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1. 发明授权

US07858081B2 IL-15 mutants having agonists/antagonists activity 有权
标题翻译：具有激动剂/拮抗剂活性的IL-15突变体
公开(公告)号：US07858081B2
公开(公告)日：2010-12-28
申请号：US10590734
申请日：2005-02-10
申请人： Jérôme Bernard , Ariane Plet , Yannick Jacques , Catherine Harb , Agnès Quemener , Erwan Mortier
发明人： Jérôme Bernard , Ariane Plet , Yannick Jacques , Catherine Harb , Agnès Quemener , Erwan Mortier
IPC分类号： A61K45/00
CPC分类号： C07K14/5443 , A61K38/00 , C07K7/06 , C07K7/08
摘要： The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor α-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (44LLELQVISL52, peptide 1) corresponds to a sequence located in the B helix and the second (64ENLIL68, peptide 2 or 64ENLIIL69, peptide 2a) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents.
摘要翻译：本发明涉及负责结合白细胞介素-15受体α链的人白细胞介素-15（IL-15）中的表位的鉴定。两个IL-15区域参与该表位的形成：第一区域（44LLELQVISL52，肽1）对应于位于B螺旋中的序列，第二区域（64ENLIL68，肽2或64ENLIIL69，肽2a）对应于位于描述了显示激动剂或拮抗剂性质的突变蛋白，并且可用作治疗剂。

2. 发明授权

US09493533B2 IL-15 mutants having antagonist activity 有权
标题翻译：具有拮抗活性的IL-15突变体
公开(公告)号：US09493533B2
公开(公告)日：2016-11-15
申请号：US12978115
申请日：2010-12-23
申请人： Jérôme Bernard , Ariane Plet , Yannick Jacques , Catherine Harb , Agnès Quemener , Erwan Mortier
发明人： Jérôme Bernard , Ariane Plet , Yannick Jacques , Catherine Harb , Agnès Quemener , Erwan Mortier
IPC分类号： A61K38/20 , C07K14/54 , C07K7/06 , C07K7/08 , A61K38/00
CPC分类号： C07K14/5443 , A61K38/00 , C07K7/06 , C07K7/08
摘要： The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor α-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (44LLELQVISL52, peptide 1) corresponds to a sequence located in the B helix and the second (64ENLII68, peptide 2 or 64ENLIIL69, peptide 2a) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents.
摘要翻译：本发明涉及负责结合白细胞介素-15受体α链的人白细胞介素-15（IL-15）中的表位的鉴定。两个IL-15区域参与该表位的形成：第一区域（44LLELQVISL52，肽1）对应于位于B螺旋中的序列，第二区（64ENLII68，肽2或64ENLIIL69，肽2a）对应于位于描述了显示激动剂或拮抗剂性质的突变蛋白，并且可用作治疗剂。

3. 发明申请

US20110158938A1 IL-15 BINDING SITE FOR IL 15-RALPHA AND SPECIFIC IL-15 MUTANTS HAVING AGONISTS / ANTAGONISTS ACTIVITY 审中-公开
标题翻译： IL-15结合位点IL 15-RALPHA和具有AGONISTS / ANTAGONISTS活性的特异性IL-15突变体
公开(公告)号：US20110158938A1
公开(公告)日：2011-06-30
申请号：US12978115
申请日：2010-12-23
申请人： Jérôme Bernard , Ariane Plet , Yannick Jacques , Catherine Harb , Agnès Quemener , Erwan Mortier
发明人： Jérôme Bernard , Ariane Plet , Yannick Jacques , Catherine Harb , Agnès Quemener , Erwan Mortier
IPC分类号： A61K38/20 , C07K14/54 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/08
CPC分类号： C07K14/5443 , A61K38/00 , C07K7/06 , C07K7/08
摘要： The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor α-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (44LLELQVISL52, peptide 1) corresponds to a sequence located in the B helix and the second (64ENLII68, peptide 2 or 64ENLIIL69, peptide 2a) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents.
摘要翻译：本发明涉及负责结合白细胞介素-15受体α链的人白细胞介素-15（IL-15）中的表位的鉴定。两个IL-15区域参与该表位的形成：第一区域（44LLELQVISL52，肽1）对应于位于B螺旋中的序列，第二区（64ENLII68，肽2或64ENLIIL69，肽2a）对应于位于描述了显示激动剂或拮抗剂性质的突变蛋白，并且可用作治疗剂。

4. 发明申请

US20140212777A1 FUEL CELL SYSTEM COMPRISING AN EJECTOR FOR RECIRCULATING OFF-GAS FROM A STACK 审中-公开
标题翻译：燃料电池系统，包括用于从堆叠再循环关闭气体的喷射器
公开(公告)号：US20140212777A1
公开(公告)日：2014-07-31
申请号：US14241976
申请日：2012-01-31
申请人： Marcel Hofer , Felix Buechi , Jérôme Bernard , Uwe Hannesen , Philipp Dietrich
发明人： Marcel Hofer , Felix Buechi , Jérôme Bernard , Uwe Hannesen , Philipp Dietrich
IPC分类号： H01M8/04
CPC分类号： H01M8/04097 , H01M8/04104 , H01M8/04619 , H01M8/04753 , H01M8/04783 , H01M2008/1095
摘要： The fuel cell system includes: at least one fuel cell adapted to generate electrical energy from a fuel gas and an oxidizer gas; a fuel feed duct provided for supplying the fuel cell with fuel gas, the fuel feed duct including an upstream part and a downstream part; a Venturi effect ejector including a high pressure inlet, a low pressure inlet and an outlet, the upstream part of the fuel feed duct being connected to the high pressure inlet of the ejector and the downstream part extending between the ejector outlet and the fuel cell; an off-gas recirculation duct extending between the fuel cell and the low pressure ejector inlet so that, in the presence of a stream of fuel gas coming from the upstream part of the fuel feed duct and passing through the ejector, the ejector draws up off-gas from the recirculation duct and ejects it into the downstream part mixed with the stream of fuel gas coming from the upstream part; a control circuit and a valve arranged in the upstream part of the fuel feed duct and arranged to be controlled by the control circuit, the valve being adapted to be placed in an open state, in which it lets the stream of fuel gas from the upstream part pass through the ejector, or in a closed state, in which no stream of gas from the upstream part can flow through the ejector. characterized in that said control circuit is arranged to place the valve alternately in the open state and then the closed state, so that the stream of fuel gas passing through the ejector is intermittent, being frequency and/or pulse width modulated by the control circuit.
摘要翻译：燃料电池系统包括：适于从燃料气体和氧化剂气体产生电能的至少一个燃料电池; 燃料供给管，其设置用于向所述燃料电池供应燃料气体，所述燃料供给管道包括上游部分和下游部分; 文丘里效应喷射器，包括高压入口，低压入口和出口，燃料供给管的上游部分连接到喷射器的高压入口和在喷射器出口和燃料电池之间延伸的下游部分; 在燃料电池和低压喷射器入口之间延伸的废气再循环管道，使得在存在来自燃料供给管道的上游部分并通过喷射器的燃料气流的存在下，喷射器消除 - 来自再循环管道的气体并将其喷射到与来自上游部分的燃料气流混合的下游部分中; 控制电路和阀，其布置在燃料供给管道的上游部分中并且被布置成由控制回路控制，该阀适于处于打开状态，其中它使来自上游的燃料气流部分通过喷射器，或处于关闭状态，其中来自上游部分的气流不能流过喷射器。其特征在于，所述控制电路被配置为将阀交替地置于打开状态，然后关闭状态，使得通过喷射器的燃料气体流是间歇的，由控制电路进行频率和/或脉冲宽度调制。

5. 发明申请

US20110111318A1 METHOD OF OPERATING A FUEL CELL/BATTERY PASSIVE HYBRID POWER SUPPLY 审中-公开
标题翻译：操作燃料电池/电池被动混合电源的方法
公开(公告)号：US20110111318A1
公开(公告)日：2011-05-12
申请号：US12943829
申请日：2010-11-10
申请人： Jérôme Bernard , Marcel Hofer , Felix Buechi , Philipp Dietrich
发明人： Jérôme Bernard , Marcel Hofer , Felix Buechi , Philipp Dietrich
IPC分类号： H01M8/04
CPC分类号： H01M8/04753 , H01M8/04089 , H01M8/04104 , H01M8/04388 , H01M8/04395 , H01M8/04552 , H01M8/04559 , H01M8/04567 , H01M8/04597 , H01M16/006 , H01M2008/1095 , H01M2250/20 , Y02T90/32
摘要： The method of operating a passive hybrid power supply in, or near, zero connected load conditions comprises the steps of: supplying a stream of substantially pure hydrogen to the anode of the fuel cell; supplying an stream of substantially pure oxygen to the cathode of the fuel cell; monitoring an electric current supplied by the storage battery; monitoring an output voltage shared by the fuel cell and the battery; evaluating a state of charge (SOC) of the battery based on the electric current and the output voltage; monitoring a hydrogen pressure in the fuel cell; monitoring an oxygen pressure in the fuel cell; limiting the stream of hydrogen and the stream of oxygen and actuating the hydrogen and oxygen recirculating pumps in such a way as to bring and maintain the hydrogen and oxygen pressures below 0.7 barabsolute while maintaining the hydrogen pressure between 70 and 130% of the oxygen pressure, in such a way as to ensure that the output voltage is maintained at a level corresponding to less than 0.90 volts/cell and does not exceed the maximum voltage limit of the battery.
摘要翻译：在零连接负载条件下或接近零连接的负载条件下操作无源混合动力电源的方法包括以下步骤：将基本上纯的氢气流供应到燃料电池的阳极; 向燃料电池的阴极供应基本上纯的氧气流; 监视由蓄电池供电的电流; 监测燃料电池和电池共用的输出电压; 基于电流和输出电压来评估电池的充电状态（SOC）; 监测燃料电池中的氢气压力; 监测燃料电池中的氧气压力; 限制氢气流和氧气流，并致动氢气和氧气再循环泵，以使氢气和氧气压力保持在0.7 bar以下，同时保持氢气压力在70至130％之间的氧气压力，以确保输出电压保持在小于0.90伏/单元的电平并且不超过电池的最大电压极限的方式。

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