , C12N15/70 , C12N15/81 , C12P7/04 , C12P7/44 , C12P13/00 , C12P17/10
摘要： The invention provides non-naturally occurring microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA. In some embodiments, the microbial organisms of the invention having such pathways also include pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation. The enhanced carbon flux through acetyl-CoA, in combination with pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation can, in some embodiments, be used for production of a bioderived compound. Accordingly, in some embodiments, the microbial organisms of the invention can include a pathway capable of producing a bioderived compound of the invention. The invention still further provides a bioderived compound produced by a microbial organism of the invention, culture medium having the bioderived compound of the invention, compositions having the bioderived compound of the invention, a biobased product comprising the bioderived compound of the invention, and a process for producing a bioderived compound of the invention.

7. 发明申请

US20210087591A1 MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 1.4-BUTANEDIOL RELATED THERETO 有权
公开(公告)号：US20210087591A1
公开(公告)日：2021-03-25
申请号：US16816064
申请日：2020-03-11
申请人： Genomatica, Inc.
发明人： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC分类号： C12P7/18 , C12N9/04 , C12N9/06 , C12N9/10 , C07D207/12 , C08G18/32 , C08G63/06 , C08G63/12 , C08G63/66 , C08G69/26 , C12N9/88 , C12P7/24 , C12P19/02
摘要： Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.

8. 发明授权

US10150976B2 Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam related thereto 有权
公开(公告)号：US10150976B2
公开(公告)日：2018-12-11
申请号：US14107832
申请日：2013-12-16
申请人： Genomatica, Inc.
发明人： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC分类号： C12P17/10 , C12P13/02 , C12P7/24 , C12P19/02 , C12P7/44 , C12P13/00 , C12N9/04 , C08G63/78 , C08G73/02 , C08G69/16 , C08G69/08 , C12N15/52 , A23L29/00
摘要： Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.

9. 发明授权

US10000758B2 Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, for producing methacrylic acid 有权
公开(公告)号：US10000758B2
公开(公告)日：2018-06-19
申请号：US15133150
申请日：2016-04-19
申请人： Genomatica, Inc.
发明人： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC分类号： C12N15/52 , C12P7/42 , C08F120/06 , C08G63/664 , C12N15/63 , C12P7/24 , C12P7/40 , C12N9/04 , C12N9/06 , C12N9/10 , C12P7/62
CPC分类号： C12N15/52 , C08F120/06 , C08G63/664 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N15/63 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/62 , C12Y101/01244 , C12Y105/0102 , C12Y201/0109
摘要： Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 3-hydroxyisobutyrate or MAA. Also provided herein are methods for using such an organism to produce 3-hydroxyisobutyrate or MAA.

10. 发明申请

US20160237410A1 ALCOHOL DEHYDROGENASE VARIANTS 审中-公开
标题翻译：酒精脱水变异
公开(公告)号：US20160237410A1
公开(公告)日：2016-08-18
申请号：US15027169
申请日：2014-10-03
申请人： GENOMATICA, INC.
发明人： Stefan Andrae , Michael Patrick Kuchinskas , Jingyi Li , Harish Nagarajan , Priti Pharkya
IPC分类号： C12N9/04 , C12P7/24
摘要： Described herein are non-natural NAD+-dependent alcohol dehydrogenases (ADHs) capable of at least two fold greater conversion of methanol or ethanol to formaldehyde or acetaldehyde, respectively, as compared to its unmodified counterpart. Nucleic acids encoding the non-natural alcohol dehydrogenases, as well as expression constructs including the nucleic acids, and engineered cells comprising the nucleic acids or expression constructs are described. Also described are engineered cells expressing a non-natural NAD+-dependent alcohol dehydrogenase, optionally include one or more additional metabolic pathway transgene(s), methanol metabolic pathway genes, target product pathway genes, cell culture compositions including the cells, methods for promoting production of the target product or intermediate thereof from the cells, compositions including the target product or intermediate, and products made from the target product or intermediate.
摘要翻译：本文描述了与其未修饰的对应物相比，能够分别甲醇或乙醇转化为甲醛或乙醛的至少两倍的非天然NAD +依赖性醇脱氢酶（ADH）。描述了编码非天然醇脱氢酶的核酸，以及包含核酸的表达构建体和包含核酸或表达构建体的工程化细胞。还描述了表达非天然NAD +依赖性醇脱氢酶的工程细胞，任选地包括一种或多种另外的代谢途径转基因，甲醇代谢途径基因，靶产物途径基因，包括细胞的细胞培养组合物，用于促进生产的方法的靶产物或其中间体，包括靶产物或中间体的组合物，以及由目标产物或中间体制成的产品。

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