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1. 发明授权

US11169166B2 Automatic analyzer 有权
公开(公告)号：US11169166B2
公开(公告)日：2021-11-09
申请号：US15552335
申请日：2016-02-05
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Hideto Tamezane , Isao Yamazaki , Masaharu Nishida , Ryota Kamoshida
IPC分类号： G01N35/02 , G01N35/00 , G01N35/10 , B01L3/00
摘要： An automatic analyzer which is capable of detecting a dispensing abnormality with a high degree of accuracy without causing the decrease in the determination performance or the increase in the calculation amount caused by the configuration balance of the reference database is implemented. A dispensing nozzle of a sample dispensing mechanism 50 is immersed in a dispensing target contained in a specimen container 11 and sucks the dispensing target, and internal pressure of the dispensing nozzle of the sample dispensing mechanism 50 of ejecting the sucked dispensing target to a reaction container 41 is detected through a pressure sensor 54. A plurality of feature quantities are extracted from a waveform of the detected pressure, and a determination result is output through a linear combination formula using an optimal coefficient for a determination function that receives a plurality of feature quantities and outputs one value. The determination result indicates whether or not dispensing of the sample dispensing mechanism 50 is performed normally in accordance with the magnitude of the output result of the determination function.

2. 发明授权

US10288637B2 Automatic analyzer 有权
公开(公告)号：US10288637B2
公开(公告)日：2019-05-14
申请号：US15310808
申请日：2015-04-22
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Hideto Tamezane , Isao Yamazaki , Masaharu Nishida , Kumiko Kamihara
IPC分类号： G01N35/10 , G01N35/02 , G01N35/00 , G01L19/00 , G01N1/14
摘要： A pressure signal process unit acquires data under a predetermined condition and a statistic distance between the acquired data and determination-purpose reference data stored in a storage unit is calculated. It is determined whether or not dispensing is abnormal and whether the determination-purpose reference data is suitable for an abnormality detection function to be properly fulfilled. If the determination-purpose reference data is not suitable for an abnormality detection function to be properly fulfilled, temporary determination-purpose reference data is prepared so as to be compared with the previously acquired data under a predetermined condition. If a difference therebetween is greater than a predetermined threshold value, a possibility that an automatic analyzer may have an abnormal component or that a failure may occur in the automatic analyzer is determined, and the result is transmitted to cause a display device to display an alarm.

3. 发明授权

US09897624B2 Automatic analyzer 有权
公开(公告)号：US09897624B2
公开(公告)日：2018-02-20
申请号：US14410113
申请日：2013-06-20
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Hideto Tamezane , Isao Yamazaki , Masaharu Nishida , Kumiko Kamihara
IPC分类号： G01N35/10 , G01N35/00
CPC分类号： G01N35/1016 , G01N35/00584 , G01N35/00663 , G01N35/1002 , G01N35/1009 , G01N2035/00673 , G01N2035/1018 , G01N2035/1025
摘要： An automatic analyzer that accurately detects dispensation abnormality in dispensation conditions with small suction quantities has a statistical distance calculation unit that calculates characteristic variables regarding a sucking operation in the first dispensation and calculates a statistical distance D from reference data to the characteristic variables extracted from a memory. A comparison unit compares the statistical distance D with a preset threshold value stored in memory and if the statistical distance D is less than the preset threshold value, the first discharging operation is performed. A controller judges whether a single-handed judgment based on a dispensation quantity condition of the second or subsequent dispensation is possible or not. If the single-handed judgment is impossible, reference data is selected based on a judgment quantity regarding the first dispensation. Whether the sucking operation in the second or subsequent dispensation is normal or abnormal is judged based on the selected reference data.

4. 发明授权

US09857388B2 Automatic analyzer 有权
公开(公告)号：US09857388B2
公开(公告)日：2018-01-02
申请号：US14763225
申请日：2014-01-27
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Hideto Tamezane , Isao Yamazaki , Masaharu Nishida , Kumiko Kamihara
IPC分类号： G01N35/00 , G01N35/10
CPC分类号： G01N35/00623 , G01N35/00871 , G01N35/1002 , G01N35/1016 , G01N2035/00633
摘要： The dispensing mechanisms dips a dispensing nozzle in a dispensing target contained in a container 11, 21, and 31, aspirates the dispensing target, and discharges the dispensing target to a reaction container 41. One item of determination-purpose reference data is selected from multiple items of the determination-purpose reference data which is stored in a storage unit 93 and used in determining whether or not the dispensing mechanisms 50, 60, and 70 are abnormal, based on the detection result from a pressure sensor 54 when the dispensing mechanisms 50, 60, and 70 dispense a reference dispensing target configured to contain a known ingredient; and whether or not the dispensing mechanisms 50, 60, and 70 are abnormal is determined, based on the detection result from the pressure sensor 54 and the selected determination-purpose reference data when the dispensing mechanisms 50, 60, and 70 dispense a dispensing target used in analysis.

5. 发明授权

US09335335B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US09335335B2
公开(公告)日：2016-05-10
申请号：US14422278
申请日：2013-07-11
申请人： Hitachi High-Technologies Corporation
发明人： Tomonori Mimura , Kumiko Kamihara , Isao Yamazaki , Hideto Tamezane
IPC分类号： G01N33/00 , G01N35/00 , G01N35/10
CPC分类号： G01N35/00623 , G01N35/00871 , G01N35/1016 , G01N2035/00891 , G01N2035/1018 , Y10T436/11
摘要： Provided is an automatic analyzer capable of detecting not only clogging and air suction of the dispensation probe but also a decrease in the dispensation quantity caused by a bubble film, air bubbles or a highly viscous sample. Each of a sample/reagent suction operation time and a sample/reagent discharge operation time of a probe is segmented into multiple time sections. For each of the time sections determined by the segmentation, a parameter is calculated by applying a detected pressure waveform to an approximation formula. For each of the time section, the presence/absence of a dispensation abnormality is judged by comparing the calculated parameter with a parameter in cases of normal dispensation. An automatic analyzer capable of judging the presence/absence of an abnormality specific to each time section and making abnormality judgments difficult for conventional techniques can be realized.
摘要翻译：本发明提供一种能够不仅检测分注用探针的堵塞和吸气的自动分析装置，还能够检测由气泡膜，气泡或高粘度样品引起的分配量的降低。探针的样品/试剂抽吸操作时间和样品/试剂放电操作时间分别被分割成多个时间段。对于通过分割确定的每个时间段，通过将检测到的压力波形应用于近似公式来计算参数。对于每个时间段，通过将计算出的参数与正常分配情况下的参数进行比较来判断分配异常的存在/不存在。可以实现能够判断各时间段特有的异常的有无的自动分析装置，并且可以实现常规技术难以进行异常判断。

6. 发明授权

US11506534B2 Automated analysis device 有权
公开(公告)号：US11506534B2
公开(公告)日：2022-11-22
申请号：US16472129
申请日：2017-10-24
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Takeshi Ishida , Isao Yamazaki , Sakuichiro Adachi , Shin Imamura
IPC分类号： G01J3/10 , G01J3/02 , G01J3/04 , G01N21/27 , G01N21/64 , G01N21/25
摘要： An automatic analysis apparatus comprises: a light source generating light having a center wavelength equal to or shorter than 340 nm; a fluorescent substance excited by the light source light, and generates light together with transmitted light from the light source, having a wavelength of 340 nm to 800 nm; a condenser lens; at least one slit; a reaction cell holding a reaction solution where a specimen and reagent are mixed, and that the light source light and the light from the fluorescent substance enter; and a detector that detects light transmitted through the reaction cell. The light source, fluorescent substance, condenser lens, and slit are provided along a straight light corresponding to the optical axis. The width of the slit's opening is equal to or narrower than the width of a ray forming an image of the light source at the position of the slit.

7. 发明授权

US10067152B2 Automatic analyzer 有权
公开(公告)号：US10067152B2
公开(公告)日：2018-09-04
申请号：US15111006
申请日：2015-01-13
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Masaru Miyazaki , Takamichi Mori , Kazuhiro Nakamura , Isao Yamazaki
IPC分类号： G01N35/10 , G01N21/75 , G01N35/04
摘要： An automatic analyzer has a washing tank providing water for washing a reagent or sample probe is. The washing water from a washing nozzle spreads from a throttle portion and is divided into right and left flows after colliding with a vent plate provided in an overflow portion of the washing tank. The washing water flows between the vent plate and the inner wall of the overflow portion, and the flows join behind the vent plate. After joining, the washing water flows downward along the vent plate and the inner wall of the overflow portion and then is drained. Because a space is created between the washing water which has collided with the vent plate and the washing water joined behind the vent plate, the washing water is prevented from completely covering the overflow portion, and the airflow can be secured during the drainage.

8. 发明授权

US09817013B2 Sample dispensing apparatus and automatic analyzer including the same 有权
公开(公告)号：US09817013B2
公开(公告)日：2017-11-14
申请号：US14185037
申请日：2014-02-20
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Hideyuki Yanami , Isao Yamazaki , Masaaki Hanawa , Hitoshi Otake
IPC分类号： G01N35/10 , G01N1/14 , G01N35/00 , G01N35/02
CPC分类号： G01N35/1095 , B01F11/008 , G01N35/0092 , G01N35/021 , G01N35/025 , G01N35/1002 , G01N35/1004 , G01N35/1009 , G01N35/1011 , G01N35/1016 , G01N35/1065 , G01N35/109 , G01N2035/00237 , G01N2035/0406 , G01N2035/1018 , G01N2035/1025 , G01N2035/1076 , G01N2035/1086 , Y10T436/11 , Y10T436/111666 , Y10T436/114998 , Y10T436/2575
摘要： The invention provides a small-sized automatic analyzer being compact, enabling a large number of analysis items to be carried out, and having a high processing speed. The automatic analyzer is particularly suitably applied to a medical analyzer used for qualitative/quantitative analysis of living body samples, such as urine and blood. A plurality of sample dispensing mechanism s capable of being operated independently of each other are provided to suck a sample from any one of a plurality of sample suction positions and to discharge the sucked sample to any one of a plurality of positions on a reaction disk. The automatic analyzer having a high processing capability can be thus realized without increasing the system size.

9. 发明申请

US20150198525A1 AUTOMATIC ANALYZER 审中-公开
标题翻译：自动分析仪
公开(公告)号：US20150198525A1
公开(公告)日：2015-07-16
申请号：US14670861
申请日：2015-03-27
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Sakuichiro Adachi , Muneo Maeshima , Isao Yamazaki , Tomonori Mimura
IPC分类号： G01N21/51
CPC分类号： G01N21/51 , G01N15/0205 , G01N21/253 , G01N2015/0065 , G01N2035/00396 , G01N2035/0453
摘要： To be adapted to various types of latex reagents for detecting scattered light and thereby measuring agglutination reactions with high sensitivity while sufficiently ensuring integration time. To be adapted to various types of latex particles of different particle sizes, a plurality of light receivers are arranged in a plane perpendicular to the direction of cell movement by rotation of a cell disk. To ensure sufficient integration time, the angle between the optical axis of the irradiation light and each of a plurality of optical axes of scattered light viewed from above the cell is made equal to or less than 17.7° including a mounting error.
摘要翻译：适用于各种类型的用于检测散射光的乳胶试剂，从而以高灵敏度测量凝集反应，同时充分确保积分时间。为了适应于各种类型的不同粒度的胶乳颗粒，多个光接收器通过旋转细胞盘而布置在垂直于细胞移动方向的平面中。为了确保足够的积分时间，使得照射光的光轴与从电池单元的上方观察的散射光的多个光轴中的每一个之间的角度等于或小于包括安装误差的17.7°。

10. 发明授权

US08632725B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US08632725B2
公开(公告)日：2014-01-21
申请号：US13927209
申请日：2013-06-26
申请人： Hitachi High-Technologies Corporation
发明人： Isao Yamazaki , Ryuji Tao , Katsuaki Takahashi
IPC分类号： G01N35/00 , G01N35/02 , C12M1/34
CPC分类号： G01N21/75 , G01N35/0092 , G01N35/025 , G01N35/1002 , G01N35/1083 , G01N2035/0094 , G01N2035/1076 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/116664 , Y10T436/119163 , Y10T436/12
摘要： An automatic analyzer according to the present invention is compact, mounting great number of reagents, having high processing ability. Reagent disks are arranged at inside and outside of a reaction disk. A reagent probe can inject a reagent into the position which is common position of both reagent disks. One of plural reagent probes approaches to one of reagent disks at one cycle. Plural reagent probes alternatively approach to the reagent disk. Therefore, the first reagents and the second reagents can be placed on both reagent disks. The mounting number of reagents can be increased without enlarging an analyzer. The cycle time can be shortened to make an automatic analyzer to have high processing ability.
摘要翻译：根据本发明的自动分析仪是紧凑的，安装大量试剂，具有高处理能力。试剂盘布置在反应盘的内部和外部。试剂探针可以将试剂注入到两个试剂盘的共同位置的位置。多个试剂探针之一在一个循环中接近一个试剂盘。多个试剂探针交替接近试剂盘。因此，可以将第一试剂和第二试剂置于两个试剂盘上。可以在不扩大分析仪的情况下增加试剂的安装数量。可以缩短循环时间，使自动分析仪具有较高的处理能力。

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