专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US10358477B2 IL-15Ralpha sushi domain—IL-15 fusion proteins 有权
公开(公告)号：US10358477B2
公开(公告)日：2019-07-23
申请号：US12090930
申请日：2006-10-06
申请人： Yannick Jacques , Ariane Plet , Erwan Mortier , Agnes Quemener , Patricia Vusio
发明人： Yannick Jacques , Ariane Plet , Erwan Mortier , Agnes Quemener , Patricia Vusio
IPC分类号： C07K14/715 , C07K14/54
摘要： The present invention relates to the stimulation of the IL-15Rbeta/gamma signalling pathway, to thereby induce and/or stimulate the activation and/or proliferation of IL-15Rbeta/gamma-positive cells, such as NK and/or T cells. Appropriate compounds include compounds comprising at least one IL-15Rbeta/gamma binding entity, directly or indirectly linked by covalence to at least one polypeptide which contains the sushi domain of the extracellular region of an IL-15Ralpha.

2. 发明申请

US20110158938A1 IL-15 BINDING SITE FOR IL 15-RALPHA AND SPECIFIC IL-15 MUTANTS HAVING AGONISTS / ANTAGONISTS ACTIVITY 审中-公开
标题翻译： IL-15结合位点IL 15-RALPHA和具有AGONISTS / ANTAGONISTS活性的特异性IL-15突变体
公开(公告)号：US20110158938A1
公开(公告)日：2011-06-30
申请号：US12978115
申请日：2010-12-23
申请人： Jérôme Bernard , Ariane Plet , Yannick Jacques , Catherine Harb , Agnès Quemener , Erwan Mortier
发明人： Jérôme Bernard , Ariane Plet , Yannick Jacques , Catherine Harb , Agnès Quemener , Erwan Mortier
IPC分类号： A61K38/20 , C07K14/54 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/08
CPC分类号： C07K14/5443 , A61K38/00 , C07K7/06 , C07K7/08
摘要： The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor α-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (44LLELQVISL52, peptide 1) corresponds to a sequence located in the B helix and the second (64ENLII68, peptide 2 or 64ENLIIL69, peptide 2a) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents.
摘要翻译：本发明涉及负责结合白细胞介素-15受体α链的人白细胞介素-15（IL-15）中的表位的鉴定。两个IL-15区域参与该表位的形成：第一区域（44LLELQVISL52，肽1）对应于位于B螺旋中的序列，第二区（64ENLII68，肽2或64ENLIIL69，肽2a）对应于位于描述了显示激动剂或拮抗剂性质的突变蛋白，并且可用作治疗剂。

3. 发明授权

US09493533B2 IL-15 mutants having antagonist activity 有权
标题翻译：具有拮抗活性的IL-15突变体
公开(公告)号：US09493533B2
公开(公告)日：2016-11-15
申请号：US12978115
申请日：2010-12-23
申请人： Jérôme Bernard , Ariane Plet , Yannick Jacques , Catherine Harb , Agnès Quemener , Erwan Mortier
发明人： Jérôme Bernard , Ariane Plet , Yannick Jacques , Catherine Harb , Agnès Quemener , Erwan Mortier
IPC分类号： A61K38/20 , C07K14/54 , C07K7/06 , C07K7/08 , A61K38/00
CPC分类号： C07K14/5443 , A61K38/00 , C07K7/06 , C07K7/08
摘要： The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor α-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (44LLELQVISL52, peptide 1) corresponds to a sequence located in the B helix and the second (64ENLII68, peptide 2 or 64ENLIIL69, peptide 2a) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents.
摘要翻译：本发明涉及负责结合白细胞介素-15受体α链的人白细胞介素-15（IL-15）中的表位的鉴定。两个IL-15区域参与该表位的形成：第一区域（44LLELQVISL52，肽1）对应于位于B螺旋中的序列，第二区（64ENLII68，肽2或64ENLIIL69，肽2a）对应于位于描述了显示激动剂或拮抗剂性质的突变蛋白，并且可用作治疗剂。

4. 发明申请

US20090238791A1 IL-15RALPHA SUSHI DOMAIN AS A SELECTIVE AND POTENT ENHANCER OF IL-15 ACTION THROUGH IL-15BETA/GAMMA, AND HYPERAGONIST (IL-15RALPHA SUSHI - IL-15) FUSION PROTEINS 审中-公开
标题翻译： IL-15RALPHA SUSHI作为通过IL-15BETA / GAMMA和高剂量IL-15RALPHA SUSHI-IL-15的IL-15作用的选择性和增加剂融合蛋白
公开(公告)号：US20090238791A1
公开(公告)日：2009-09-24
申请号：US12090930
申请日：2006-10-06
申请人： Yannick Jacques , Ariane Plet , Erwan Mortier , Agnes Quemener , Patricia Vusio
发明人： Yannick Jacques , Ariane Plet , Erwan Mortier , Agnes Quemener , Patricia Vusio
IPC分类号： A61K38/20 , C07K14/54 , C07H21/00 , C12N15/63 , C12N5/00 , A61P37/04
CPC分类号： C07K14/7155 , C07K14/5443 , C07K2319/00
摘要： The present invention relates to the stimulation of the IL-15R beta/gamma signalling pathway, to thereby induce and/or stimulate the activation and/or proliferation of IL-15Rbeta/gamma-positive cells, such as NK and/or T cells. Appropriate compounds include compounds comprising at least one IL-15Rbeta/gamma binding entity, directly or indirectly linked by covalence to at least one polypeptide which contains the sushi domain of the extracellular region of an IL-15Ralpha.
摘要翻译：本发明涉及IL-15Rβ/γ信号传导途径的刺激，从而诱导和/或刺激IL-15Rβ/γ阳性细胞如NK和/或T细胞的活化和/或增殖。合适的化合物包括包含至少一个IL-15Rβ/γ结合实体的化合物，其通过共价直接或间接连接至含有IL-15Rα的细胞外区域的寿命结构域的至少一种多肽。

5. 发明申请

US20080255039A1 Il-15 Binding Site for Il 15-Ralpha and Specific Il-15 Mutants Having Agonists/Antagonists Activity 有权
标题翻译：具有激动剂/拮抗剂活性的Il 15-Ralpha和特异性II-15突变体的II-15结合位点
公开(公告)号：US20080255039A1
公开(公告)日：2008-10-16
申请号：US10590734
申请日：2005-02-10
申请人： Jerome Bernard , Ariane Plet , Yannick Jacques , Catherine Harb , Agnes Quemener , Erwan Mortier
发明人： Jerome Bernard , Ariane Plet , Yannick Jacques , Catherine Harb , Agnes Quemener , Erwan Mortier
IPC分类号： A61K38/20 , C07K7/00 , C07H21/00 , C07K14/54 , A61P37/00 , G01N33/53 , A61P35/00 , C12N15/63 , A61K38/08
CPC分类号： C07K14/5443 , A61K38/00 , C07K7/06 , C07K7/08
摘要： The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor α-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (44LLELQVISL52, peptide 1) corresponds to a sequence located in the B helix and the second (64ENLIL68, peptide 2 or 64ENLIIL69, peptide 2a) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents.
摘要翻译：本发明涉及负责结合白细胞介素-15受体α链的人白介素-15（IL-15）中的表位的鉴定。两个IL-15区域参与形成该表位：第一个区域（肽1）对应于位于B螺旋中的序列，第二个（64位，68位）肽2或肽64位，肽2a）到位于螺旋中的序列描述显示激动剂或拮抗剂性质的突变蛋白，并且可用作治疗剂。

6. 发明申请

US20070190024A1 Il-11 muteins 审中-公开
标题翻译： Il-11突变蛋白
公开(公告)号：US20070190024A1
公开(公告)日：2007-08-16
申请号：US10565626
申请日：2004-07-29
申请人： Francois Paris , Yannick Jacques , Jean Content , Xiao-Ming Wang , Dimitri Harmegnies , Joachim Grotzinger
发明人： Francois Paris , Yannick Jacques , Jean Content , Xiao-Ming Wang , Dimitri Harmegnies , Joachim Grotzinger
IPC分类号： A61K38/20 , A61K48/00 , C07K14/54 , C07H21/04 , C12P21/04
CPC分类号： C07K14/5431 , A01K2227/105 , A61K38/00
摘要： The present invention relates to new IL-11 muteins of which site I hydrophobocity has been increased. These muteins act as IL-11 agonist or hyperagonist, and are notably useful as anti-thrombocytopenia agents, and as agents improving the resistance of an organism to the deleterious in vivo effects induced by radiation or chemotherapy during the treatment of cancer or for the preparation of patient to transplantation.
摘要翻译：本发明涉及位点I疏水性增加的新的IL-11突变蛋白。这些突变蛋白作为IL-11激动剂或拮抗剂，并且特别用作抗血小板减少症剂，以及作为改善生物体对癌症治疗期间辐射或化学疗法诱导的有害体内作用的药物或制剂的药剂的患者移植。

7. 发明申请

US20130056119A1 Slim Wallet with Attached Elastic Band 审中-公开
标题翻译：带有弹性乐队的修身钱包
公开(公告)号：US20130056119A1
公开(公告)日：2013-03-07
申请号：US13605336
申请日：2012-09-06
申请人： Yannick Jacques Henriette
发明人： Yannick Jacques Henriette
IPC分类号： A45C1/06
CPC分类号： A45C1/06 , A45C11/182
摘要： This device is a billfold and credit card carrier engineered for minimum thickness. Whereas most wallets have compartments for currency and vertically stacked compartments for plastic ID and credit cards, this wallet has singular pockets on either side holding cards stacked one directly on top of the other (versus the usual offset stacking). Paper currency, business cards and other paper items are, held securely by an attached elastic band which closes over the other side of the wallet when folded. This omission of a separate pouch dedicated to paper currency or other hardware allows the wallet a very thin profile, which offers users a lighter, smaller, more comfortable wallet in their pocket.
摘要翻译：该设备是最小厚度的折叠和信用卡运营商。大多数钱包都有货币隔间和塑料ID和信用卡的垂直堆叠隔间，这个钱包在任何一侧都有独特的口袋，将卡片直接堆叠在另一个顶部（相对于通常的偏移堆叠）。纸币，名片和其他纸品通过附着的弹性带牢固地固定，折叠时在钱包的另一侧封闭。这种省略专用于纸币或其他硬件的单独的小包允许钱包非常薄的轮廓，为用户提供一个更轻，更小，更舒适的钱包在他们的口袋里。

8. 发明授权

US07858081B2 IL-15 mutants having agonists/antagonists activity 有权
标题翻译：具有激动剂/拮抗剂活性的IL-15突变体
公开(公告)号：US07858081B2
公开(公告)日：2010-12-28
申请号：US10590734
申请日：2005-02-10
申请人： Jérôme Bernard , Ariane Plet , Yannick Jacques , Catherine Harb , Agnès Quemener , Erwan Mortier
发明人： Jérôme Bernard , Ariane Plet , Yannick Jacques , Catherine Harb , Agnès Quemener , Erwan Mortier
IPC分类号： A61K45/00
CPC分类号： C07K14/5443 , A61K38/00 , C07K7/06 , C07K7/08
摘要： The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor α-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (44LLELQVISL52, peptide 1) corresponds to a sequence located in the B helix and the second (64ENLIL68, peptide 2 or 64ENLIIL69, peptide 2a) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents.
摘要翻译：本发明涉及负责结合白细胞介素-15受体α链的人白细胞介素-15（IL-15）中的表位的鉴定。两个IL-15区域参与该表位的形成：第一区域（44LLELQVISL52，肽1）对应于位于B螺旋中的序列，第二区域（64ENLIL68，肽2或64ENLIIL69，肽2a）对应于位于描述了显示激动剂或拮抗剂性质的突变蛋白，并且可用作治疗剂。

9. 发明申请

US20120058110A1 Method for Predicting the Responsiveness to an Anti-TNF Alpha Antibody Treatment 审中-公开
标题翻译：预防抗TNFα抗体治疗反应的方法
公开(公告)号：US20120058110A1
公开(公告)日：2012-03-08
申请号：US13255291
申请日：2009-03-10
申请人： Yannick Jacques
发明人： Yannick Jacques
IPC分类号： A61K39/395 , A61P29/00 , A61P17/06 , G01N33/577 , A61P1/00
CPC分类号： G01N33/6869 , A61K2039/505 , C07K16/241 , C07K2317/24 , G01N2333/525 , G01N2333/5443 , G01N2800/065 , G01N2800/52
摘要： The present invention relates to a method for predicting the responsiveness of a patient to an anti-TNFα antibody treatment.
摘要翻译：本发明涉及一种预测患者对抗TNFα抗体治疗的反应性的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式