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1. 发明授权

US09176206B2 Effective-inductance-change based magnetic particle sensing 有权
标题翻译：基于有效电感变化的磁性粒子感应
公开(公告)号：US09176206B2
公开(公告)日：2015-11-03
申请号：US12399603
申请日：2009-03-06
申请人： Hua Wang , Seyed Ali Hajimiri , Yan Chen
发明人： Hua Wang , Seyed Ali Hajimiri , Yan Chen
IPC分类号： G01N27/00 , G01N33/00 , G01R33/12
CPC分类号： G01R33/1269
摘要： The invention relates to an integrated measurement system to detect a quantity of magnetic particles in a sample. The measurement system includes a substrate. An electromagnetic (EM) structure disposed on the surface of the substrate is configured to receive a sample including the magnetic particles in proximity thereof. The integrated measurement system also includes an electrical current generator disposed on the surface of the substrate which is electro-magnetically coupled to the EM structure. The electrical current generator is configured to cause an electrical current to flow in the EM structure. The integrated measurement system also includes an effective inductance sensor disposed on the surface of the substrate which is configured to measure a selected one of an effective inductance and a change in effective inductance. The invention also relates to a method to determine the number of and/or the locations of the magnetic particles in a sample.
摘要翻译：本发明涉及一种用于检测样品中的磁性颗粒的量的综合测量系统。测量系统包括基板。设置在基板的表面上的电磁（EM）结构被配置为接收包括邻近的磁性颗粒的样品。集成测量系统还包括设置在基板的表面上的电流发生器，其电磁耦合到EM结构。电流发生器被配置为使得电流在EM结构中流动。集成测量系统还包括设置在衬底的表面上的有效电感传感器，其被配置为测量有效电感和有效电感的变化中选定的一个。本发明还涉及确定样品中磁性颗粒数量和/或位置的方法。

2. 发明申请

US20090267596A1 EFFECTIVE-INDUCTANCE-CHANGE BASED MAGNETIC PARTICLE SENSING 有权
标题翻译：基于有效电感变化的磁性粒子感测
公开(公告)号：US20090267596A1
公开(公告)日：2009-10-29
申请号：US12399603
申请日：2009-03-06
申请人： Hua Wang , Seyed Ali Hajimiri , Yan Chen
发明人： Hua Wang , Seyed Ali Hajimiri , Yan Chen
IPC分类号： G01N27/00 , G01R33/00
CPC分类号： G01R33/1269
摘要： The invention relates to an integrated measurement system to detect a quantity of magnetic particles in a sample. The measurement system includes a substrate. An electromagnetic (EM) structure disposed on the surface of the substrate is configured to receive a sample including the magnetic particles in proximity thereof. The integrated measurement system also includes an electrical current generator disposed on the surface of the substrate which is electro-magnetically coupled to the EM structure. The electrical current generator is configured to cause an electrical current to flow in the EM structure. The integrated measurement system also includes an effective inductance sensor disposed on the surface of the substrate which is configured to measure a selected one of an effective inductance and a change in effective inductance. The invention also relates to a method to determine the number of and/or the locations of the magnetic particles in a sample.
摘要翻译：本发明涉及一种用于检测样品中的磁性颗粒的量的综合测量系统。测量系统包括基板。设置在基板的表面上的电磁（EM）结构被配置为接收包括邻近的磁性颗粒的样品。集成测量系统还包括设置在基板的表面上的电流发生器，其电磁耦合到EM结构。电流发生器被配置为使得电流在EM结构中流动。集成测量系统还包括设置在衬底的表面上的有效电感传感器，其被配置为测量有效电感和有效电感的变化中选定的一个。本发明还涉及确定样品中磁性颗粒数量和/或位置的方法。

3. 发明授权

US08878684B2 Ultrasensitive detection platform for sensing magnetic and/or electrical energy change 有权
标题翻译：用于感测磁和/或电能变化的超灵敏检测平台
公开(公告)号：US08878684B2
公开(公告)日：2014-11-04
申请号：US12959331
申请日：2010-12-02
申请人： Hua Wang , Seyed Ali Hajimiri
发明人： Hua Wang , Seyed Ali Hajimiri
IPC分类号： G08B21/00
CPC分类号： G01R29/26 , G01R31/31709 , G01R33/1269
摘要： A scalable and ultrasensitive frequency-shift magnetic array scheme. The theoretical limit of the sensor noise floor is shown to be dominated by the phase noise of the sensing oscillators. To increase the sensitivity, a noise suppression technique, Correlated Double Counting (CDC), is described with no power overhead. As an implementation example, a 64-cell sensor array is designed in a standard 65 nm CMOS process. The CDC scheme achieves an additional 6 dB noise suppression. The magnetic sensing capability of the presented sensor is verified by detecting micron size magnetic particles with an SNR of 14.6 dB for a single bead and an effective dynamic range of at least 74.5 dB. Applications in biosensing are contemplated, among other possible uses. Measurement of electrical properties is also contemplated.
摘要翻译：可扩展和超灵敏的频移磁阵列方案。传感器本底噪声的理论极限显示为感知振荡器的相位噪声。为了提高灵敏度，在没有功率开销的情况下描述了噪声抑制技术相关双计数（CDC）。作为实现示例，64标准的传感器阵列被设计在标准的65nm CMOS工艺中。 CDC方案实现了额外的6 dB噪声抑制。通过检测单个珠的SNR为14.6 dB的微米尺寸磁性颗粒和至少74.5 dB的有效动态范围来验证所呈现的传感器的磁感测能力。考虑到生物传感中的应用以及其它可能的用途。还考虑了电性能的测量。

4. 发明申请

US20100134097A1 FREQUENCY-SHIFT CMOS MAGNETIC BIOSENSOR ARRAY WITH SINGLE BEAD SENSITIVITY AND NO EXTERNAL MAGNET 有权
标题翻译：频率移动CMOS磁性生物传感器阵列，具有单根光纤灵敏度，无外部磁铁
公开(公告)号：US20100134097A1
公开(公告)日：2010-06-03
申请号：US12559517
申请日：2009-09-15
申请人： Hua Wang , Seyed Ali Hajimiri
发明人： Hua Wang , Seyed Ali Hajimiri
IPC分类号： G01R33/12
CPC分类号： G01R33/1269
摘要： According to one aspect, an integrated magnetic particle measurement device for detecting a presence or absence of magnetic particles in a sample volume includes at least one sensor cell having a differential sensor pair. An active sensor oscillator frequency is responsive to one or more magnetic particles situated within a sample volume. The sensor cell is configured to be operative in the absence of an externally applied magnetic field. A frequency measurement circuit provides as a time-multiplexed output a first count representative of the active sensor oscillator frequency and a second count representative of the reference sensor oscillator frequency. A calculated difference between the first count and the second count is indicative of a presence or an absence of one or more magnetic particles within the sample volume. An integrated magnetic particle measurement system array and a method for detecting one or more magnetic particles are also described.
摘要翻译：根据一个方面，用于检测样品体积中磁性颗粒存在或不存在的集成磁性颗粒测量装置包括至少一个具有差分传感器对的传感器单元。主动传感器振荡器频率响应于位于样品体积内的一个或多个磁性颗粒。传感器单元被配置为在没有外部施加的磁场的情况下操作。频率测量电路提供代表有源传感器振荡器频率的第一计数的时间复用输出和表示参考传感器振荡器频率的第二计数。第一计数和第二计数之间的计算差异表示样品体积内存在或不存在一个或多个磁性颗粒。还描述了集成磁性粒子测量系统阵列和用于检测一个或多个磁性粒子的方法。

5. 发明授权

US08993236B2 Electromagnetic molecular sensors and methods of using same 有权
标题翻译：电磁分子传感器及其使用方法
公开(公告)号：US08993236B2
公开(公告)日：2015-03-31
申请号：US12762229
申请日：2010-04-16
申请人： Seyed Ali Hajimiri , Hua Wang
发明人： Seyed Ali Hajimiri , Hua Wang
IPC分类号： C12Q1/68 , G01N27/74 , G01N27/72 , G01N33/543 , G01N27/327
CPC分类号： G01N27/745 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C12Q1/6832 , C12Q1/6834 , C12Q2525/161 , C12Q2525/197 , C12Q2525/301 , C12Q2563/143 , C12Q2565/519 , G01N27/3278 , G01N27/72 , G01N33/54326 , G01N33/54333 , G01N2446/00 , Y10T436/143333
摘要： Devices having an electromagnetic detector for the detection of analytes are disclosed. The devices include an electromagnetic detector, including effective inductance-change magnetic detectors, and a binding moiety. The device can include an electromagnetic material that can be detected by the detector. The device is configured such that binding of an analyte to the binding moiety changes the relationship between the electromagnetic detector and the electromagnetic material such that a change in electromagnetic field is detected by the electromagnetic detector.
摘要翻译：公开了具有用于检测分析物的电磁检测器的装置。这些装置包括电磁检测器，包括有效的电感变化磁性检测器和结合部分。该装置可以包括可由检测器检测的电磁材料。该装置被配置为使得分析物与结合部分的结合改变了电磁检测器和电磁材料之间的关系，使得电磁检测器检测到电磁场的变化。

6. 发明授权

US08305106B2 Electronic self-healing methods for radio-frequency receivers 有权
标题翻译：射频接收机的电子自愈方法
公开(公告)号：US08305106B2
公开(公告)日：2012-11-06
申请号：US12806906
申请日：2010-08-24
申请人： Florian Bohn , Seyed Ali Hajimiri , Hua Wang , Yu-Jiu Wang
发明人： Florian Bohn , Seyed Ali Hajimiri , Hua Wang , Yu-Jiu Wang
IPC分类号： G01R31/02
CPC分类号： H04B1/40 , H04B17/0085
摘要： Systems and methods for providing self-healing integrated circuits. The method is characterized in that the behavior of a circuit or a device in response to an input signal is observed. One or more operational parameters or characteristics of the circuit or the device are derived. A corrective action to bring the operational parameters or characteristics of the circuit or device within a desired range is deduced, if needed. The corrective action can be the application of a correction signal or a modification of one or more parameters or characteristics of an element in the circuit. The calculated corrective action, if needed, is applied to bring the operational parameters or characteristics of the circuit or device within the desired range. Optionally, the operational parameters or characteristics of the circuit or the device after the correction is effectuated can be checked.
摘要翻译：提供自愈式集成电路的系统和方法。该方法的特征在于，观察到响应于输入信号的电路或设备的行为。导出电路或器件的一个或多个操作参数或特性。如果需要，可以推导出将电路或设备的操作参数或特性置于所需范围内的纠正措施。校正动作可以是在电路中应用校正信号或修改元件的一个或多个参数或特性。如果需要，应用计算的校正动作将电路或设备的操作参数或特性置于所需范围内。可选地，可以检查校正后的电路或设备的操作参数或特性。

7. 发明申请

US20120155580A1 BROADBAND PHASE SYNTHESIS NETWORK WITH SELF-HEALING CAPABILITY 有权
标题翻译：具有自愈能力的宽带相位合成网络
公开(公告)号：US20120155580A1
公开(公告)日：2012-06-21
申请号：US12949679
申请日：2010-11-18
申请人： Hua Wang , Seyed Ali Hajimiri
发明人： Hua Wang , Seyed Ali Hajimiri
IPC分类号： H04L27/38
CPC分类号： H04L27/3863 , H04L27/3872
摘要： A phase synthesis network having self healing capability. The phase synthesis network includes two phase rotators that receive I and Q input LO signals, that receive a digital control signal, and that can adjust a phase and a gain in response to the digital control signal. An output of each of the phase rotators provides a respective output signal to a switch. The switch provides a selected one of the respective output signals for mixing with a predetermined one of the respective output signals. Two mixers mix signals from the phase rotators with an RF signal. Two analog-to-digital converters provide a respective digital signal representative of the output of the mixers. A baseband digital processor generates digital control signals that are provided to the phase rotators. The circuit has an output terminal configured to provide an output signal representative of the RF signal.
摘要翻译：具有自愈能力的相位合成网络。相位合成网络包括接收I和Q输入LO信号的两个相位旋转器，其接收数字控制信号，并且可以响应于数字控制信号来调节相位和增益。每个相位旋转器的输出向开关提供相应的输出信号。开关提供相应输出信号中的所选择的一个，用于与各个输出信号中的预定的一个混合。两个混频器将来自相位旋转器的信号与RF信号混合。两个模拟 - 数字转换器提供代表混频器输出的各自的数字信号。基带数字处理器产生提供给相位旋转器的数字控制信号。电路具有被配置为提供表示RF信号的输出信号的输出端子。

8. 发明申请

US20110057682A1 Electronic self-healing methods for radio-frequency receivers 有权
标题翻译：射频接收机的电子自愈方法
公开(公告)号：US20110057682A1
公开(公告)日：2011-03-10
申请号：US12806906
申请日：2010-08-24
申请人： Florian Bohn , Seyed Ali Hajimiri , Hua Wang , Yu-Jiu Wang
发明人： Florian Bohn , Seyed Ali Hajimiri , Hua Wang , Yu-Jiu Wang
IPC分类号： G01R31/26
CPC分类号： H04B1/40 , H04B17/0085
摘要： Systems and methods for providing self-healing integrated circuits. The method is characterized in that the behavior of a circuit or a device in response to an input signal is observed. One or more operational parameters or characteristics of the circuit or the device are derived. A corrective action to bring the operational parameters or characteristics of the circuit or device within a desired range is deduced, if needed. The corrective action can be the application of a correction signal or a modification of one or more parameters or characteristics of an element in the circuit. The calculated corrective action, if needed, is applied to bring the operational parameters or characteristics of the circuit or device within the desired range. Optionally, the operational parameters or characteristics of the circuit or the device after the correction is effectuated can be checked.
摘要翻译：提供自愈式集成电路的系统和方法。该方法的特征在于，观察到响应于输入信号的电路或设备的行为。导出电路或器件的一个或多个操作参数或特性。如果需要，可以推导出将电路或设备的操作参数或特性置于所需范围内的纠正措施。校正动作可以是在电路中应用校正信号或修改元件的一个或多个参数或特性。如果需要，应用计算的校正动作将电路或设备的操作参数或特性置于所需范围内。可选地，可以检查校正后的电路或设备的操作参数或特性。

9. 发明申请

US20100163545A1 FULLY INTEGRATED TEMPERATURE REGULATOR FOR BIOCHEMICAL APPLICATIONS 有权
标题翻译：全面综合温度调节器用于生物化学应用
公开(公告)号：US20100163545A1
公开(公告)日：2010-07-01
申请号：US12399320
申请日：2009-03-06
申请人： Hua Wang , Seyed Ali Hajimiri
发明人： Hua Wang , Seyed Ali Hajimiri
IPC分类号： H05B1/02
CPC分类号： G05D23/24 , G05D23/1906 , G05D23/22 , G05D23/27
摘要： The invention is an integrated temperature regulator that can be fabricated using conventional semiconductor processing technology. The integrated temperature regulator can include a reaction chamber, for example fabricated from PDMS, in which chemical or biochemical reactions of interest can be carried out. The temperature regular can also be used to regulate the temperature of some circuits, e.g. an effective-inductance-change based magnetic particle sensor, to achieve a stable operation performance, such as an improved sensitivity. The integrated temperature regulator includes as subcomponents a temperature sensing circuit that receives a thermal signal from the vicinity of the reaction chamber, a temperature reference circuit, and a temperature control circuit that controls a heater based at least in part on the difference between the sensed temperature and the reference temperature. The various subcomponents can be programmable.
摘要翻译：本发明是可以使用常规半导体处理技术制造的集成温度调节器。集成温度调节器可以包括例如由PDMS制造的反应室，其中可以进行感兴趣的化学或生物化学反应。温度常数也可用于调节某些电路的温度，例如基于有效电感变化的磁性粒子传感器，以实现稳定的操作性能，例如提高的灵敏度。集成温度调节器包括作为子部件的温度感测电路，其接收来自反应室附近的热信号，温度参考电路和温度控制电路，其至少部分地基于感测温度之间的差异来控制加热器和参考温度。各个子部件可以编程。

10. 发明授权

US08391426B2 Broadband phase synthesis network with self-healing capability 有权
标题翻译：具有自愈能力的宽带相位综合网络
公开(公告)号：US08391426B2
公开(公告)日：2013-03-05
申请号：US12949679
申请日：2010-11-18
申请人： Hua Wang , Seyed Ali Hajimiri
发明人： Hua Wang , Seyed Ali Hajimiri
IPC分类号： H04L20/00
CPC分类号： H04L27/3863 , H04L27/3872
摘要： A phase synthesis network having self healing capability. The phase synthesis network includes two phase rotators that receive I and Q input LO signals, that receive a digital control signal, and that can adjust a phase and a gain in response to the digital control signal. An output of each of the phase rotators provides a respective output signal to a switch. The switch provides a selected one of the respective output signals for mixing with a predetermined one of the respective output signals. Two mixers mix signals from the phase rotators with an RF signal. Two analog-to-digital converters provide a respective digital signal representative of the output of the mixers. A baseband digital processor generates digital control signals that are provided to the phase rotators. The circuit has an output terminal configured to provide an output signal representative of the RF signal.
摘要翻译：具有自愈能力的相位合成网络。相位合成网络包括接收I和Q输入LO信号的两个相位旋转器，其接收数字控制信号，并且可以响应于数字控制信号来调节相位和增益。每个相位旋转器的输出向开关提供相应的输出信号。开关提供相应输出信号中的所选择的一个，用于与各个输出信号中的预定的一个混合。两个混频器将来自相位旋转器的信号与RF信号混合。两个模拟 - 数字转换器提供代表混频器输出的各自的数字信号。基带数字处理器产生提供给相位旋转器的数字控制信号。电路具有被配置为提供表示RF信号的输出信号的输出端子。

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