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1. 发明授权

US06224665B1 Process for the preparation of highly chromatic perylene pigments 失效
标题翻译：制备高色苝颜料的方法
公开(公告)号：US06224665B1
公开(公告)日：2001-05-01
申请号：US09491493
申请日：2000-01-25
申请人： Gregory R. Schulz , Michael J. Greene
发明人： Gregory R. Schulz , Michael J. Greene
IPC分类号： C09B318
CPC分类号： C07D207/26 , C09B57/08 , C09B67/0034
摘要： This invention relates to a process for preparing perylene pigment compositions by reaction of (a) a perylene tetracarboxylic compound; (b) about 0.01 to about 20% by weight, relative to the perylene tetracarboxylic compound, of a non-pigmentary cyclic anhydride or imide of formula (I) wherein W is O or NR1 (where R1 is hydrogen, a metal, or optionally substituted alkyl, cycloalkyl, aralkyl, or aryl), R2, R3, and R4 are various combinations of substituents and/or fused-on rings, and the dotted line is an optional double bond representing R2−C=C—R3; (c) ammonia or a primary alkyl, aralkyl, or aryl amine; optionally in the presence of (d) a solvent and/or (e) one or more dispersants.
摘要翻译：本发明涉及通过（a）苝四羧酸化合物的反应制备苝颜料组合物的方法;（b）相对于苝四羧酸化合物为非颜料环状酸酐或酰亚胺的约0.01至约20重量％其中W是O或NR 1（其中R 1是氢，金属或任选取代的烷基，环烷基，芳烷基或芳基）的式（I），R 2，R 3和R 4是取代基和/或稠合的各种组合并且虚线是表示R2-C = C-R3的任选的双键;（c）氨或伯烷基，芳烷基或芳基胺;任选地在（d）溶剂和/或）一种或多种分散剂。

2. 发明授权

US6143068A Process for the preparation of highly chromatic perylene pigments 有权
标题翻译：制备高色苝颜料的方法
公开(公告)号：US6143068A
公开(公告)日：2000-11-07
申请号：US491600
申请日：2000-01-25
申请人： Gregory R. Schulz , Michael J. Greene
发明人： Gregory R. Schulz , Michael J. Greene
IPC分类号： C09B5/62 , C07D207/26 , C09B3/18 , C09B57/08 , C09B67/22 , C09B67/20 , C07D307/26
CPC分类号： C07D207/26 , C09B57/08 , C09B67/0034
摘要： This invention relates to a process for preparing perylene pigment compositions by reaction of(a) a perylene tetracarboxylic compound;(b) about 0.01 to about 20% by weight, relative to the perylene tetracarboxylic compound, of a non-pigmentary cyclic anhydride or imide of formula (I) ##STR1## wherein W is O or NR' (where R.sup.1 is hydrogen, a metal, or optionally substituted alkyl, cycloalkyl, aralkyl, or aryl), R.sup.2, R.sup.3, and R.sup.4 are various combinations of substituents and/or fused-on rings, and the dotted line is an optional double bond representing R.sup.2 --C.dbd.C--R.sup.3 ;(c) ammonia or a primary alkyl, aralkyl, or aryl amine; optionally in the presence of(d) a solvent and/or(e) one or more dispersants.
摘要翻译：本发明涉及通过（a）苝四羧酸化合物的反应制备苝颜料组合物的方法; （b）相对于苝四羧酸化合物，其中W是O或NR'（其中R 1是氢，金属或其中的）的式（I）的非颜料环状酸酐或酰亚胺的约0.01至约20重量％任选取代的烷基，环烷基，芳烷基或芳基），R 2，R 3和R 4是取代基和/或稠合环的各种组合，虚线是任选的表示R2-C = C-R3的双键; （c）氨或伯烷基，芳烷基或芳基胺; 任选地在（d）溶剂和/或（e）一种或多种分散剂的存在下。

3. 发明授权

US06410619B2 Method for conditioning organic pigments 有权
标题翻译：有机颜料调理方法
公开(公告)号：US06410619B2
公开(公告)日：2002-06-25
申请号：US09444589
申请日：1999-11-22
申请人： Michael J. Greene , Patrick F. McIntyre , James G. King , Gregory R. Schulz , Karyn B. Visscher
发明人： Michael J. Greene , Patrick F. McIntyre , James G. King , Gregory R. Schulz , Karyn B. Visscher
IPC分类号： C09B6750
CPC分类号： C09B67/0063 , C09B67/0002 , C09B67/0022
摘要： This invention relates to a process for preparing conditioned organic pigments by (a) milling a mixture comprising: (1) one or more crude organic pigments; (2) at least about 0.1% by weight, relative to the organic pigment, of one or more acrylic copolymer dispersants; and (3) 0 to about 100 parts by weight, relative to the organic pigment, of a milling liquid in which the organic pigment is substantially insoluble; and (b) isolating the milled organic pigment.
摘要翻译：本发明涉及通过（a）研磨混合物来制备调节的有机颜料的方法，所述混合物包含：（1）一种或多种粗有机颜料;（2）相对于有机颜料，至少约0.1重量％更多丙烯酸共聚物分散剂; 和（3）相对于有机颜料0至约100重量份的有机颜料基本上不溶的研磨液体; 和（b）分离研磨的有机颜料。

4. 发明授权

US6039769A Process for the preparation of highly chromatic perylene pigments 有权
公开(公告)号：US6039769A
公开(公告)日：2000-03-21
申请号：US211728
申请日：1998-12-15
申请人： Gregory R. Schulz , Michael J. Greene
发明人： Gregory R. Schulz , Michael J. Greene
IPC分类号： C09B5/62 , C07D207/26 , C09B3/18 , C09B57/08 , C09B67/22 , C09B67/20
CPC分类号： C07D207/26 , C09B57/08 , C09B67/0034
摘要： This invention relates to a process for preparing perylene pigment compositions by reaction of(a) a perylene tetracarboxylic compound;(b) about 0.01 to about 20% by weight, relative to the perylene tetracarboxylic compound, of a non-pigmentary cyclic anhydride or imide of formula (I) ##STR1## wherein W is O or NR.sup.1 (where R.sup.1 is hydrogen, a metal, or optionally substituted alkyl, cycloalkyl, aralkyl, or aryl), R.sup.2, R.sup.3, and R.sup.4 are various combinations of substituents and/or fused-on rings, and the dotted line is an optional double bond representing R.sup.2 --C.dbd.C--R.sup.3 ;(c) ammonia or a primary alkyl, aralkyl, or aryl amine; optionally in the presence of(d) a solvent and/or(e) one or more dispersants.

5. 发明授权

US6015458A Process for the preparation of highly chromatic perylene pigments 有权
标题翻译：制备高色苝颜料的方法
公开(公告)号：US6015458A
公开(公告)日：2000-01-18
申请号：US211349
申请日：1998-12-15
申请人： Gregory R. Schulz , Michael J. Greene
发明人： Gregory R. Schulz , Michael J. Greene
IPC分类号： C09B67/20 , C07D221/14 , C07D471/04 , C09B3/18 , C09B5/62 , C07D221/00 , C07D309/00 , C09B3/14
CPC分类号： C07D221/14 , C07D471/04 , C09B5/62
摘要： This invention relates to a process for preparing perylene pigment compositions by reaction of(a) a perylene tetracarboxylic compound;(b) about 0.01 to about 20% by weight, relative to the perylene tetracarboxylic compound, of a non-pigmentary cyclic anhydride or imide of formula (I) ##STR1## wherein W is O or NR.sup.1 (where R.sup.1 is hydrogen, a metal, or optionally substituted alkyl, cycloalkyl, aralkyl, or aryl), R.sup.2, R.sup.3, and R.sup.4 are various combinations of substituents and/or fused-on rings, and the dotted line is an optional double bond representing R.sup.2 --C.dbd.C--R.sup.3 or R.sup.3 --C.dbd.C--R.sup.4 ; and(c) ammonia or a primary alkyl, aralkyl, or aryl amine;optionally in the presence of(d) a solvent and/or(e) one or more dispersants.
摘要翻译：本发明涉及通过（a）苝四羧酸化合物的反应制备苝颜料组合物的方法; （b）相对于苝四羧酸化合物，其中W为O或NR 1（其中R 1为氢，金属或任选地（其中R 1为氢）的式（I）的非颜料环状酸酐或酰亚胺为约0.01至约20重量％取代的烷基，环烷基，芳烷基或芳基），R2，R3和R4是取代基和/或稠合环的各种组合，虚线是任选的双键，表示R2-C = C-R3或R3- C = C-R4; 和（c）氨或伯烷基，芳烷基或芳基胺; 任选地在（d）溶剂和/或（e）一种或多种分散剂的存在下。

6. 发明授权

US06403797B1 Process for the preparation of perylene pigments 有权
标题翻译：苝颜料的制备方法
公开(公告)号：US06403797B1
公开(公告)日：2002-06-11
申请号：US09747058
申请日：2000-12-22
申请人： Charles W. Sandefur , Brian L. Thompson , Michael J. Greene , Gregory R. Schulz
发明人： Charles W. Sandefur , Brian L. Thompson , Michael J. Greene , Gregory R. Schulz
IPC分类号： C07D22100
CPC分类号： C09B5/62 , C09B67/0033
摘要： This invention relates to a process for preparing perylene pigment compositions by (a) reacting, at a temperature of less than about 25° C., a mixture of (1) a perylene tetracarboxylic compound, (2) at least about 0.1% by weight, relative to the perylene tetracarboxylic compound, of a surfactant of formula (I) wherein R1, R2, R3, X, Y, Z, and Z′ are defined herein, (3) an equivalent excess, relative to the amount of the perylene tetracarboxylic compound, of ammonia or a primary amine RA—NH2, wherein RA is defined herein, and (4) optionally, a solvent, to form a perylene intermediate; (b) heating the perylene intermediate at a temperature of about 50° C. to about 250° C., optionally in the presence of certain non-pigmentary cyclic anhydrides or imides and/or solvents; and (c) collecting the perylene pigment composition.
摘要翻译：本发明涉及一种制备苝颜料组合物的方法，该方法是（a）在小于约25℃的温度下使（1）苝四羧酸化合物，（2）至少约0.1重量％相对于苝四羧酸化合物，其中R 1，R 2，R 3，X，Y，Z和Z'在本文中定义的式（I）表面活性剂，（3）相对于苝的量的当量过量四羧酸化合物，氨或伯胺RA-NH 2，其中RA在本文中定义，和（4）任选的溶剂，以形成苝中间体;（b）在约50℃的温度下加热苝中间体至约250℃，任选地在某些非颜料环状酸酐或酰亚胺和/或溶剂的存在下进行; 和（c）收集苝颜料组合物。

7. 发明授权

US6153764A Process for the preparation of highly chromatic perylene pigments 失效
标题翻译：制备高色苝颜料的方法
公开(公告)号：US6153764A
公开(公告)日：2000-11-28
申请号：US491499
申请日：2000-01-25
申请人： Gregory R. Schulz , Michael J. Greene
发明人： Gregory R. Schulz , Michael J. Greene
IPC分类号： C09B5/62 , C07D207/26 , C09B3/18 , C09B57/08 , C09B67/22 , C07D487/02 , C07D307/89 , C09B67/20 , D06P1/44 , C07D493/82
CPC分类号： C07D207/26 , C09B57/08 , C09B67/0034
摘要： This invention relates to a process for preparing perylene pigment compositions by reaction of(a) a perylene tetracarboxylic compound;(b) about 0.01 to about 20% by weight, relative to the perylene tetracarboxylic compound, of a non-pigmentary cyclic anhydride or imide of formula (I) ##STR1## wherein W is O or NR.sup.1 (where R.sup.1 is hydrogen, a metal, or optionally substituted alkyl, cycloalkyl, aralkyl, or aryl), R.sup.2, R.sup.3, and R.sup.4 are various combinations of substituents and/or fused-on rings, and the dotted line is an optional double bond representing R.sup.2 --C.dbd.C--R.sup.3 ;(c) ammonia or a primary alkyl, aralkyl, or aryl amine; optionally in the presence of(d) a solvent and/or(e) one or more dispersants.
摘要翻译：本发明涉及通过（a）苝四羧酸化合物的反应制备苝颜料组合物的方法; （b）相对于苝四羧酸化合物，其中W为O或NR 1（其中R 1为氢，金属或任选地（其中R 1为氢）的式（I）的非颜料环状酸酐或酰亚胺为约0.01至约20重量％取代的烷基，环烷基，芳烷基或芳基），R 2，R 3和R 4是取代基和/或稠环的各种组合，虚线是任选的表示R2-C = C-R3的双键; （c）氨或伯烷基，芳烷基或芳基胺; 任选地在（d）溶剂和/或（e）一种或多种分散剂的存在下。

8. 发明申请

US20130203083A1 SERUM CLUSTERIN LEVELS IN SYSTEMIC AMYLOIDOSIS FEATURING CARDIOMYOPATHY 审中-公开
标题翻译：系统性淀粉样变性细胞因子血清白蛋白水平
公开(公告)号：US20130203083A1
公开(公告)日：2013-08-08
申请号：US13578294
申请日：2011-02-10
申请人： Lawreen Connors , Michael J. Greene
发明人： Lawreen Connors , Michael J. Greene
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2333/775
摘要： The present invention relates generally to diagnostic methods, systems, assays and kits for identification of subjects with cardiac amyloid deposits, where a low level of clusterin protein in a peripheral fluid sample, e.g., a serum sample from the subject, indicates the subject likely has cardiac amyloid deposits. Other aspects relate to methods of treatment of diseases or disorders characterized by cardiac amyloid deposits and transthyretin (TTR) amyloidosis, and more particularly to methods of treatment of cardiac-related amyloidosis and cardiac amyloid deposits in subjects with familial transthyretin (TTR), senile systemic amyloidosis (SSA), or familial amyloidodic polyneuropathy (FAP), or immunoglobulin light chain (AL) amyloidosis. Other aspects relate to methods and compositions comprising clusterin (CLU) or a clusterin agent (e.g. an agonist of clusterin activity or a biologically active fragment or derivative thereof), and their use in methods to treat a disease or disorder characterized by transthyretin (TTR) amyloidosis, e.g. senile systemic amyloidosis (SSA) or familial amyloidodic polyneuropathy (FAP), and their use in methods to treat amyloidotic cardiomyopathy associated with transthyretin (TTR) amyloidosis.
摘要翻译：本发明一般涉及用于鉴定具有心脏淀粉样蛋白沉积物的受试者的诊断方法，系统，测定和试剂盒，其中外周液体样品中的低水平的蛋白聚糖蛋白，例如来自受试者的血清样品，表明受试者可能具有心脏淀粉样蛋白沉积其他方面涉及以心脏淀粉样沉积物和转甲状腺素蛋白淀粉样变性（TTR）淀粉样变性为特征的疾病或病症的治疗方法，更具体地涉及治疗家族性甲状腺激素（TTR）的老年性系统性心脏淀粉样变性和心脏淀粉样蛋白沉积的方法淀粉样变性（SSA）或家族性淀粉样多发性神经病（FAP）或免疫球蛋白轻链（AL）淀粉样变性。其它方面涉及包含聚蛋白（CLU）或聚集蛋白剂（例如聚集蛋白活性的激动剂或其生物活性片段或衍生物）的方法和组合物，以及它们在治疗以转甲状腺素蛋白（TTR）为特征的疾病或病症的方法中的用途，淀粉样变性，例如老年性系统性淀粉样变性病（SSA）或家族性淀粉样变性多发性神经病变（FAP），以及它们用于治疗与转甲状腺素蛋白（TTR）淀粉样变性相关的淀粉样变性心肌病的方法。

9. 发明授权

US5972099A Process for preparing organic pigment compositions 失效
标题翻译：制备有机颜料组合物的方法
公开(公告)号：US5972099A
公开(公告)日：1999-10-26
申请号：US991980
申请日：1997-12-17
申请人： Ibraheem T. Badejo , Daphne J. Rice , Michael J. Greene
发明人： Ibraheem T. Badejo , Daphne J. Rice , Michael J. Greene
IPC分类号： C09B67/20 , C09B67/18 , C09B67/22 , C08K5/17 , C09B48/00 , C09B67/52
CPC分类号： C09B67/0034 , C09B67/002
摘要： This invention relates to a process for preparing pigment compositions by(a) treating an organic pigment with(1) a sterically hindered and/or bulky primary amine, and(2) a liquid in which the organic pigment is insoluble, and(b) blending the resultant surface-treated pigment composition from step (a) with a pigment derivative of formula (I) ##STR1## wherein Q represents an organic pigment moiety,X is O, S, NR.sup.1, --SO.sub.2 --, --CO--, --Alk--, --Ar--, or combinations thereof,Y is --OR.sup.2, --NR.sup.3 R.sup.4, or Het,Alk is C.sub.1 -C.sub.5 alkylene, C.sub.2 -C.sub.5 alkenylene, or C.sub.4 -C.sub.5 alkadienylene, or substituted derivatives thereof,Ar is arylene,R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.5 -C.sub.7 cycloalkyl, C.sub.7 -C.sub.16 aralkyl, or C.sub.6 -C.sub.10 aryl,Het is a heterocycle, andn is 1 to 4.
摘要翻译：本发明涉及一种制备颜料组合物的方法，该方法是（a）用（1）空间位阻和/或体积大的伯胺处理有机颜料，和（2）有机颜料不溶的液体，和（b）将来自步骤（a）的所得表面处理的颜料组合物与式（I）的颜料衍生物（其中Q表示有机颜料部分，X为O，S，NR 1，-SO 2 - ， - CO - ， - Alk-， -Ar-或其组合，Y为-OR2，-NR3R4或Het，Alk为C1-C5亚烷基，C2-C5亚烯基或C4-C5链二烯或其取代衍生物，Ar为亚芳基，R1，R2， R 3和R 4独立地为氢，C 1 -C 6烷基，C 5 -C 7环烷基，C 7 -C 16芳烷基或C 6 -C 10芳基，Het为杂环，n为1至4。

10. 发明授权

US5713999A Incorporation of pigment derivatives in quinacridone processes 失效
标题翻译：颜料衍生物在喹吖啶酮工艺中的结合
公开(公告)号：US5713999A
公开(公告)日：1998-02-03
申请号：US639598
申请日：1996-04-29
申请人： Ibraheem T. Badejo , Margot Campos , Michael J. Greene , Daphne J. Rice
发明人： Ibraheem T. Badejo , Margot Campos , Michael J. Greene , Daphne J. Rice
IPC分类号： C07D471/04 , C09B48/00 , C09B67/20 , C09B67/22 , C09B67/52
CPC分类号： C09B48/00 , C09B67/0036
摘要： This invention relates to a process for the preparation of quinacridone pigments by (a) heating, at a temperature of about 80.degree. C. to about 145.degree. C., a reaction mixture containing (i) 2,5-dianilinoterephthalic acid, a 2,5-dianilino-3,6-dihydroterephthalic acid ester, and/or a derivative thereof, (ii) about 3 to about 15 parts by weight, per part of component (a)(i), of a dehydrating agent, and (iii) about 0.1 to about 15 percent by weight, based on component (a)(i), of one or more non-quinacridone pigments, with the proviso that if component (a)(i) is a 2,5-dianilino-3,6-dihydroterephthalic acid ester or a derivative thereof, reaction step (a) additionally comprises an oxidation step; (b) drowning the reaction mixture from step (a) by adding said reaction mixture to about 3 to about 15 parts by weight, per part of component (a)(i), of a liquid in which the quinacridone pigment is substantially insoluble; (c) isolating the quinacridone pigment; (d) optionally, conditioning the quinacridone pigment; and (e) optionally, blending the resultant pigment with one or more quinacridone derivatives.
摘要翻译：本发明涉及通过以下步骤制备喹吖啶酮颜料的方法：（a）在约80℃至约145℃的温度下加热反应混合物，该反应混合物含有（i）2,5-二苯胺基对苯二甲酸，2 ，5-二苯胺基-3,6-二氢对苯二甲酸酯和/或其衍生物，（ii）每份组分（a）（i）约3至约15重量份的脱水剂和（ iii）基于组分（a）（i）约0.1至约15重量％的一种或多种非喹吖啶酮颜料，条件是如果组分（a）（i）是2,5-二苯胺基 - 3,6-二氢对苯二甲酸酯或其衍生物，反应步骤（a）还包括氧化步骤; （b）通过将所述反应混合物加入到每份组分（a）（i）中的约3至约15重量份的喹吖啶酮颜料基本上不溶的液体中来淹没来自步骤（a）的反应混合物; （c）分离喹吖啶酮颜料; （d）任选地调节喹吖啶酮颜料; 和（e）任选地，将所得颜料与一种或多种喹吖啶酮衍生物共混。

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