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1. 发明授权

US08352029B2 Flexible neural stimulation engine 有权
标题翻译：灵活的神经刺激引擎
公开(公告)号：US08352029B2
公开(公告)日：2013-01-08
申请号：US12785954
申请日：2010-05-24
申请人： David J. Ternes , Doug M. Birkholz , David W. Yost , James A. Esler
发明人： David J. Ternes , Doug M. Birkholz , David W. Yost , James A. Esler
IPC分类号： A61N1/00
CPC分类号： A61N1/362
摘要： A method for implementing a neural stimulation therapy mode in an implantable medical device (IMD) comprising the acts of mapping respective device states, defined by one or more timer states that include at least one neural event timer or one or more indications of one or more sensed physiologic events, to associated device actions in a stored neural table, storing an event represented as a device status word and a time stamp in a queue in response to an action input, and comparing one or more current timer states or one or more indications of one or more sensed physiologic events to a device state contained in the neural table and, if found to match, causing performance of one or more associated device actions, wherein the device actions include one or more of a neural stimulation energy delivery or a change in one or more timer states.
摘要翻译：一种用于在可植入医疗装置（IMD）中实现神经刺激治疗模式的方法，包括映射由包括至少一个神经事件计时器或一个或多个指示的一个或多个定时器状态定义的各个装置状态的动作检测到的生理事件，到存储的神经表中的相关设备动作，响应于动作输入将表示为设备状态字的事件和时间戳存储在队列中，以及比较一个或多个当前定时器状态或一个或多个指示一个或多个感测到的生理事件到包含在神经表中的设备状态，并且如果发现匹配，导致一个或多个相关联的设备动作的性能，其中设备动作包括神经刺激能量递送或改变中的一个或多个在一个或多个定时器状态。

2. 发明授权

US07801606B2 Implantable pulse generator and method having adjustable signal blanking 有权
标题翻译：可植入脉冲发生器和方法具有可调信号消隐
公开(公告)号：US07801606B2
公开(公告)日：2010-09-21
申请号：US11674758
申请日：2007-02-14
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N1/00
CPC分类号： A61N1/3702 , A61N1/3706
摘要： An implantable pulse generator senses a cardiac signal, identifies cardiac events in the cardiac signal, and starts a blanking interval including a repeatable noise window blanking interval in response to each cardiac event. When noise is detected during the repeatable noise window blanking interval, the noise window blanking interval is repeated. In one embodiment, the duration of repeated repeatable noise window blanking intervals is summed and compared to a pacing escape interval. When the sum is greater than the pacing escape interval, asynchronous pacing pulses are delivered until the noise ceases. Alternatively, when the sum is greater than the pacing escape interval, the pace escape interval is repeated.
摘要翻译：植入式脉冲发生器感测心脏信号，识别心脏信号中的心脏事件，并且响应于每个心脏事件开始包括可重复噪声窗口消隐间隔的消隐间隔。当在可重复的噪声窗消隐间隔期间检测到噪声时，重复噪声窗消隐间隔。在一个实施例中，将重复的可重复噪声窗口消隐间隔的持续时间相加并与起搏逃逸间隔进行比较。当总和大于起搏逃生间隔时，异步起搏脉冲被传送，直到噪声停止。或者，当总和大于起搏逃逸间隔时，重复起搏逃逸间隔。

3. 发明授权

US06687539B2 Implantable defibrillators with programmable cross-chamber blanking 有权
公开(公告)号：US06687539B2
公开(公告)日：2004-02-03
申请号：US09981326
申请日：2001-10-16
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N139
CPC分类号： A61N1/3956
摘要： Miniature defibrillators and cardioverters detect abnormal heart rhythms and automatically apply electrical therapy to restore normal heart function. Therapy decisions are typically based on the time between successive beats of various chambers of the heart, such as the left atrium and left ventricle. To prevent confusing a left ventricle beat for a left atrium beat, some devices use cross-chamber blanking, a technique which disables sensing of atrial beats for a certain time period after sensing. Conventionally, these devices lack any mechanism for adjusting length of this period. Accordingly, the inventor devised a implantable device including a mechanism for adjusting this time period. This mechanism ultimately allows tailoring of the cross-chamber blanking period to fit the needs of individual patients.

4. 发明授权

US06427084B2 Multi-site hybrid hardware-based cardiac pacemaker 有权
标题翻译：多站点混合硬件心脏起搏器
公开(公告)号：US06427084B2
公开(公告)日：2002-07-30
申请号：US09514813
申请日：2000-02-28
申请人： Kenneth L. Baker , Doug M. Birkholz , David L. Perschbacher , Andrew P. Kramer , Gary T. Seim
发明人： Kenneth L. Baker , Doug M. Birkholz , David L. Perschbacher , Andrew P. Kramer , Gary T. Seim
IPC分类号： A61N1362
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3684
摘要： A hybrid cardiac pacemaker in which the operation of the device is controlled by hardware-based controller as supervised by a microprocessor-based controller. The hardware-based controller comprises a plurality of timers that expire when they reach timer limit values stored in registers updatable by the microprocessor, and a combinational logic array for causing the device to generate pace outputs in accordance with timer expirations and sense signals. The combinational logic array may operate the pacemaker in a number of programmed modes in accordance with a mode value stored in a mode control register by the microprocessor.
摘要翻译：一种混合心脏起搏器，其中由基于微处理器的控制器监控的由基于硬件的控制器控制该设备的操作。基于硬件的控制器包括多个定时器，当它们达到存储在可由微处理器更新的寄存器中的定时器限制值时，该定时器到期，以及组合逻辑阵列，用于使该设备根据定时器期满和感测信号产生步进输出。组合逻辑阵列可以根据由微处理器存储在模式控制寄存器中的模式值，以多种编程模式操作起搏器。

5. 发明申请

US20110257699A1 IMPLANTABLE PULSE GENERATOR AND METHOD HAVING ADJUSTABLE SIGNAL BLANKING 有权
标题翻译：可植入脉冲发生器和具有可调信号滤波的方法
公开(公告)号：US20110257699A1
公开(公告)日：2011-10-20
申请号：US13174136
申请日：2011-06-30
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N1/362
CPC分类号： A61N1/3702 , A61N1/3706
摘要： An implantable pulse generator senses a cardiac signal, identifies cardiac events in the cardiac signal, and starts a blanking interval including a repeatable noise window blanking interval in response to each cardiac event. When noise is detected during the repeatable noise window blanking interval, the noise window blanking interval is repeated. In one embodiment, the duration of repeated repeatable noise window blanking intervals is summed and compared to a pacing escape interval. When the sum is greater than the pacing escape interval, asynchronous pacing pulses are delivered until the noise ceases. Alternatively, when the sum is greater than the pacing escape interval, the pace escape interval is repeated.
摘要翻译：植入式脉冲发生器感测心脏信号，识别心脏信号中的心脏事件，并且响应于每个心脏事件开始包括可重复噪声窗口消隐间隔的消隐间隔。当在可重复的噪声窗消隐间隔期间检测到噪声时，重复噪声窗消隐间隔。在一个实施例中，将重复的可重复噪声窗口消隐间隔的持续时间相加并与起搏逃逸间隔进行比较。当总和大于起搏逃生间隔时，异步起搏脉冲被传送，直到噪声停止。或者，当总和大于起搏逃逸间隔时，重复起搏逃逸间隔。

6. 发明授权

US07974692B2 Implantable pulse generator and method having adjustable signal blanking 有权
标题翻译：可植入脉冲发生器和方法具有可调信号消隐
公开(公告)号：US07974692B2
公开(公告)日：2011-07-05
申请号：US12872383
申请日：2010-08-31
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N1/00
CPC分类号： A61N1/3702 , A61N1/3706
摘要： An implantable pulse generator senses a cardiac signal, identifies cardiac events in the cardiac signal, and starts a blanking interval including a repeatable noise window blanking interval in response to each cardiac event. When noise is detected during the repeatable noise window blanking interval, the noise window blanking interval is repeated. In one embodiment, the duration of repeated repeatable noise window blanking intervals is summed and compared to a pacing escape interval. When the sum is greater than the pacing escape interval, asynchronous pacing pulses are delivered until the noise ceases. Alternatively, when the sum is greater than the pacing escape interval, the pace escape interval is repeated.
摘要翻译：植入式脉冲发生器感测心脏信号，识别心脏信号中的心脏事件，并且响应于每个心脏事件开始包括可重复噪声窗口消隐间隔的消隐间隔。当在可重复的噪声窗消隐间隔期间检测到噪声时，重复噪声窗消隐间隔。在一个实施例中，将重复的可重复噪声窗口消隐间隔的持续时间相加并与起搏逃逸间隔进行比较。当总和大于起搏逃生间隔时，异步起搏脉冲被传送，直到噪声停止。或者，当总和大于起搏逃逸间隔时，重复起搏逃逸间隔。

7. 发明申请

US20100324622A1 IMPLANTABLE PULSE GENERATOR AND METHOD HAVING ADJUSTABLE SIGNAL BLANKING 有权
标题翻译：可植入脉冲发生器和具有可调信号滤波的方法
公开(公告)号：US20100324622A1
公开(公告)日：2010-12-23
申请号：US12872383
申请日：2010-08-31
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N1/365
CPC分类号： A61N1/3702 , A61N1/3706
摘要： An implantable pulse generator senses a cardiac signal, identifies cardiac events in the cardiac signal, and starts a blanking interval including a repeatable noise window blanking interval in response to each cardiac event. When noise is detected during the repeatable noise window blanking interval, the noise window blanking interval is repeated. In one embodiment, the duration of repeated repeatable noise window blanking intervals is summed and compared to a pacing escape interval. When the sum is greater than the pacing escape interval, asynchronous pacing pulses are delivered until the noise ceases. Alternatively, when the sum is greater than the pacing escape interval, the pace escape interval is repeated.
摘要翻译：植入式脉冲发生器感测心脏信号，识别心脏信号中的心脏事件，并且响应于每个心脏事件开始包括可重复噪声窗口消隐间隔的消隐间隔。当在可重复的噪声窗消隐间隔期间检测到噪声时，重复噪声窗消隐间隔。在一个实施例中，将重复的可重复噪声窗口消隐间隔的持续时间相加并与起搏逃逸间隔进行比较。当总和大于起搏逃生间隔时，异步起搏脉冲被传送，直到噪声停止。或者，当总和大于起搏逃逸间隔时，重复起搏逃逸间隔。

8. 发明授权

US07769447B2 Cardiac pacemaker with table-based pacing mode implementation 有权
标题翻译：心脏起搏器与基于表的起搏模式实现
公开(公告)号：US07769447B2
公开(公告)日：2010-08-03
申请号：US11116596
申请日：2005-04-28
申请人： David W. Yost , Doug M. Birkholz , James A. Esler
发明人： David W. Yost , Doug M. Birkholz , James A. Esler
IPC分类号： A61N1/08
CPC分类号： A61N1/362
摘要： A device and method for implementing a bradycardia pacing mode are disclosed which is mostly hardware-based but still allows the flexibility for making major changes in brady behavior normally found only in firmware-based implementations. The brady behavior of the device is encapsulated by a table in an area of RAM referred to as brady RAM, and the brady behavior can be changed by re-loading the brady RAM with a different table.
摘要翻译：公开了一种用于实现心动过缓起搏模式的装置和方法，其基本上是基于硬件的，但是仍然允许在通常仅在基于固件的实现中通常发现的轻度行为的主要变化的灵活性。设备的缓冲行为由RAM中称为brady RAM的RAM中的表封装，并且可以通过用不同的表重新加载brady RAM来改变brady行为。

9. 发明授权

US06873875B1 Implantable pulse generator and method having adjustable signal blanking 有权
标题翻译：可植入脉冲发生器和方法具有可调信号消隐
公开(公告)号：US06873875B1
公开(公告)日：2005-03-29
申请号：US09650913
申请日：2000-08-29
申请人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
发明人： James O. Gilkerson , Doug M. Birkholz , David L. Perschbacher
IPC分类号： A61N1/39 , A61N1/36
CPC分类号： A61N1/3956
摘要： An implantable pulse generator and a method of operation, where the pulse generator is adapted to sense at least a first cardiac signal. Cardiac events are identified in the first cardiac signal, in response to which a blanking interval is started. The blanking interval includes a repeatable noise window blanking interval. When noise is detected during the repeatable noise window blanking interval, the noise window blanking interval is repeated. Depending upon the type of sensed cardiac event (paced or intrinsic) the blanking interval is adjusted to either to a first overall duration or a second overall duration. The second overall duration includes a first timed interval that has a programmable value. The repeatable noise window blanking interval starts after the first timed interval of the second overall duration. The duration of repeated repeatable noise window blanking intervals is summed and compared to a pacing escape interval. When the sum is greater than the pacing escape interval, asynchronous pacing pulses are delivered. When the noise ceases, so does the delivery of asynchronous pacing pulses. Alternatively, when the sum is greater than the pacing escape interval, the pace escape interval is repeated. Pacing is resumed after one pacing escape interval after the noise signal ceases.
摘要翻译：一种可植入脉冲发生器和操作方法，其中所述脉冲发生器适于感测至少第一心脏信号。心脏事件在第一心脏信号中被识别，响应于此，开始消隐间隔。消隐间隔包括可重复的噪声窗消隐间隔。当在可重复的噪声窗消隐间隔期间检测到噪声时，重复噪声窗消隐间隔。取决于感测的心脏事件的类型（起搏或内在的），消隐间隔被调整到第一整体持续时间或第二总持续时间。第二总持续时间包括具有可编程值的第一定时间隔。可重复的噪声窗消隐间隔在第二个总持续时间的第一个定时间隔之后开始。将重复的可重复噪声窗口消隐间隔的持续时间相加并与起搏逃逸间隔进行比较。当和大于起搏逃逸间隔时，异步起搏脉冲被传递。当噪声停止时，异步起搏脉冲的传递也是如此。或者，当总和大于起搏逃逸间隔时，重复起搏逃逸间隔。在噪声信号停止后，起搏间隔恢复一段起搏。

10. 发明申请

US20100298900A1 CARDIAC PACEMAKER WITH TABLE-BASED PACING MODE IMPLEMENTATION 审中-公开
标题翻译：具有基于表的PACING模式实现的CARDIAC PACEMAKER
公开(公告)号：US20100298900A1
公开(公告)日：2010-11-25
申请号：US12848894
申请日：2010-08-02
申请人： David W. Yost , Doug M. Birkholz , James A. Esler
发明人： David W. Yost , Doug M. Birkholz , James A. Esler
IPC分类号： A61N1/362
CPC分类号： A61N1/362
摘要： A device and method for implementing a bradycardia pacing mode are disclosed which is mostly hardware-based but still allows the flexibility for making major changes in brady behavior normally found only in firmware-based implementations. The brady behavior of the device is encapsulated by a table in an area of RAM referred to as brady RAM, and the brady behavior can be changed by re-loading the brady RAM with a different table.
摘要翻译：公开了一种用于实现心动过缓起搏模式的装置和方法，其基本上是基于硬件的，但是仍然允许在通常仅在基于固件的实现中通常发现的轻度行为的主要变化的灵活性。设备的缓冲行为由RAM中称为brady RAM的RAM中的表封装，并且可以通过用不同的表重新加载brady RAM来改变brady行为。

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