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1. 发明授权

US11634746B2 Portable genetic detection and analysis system and method 有权
公开(公告)号：US11634746B2
公开(公告)日：2023-04-25
申请号：US16540769
申请日：2019-08-14
申请人： Illumina, Inc.
发明人： Robert C. Kain , Min-Jui Richard Shen , John A. Moon , Helmy A. Eltoukhy
IPC分类号： C12Q1/68 , C12Q1/6837 , C12Q1/6869 , G01N33/487 , B01L3/00 , G01N35/00
摘要： A portable detector is disclosed for detecting certain analytes of interest, such as genetic material (e.g., nucleic acids). The detector includes a reading component for the detection of the analytes, and control circuitry for controlling operation of the reading component. Processing circuitry may be included to perform both primary analysis of acquired data, and where desired, secondary analysis. Where desired, some or all of the computationally intensive tasks may be off-loaded to enhance the portability and speed of the device. The device may incorporate various types of interface, technologies for reading and analysis, positioning system interfaces, and so forth. A number of exemplary use cases and methods are also disclosed.

2. 发明授权

US11499191B2 Independently removable nucleic acid sequencing system and method 有权
公开(公告)号：US11499191B2
公开(公告)日：2022-11-15
申请号：US16105262
申请日：2018-08-20
申请人： Illumina, Inc.
发明人： Robert C. Kain , David L. Heiner , Chanfeng Zhao , Kevin Gunderson
IPC分类号： C12Q1/6874 , C12Q1/686 , C12Q1/6869
摘要： A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected.

3. 发明申请

US20190144939A1 SUPER RESOLUTION IMAGING 审中-公开
公开(公告)号：US20190144939A1
公开(公告)日：2019-05-16
申请号：US16247949
申请日：2019-01-15
申请人： Illumina, Inc.
发明人： Robert C. Kain , Tarun Khurana , Kevin L. Gunderson , Yir-Shyuan Wu
IPC分类号： C12Q1/6874 , G01N21/64 , C12Q1/6825 , C12Q1/6837
摘要： A detection apparatus that includes (a) an array of responsive pads on a substrate surface; (b) an array of pixels, wherein each pixel in the array has a detection zone on the surface that includes a subset of at least two of the pads; and (c) an activation circuit to apply a force at a first and second pad in the subset, wherein the activation circuit is configured to apply a different force at the first pad compared to the second pad, and wherein the activation circuit has a switch to selectively alter the force at the first pad and the second pad.

4. 发明授权

US09990381B2 Biosensors for biological or chemical analysis and systems and methods for same 有权
公开(公告)号：US09990381B2
公开(公告)日：2018-06-05
申请号：US14552673
申请日：2014-11-25
申请人： ILLUMINA, INC.
发明人： Helmy A. Eltoukhy , Robert C. Kain , Wenyi Feng , Mark Pratt , Bernard Hirschbein , Poorya Sabounchi
IPC分类号： G01N21/64 , G06F17/30 , G01N33/68
CPC分类号： G06F17/303 , G01N21/6486 , G01N33/6875
摘要： Method of analyzing signal data from a biosensor including a detection device having an array of light detectors. The method includes obtaining signal data from the light detectors. The signal data includes light scores that are based on an amount of light detected by the light detectors during a plurality of imaging events. The method also includes analyzing the light scores from a group of light detectors for each of the plurality of the imaging events. The method also includes determining respective crosstalk functions of the light detectors in the group. Each of the crosstalk functions for a corresponding light detector is based on the amount of light detected by other light detectors in the group. The method also includes analyzing the signal data for each of the imaging events using the crosstalk functions to determine characteristics of the analytes-of-interest.

5. 发明授权

US09989544B2 Sequence scheduling and sample distribution techniques 有权
公开(公告)号：US09989544B2
公开(公告)日：2018-06-05
申请号：US14795285
申请日：2015-07-09
申请人： Illumina, Inc.
发明人： Robert C. Kain , Alexander G. Dickinson , Min-Jui Richard Shen , Helmy A. Eltoukhy , Francisco Jose Garcia
IPC分类号： G01N35/00 , B01J19/00
CPC分类号： G01N35/0092 , B01J19/00 , G01N35/00871
摘要： A technique is disclosed for sample management for use in conjunction with sequencing devices that sequence biological samples, e.g., DNA and RNA. A sequencing device or a network of sequencing devices may be scheduled according to the characteristics of the samples in queue and the capabilities and availability of sequencing devices. Biological samples may be automatically queued and loaded via a sample distribution system. A sample distribution system may be used to reduce operator intervention.

6. 发明授权

US08906320B1 Biosensors for biological or chemical analysis and systems and methods for same 有权
标题翻译：用于生物或化学分析的生物传感器及其系统和方法
公开(公告)号：US08906320B1
公开(公告)日：2014-12-09
申请号：US13833619
申请日：2013-03-15
申请人： Illumina Inc.
发明人： Helmy A. Eltoukhy , Robert C. Kain , Wenyi Feng , Mark Pratt , Bernard Hirschbein , Poorya Sabounchi
IPC分类号： G01N21/75 , G01N15/06
CPC分类号： G06F17/303 , G01N21/6486 , G01N33/6875
摘要： A biosensor is provided including a detection device and a flow cell mounted to the detection device. The detection device has a detector surface with a plurality of reaction sites. The detection device also includes a filter layer that is configured to at least one of (a) filter unwanted excitation light signals; (b) direct emission signals from a designated reaction site toward one or more associated light detectors that are configured to detect the emission signals from the designated reaction site; or (c) block or prevent detection of crosstalk emission signals from adjacent reaction sites.
摘要翻译：提供了一种生物传感器，包括检测装置和安装在检测装置上的流通池。该检测装置具有多个反应位置的检测器表面。检测装置还包括滤波器层，其被配置为以下中的至少一个：（a）滤除不需要的激发光信号; （b）从被指定的反应部位向被配置成检测来自指定反应部位的发射信号的一个或多个相关联的光检测器的直接发射信号; 或（c）阻止或阻止从相邻反应位点检测串扰发射信号。

7. 发明申请

US20130288931A1 INDEPENDENTLY REMOVABLE NUCLEIC ACID SEQUENCING SYSTEM AND METHOD 有权
标题翻译：独立的可除去的核酸序列系统和方法
公开(公告)号：US20130288931A1
公开(公告)日：2013-10-31
申请号：US13653979
申请日：2012-10-17
申请人： Illumina, Inc.
发明人： Robert C. Kain , David L. Heiner , Chanfeng Zhao , Kevin Gunderson
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/686 , C12Q1/6869 , C12Q2565/501 , C12Q2537/143
摘要： A system for sequencing nucleic acids, that includes (a) a table having an arrangement of sites, including a site for receiving a first substrate, and a site for receiving a second substrate, the substrates each having an array for providing sequencing data for a plurality of different nucleic acids in parallel; (b) a plurality of stations configured to carry out manipulations in a sequencing procedure; and (c) a system control interface configured to direct relative movement between the table and the plurality of stations, and to direct different steps of the sequencing procedure to occur at the sites for receiving the different substrates, wherein the first substrate can be removed from the system independently of the second substrate such that the second substrate can be processed to obtain sequencing data independently of the first substrate.
摘要翻译：一种用于对核酸进行测序的系统，其包括（a）具有位置排列的表，包括用于接收第一底物的位点和用于接收第二底物的位点，所述基底各自具有阵列，用于提供用于多个不同的核酸并行; （b）多个站，被配置为在排序过程中执行操作; 以及（c）系统控制接口，被配置为引导所述台与所述多个站之间的相对运动，并且引导所述排序程序的不同步骤在用于接收所述不同衬底的位置处发生，其中所述第一衬底可以从所述系统独立于所述第二衬底，使得可以处理所述第二衬底以获得独立于所述第一衬底的测序数据。

8. 发明授权

US11604775B2 Biosensors for biological or chemical analysis and systems and methods for same 有权
公开(公告)号：US11604775B2
公开(公告)日：2023-03-14
申请号：US17304758
申请日：2021-06-25
申请人： Illumina, Inc.
发明人： Helmy A. Eltoukhy , Robert C. Kain , Wenyi Feng , Mark Pratt , Bernard Hirschbein , Poorya Sabounchi , Tarun Khurana
IPC分类号： G06F16/21 , G01N21/64 , G01N33/68
摘要： A biosensor is provided including a detection device and a flow cell mounted to the detection device. The detection device has a detector surface with a plurality of reaction sites. The detection device also includes a filter layer that is configured to at least one of (a) filter unwanted excitation light signals; (b) direct emission signals from a designated reaction site toward one or more associated light detectors that are configured to detect the emission signals from the designated reaction site; or (c) block or prevent detection of crosstalk emission signals from adjacent reaction sites.

9. 发明授权

US11031132B2 Cloud computing environment for biological data 有权
公开(公告)号：US11031132B2
公开(公告)日：2021-06-08
申请号：US16259434
申请日：2019-01-28
申请人： Illumina, Inc.
发明人： Alexander G. Dickinson , Francisco Jose Garcia , Robert C. Kain , Scott D. Kahn , Andrew R. Nelson
IPC分类号： G16H40/67 , H04L29/08 , G16B50/00 , G16H40/40 , G06F21/62 , H04L29/06 , G16H40/63 , G16B30/10
摘要： The present invention provides a novel approach for storing, analyzing, and/or accessing biological data in a cloud computing environment. Sequence data generated by a particular sequencing device may be uploaded to the cloud computing environment during a sequencing run, which reduces the on-site storage needs for the sequence data. Analysis of the data may also be performed in the cloud computing environment, and the instructions for such analysis may be set at the originating sequencing device. The sequence data in the cloud computing environment may be shared according to permissions. Further, the sequence data may be modified or annotated by authorized secondary users.

10. 发明申请

US20190164629A1 CLOUD COMPUTING ENVIRONMENT FOR BIOLOGICAL DATA 审中-公开
公开(公告)号：US20190164629A1
公开(公告)日：2019-05-30
申请号：US16259434
申请日：2019-01-28
申请人： Illumina, Inc.
发明人： Alexander G. Dickinson , Francisco Jose Garcia , Robert C. Kain , Scott D. Kahn , Andrew R. Nelson
IPC分类号： G16B30/10 , H04L29/08 , H04L29/06 , G16B50/00 , G06F21/62
摘要： The present invention provides a novel approach for storing, analyzing, and/or accessing biological data in a cloud computing environment. Sequence data generated by a particular sequencing device may be uploaded to the cloud computing environment during a sequencing run, which reduces the on-site storage needs for the sequence data. Analysis of the data may also be performed in the cloud computing environment, and the instructions for such analysis may be set at the originating sequencing device. The sequence data in the cloud computing environment may be shared according to permissions. Further, the sequence data may be modified or annotated by authorized secondary users.

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