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1. 发明申请

US20190241948A1 BIOMOLECULE ANALYSIS METHOD 审中-公开
公开(公告)号：US20190241948A1
公开(公告)日：2019-08-08
申请号：US16387241
申请日：2019-04-17
申请人： TOPPAN PRINTING CO., LTD.
发明人： Yoichi Makino , Tomoko Kunitomi
IPC分类号： C12Q1/6858 , C12Q1/686 , G01N21/64 , B01L3/00
CPC分类号： C12Q1/6858 , B01L3/502715 , B01L3/502746 , B01L2200/0642 , B01L2200/0673 , B01L2200/0689 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/0887 , B01L2300/123 , B01L2300/161 , B01L2300/168 , B01L2400/0487 , B01L2400/086 , C12Q1/686 , G01N21/6428 , G01N21/6452 , G01N2021/6439
摘要： A biomolecule analysis method including: feeding a reagent into a reaction container which includes a plurality of wells and filing the reagent in the plurality of wells, the reagent being for causing an enzymatic reaction with regard to a target substance of analysis; feeding an oil sealing solution over the plurality of wells and sealing the reagent into the plurality of wells with the oil sealing solution so that the plurality of wells become a plurality of independent reaction containers; performing the enzymatic reaction by incubating the reaction container; and detecting a signal amplified by the enzymatic reaction.

2. 发明申请

US20190234530A1 IMPROVEMENTS IN OR RELATING TO VALVES FOR MICROFLUIDIC DEVICES 审中-公开
公开(公告)号：US20190234530A1
公开(公告)日：2019-08-01
申请号：US16330118
申请日：2017-09-11
申请人： Fluidic Analytics Limited
发明人： Anthony Douglas , Tuomas Pertti Jonathan Knowles , Thomas Mueller , Liam Dower
IPC分类号： F16K99/00 , B01L3/00
CPC分类号： F16K99/0015 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/0689 , B01L2300/049 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , F16K99/0057 , F16K2099/0084
摘要： A single-layer valve is provided. The valve comprises a microfluidic pathway at least partially defined by a flexible membrane which is configured to deform when subjected to an actuation torque, and a discontinuity bounded by a first surface. The length of the discontinuity is constant across the full width of the first surface. The valve is configured such that the actuation torque on the membrane is larger in a first direction than a second direction substantially opposite to the first direction.

3. 发明申请

US20190233888A1 VALVED CARTRIDGE AND SYSTEM 审中-公开
公开(公告)号：US20190233888A1
公开(公告)日：2019-08-01
申请号：US16264389
申请日：2019-01-31
申请人： IntegenX, Inc.
发明人： Philip Justus Wunderle , Chungsoo Charles Park , David King , Dennis Lehto
IPC分类号： C12Q1/6874 , C12Q1/686 , F16K99/00 , B01L3/00
CPC分类号： C12Q1/6874 , B01F13/0059 , B01F13/02 , B01L3/502738 , B01L3/502753 , B01L7/52 , B01L2200/04 , B01L2200/0668 , B01L2200/16 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/043 , B01L2400/0478 , B01L2400/0655 , C12Q1/686 , F16K99/0015 , F16K99/0034 , F16K2099/0078 , F16K2099/0084
摘要： This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface, wherein (II) the cartridge interface comprises: (A) at least one mechanical actuator, each mechanical actuator positioned to actuate a valve; and (B) at least one motor operatively coupled to actuate a mechanical actuator toward or away from a valve.

4. 发明申请

US20190232293A1 CARTRIDGE-BASED THERMOCYCLER 审中-公开
公开(公告)号：US20190232293A1
公开(公告)日：2019-08-01
申请号：US16228709
申请日：2018-12-20
申请人： Click Diagnostics, Inc.
发明人： Hamilton R. TANG , Adam DE LA ZERDA , Kenneth I. LI , Kevin M. LIMTAO , Alan D. BALDWIN , Gregory C. LONEY
IPC分类号： B01L7/00 , B01L3/00 , C12Q1/6844 , C12Q1/686
CPC分类号： B01L7/525 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2300/1822 , B01L2300/1827 , B01L2400/0478 , B01L2400/0481 , B01L2400/0655 , C12Q1/6844 , C12Q1/686
摘要： Cartridge-based thermocyclers can include cartridges that are configured to move a fluid between distinct chambers. In some cases, the cartridge-based thermocyclers can be used for thermocycling a sample fluid comprising a deoxyribonucleic acid (DNA) target to perform polymerase chain reaction (PCR). Individual chambers can be heated, cooled, and/or compressed to mix fluid within the chamber or to propel fluid in the chamber into another chamber. The cartridges can have a laminate construction. The cartridges can be configured to enable multiplexed thermocycling and/or detection.

5. 发明申请

US20190195806A1 METHOD AND DEVICE FOR CHEMILUMINESCENCE-BASED ANALYSIS 审中-公开
公开(公告)号：US20190195806A1
公开(公告)日：2019-06-27
申请号：US16312821
申请日：2017-06-25
申请人： B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY
发明人： Alina KARABCHEVSKY
IPC分类号： G01N21/76 , G01N33/58 , G01N33/72 , B01L3/00 , G01N21/05
CPC分类号： G01N21/76 , B01L3/5027 , B01L2300/0663 , B01L2300/0877 , B01L2300/0883 , B01L2300/123 , G01N21/05 , G01N33/582 , G01N33/587 , G01N33/725 , G01N2021/0346
摘要： A method for detecting an analyte reactive towards luminol, comprising the steps of: feeding into a reaction chamber an alkaline solution of luminol, noble metal nanoparticles and at least one analyte reactive towards luminol, wherein the reaction chamber is in the form of a curved channel; detecting the light emitted due to a chemiluminescence reaction taking place in said channel; and discharging a reaction mass from said channel, characterized in that the average diameter of the metal nanoparticles is greater than 25 nm. Also provided is a microfluidic device for carrying out the method.

6. 发明申请

US20190001321A1 APPARATUS AND METHOD FOR PREPARING A BIOLOGICAL SAMPLE FOR ANALYSIS 审中-公开
公开(公告)号：US20190001321A1
公开(公告)日：2019-01-03
申请号：US16124715
申请日：2018-09-07
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： JON A. KIRSCHHOFFER , GREGORY W. SITTON , ANDREW H. TILSTRA
IPC分类号： B01L3/00 , C12Q1/24
CPC分类号： B01L3/502 , B01L2200/0689 , B01L2300/0681 , B01L2300/0832 , B01L2300/087 , B01L2300/123 , B01L2400/0478 , B01L2400/0605 , B01L2400/0611 , C12Q1/24
摘要： An apparatus for processing a biological sample is provided. The apparatus comprises a body having a processing chamber, a first reservoir, a second reservoir, a filter, a first one-way valve, a second one-way valve, a first fluid pathway, and a second fluid pathway. The first fluid pathway and the second fluid pathway pass through the filter. A method of processing a sample using the apparatus is also provided. The method comprises placing a sample comprising a liquid into the processing chamber; urging at least a portion of the liquid through the filter; after urging the at least a portion of the liquid through the filter, urging a portion of a back-flush liquid through the filter into the process chamber to form a first processed sample; and analyzing at least a portion of the first processed sample to detect an indication of a microorganism.

7. 发明申请

US20180360023A1 PORTABLE THAWER COMPONENTS AND FEATURES 审中-公开
公开(公告)号：US20180360023A1
公开(公告)日：2018-12-20
申请号：US15872676
申请日：2018-01-16
申请人： MedCision, Inc.
发明人： Thomas McPherson , Brian Schryver , Scott Comiso
IPC分类号： A01N1/02 , B01L7/00 , H05B3/06
CPC分类号： A01N1/0252 , A01N1/0242 , A01N1/0284 , B01L7/00 , B01L7/52 , B01L9/06 , B01L2200/02 , B01L2200/04 , B01L2300/123 , B01L2300/1805 , B01L2300/1827 , H05B3/06
摘要： The present disclosure is related to sample thawing. Features described herein may limit power requirements of the thawing device and may thereby increase the portability of the thawing device. The device may include a housing; a heater block housed within the housing and forming a vial receptacle; a thermally-conductive compliant material may line an inner surface of the receptacle; and a heating element may be coupled with the heater block. The thermally-conductive compliant material may be molded to a shape of a bottom portion of the vial so as to fittingly mate with the bottom portion of the vial. In some embodiments, the heater block does not have moveable components and may be a single non-segmented piece. An ejection pin may be provided configured to break contact between the vial and the thermally-conductive compliant material. Additionally, the receptacle may be localized to the vial region adjacent to the frozen sample.

8. 发明申请

US20180304250A1 INTEGRATED PIPETTE TIP DEVICES 审中-公开
公开(公告)号：US20180304250A1
公开(公告)日：2018-10-25
申请号：US15852614
申请日：2017-12-22
申请人： BIOTIX, INC.
发明人： Arta MOTADEL , Phillip HAIRFIELD , Peter Paul BLASZCAK
IPC分类号： B01L3/02 , G01N35/10
CPC分类号： B01L3/0275 , B01L2200/0689 , B01L2200/08 , B01L2300/06 , B01L2300/0816 , B01L2300/0829 , B01L2300/123 , G01N35/1074
摘要： Disclosed herein are fluid handling devices that include integrated card and pipette tip devices, for use with multichannel liquid dispensing devices.

9. 发明申请

US20180304249A1 CONTROLLED ATMOSPHERE BAG SUITABLE FOR MICROSCOPY AND SPECTROSCOPY 审中-公开
公开(公告)号：US20180304249A1
公开(公告)日：2018-10-25
申请号：US15758979
申请日：2016-09-09
申请人： THE SECRETARY OF STATE FOR DEFENCE
发明人： Emma Grace HANDLEY , Andrew Stuart KIRK
IPC分类号： B01L1/02 , G02B21/24 , G01N21/01
CPC分类号： B01L1/025 , B01L1/00 , B01L2200/026 , B01L2300/123 , G01N21/01 , G02B21/24
摘要： A controlled atmosphere bag suitable for microscopy and spectroscopy, having an optic attachment (7) a sample support attachment (6), gas inlet means (2), gas outlet means (4) and a sample insertion means (3) that allow a sample to be analysed to be enclosed in a relatively small and controlled gas atmosphere chamber allowing the remainder of the analysis device to remain outside the chamber retaining full dexterity for the operator.

10. 发明申请

US20180283994A1 CORRUGATED-TUBE CONSTANT-PRESSURE CYLINDER APPARATUS HAVING NO MICROLEAKAGE AND METHOD FOR USING SAME 审中-公开
公开(公告)号：US20180283994A1
公开(公告)日：2018-10-04
申请号：US15524425
申请日：2015-06-04
申请人： Korea Research Institute of Standards and Science
发明人： Jin Choon WOO , Yong Doo KIM , Hyeon Gil BAE , Nam Goo GANG
IPC分类号： G01N1/14 , F16J3/06 , G01N1/22 , B01L3/00
CPC分类号： G01N1/14 , B01L3/508 , B01L2200/0689 , B01L2200/142 , B01L2200/18 , B01L2300/0832 , B01L2300/0861 , B01L2300/10 , B01L2300/123 , B01L2300/14 , B01L2400/0478 , B01L2400/0487 , F16J3/06 , G01N1/00 , G01N1/22 , G01N2001/002 , G01N2001/1062 , G01N2001/1454
摘要： The present invention relates to a corrugated constant pressure cylinder apparatus having no micro leaks and its method of use, and more specifically, a corrugated constant pressure cylinder apparatus having no micro leaks and its method of use where the internal pressure of the cylinder is maintained at a constant pressure so as to allow for transport or storage in a state without micro leaks. Therefore, this invention relates to a corrugated constant pressure cylinder apparatus having no micro leaks and its method of use where mixed refrigerant gases, volatile organic compounds (VOC), hydrocarbon mixtures, and other such substances that exist in gaseous or liquid form at room temperature are kept in a cylinder that maintains a constant internal pressure to keep the contents in liquid form, or is able to keep the pressure constant even if the internal volume changes due to the contents inside the cylinder.In order to fulfill the aforementioned purpose, the corrugated constant pressure cylinder apparatus having no micro leaks of the present invention is characterized by being comprised of a fixed plate (100) comprised of a circular steel plate with a fixed thickness that has a sample inlet (101) in the middle that goes through the plate, and is coupled with the bottom portion of a cylinder (200) to form chamber (a) and; a cylinder (200) comprised of a steel tube open at the bottom section and closed at the upper section with the flared bottom section comprised of a flange (210) that has a plurality of fastening holes (211) going through it and is coupled with the aforementioned fixed plate (100) to form chamber (a) and; fastening bolts (300) and fastening nuts (300′) that fasten together with bolts the aforementioned fixed plate's (100) inner side with the outer side of the flange (210) on the bottom section of the aforementioned cylinder (200) to form chamber (a) and; a pressure gauge (400) coupled to the coupling pipe (226) of the pressure gauge coupling hole (224) that checks the pressure within chamber (a) in order to control the amount of inert gas that is injected and; opening/closing valves (500) connected to the sample inlet (101) and the inert gas inlet (223) and; a sample chamber (b) inside the aforementioned chamber (a) that stores the collected sample and creates and maintains constant pressure.In addition, the method of use for the corrugated constant pressure cylinder having no micro leaks of the present invention is characterized by collecting a fixed amount of the sample in sample chamber (b) then closing the opening/closing valve (500), opening the opening/closing valve (500′) of the inert gas inlet (223) on the cylinder (200) then gradually injecting inert gas through the inert gas inlet (223), making the corrugated cylinder (b10) of sample chamber (b) adjust in accordance with the increase in inert gas injected into the aforementioned chamber (a) until the internal pressure of chamber (a) and the internal pressure of sample chamber (b) reach equilibrium at a predetermined pressure, at which time the opening/closing valve (500′) of the inert gas inlet (223) is closed.According to the corrugated constant pressure cylinder having no micro leaks and its method of use of the present invention as set forth above, a corrugated constant pressure cylinder having no micro leaks and its method of use is provided that removes the cause of gas leaks in the chamber and the sample chamber, allowing for the sample within the sample chamber to be maintained at a constant pressure to keep it in a liquid state during transport to the laboratory, which then allows it to be directly installed onto the analyzer to have the sample's composition be analyzed, resulting in reliable composition analysis results.

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