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1. 发明授权

US07801606B2 Implantable pulse generator and method having adjustable signal blanking 有权
标题翻译：可植入脉冲发生器和方法具有可调信号消隐
公开(公告)号：US07801606B2
公开(公告)日：2010-09-21
申请号：US11674758
申请日：2007-02-14
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N1/00
CPC分类号： A61N1/3702 , A61N1/3706
摘要： An implantable pulse generator senses a cardiac signal, identifies cardiac events in the cardiac signal, and starts a blanking interval including a repeatable noise window blanking interval in response to each cardiac event. When noise is detected during the repeatable noise window blanking interval, the noise window blanking interval is repeated. In one embodiment, the duration of repeated repeatable noise window blanking intervals is summed and compared to a pacing escape interval. When the sum is greater than the pacing escape interval, asynchronous pacing pulses are delivered until the noise ceases. Alternatively, when the sum is greater than the pacing escape interval, the pace escape interval is repeated.
摘要翻译：植入式脉冲发生器感测心脏信号，识别心脏信号中的心脏事件，并且响应于每个心脏事件开始包括可重复噪声窗口消隐间隔的消隐间隔。当在可重复的噪声窗消隐间隔期间检测到噪声时，重复噪声窗消隐间隔。在一个实施例中，将重复的可重复噪声窗口消隐间隔的持续时间相加并与起搏逃逸间隔进行比较。当总和大于起搏逃生间隔时，异步起搏脉冲被传送，直到噪声停止。或者，当总和大于起搏逃逸间隔时，重复起搏逃逸间隔。

2. 发明授权

US06687539B2 Implantable defibrillators with programmable cross-chamber blanking 有权
公开(公告)号：US06687539B2
公开(公告)日：2004-02-03
申请号：US09981326
申请日：2001-10-16
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N139
CPC分类号： A61N1/3956
摘要： Miniature defibrillators and cardioverters detect abnormal heart rhythms and automatically apply electrical therapy to restore normal heart function. Therapy decisions are typically based on the time between successive beats of various chambers of the heart, such as the left atrium and left ventricle. To prevent confusing a left ventricle beat for a left atrium beat, some devices use cross-chamber blanking, a technique which disables sensing of atrial beats for a certain time period after sensing. Conventionally, these devices lack any mechanism for adjusting length of this period. Accordingly, the inventor devised a implantable device including a mechanism for adjusting this time period. This mechanism ultimately allows tailoring of the cross-chamber blanking period to fit the needs of individual patients.

3. 发明申请

US20110257699A1 IMPLANTABLE PULSE GENERATOR AND METHOD HAVING ADJUSTABLE SIGNAL BLANKING 有权
标题翻译：可植入脉冲发生器和具有可调信号滤波的方法
公开(公告)号：US20110257699A1
公开(公告)日：2011-10-20
申请号：US13174136
申请日：2011-06-30
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N1/362
CPC分类号： A61N1/3702 , A61N1/3706
摘要： An implantable pulse generator senses a cardiac signal, identifies cardiac events in the cardiac signal, and starts a blanking interval including a repeatable noise window blanking interval in response to each cardiac event. When noise is detected during the repeatable noise window blanking interval, the noise window blanking interval is repeated. In one embodiment, the duration of repeated repeatable noise window blanking intervals is summed and compared to a pacing escape interval. When the sum is greater than the pacing escape interval, asynchronous pacing pulses are delivered until the noise ceases. Alternatively, when the sum is greater than the pacing escape interval, the pace escape interval is repeated.
摘要翻译：植入式脉冲发生器感测心脏信号，识别心脏信号中的心脏事件，并且响应于每个心脏事件开始包括可重复噪声窗口消隐间隔的消隐间隔。当在可重复的噪声窗消隐间隔期间检测到噪声时，重复噪声窗消隐间隔。在一个实施例中，将重复的可重复噪声窗口消隐间隔的持续时间相加并与起搏逃逸间隔进行比较。当总和大于起搏逃生间隔时，异步起搏脉冲被传送，直到噪声停止。或者，当总和大于起搏逃逸间隔时，重复起搏逃逸间隔。

4. 发明授权

US08214037B2 Implantable pulse generator and method having adjustable signal blanking 有权
标题翻译：可植入脉冲发生器和具有可调信号消隐的方法
公开(公告)号：US08214037B2
公开(公告)日：2012-07-03
申请号：US13174136
申请日：2011-06-30
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N1/00
CPC分类号： A61N1/3702 , A61N1/3706
摘要： An implantable pulse generator senses a cardiac signal, identifies cardiac events in the cardiac signal, and starts a blanking interval including a repeatable noise window blanking interval in response to each cardiac event. When noise is detected during the repeatable noise window blanking interval, the noise window blanking interval is repeated. In one embodiment, the duration of repeated repeatable noise window blanking intervals is summed and compared to a pacing escape interval. When the sum is greater than the pacing escape interval, asynchronous pacing pulses are delivered until the noise ceases. Alternatively, when the sum is greater than the pacing escape interval, the pace escape interval is repeated.
摘要翻译：植入式脉冲发生器感测心脏信号，识别心脏信号中的心脏事件，并且响应于每个心脏事件开始包括可重复噪声窗口消隐间隔的消隐间隔。当在可重复的噪声窗消隐间隔期间检测到噪声时，重复噪声窗消隐间隔。在一个实施例中，将重复的可重复噪声窗口消隐间隔的持续时间相加并与起搏逃逸间隔进行比较。当总和大于起搏逃生间隔时，异步起搏脉冲将被传递，直到噪声停止。或者，当总和大于起搏逃逸间隔时，重复起搏逃逸间隔。

5. 发明授权

US06381494B1 Response to ambient noise in implantable pulse generator 有权
标题翻译：可植入脉冲发生器对环境噪声的响应
公开(公告)号：US06381494B1
公开(公告)日：2002-04-30
申请号：US09378321
申请日：1999-08-20
申请人： James O. Gilkerson , David L. Perschbacher , Doug M. Birkholz , Thomas J. Harris
发明人： James O. Gilkerson , David L. Perschbacher , Doug M. Birkholz , Thomas J. Harris
IPC分类号： A61N136
CPC分类号： A61N1/37 , A61N1/3718
摘要： A method and system for response to ambient noise in implantable pulse generator. At least one cardiac signal is sensed with an implantable pulse generator. Cardiac depolarizations are identified in the at least one cardiac signal and cardiac depolarization markers are generated. The at least one cardiac signals are then analyzed for a noise event during a refractory period following the detected cardiac depolarization. The refractory period includes a noise window interval during which noise events are recognized. When a noise event, or events, occur during the noise window interval a first noise marker is generated. The noise window interval is then repeated as long as noise is detected in the noise window intervals. When the noise persists for a predetermined time interval a second noise marker is generated.
摘要翻译：一种可植入式脉冲发生器中环境噪声响应的方法和系统。用可植入脉冲发生器检测至少一个心脏信号。在至少一个心脏信号中鉴定心脏去极化，并且产生心脏去极化标记。然后在检测到的心脏去极化之后的不应期内，分析至少一个心脏信号的噪声事件。不良期间包括噪声窗间隔，在此期间噪声事件被识别。当在噪声窗间隔期间发生噪声事件或事件时，产生第一噪声标记。只要在噪声窗间隔中检测到噪声，噪声窗口间隔就被重复。当噪声持续预定的时间间隔时，产生第二噪声标记。

6. 发明授权

US06304778B1 Implantable defibrillators with programmable cross-chamber blanking 有权
标题翻译：可植入除颤器，具有可编程的横隔室消隐
公开(公告)号：US06304778B1
公开(公告)日：2001-10-16
申请号：US09377803
申请日：1999-08-20
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N139
CPC分类号： A61N1/3956
摘要： Miniature defibrillators and cardioverters detect abnormal heart rhythms and automatically apply electrical therapy to restore normal heart function. Therapy decisions are typically based on the time between successive beats of various chambers of the heart, such as the left atrium and left ventricle. To prevent confusing a left ventricle beat for a left atrium beat, some devices use cross-chamber blanking, a technique which disables sensing of atrial beats for a certain time period after sensing. Conventionally, these devices lack any mechanism for adjusting length of this period. Accordingly, the inventor devised a implantable device including a mechanism for adjusting this time period. This mechanism ultimately allows tailoring of the cross-chamber blanking period to fit the needs of individual patients.
摘要翻译：微型除颤器和心脏转复器检测异常心律，并自动应用电疗法恢复正常的心脏功能。治疗决定通常基于心脏各个腔室的连续搏动之间的时间，例如左心房和左心室。为了防止左心室搏动混淆左心房搏动，一些装置使用跨室消隐，这种技术在感测后一段时间内不能检测心房搏动。通常，这些设备没有任何调整这一时期长度的机制。因此，本发明人设计了一种可植入装置，其包括用于调整该时间段的机构。该机制最终允许剪裁跨室消隐期以适应个体患者的需要。

7. 发明授权

US07200436B2 Implantable pulse generator and method having adjustable signal blanking 有权
标题翻译：可植入脉冲发生器和方法具有可调信号消隐
公开(公告)号：US07200436B2
公开(公告)日：2007-04-03
申请号：US10889348
申请日：2004-07-12
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N1/00
CPC分类号： A61N1/3956
摘要： An implantable pulse generator senses a cardiac signal, identifies cardiac events in the cardiac signal, and starts a blanking interval including a repeatable noise window blanking interval in response to each cardiac event. When noise is detected during the repeatable noise window blanking interval, the noise window blanking interval is repeated. In one embodiment, the duration of repeated repeatable noise window blanking intervals is summed and compared to a pacing escape interval. When the sum is greater than the pacing escape interval, asynchronous pacing pulses are delivered until the noise ceases. Alternatively, when the sum is greater than the pacing escape interval, the pace escape interval is repeated.
摘要翻译：植入式脉冲发生器感测心脏信号，识别心脏信号中的心脏事件，并且响应于每个心脏事件开始包括可重复噪声窗口消隐间隔的消隐间隔。当在可重复的噪声窗消隐间隔期间检测到噪声时，重复噪声窗消隐间隔。在一个实施例中，将重复的可重复噪声窗口消隐间隔的持续时间相加并与起搏逃逸间隔进行比较。当总和大于起搏逃生间隔时，异步起搏脉冲被传送，直到噪声停止。或者，当总和大于起搏逃逸间隔时，重复起搏逃逸间隔。

8. 发明授权

US07974692B2 Implantable pulse generator and method having adjustable signal blanking 有权
标题翻译：可植入脉冲发生器和方法具有可调信号消隐
公开(公告)号：US07974692B2
公开(公告)日：2011-07-05
申请号：US12872383
申请日：2010-08-31
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N1/00
CPC分类号： A61N1/3702 , A61N1/3706
摘要： An implantable pulse generator senses a cardiac signal, identifies cardiac events in the cardiac signal, and starts a blanking interval including a repeatable noise window blanking interval in response to each cardiac event. When noise is detected during the repeatable noise window blanking interval, the noise window blanking interval is repeated. In one embodiment, the duration of repeated repeatable noise window blanking intervals is summed and compared to a pacing escape interval. When the sum is greater than the pacing escape interval, asynchronous pacing pulses are delivered until the noise ceases. Alternatively, when the sum is greater than the pacing escape interval, the pace escape interval is repeated.
摘要翻译：植入式脉冲发生器感测心脏信号，识别心脏信号中的心脏事件，并且响应于每个心脏事件开始包括可重复噪声窗口消隐间隔的消隐间隔。当在可重复的噪声窗消隐间隔期间检测到噪声时，重复噪声窗消隐间隔。在一个实施例中，将重复的可重复噪声窗口消隐间隔的持续时间相加并与起搏逃逸间隔进行比较。当总和大于起搏逃生间隔时，异步起搏脉冲被传送，直到噪声停止。或者，当总和大于起搏逃逸间隔时，重复起搏逃逸间隔。

9. 发明申请

US20100324622A1 IMPLANTABLE PULSE GENERATOR AND METHOD HAVING ADJUSTABLE SIGNAL BLANKING 有权
标题翻译：可植入脉冲发生器和具有可调信号滤波的方法
公开(公告)号：US20100324622A1
公开(公告)日：2010-12-23
申请号：US12872383
申请日：2010-08-31
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N1/365
CPC分类号： A61N1/3702 , A61N1/3706
摘要： An implantable pulse generator senses a cardiac signal, identifies cardiac events in the cardiac signal, and starts a blanking interval including a repeatable noise window blanking interval in response to each cardiac event. When noise is detected during the repeatable noise window blanking interval, the noise window blanking interval is repeated. In one embodiment, the duration of repeated repeatable noise window blanking intervals is summed and compared to a pacing escape interval. When the sum is greater than the pacing escape interval, asynchronous pacing pulses are delivered until the noise ceases. Alternatively, when the sum is greater than the pacing escape interval, the pace escape interval is repeated.
摘要翻译：植入式脉冲发生器感测心脏信号，识别心脏信号中的心脏事件，并且响应于每个心脏事件开始包括可重复噪声窗口消隐间隔的消隐间隔。当在可重复的噪声窗消隐间隔期间检测到噪声时，重复噪声窗消隐间隔。在一个实施例中，将重复的可重复噪声窗口消隐间隔的持续时间相加并与起搏逃逸间隔进行比较。当总和大于起搏逃生间隔时，异步起搏脉冲被传送，直到噪声停止。或者，当总和大于起搏逃逸间隔时，重复起搏逃逸间隔。

10. 发明授权

US06873875B1 Implantable pulse generator and method having adjustable signal blanking 有权
标题翻译：可植入脉冲发生器和方法具有可调信号消隐
公开(公告)号：US06873875B1
公开(公告)日：2005-03-29
申请号：US09650913
申请日：2000-08-29
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N1/39 , A61N1/36
CPC分类号： A61N1/3956
摘要： An implantable pulse generator and a method of operation, where the pulse generator is adapted to sense at least a first cardiac signal. Cardiac events are identified in the first cardiac signal, in response to which a blanking interval is started. The blanking interval includes a repeatable noise window blanking interval. When noise is detected during the repeatable noise window blanking interval, the noise window blanking interval is repeated. Depending upon the type of sensed cardiac event (paced or intrinsic) the blanking interval is adjusted to either to a first overall duration or a second overall duration. The second overall duration includes a first timed interval that has a programmable value. The repeatable noise window blanking interval starts after the first timed interval of the second overall duration. The duration of repeated repeatable noise window blanking intervals is summed and compared to a pacing escape interval. When the sum is greater than the pacing escape interval, asynchronous pacing pulses are delivered. When the noise ceases, so does the delivery of asynchronous pacing pulses. Alternatively, when the sum is greater than the pacing escape interval, the pace escape interval is repeated. Pacing is resumed after one pacing escape interval after the noise signal ceases.
摘要翻译：一种可植入脉冲发生器和操作方法，其中所述脉冲发生器适于感测至少第一心脏信号。心脏事件在第一心脏信号中被识别，响应于此，开始消隐间隔。消隐间隔包括可重复的噪声窗消隐间隔。当在可重复的噪声窗消隐间隔期间检测到噪声时，重复噪声窗消隐间隔。取决于感测的心脏事件的类型（起搏或内在的），消隐间隔被调整到第一整体持续时间或第二总持续时间。第二总持续时间包括具有可编程值的第一定时间隔。可重复的噪声窗消隐间隔在第二个总持续时间的第一个定时间隔之后开始。将重复的可重复噪声窗口消隐间隔的持续时间相加并与起搏逃逸间隔进行比较。当和大于起搏逃逸间隔时，异步起搏脉冲被传递。当噪声停止时，异步起搏脉冲的传递也是如此。或者，当总和大于起搏逃逸间隔时，重复起搏逃逸间隔。在噪声信号停止后，起搏间隔恢复一段起搏。

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