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1. 发明授权

US11360047B2 Capillary electrophoresis device 有权
公开(公告)号：US11360047B2
公开(公告)日：2022-06-14
申请号：US16633641
申请日：2017-07-31
申请人： Hitachi High-Technologies Corporation
发明人： Katsuhiro Aritome , Ryusuke Kimura , Motohiro Yamazaki
IPC分类号： G01N27/447 , G01N27/416
摘要： An electrophoresis device has: a sample tray (112) on which there are placed a positive-electrode-side buffer solution container (103) containing a buffer solution and a phoresis medium container (102) containing a phoresis medium, and which is driven in a vertical direction and a horizontal direction; a thermostat oven unit (113) that holds a capillary array having a capillary head in which a plurality of capillaries are bundled in a single unit at one end thereof in a state where the capillary array being held in a state in which the capillary head protrudes downward, and that keeps the interior temperature constant; a solution-delivering mechanism (106) for delivering the phoresis medium in the phoresis medium container to the capillary array from the capillary head; and a power source for applying a voltage to both ends of the capillary array. Holes for insertion of the capillary head are provided in upper sections of the positive-electrode-side buffer solution container and the phoresis medium container. The thermostat oven unit is provided with a first lid member (207) that is positioned above the sample tray and seals the upper section of the positive-electrode-side buffer solution container while the phoresis medium is being delivered by the solution-delivering mechanism.

2. 发明授权

US10705046B2 Electrophoresis device and electrophoresis method 有权
公开(公告)号：US10705046B2
公开(公告)日：2020-07-07
申请号：US15560395
申请日：2015-03-27
申请人： Hitachi High-Technologies Corporation
发明人： Ryusuke Kimura , Motohiro Yamazaki , Hitoshi Miyata , Hiroyuki Higashino
IPC分类号： G01N27/447
摘要： Provided is an electrophoresis device that, by electrophoresis, feeds a sample into capillaries and optically detects the sample, the electrophoresis device being provided with capillaries, a capillary head provided at the distal end of the capillaries, a phoretic medium-filled container used for electrophoresis and filled with a phoretic medium, a guide member that covers the side surface of the phoretic medium-filled container, a seal member that seals from below the phoretic medium filled in the phoretic medium-filled container, and a plunger that presses the seal member.

3. 发明授权

US11029281B2 Drive screw device, liquid delivery mechanism, and liquid delivery method 有权
公开(公告)号：US11029281B2
公开(公告)日：2021-06-08
申请号：US16333258
申请日：2016-09-23
申请人： Hitachi High-Technologies Corporation
发明人： Katsuhiro Aritome , Ryusuke Kimura , Motohiro Yamazaki , Go Nakajima , Naomichi Kawasaki
IPC分类号： G01N27/447 , B05C7/08 , B29C45/50 , G01N1/14
摘要： This drive screw device is provided with: a drive screw; a drive unit which causes the drive screw to rotate; a slider which moves along the drive screw by means of the rotation of the drive screw; and an external load which is provided on the drive screw and applies a rotational load to the drive screw. By this means it is possible to provide a drive screw device with which there is little pressure variation even if a frictional force varies.

4. 发明授权

US11243187B2 Electrophoretic medium container 有权
公开(公告)号：US11243187B2
公开(公告)日：2022-02-08
申请号：US16620961
申请日：2017-06-28
申请人： Hitachi High-Technologies Corporation
发明人： Naomichi Kawasaki , Ryusuke Kimura , Katsuhiro Aritome , Go Nakajima , Takashi Gomi , Motohiro Yamazaki
IPC分类号： G01N27/447
摘要： The present invention addresses the problem of providing an electrophoretic medium container capable of stabilizing a liquid delivery pressure while ensuring sealing of an electrophoretic medium. In order to resolve this problem, this electrophoretic medium container is provided with a syringe part for holding an electrophoretic medium, and a sealing component for sealing one end of the syringe part, the electrophoretic medium container being characterized in that the sealing component has a sealing surface, a body part, and a groove provided between the sealing surface and the body part, wherein the sealing surface is in contact with the inner wall of the syringe part.

5. 发明授权

US09415391B2 Cartridge for biochemical use and biochemical processing device 有权
标题翻译：滤芯生化用途及生化处理装置
公开(公告)号：US09415391B2
公开(公告)日：2016-08-16
申请号：US14416084
申请日：2013-06-18
申请人： Hitachi High-Technologies Corporation
发明人： Ryusuke Kimura , Hiromi Yamashita , Motohiro Yamazaki
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L2200/0605 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/123 , B01L2400/0481 , B01L2400/0655
摘要： A cartridge sealed from an external air is used to enable mixing with a reagent, agitating, purification, reaction, etc. Provided inside the cartridge sealed from the external air are a chamber for the reagent to be transported, a chamber to which the reagent is transported, and the chambers are connected by a liquid transport channel. A groove is made in a cartridge body and a membrane as an elastic body is pasted onto the groove to form the liquid transport channel. Air pressure is given to the membrane to change the volume of the liquid transport channel and thereby move the fluid inside. The inlet of each chamber has a valve function to move the fluid inside in a desired direction according to change of the liquid transport channel. This enables transportation of the liquid inside the cartridge sealed from the external air.
摘要翻译：使用与外部空气密封的盒，以使其能够与试剂混合，搅拌，净化，反应等。在从外部空气密封的盒中设置有用于待运送试剂的室，试剂为运输，并且室通过液体输送通道连接。在盒体中形成凹槽，将作为弹性体的膜粘贴到凹槽上以形成液体输送通道。给予膜的空气压力以改变液体输送通道的体积，从而使流体在内部移动。每个室的入口具有阀功能，以根据液体输送通道的变化在所需方向内移动流体。这使得能够将盒内的液体从外部空气密封。

6. 发明授权

US11426721B2 Bubble eliminating structure, bubble eliminating method, and agitating method using the same 有权
公开(公告)号：US11426721B2
公开(公告)日：2022-08-30
申请号：US16313485
申请日：2017-06-26
申请人： Hitachi High-Technologies Corporation
发明人： Yoshihiro Nagaoka , Taro Nakazawa , Mitsuhiro Miyazaki , Ryusuke Kimura , Motohiro Yamazaki
IPC分类号： G01N35/08 , G01N21/05 , B01L3/00 , G01N37/00 , C12M1/00
摘要： Provided are a bubble eliminating structure and a bubble eliminating method which eliminate bubbles in a liquid by agitating the liquid, and an agitating method using the same. A first groove 114, which is an upstream bubble eliminating groove, and a second groove 131, which is a downstream bubble eliminating groove, are branched from a mixing well 13. After starting suction of the liquid from mixing well 13 into the first groove 114, suction of the liquid from the mixing well 13 into the second groove 131 is started, and after completion of discharge of the liquid from the first groove 114 into the mixing well 13, discharge of the liquid from the second groove 131 into the mixing well 13 is completed. This operation is repeated to eliminate bubbles.

7. 发明授权

US10246675B2 Biochemical cartridge, and biochemical cartridge and cartridge holder set 有权
公开(公告)号：US10246675B2
公开(公告)日：2019-04-02
申请号：US14762301
申请日：2014-01-27
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Ryusuke Kimura , Hiromi Yamashita , Motohiro Yamazaki , Taro Nakazawa
IPC分类号： C12M3/00 , F16K31/126 , F16K7/17 , G01N35/08 , B01L3/00 , C12M1/40 , C12M1/107
摘要： A cartridge sealed from ambient air is used to send a liquid without causing the liquid to contact the fluid inside the cartridge. Inside of the cartridge 1 sealed from ambient air are provided chambers that send and receive reagents, and an elastic body membrane 51 is attached to the bottom surface. The cartridge main body 51 does not have a groove or anything else that becomes a channel, and the membrane 51 is not bonded to portions that become channels. A channel, not formed in a normal state, is formed upon deforming the membrane 51 under air pressure in the unbonded portion, and the fluid is moved inside. A valve function is provided at an inlet of each chamber, and the fluid is internally moved in any direction with channel deformation.

8. 发明申请

US20150151295A1 CARTRIDGE FOR BIOCHEMICAL USE AND BIOCHEMICAL PROCESSING DEVICE 有权
标题翻译：生物化学用途和生物化学处理装置
公开(公告)号：US20150151295A1
公开(公告)日：2015-06-04
申请号：US14416084
申请日：2013-06-18
申请人： Hitachi High-Technologies Corporation
发明人： Ryusuke Kimura , Hiromi Yamashita , Motohiro Yamazaki
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L2200/0605 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/123 , B01L2400/0481 , B01L2400/0655
摘要： A cartridge sealed from an external air is used to enable mixing with a reagent, agitating, purification, reaction, etc. Provided inside the cartridge 1 sealed from the external air are a chamber 38 for the reagent to be transported, a chamber 39 to which the reagent is transported, and the chambers are connected by a liquid transport channel. A groove is made in a cartridge body 30 and a membrane 31 as an elastic body is pasted onto the groove to form the liquid transport channel 36. Air pressure is given to the membrane 31 to change the volume of the liquid transport channel 31 and thereby move the fluid inside. The inlet of each chamber has a valve function to move the fluid inside in a desired direction according to change of the liquid transport channel. This enables transportation of the liquid inside the cartridge sealed from the external air so that mixing with the reagent, agitating, purification, reaction, etc. can be performed in the cartridge. In addition, a valve structure is provided not in the cartridge but in a holder 2 on which the cartridge is loaded, so the cost of the cartridge can be reduced.
摘要翻译：使用与外部空气密封的筒，以使其能够与试剂混合，搅拌，净化，反应等。在从外部空气密封的盒1内设置有用于待运送试剂的室38，室39，试剂被输送，并且室通过液体输送通道连接。在盒主体30中形成凹槽，将作为弹性体的膜31粘贴到凹槽上以形成液体输送通道36.空气压力被施加到膜31以改变液体输送通道31的体积，从而移动流体内。每个室的入口具有阀功能，以根据液体输送通道的变化在所需方向内移动流体。这使得能够将盒内的液体从外部空气密封，使得可以在盒中进行与试剂的混合，搅拌，净化，反应等。此外，阀结构不设置在盒中，而是设置在其上装载盒的保持器2中，因此可以降低盒的成本。

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