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1. 发明申请

US20060182217A1 Method and imaging system for imaging the spatial distrubution of an x-ray fluorescence marker 失效
标题翻译：用于对X射线荧光标记的空间分布进行成像的方法和成像系统
公开(公告)号：US20060182217A1
公开(公告)日：2006-08-17
申请号：US10547588
申请日：2004-03-02
申请人： Geoffrey Harding , Jens-Peter Schlomka , Gerhard Martens
发明人： Geoffrey Harding , Jens-Peter Schlomka , Gerhard Martens
IPC分类号： G01N23/223 , G01T1/36
CPC分类号： A61B6/485 , A61B6/00 , A61B6/4092 , G01N23/223 , G01N2223/076
摘要： The invention describes a method of generating metabolic images of an investigation region (3) of a body (1) by irradiating an X-ray fluorescence marker in that region and detecting the resulting X-ray fluorescence with a fluorescence detector (30). A fan beam (12) is used as a source of primary X-radiation, thus allowing the scanning of a whole body slice (3) in one step. The fluorescence image may be directly measured, e.g. by mapping voxels (104) of the investigation region onto pixels (134) of the detector (130) with the help of a pinhole collimator (132), or it may be reconstructed by procedures of computed tomography. Moreover, a morphological image may be generated by simultaneously recording X-ray transmission through the body (1).
摘要翻译：本发明描述了通过在该区域中照射X射线荧光标记物并用荧光检测器（30）检测所得X射线荧光来产生身体（1）的调查区域（3）的代谢图像的方法。扇形光束（12）被用作初级X辐射源，从而允许在一个步骤中扫描全身切片（3）。可以直接测量荧光图像，例如。通过借助于针孔准直器（132）将调查区域的体素（104）映射到检测器（130）的像素（134）上，或者可以通过计算机断层摄影的程序来重构。此外，可以通过同时记录穿过身体（1）的X射线透射来产生形态学图像。

2. 发明授权

US07545910B2 Method and imaging system for imaging the spatial distribution of an x-ray fluorescence marker 失效
标题翻译：用于对X射线荧光标记的空间分布进行成像的方法和成像系统
公开(公告)号：US07545910B2
公开(公告)日：2009-06-09
申请号：US10547588
申请日：2004-03-02
申请人： Geoffrey Harding , Jens-Peter Schlomka , Gerhard Martens
发明人： Geoffrey Harding , Jens-Peter Schlomka , Gerhard Martens
IPC分类号： G01N23/223
CPC分类号： A61B6/485 , A61B6/00 , A61B6/4092 , G01N23/223 , G01N2223/076
摘要： The invention describes a method of generating metabolic images of an investigation region (3) of a body (1) by irradiating an X-ray fluorescence marker in that region and detecting the resulting X-ray fluorescence with a fluorescence detector (30). A fan beam (12) is used as a source of primary X-radiation, thus allowing the scanning of a whole body slice (3) in one step. The fluorescence image may be directly measured, e.g. by mapping voxels (104) of the investigation region onto pixels (134) of the detector (130) with the help of a pinhole collimator (132), or it may be reconstructed by procedures of computed tomography. Moreover, a morphological image may be generated by simultaneously recording X-ray transmission through the body (1).
摘要翻译：本发明描述了通过在该区域中照射X射线荧光标记物并用荧光检测器（30）检测所得到的X射线荧光来产生身体（1）的调查区域（3）的代谢图像的方法。扇形光束（12）被用作初级X辐射源，从而允许在一个步骤中扫描全身切片（3）。可以直接测量荧光图像，例如。通过借助于针孔准直器（132）将调查区域的体素（104）映射到检测器（130）的像素（134）上，或者可以通过计算机断层摄影的程序来重构。此外，可以通过同时记录穿过身体（1）的X射线透射来产生形态学图像。

3. 发明授权

US07551709B2 Fan-beam coherent-scatter computer tomography 失效
标题翻译：扇梁相干散射计算机断层扫描
公开(公告)号：US07551709B2
公开(公告)日：2009-06-23
申请号：US10557688
申请日：2004-05-18
申请人： Jens-Peter Schlomka , Geoffrey Harding
发明人： Jens-Peter Schlomka , Geoffrey Harding
IPC分类号： A61B6/03
CPC分类号： A61B6/483 , A61B6/032 , A61B6/4241 , A61B6/482 , G01N23/046 , G01N2223/419
摘要： In CSCT, by using a fan-shaped primary beam, combined with a 2D detector, single-slice transmission tomography and scatter tomography can be measured simultaneously. In such a System blurred scatter functions are measured unless a monochromatic source of radiation is used. According to the present invention, an energy resolving 1D or 2D detector System is proposed, which, in combination with a tomographic reconstruction, provides a good spectral resolution, even with a polychromatic primary beam. Furthermore, according to an aspect of the present invention, only one energy resolving detector-line is required to achieve the fall spectrum. Advantageous applications of the system and method according to the present invention are in medical imaging and material analysis, such as baggage inspection.
摘要翻译：在CSCT中，通过使用扇形主光束，与2D检测器结合，可以同时测量单层透射层析成像和散射层析成像。在这样的系统中，模糊散射函数被测量，除非使用单色辐射源。根据本发明，提出了能量分辨1D或2D检测器系统，其结合断层重建，即使使用多色主波束也提供良好的光谱分辨率。此外，根据本发明的一个方面，仅需要一个能量分辨检测器线来实现坠落光谱。根据本发明的系统和方法的有利应用是在医疗成像和材料分析中，例如行李检查。

4. 发明授权

US07474728B2 Computed tomography apparatus 失效
标题翻译：计算机断层摄影仪
公开(公告)号：US07474728B2
公开(公告)日：2009-01-06
申请号：US10518848
申请日：2003-06-19
申请人： Jens-Peter Schlomka , Geoffrey Harding
发明人： Jens-Peter Schlomka , Geoffrey Harding
IPC分类号： G01N23/00 , G01N23/201
CPC分类号： A61B6/032 , A61B6/027 , A61B6/06 , A61B6/4291 , A61B6/4417 , A61B6/483
摘要： The invention relates to a computed tomography apparatus (CT apparatus) for imaging by means of radiation having traversed an object to be examined (that is, directly transmitted radiation), as well as by means of radiation scattered by the object to be examined, which apparatus includes a radiation source (S), a detector arrangement (16) and a device whereby the radiation (41a) having traversed the object to be examined can be blocked at least to an extent that the intensity incident on the detector arrangement (16) does not substantially exceed the intensity of radiation (41b) scattered by the object (13) to be examined and incident on the detector arrangement (16). The invention enables the detection of scattered radiation (CSCT mode) which is not affected by crosstalk from the transmitted radiation, even when the detector arrangement does not satisfy severe requirements as regards crosstalk properties and/or is configured as a single-row detector arrangement.
摘要翻译：本发明涉及一种用于通过已经穿过被检查物体（即，直接传播的辐射）的辐射进行成像的计算机断层摄影装置（CT装置），以及通过待检查对象散射的辐射，其中装置包括辐射源（S），检测器装置（16）和装置，其中穿过被检查物体的辐射（41a）至少可以被阻挡至入射到检测器装置（16）上的强度的程度，基本上不超过待检测物体（13）散射并入射在检测器装置（16）上的辐射强度（41b）。即使当检测器装置不满足关于串扰特性的严格要求和/或被配置为单行检测器装置时，本发明能够检测不受来自透射辐射的串扰影响的散射辐射（CSCT模式）。

5. 发明申请

US20070172026A1 Fan-beam coherent-scatter computer tomography 失效
标题翻译：扇梁相干散射计算机断层扫描
公开(公告)号：US20070172026A1
公开(公告)日：2007-07-26
申请号：US10557688
申请日：2004-05-18
申请人： Jens-Peter Schlomka , Geoffrey Harding
发明人： Jens-Peter Schlomka , Geoffrey Harding
IPC分类号： H05G1/60 , A61B6/00 , G01N23/00 , G21K1/12 , G01N23/04
CPC分类号： A61B6/483 , A61B6/032 , A61B6/4241 , A61B6/482 , G01N23/046 , G01N2223/419
摘要： In CSCT, by using a fan-shaped primary beam, combined with a 2D detector, single-slice transmission tomography and scatter tomography can be measured simultaneously. In such a System blurred scatter functions are measured unless a monochromatic source of radiation is used. According to the present invention, an energy resolving 1D or 2D detector System is proposed, which, in combination with a tomographic reconstruction, provides a good spectral resolution, even with a polychromatic primary beam. Furthermore, according to an aspect of the present invention, only one energy resolving detector-line is required to achieve the fall spectrum. Advantageous applications of the system and method according to the present invention are in medical imaging and material analysis, such as baggage inspection.
摘要翻译：在CSCT中，通过使用扇形主光束，与2D检测器结合，可以同时测量单层透射层析成像和散射层析成像。在这样的系统中，模糊散射函数被测量，除非使用单色辐射源。根据本发明，提出了能量分辨1D或2D检测器系统，其结合断层重建，即使使用多色主波束也提供良好的光谱分辨率。此外，根据本发明的一个方面，仅需要一个能量分辨检测器线来实现坠落光谱。根据本发明的系统和方法的有利应用是在医疗成像和材料分析中，例如行李检查。

6. 发明申请

US20060171502A1 Computed tomography apparatus 失效
标题翻译：计算机断层摄影仪
公开(公告)号：US20060171502A1
公开(公告)日：2006-08-03
申请号：US10518848
申请日：2003-06-19
申请人： Jens-Peter Schlomka , Geoffrey Harding
发明人： Jens-Peter Schlomka , Geoffrey Harding
IPC分类号： A61B6/00 , G01N23/00 , G21K1/12 , H05G1/60
CPC分类号： A61B6/032 , A61B6/027 , A61B6/06 , A61B6/4291 , A61B6/4417 , A61B6/483
摘要： The invention relates to a computed tomography apparatus (CT apparatus) for imaging by means of radiation having traversed an object to be examined (that is, directly transmitted radiation), as well as by means of radiation scattered by the object to be examined, which apparatus includes a radiation source (S), a detector arrangement (16) and a device whereby the radiation (41a) having traversed the object to be examined can be blocked at least to an extent that the intensity incident on the detector arrangement (16) does not substantially exceed the intensity of radiation (41b) scattered by the object (13) to be examined and incident on the detector arrangement (16). The invention enables the detection of scattered radiation (CSCT mode) which is not affected by crosstalk from the transmitted radiation, even when the detector arrangement does not satisfy severe requirements as regards crosstalk properties and/or is configured as a single-row detector arrangement.
摘要翻译：本发明涉及一种用于通过已经穿过被检查物体（即，直接传播的辐射）的辐射进行成像的计算机断层摄影装置（CT装置），以及通过待检查对象散射的辐射，其中装置包括辐射源（S），检测器装置（16）和装置，其中穿过被检查物体的辐射（41a）至少能够被阻挡到入射到检测器装置（16）上的强度）基本上不超过被检查物体（13）散射并入射在检测器装置（16）上的辐射强度（41b）。即使当检测器装置不满足关于串扰特性的严格要求和/或被配置为单行检测器装置时，本发明能够检测不受来自透射辐射的串扰影响的散射辐射（CSCT模式）。

7. 发明申请

US20060083346A1 Automatic material discrimination by using computer tomography 失效
标题翻译：使用计算机断层扫描的自动材料鉴别
公开(公告)号：US20060083346A1
公开(公告)日：2006-04-20
申请号：US10546392
申请日：2004-02-10
申请人： Jens-Peter Schlomka , Geoffrey Harding , Bernd Schreiber
发明人： Jens-Peter Schlomka , Geoffrey Harding , Bernd Schreiber
IPC分类号： G01N23/04
CPC分类号： G01V5/0025 , G01V5/005
摘要： In conventional material discrimination, for example in baggage inspection, the attenuation coefficient of an item of baggage is used to identify the material in the baggage. However, the result can be ambiguous since there are often dangerous and non-dangerous materials having the same attenuation coefficient. According to the present invention, a method and apparatus are provided combining the information obtained from CT and Coherent Scatter Computed Tomography to better determine whether there are dangerous materials in the baggage or not. Hence, according to the present invention the attenuation coefficient and the diffraction pattern of the item of baggage are used to determine whether the baggage can be cleared or not.
摘要翻译：在传统的材料鉴别中，例如在行李检查中，行李物品的衰减系数用于识别行李中的物料。然而，结果可能是模糊的，因为经常有危险和非危险的材料具有相同的衰减系数。根据本发明，提供了一种结合从CT和相干散射计算机断层摄影获得的信息以更好地确定行李中是否存在危险物质的方法和装置。因此，根据本发明，使用行李物品的衰减系数和衍射图来确定行李是否可以被清除。

8. 发明授权

US07529341B2 Automatic material discrimination by using computer tomography 失效
标题翻译：使用计算机断层扫描的自动材料鉴别
公开(公告)号：US07529341B2
公开(公告)日：2009-05-05
申请号：US10546392
申请日：2004-02-10
申请人： Jens-Peter Schlomka , Geoffrey Harding , Bernd Schreiber
发明人： Jens-Peter Schlomka , Geoffrey Harding , Bernd Schreiber
IPC分类号： G01N23/10 , G01N23/083 , G01N23/20 , G01N23/201
CPC分类号： G01V5/0025 , G01V5/005
摘要： Method and apparatus are provided for combining information obtained from CT and Coherent Scatter Computed Tomography to better determine whether there are dangerous materials in the baggage or not. Hence, the attenuation coefficient and the diffraction pattern of the item of baggage are used to determine whether the baggage should be cleared.
摘要翻译：提供了用于组合从CT和相干散射计算机断层摄影获得的信息以更好地确定行李中是否存在危险物质的方法和装置。因此，行李物品的衰减系数和衍射图案用于确定行李是否应该被清除。

9. 发明申请

US20080285706A1 Coherent-Scatter Computer Tomograph 失效
标题翻译：相干散射计算机断层扫描仪
公开(公告)号：US20080285706A1
公开(公告)日：2008-11-20
申请号：US11569806
申请日：2005-06-01
申请人： Jens-Peter Schlomka
发明人： Jens-Peter Schlomka
IPC分类号： A61B6/02
CPC分类号： A61B6/032 , A61B6/06 , A61B6/4291 , A61B6/483 , G01N23/201
摘要： Conventional CSCT may require a complex reconstruction involving a large number of calculations. According to an exemplary embodiment of the present invention, additional collimators are used in combination with energy revolving detectors, which may allow that a CSCT image may be reconstructed by a simple superposition of images obtained from different viewing angles in a direct tomography data acquisition scheme. Advantageously, a reconstruction may be avoided. Advantageously, this may allow for an improved image quality while reducing an amount of calculations required for generating the output image.
摘要翻译：常规CSCT可能需要涉及大量计算的复杂重构。根据本发明的示例性实施例，附加的准直器与能量循环检测器组合使用，这可以允许通过在直接层析成像数据采集方案中从不同视角获得的图像的简单叠加来重构CSCT图像。有利地，可以避免重建。有利地，这可以允许改善图像质量，同时减少生成输出图像所需的计算量。

10. 发明授权

US07453974B2 Beam-hardening and attenuation correction for coherent-scatter CT 失效
标题翻译：相干散射CT的束强化和衰减校正
公开(公告)号：US07453974B2
公开(公告)日：2008-11-18
申请号：US10598835
申请日：2005-03-15
申请人： Udo Van Steven-Daal , Jens-Peter Schlomka
发明人： Udo Van Steven-Daal , Jens-Peter Schlomka
IPC分类号： H05G1/60
CPC分类号： G01T1/1647 , A61B6/032 , A61B6/483 , A61B6/505 , G06T11/005
摘要： In CSCT, an exact reconstruction of a scattering function for each voxel is not known for polychromatic primary radiation. According to an exemplary embodiment of the present invention, a beam hardening compensation is performed prior to reconstruction allowing to perform a quasi-exact reconstruction on the basis of the primary radiation mean attenuation values are determined, from which an equivalent water thickness is derived. From the equivalent water thickness an energy shift is calculated, which is used to correct the initial mean energy of the scatter radiation. Furthermore, a CT reconstruction may be performed prior to a CSCT reconstruction allowing for a beam-hardening correction. Advantageously, this may allow for an improved image quality and an improved resolution of the scatter function.
摘要翻译：在CSCT中，对于多色初级辐射，每个体素的散射函数的精确重建是未知的。根据本发明的示例性实施例，在重建之前执行光束硬化补偿，允许基于确定主要辐射平均衰减值来执行准精确重建，从其导出等效的水厚度。从等效水厚度计算能量偏移，用于校正散射辐射的初始平均能量。此外，可以在允许进行光束硬化校正的CSCT重建之前执行CT重建。有利地，这可以允许改进的图像质量和改进的散射函数分辨率。

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