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1. 发明授权

US09367018B1 Image forming device having tripod type constant-velocity joint for coupling rotary member with driving source 有权
标题翻译：具有用于将旋转构件与驱动源耦合的三脚架型等速接头的图像形成装置
公开(公告)号：US09367018B1
公开(公告)日：2016-06-14
申请号：US14712000
申请日：2015-05-14
申请人： Hiroshi Yanagawa , Kazuo Hirose , Hiroaki Takagi , Junichi Ichikawa
发明人： Hiroshi Yanagawa , Kazuo Hirose , Hiroaki Takagi , Junichi Ichikawa
IPC分类号： G03G15/00
CPC分类号： G03G15/757
摘要： An image forming device includes a tripod type constant-velocity joint through which a rotary member shaft of a rotary member is connected to the drive shaft of a motor. The constant-velocity joint includes a pair of outer rings each having three axially extending track grooves in its inner periphery, and a tripod member having three protrusions formed on each of the axial ends thereof and axially slidably received in the corresponding track grooves. The outer rings and the tripod member are formed of synthetic resin. One of the outer rings and the tripod member are inseparably coupled to the drive shaft so that the other of the outer rings is always disconnected from the tripod member when the rotary member is pulled away from the motor.
摘要翻译：图像形成装置包括三脚架型等速接头，旋转构件的旋转构件轴通过该三角架等速接头连接到电动机的驱动轴。等速万向节包括一对在其内周边具有三个轴向延伸的轨道槽的外圈，以及三角架构件，其三个突起形成在其每个轴向端上，并可轴向滑动地容纳在相应的轨道槽中。外圈和三脚架构件由合成树脂形成。外环和三脚架构件中的一个不可分离地联接到驱动轴，使得当旋转构件被拉离电动机时，另一个外环总是与三脚架构件分离。

2. 发明授权

US07670787B2 Protein forming complex with c-Fos protein, nucleic acid encoding the same and method of using the same 失效
标题翻译：蛋白质与c-Fos蛋白形成复合物，核酸编码相同，使用方法相同
公开(公告)号：US07670787B2
公开(公告)日：2010-03-02
申请号：US11976827
申请日：2007-10-29
申请人： Etsuko Miyamoto , Masamichi Ishizaka , Hiroshi Yanagawa
发明人： Etsuko Miyamoto , Masamichi Ishizaka , Hiroshi Yanagawa
IPC分类号： G01N33/53
CPC分类号： C12N15/1055 , C07K14/47 , G01N2500/04
摘要： Proteins that interact with c-Fos, nucleic acids encoding them and inhibitors utilizing them as well as methods for detecting an interaction and screening methods utilizing a protein that interacts with c-Fos are provided. Comprehensive analysis of transcription control factor complexes in a mouse brain cDNA library with c-Fos as a bait by using the cotranslation selection and screening of in vitro virus (IVV) and the C-terminal labeling method are conducted, thereby to analyze proteins unknown so far, proteins known so far, but unknown to form a complex with the c-Fos protein, and so forth.
摘要翻译：提供了与c-Fos相互作用的蛋白质，编码它们的核酸和利用它们的抑制剂以及利用与c-Fos相互作用的蛋白质的相互作用和筛选方法的方法。通过使用共转染选择和筛选体外病毒（IVV）和C末端标记方法，将c-Fos作为诱饵的小鼠脑cDNA文库中的转录控制因子复合物进行综合分析，从而分析蛋白质未知迄今为止已知的蛋白质，但未知与c-Fos蛋白质形成复合物等等。

3. 发明申请

US20080177030A1 Protein forming complex with c-Fos protein, nucleic acid encoding the same and method of using the same 失效
标题翻译：蛋白质与c-Fos蛋白形成复合物，核酸编码相同，使用方法相同
公开(公告)号：US20080177030A1
公开(公告)日：2008-07-24
申请号：US11976827
申请日：2007-10-29
申请人： Etsuko Miyamoto , Masamichi Ishizaka , Hiroshi Yanagawa
发明人： Etsuko Miyamoto , Masamichi Ishizaka , Hiroshi Yanagawa
IPC分类号： C07K14/47 , C07K14/00
CPC分类号： C12N15/1055 , C07K14/47 , G01N2500/04
摘要： Proteins that interact with c-Fos, nucleic acids encoding them and inhibitors utilizing them as well as methods for detecting an interaction and screening methods utilizing a protein that interacts with c-Fos are provided. Comprehensive analysis of transcription control factor complexes in a mouse brain cDNA library with c-Fos as a bait by using the cotranslation selection and screening of in vitro virus (IVV) and the C-terminal labeling method are conducted, thereby to analyze proteins unknown so far, proteins known so far, but unknown to form a complex with the c-Fos protein, and so forth.
摘要翻译：提供了与c-Fos相互作用的蛋白质，编码它们的核酸和利用它们的抑制剂以及利用与c-Fos相互作用的蛋白质的相互作用和筛选方法的方法。通过使用共转染选择和筛选体外病毒（IVV）和C末端标记方法，将c-Fos作为诱饵的小鼠脑cDNA文库中的转录控制因子复合物进行综合分析，从而分析蛋白质未知迄今为止已知的蛋白质，但未知与c-Fos蛋白质形成复合物等等。

4. 发明授权

US07041446B2 Labeled protein and its producing method, labeling compound to be used in the method, and method for analyzing function of genes 有权
标题翻译：标记蛋白及其制备方法，方法中使用的标记化合物和分析基因功能的方法
公开(公告)号：US07041446B2
公开(公告)日：2006-05-09
申请号：US09794128
申请日：2001-02-28
申请人： Hiroshi Yanagawa , Naoto Nemoto , Etsuko Miyamoto
发明人： Hiroshi Yanagawa , Naoto Nemoto , Etsuko Miyamoto
IPC分类号： C12Q1/68 , C07K1/13
CPC分类号： C07H19/20 , C07H19/04 , C07K1/13
摘要： A protein having a labeling compound attached to its C-terminal, in which the compound comprises a label portion comprising a label substance and an acceptor portion comprising a compound having an ability of binding to a C-terminal of a synthesized protein when protein synthesis is carried out in a cell-free protein synthesis system or in a living cell is provided. Also, a method for producing the protein comprising the step of performing synthesis of a protein in a cell-free protein synthesis system or in a living cell in the presence of a labeling compound comprising a label portion comprising a label substance and an acceptor portion comprising a compound having an ability of binding to a C-terminal of a synthesized protein when protein synthesis is carried out in the cell-free protein synthesis system or in the living cell, the labeling compound being present at a concentration effective for the labeling compound to bind to the C-terminal of the synthesized protein is provided. Also, the labeling compound and a method for analyzing a function of a gene are further provided.
摘要翻译：一种具有附着于其C-末端的标记化合物的蛋白质，其中所述化合物包含标记物部分，所述标记物包含标记物质和受体部分，所述受体部分包含当蛋白质合成为蛋白质合成时具有与合成蛋白质C末端结合的能力的化合物在无细胞蛋白质合成系统或活细胞中进行。另外，制备蛋白质的方法包括以下步骤：在标记化合物存在下，在无细胞蛋白质合成系统或活细胞中进行蛋白质的合成，所述标记化合物包含标记物质和受体部分，所述标记物包含当在无细胞蛋白质合成系统或活细胞中进行蛋白质合成时，具有与合成蛋白质C末端结合的能力的化合物，标记化合物以对标记化合物有效的浓度存在提供了与合成蛋白质的C-末端结合。此外，还提供了标记化合物和分析基因功能的方法。

5. 发明申请

US20060183885A1 Protein forming complex with c-fos protein, nucleic acid encoding the same and method of using the same 审中-公开
标题翻译：蛋白质与c-fos蛋白形成复合物，核酸编码相同，使用方法相同
公开(公告)号：US20060183885A1
公开(公告)日：2006-08-17
申请号：US10538410
申请日：2003-11-19
申请人： Etsuko Miyamoto , Masamichi Ishizaka , Hiroshi Yanagawa
发明人： Etsuko Miyamoto , Masamichi Ishizaka , Hiroshi Yanagawa
IPC分类号： C07K14/705 , C12Q1/68 , G01N33/53 , C07H21/04
CPC分类号： C12N15/1055 , C07K14/47 , G01N2500/04
摘要： Proteins that interact with c-Fos, nucleic acids encoding them and inhibitors utilizing them as well as methods for detecting an interaction and screening methods utilizing a protein that interacts with c-Fos are provided. Comprehensive analysis of transcription control factor complexes in a mouse brain cDNA library with c-Fos as a bait by using the cotranslation selection and screening of in vitro virus (IVV) and the C-terminal labeling method are conducted, thereby to analyze proteins unknown so far, proteins known so far, but unknown to form a complex with the c-Fos protein, and so forth.
摘要翻译：提供了与c-Fos相互作用的蛋白质，编码它们的核酸和利用它们的抑制剂以及利用与c-Fos相互作用的蛋白质的相互作用和筛选方法的方法。通过使用共转染选择和筛选体外病毒（IVV）和C末端标记方法，将c-Fos作为诱饵的小鼠脑cDNA文库中的转录控制因子复合物进行综合分析，从而分析蛋白质未知迄今为止已知的蛋白质，但未知与c-Fos蛋白质形成复合物等等。

6. 发明授权

US06977160B2 Sensor protein and use thereof 失效
标题翻译：传感器蛋白及其用途
公开(公告)号：US06977160B2
公开(公告)日：2005-12-20
申请号：US09853939
申请日：2001-05-11
申请人： Hiroshi Yanagawa , Nobuhide Doi , Naoto Nemoto
发明人： Hiroshi Yanagawa , Nobuhide Doi , Naoto Nemoto
IPC分类号： C07K14/435 , C12N9/16 , C12P21/06 , C07H21/04 , C07K19/00 , G01N33/53
CPC分类号： C07K14/43595 , C07K2319/00 , C12N9/16
摘要： The object of the present invention is to utilize, as a sensor protein, a molecular recognizing ability of a protein that scarcely undergoes any structural change by the binding of a target substance. According to the present invention, there is provided a sensor protein comprising an insert-type fusion protein composed of a reporter protein and a biding protein wherein said binding protein is inserted into the amino acid sequence of said reporter protein.
摘要翻译：本发明的目的是利用目标物质的结合几乎不发生任何结构变化的蛋白质的分子识别能力作为传感器蛋白质。根据本发明，提供一种传感器蛋白，其包含由报道蛋白和结合蛋白构成的插入型融合蛋白，其中所述结合蛋白插入所述报道蛋白的氨基酸序列。

7. 发明申请

US20060210982A1 Cleavable assigned molecules and screening method using the same 审中-公开
标题翻译：可拆分的分子和筛选方法使用相同
公开(公告)号：US20060210982A1
公开(公告)日：2006-09-21
申请号：US10543682
申请日：2004-02-02
申请人： Hiroshi Yanagawa , Nobuhide Doi , Tetsuya Nagano , Hideaki Takashima
发明人： Hiroshi Yanagawa , Nobuhide Doi , Tetsuya Nagano , Hideaki Takashima
IPC分类号： C40B40/08
CPC分类号： C40B30/04 , C07K14/00 , C12N15/1075
摘要： A method for screening a nucleic acid library for a nucleic acid encoding a protein that interacts with a target substance, which comprises: the step of producing a library of assigning molecules each comprising a protein and a nucleic acid encoding the protein linked to each other via a linker cleavable under a condition that does not change a nucleotide sequence of the nucleic acid; the step of mixing the library of assigning molecules and the target substance; the step of separating an assigning molecule binding to the target substance; the step of cleaving a linker of the separated assigning molecule under a condition that does not change a nucleotide sequence of the nucleic acid to release the nucleic acid; and the step of collecting the released nucleic acid. By this method, screening for an assigning molecule that specifically binds to a target substance can be conducted with high efficiency.
摘要翻译：一种用于筛选编码与靶物质相互作用的蛋白质的核酸的核酸文库的方法，该方法包括：产生分配分子的文库的步骤，每个分子包含蛋白质和编码相互连接的蛋白质的核酸通过在不改变核酸的核苷酸序列的条件下可切割的接头; 分配分子的文库和目标物质的步骤; 分离与靶物质结合的分配分子的步骤; 在不改变核酸的核苷酸序列以释放核酸的条件下切割分离的分配分子的接头的步骤; 以及收集释放的核酸的步骤。通过该方法，可以高效率地进行与目标物质特异性结合的分配分子的筛选。

8. 发明申请

US20050142623A1 SENSOR PROTEIN AND USE THEREOF 失效
标题翻译：传感器蛋白及其用途
公开(公告)号：US20050142623A1
公开(公告)日：2005-06-30
申请号：US09853939
申请日：2001-05-11
申请人： Hiroshi Yanagawa , Nobuhide Doi , Naoto Nemoto
发明人： Hiroshi Yanagawa , Nobuhide Doi , Naoto Nemoto
IPC分类号： C07K14/435 , C12N9/16 , G01N33/53 , C07H21/04 , C12N9/10 , C12P21/04 , G01N33/537 , G01N33/543
CPC分类号： C07K14/43595 , C07K2319/00 , C12N9/16
摘要： The object of the present invention is to utilize, as a sensor protein, a molecular recognizing ability of a protein that scarcely undergoes any structural change by the binding of a target substance. According to the present invention, there is provided a sensor protein comprising an insert-type fusion protein composed of a reporter protein and a biding protein wherein said binding protein is inserted into the amino acid sequence of said reporter protein.
摘要翻译：本发明的目的是利用目标物质的结合几乎不发生任何结构变化的蛋白质的分子识别能力作为传感器蛋白质。根据本发明，提供一种传感器蛋白，其包含由报道蛋白和结合蛋白构成的插入型融合蛋白，其中所述结合蛋白插入所述报道蛋白的氨基酸序列。

9. 发明授权

US06361943B1 Molecule that homologizes genotype and phenotype and utilization thereof 有权
标题翻译：分子基因型和表型同源化及其利用
公开(公告)号：US06361943B1
公开(公告)日：2002-03-26
申请号：US09284627
申请日：1999-06-02
申请人： Hiroshi Yanagawa , Naoto Nemoto , Etsuko Miyamoto , Yuzuru Husimi
发明人： Hiroshi Yanagawa , Naoto Nemoto , Etsuko Miyamoto , Yuzuru Husimi
IPC分类号： C12Q168
CPC分类号： C12N15/11 , C12N15/1062
摘要： A molecule comprising a nucleic acid portion and a protein portion directly bound to said nucleic acid portion with a covalent bond, wherein said nucleic acid portion comprises a polymer of nucleoside, and said protein portion is encoded by said nucleic acid portion, and a method for constructing the molecule, which comprises (a) preparing a DNA containing a gene which has no termination codon, (b) transcribing the prepared DNA into RNA, (c) bonding a chimeric spacer composed of DNA and RNA to a 3′-terminal end of the obtained RNA, (d) bonding to a 3′-terminal end of the obtained bonded product, a nucleoside or a substance having a chemical structure analogous to that of a nucleoside, which can be covalently bound to an amino acid or substance having a chemical structure analogous to that of an amino acid, and (e) performing protein synthesis in a cell-free protein synthesis system using the obtained bonded product as mRNA to bond a nucleic acid portion containing the gene to a translation product of the gene. The molecule of the present invention is an extremely useful substance that can be used for evolutionary molecular engineering, i.e., modification of functional biopolymers such as enzymes, antibodies, and ribozymes, and creation of biopolymers having functions which cannot be found in living organisms.
摘要翻译：包含核酸部分和与所述核酸部分直接键合有共价键的蛋白质部分的分子，其中所述核酸部分包含核苷聚合物，所述蛋白质部分由所述核酸部分编码，构建分子，其包括（a）制备含有不具有终止密码子的基因的DNA，（b）将制备的DNA转录成RNA，（c）将由DNA和RNA组成的嵌合间隔物结合至3'末端的所得RNA，（d）与获得的结合产物的3'-末端结合，具有与核苷类似的化学结构的核苷或物质，其可共价结合于具有与氨基酸类似的化学结构，和（e）使用获得的结合产物作为mRNA将含有该基因的核酸部分键合到无转化蛋白质合成系统中进行蛋白质合成该基因的产物。本发明的分子是可用于进化分子工程，即功能性生物聚合物如酶，抗体和核酶的修饰以及具有在活生物体中不能发现的功能的生物聚合物的非常有用的物质。

10. 发明授权

US06228994B1 Labeled protein and its producing method, labeling compound to be used in the method, and method for analyzing function of genes 有权
公开(公告)号：US06228994B1
公开(公告)日：2001-05-08
申请号：US09190276
申请日：1998-11-13
申请人： Hiroshi Yanagawa , Naoto Nemoto , Etsuko Miyamoto
发明人： Hiroshi Yanagawa , Naoto Nemoto , Etsuko Miyamoto
IPC分类号： C07K113
CPC分类号： C07H19/20 , C07H19/04 , C07K1/13
摘要： A protein having a labeling compound attached to its C-terminal, in which the compound comprises a label portion comprising a label substance and an acceptor portion comprising a compound having an ability of binding to a C-terminal of a synthesized protein when protein synthesis is carried out in a cell-free protein synthesis system or in a living cell is provided. Also, a method for producing the protein comprising the step of performing synthesis of a protein in a cell-free protein synthesis system or in a living cell in the presence of a labeling compound comprising a label portion comprising a label substance and an acceptor portion comprising a compound having an ability of binding to a C-terminal of a synthesized protein when protein synthesis is carried out in the cell-free protein synthesis system or in the living cell, the labeling compound being present at a concentration effective for the labeling compound to bind to the C-terminal of the synthesized protein is provided. Also, the labeling compound and a method for analyzing a function of a gene are further provided.

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