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1. 发明授权

US09370670B2 Gamma source tracking system 有权
标题翻译：伽马源跟踪系统
公开(公告)号：US09370670B2
公开(公告)日：2016-06-21
申请号：US14158568
申请日：2012-07-19
申请人： Johan Henning , Bas Woudstra , Jeroen Schuurman
发明人： Johan Henning , Bas Woudstra , Jeroen Schuurman
IPC分类号： G01T1/16 , A61N5/10 , G01T1/164
CPC分类号： A61N5/1001 , A61N5/1027 , A61N5/1048 , A61N2005/1052 , G01T1/1644
摘要： An embodiment of the present disclosure is directed to a radioactive source tracking system adapted to determine in real time a spatial position of a gamma source in a volume, including a set of spatially distributed position sensitive detectors operable in real time arranged about the volume. The system includes a real time computer system adapted to calculate the spatial position per time stamp of the gamma source in the volume based on respective signals generated by the position sensitive detectors. In addition, the radioactive source is represented by a 3D or 4D data stream in real time. Other embodiments of the present disclosure are directed to a method for tracking a radioactive gamma source and a computer program product for causing a processor to determine a real time 3D or a 4D spatial position of a gamma source.
摘要翻译：本公开的实施例涉及一种放射源跟踪系统，其适于实时地确定体积中的伽马源的空间位置，包括一组空间分布的位置敏感检测器，其可实时地布置在体积周围。该系统包括实时计算机系统，其适于基于由位置敏感检测器产生的相应信号计算体积中伽马源的每个时间戳的空间位置。此外，放射源由3D或4D数据流实时表示。本公开的其他实施例涉及用于跟踪放射性伽马源的方法和用于使处理器确定伽马源的实时3D或4D空间位置的计算机程序产品的方法。

2. 发明授权

US09730608B2 Method and apparatus for determining the position of a surgical tool relative to a target volume inside an animal body 有权
公开(公告)号：US09730608B2
公开(公告)日：2017-08-15
申请号：US13347225
申请日：2012-01-10
申请人： Wilco Van Der Lugt , Jeroen Schuurman , Johan Henning , Stefan Kwa , Johann Kindlein
发明人： Wilco Van Der Lugt , Jeroen Schuurman , Johan Henning , Stefan Kwa , Johann Kindlein
IPC分类号： A61B8/00 , A61B5/055 , G06T11/00 , A61B6/06 , A61B8/12 , A61B17/00 , A61B18/00 , A61N5/10 , A61B8/08 , A61B90/00
CPC分类号： A61B5/055 , A61B6/06 , A61B8/12 , A61B8/4461 , A61B8/483 , A61B90/36 , A61B2017/00274 , A61B2018/00547 , A61N5/1027 , A61N5/1049 , A61N2005/1011 , G06T11/008 , G06T2211/428
摘要： The invention relates to a method for determining the position of a surgical tool relative to a target volume inside an animal body according to a pre-plan comprising the steps of i) obtaining a plurality of two-dimensional images of said target volume using imaging means, each 2D-image being represented by an image data slice I(x,y,z); ii) reconstructing from said plurality of image data slices I(x,y,z) a three-dimensional image of said target volume using transformation means, said 3D-image being represented by a volumetric image data array V(x,y,z); iii) displaying said three-dimensional image of said target volume to an user using displaying means.

3. 发明授权

US08105238B2 Method and apparatus for determining the position of a surgical tool relative to a target volume inside an animal body 有权
标题翻译：用于确定外科手术工具相对于动物体内目标体积的位置的方法和装置
公开(公告)号：US08105238B2
公开(公告)日：2012-01-31
申请号：US10921896
申请日：2004-08-20
申请人： Wilco Van Der Lugt , Jeroen Schuurman , Johan Henning , Stefan Kwa , Johann Kindlein
发明人： Wilco Van Der Lugt , Jeroen Schuurman , Johan Henning , Stefan Kwa , Johann Kindlein
IPC分类号： A61B8/00
CPC分类号： A61B5/055 , A61B6/06 , A61B8/12 , A61B8/4461 , A61B8/483 , A61B90/36 , A61B2017/00274 , A61B2018/00547 , A61N5/1027 , A61N5/1049 , A61N2005/1011 , G06T11/008 , G06T2211/428
摘要： A method for determining the position of a surgical tool relative to a target volume inside an animal body according to a pre-plan. The method includes the steps of i) obtaining a plurality of two-dimensional images of said target volume using an imaging device, each 2D-image being represented by an image data slice I(x,y,z); ii) reconstructing from said plurality of image data slices I(x,y,z) a three-dimensional image of said target volume using a transformation device, said 3D-image being represented by a volumetric image data array V(x,y,z); iii) displaying said three-dimensional image of said target volume to an user using a display.
摘要翻译：根据预先计划确定外科手术工具相对于动物体内目标体积的位置的方法。该方法包括以下步骤：i）使用成像装置获得所述目标体积的多个二维图像，每个2D图像由图像数据切片I（x，y，z）表示; ii）使用变换装置从所述多个图像数据切片I（x，y，z）重建所述目标体积的三维图像，所述3D图像由体积图像数据阵列V（x，y， z）; iii）使用显示器将所述目标体积的所述三维图像显示给用户。

4. 发明申请

US20050090733A1 Method and apparatus for determining the position of a surgical tool relative to a target volume inside an animal body 有权
标题翻译：用于确定外科手术工具相对于动物体内目标体积的位置的方法和装置
公开(公告)号：US20050090733A1
公开(公告)日：2005-04-28
申请号：US10921896
申请日：2004-08-20
申请人： Wilco Van Der Lugt , Jeroen Schuurman , Johan Henning , Stefan Kwa , Johann Kindlein
发明人： Wilco Van Der Lugt , Jeroen Schuurman , Johan Henning , Stefan Kwa , Johann Kindlein
IPC分类号： G01R33/28 , A61B5/055 , A61B5/06 , A61B6/06 , A61B8/12 , A61B17/00 , A61B19/00 , A61N5/10 , A61B5/05
CPC分类号： A61B5/055 , A61B6/06 , A61B8/12 , A61B8/4461 , A61B8/483 , A61B90/36 , A61B2017/00274 , A61B2018/00547 , A61N5/1027 , A61N5/1049 , A61N2005/1011 , G06T11/008 , G06T2211/428
摘要： The invention relates to a method for determining the position of a surgical tool relative to a target volume inside an animal body according to a pre-plan comprising the steps of i) obtaining a plurality of two-dimensional images of said target volume using imaging means, each 2D-image being represented by an image data slice I(x,y,z); ii) reconstructing from said plurality of image data slices I(x,y,z) a three-dimensional image of said target volume using transformation means, said 3D-image being represented by a volumetric image data array V(x,y,z); iii) displaying said three-dimensional image of said target volume to an user using displaying means.
摘要翻译：本发明涉及一种用于根据预先计划确定外科手术工具相对于动物体内的目标体积的位置的方法，包括以下步骤：i）使用成像装置获得所述目标体积的多个二维图像每个2D图像由图像数据切片I（x，y，z）表示; ii）使用变换装置从所述多个图像数据切片I（x，y，z）重建所述目标体积的三维图像，所述3D图像由体积图像数据阵列V（x，y，z）表示）; iii）使用显示装置将所述目标体积的所述三维图像显示给用户。

5. 发明授权

US07288061B2 Device for implanting a row of radioactive seeds and non-radioactive spacers in an animal body 有权
标题翻译：用于在动物体内植入一排放射性种子和非放射性隔离物的装置
公开(公告)号：US07288061B2
公开(公告)日：2007-10-30
申请号：US10674356
申请日：2003-10-01
申请人： Johann Kindlein , Arie Luite Visscher , Ulrike Lutz , Jeroen Schuurman , Mark Alexander Adam
发明人： Johann Kindlein , Arie Luite Visscher , Ulrike Lutz , Jeroen Schuurman , Mark Alexander Adam
IPC分类号： A61N5/00
CPC分类号： A61N5/1007 , A61N2005/1011 , A61N2005/1023
摘要： A device for implanting radioactive seeds and non-radioactive spacers in a desired configuration in an animal body for effecting radiation therapy. An elongated hollow needle is inserted in the body. A pushing element implants the row of seeds and spacers though the hollow needle towards the desired location. A tube shaped element receives the row of seeds and spacers. A lube shaped sleeve having open ends is used to insert the tube shaped element through the needle and toward the location. The pushing elements pushes the row of seeds and spacers into the desired location while still being carried in the tube shaped element.
摘要翻译：用于在动物体内植入放射性种子和非放射性间隔物的装置，用于实现放射治疗。细长的中空针插入体内。推动元件通过中空针将所述种子和间隔物排排列到期望的位置。管形元件接收一排种子和间隔物。使用具有开口端的润滑脂套筒将管形元件穿过针头并朝向该位置。推动元件将种子和间隔物排推入期望的位置，同时仍被携带在管状元件中。

6. 发明申请

US20050177020A1 Device for implanting a row of radioactive seeds and non-radioactive spacers in an animal body 有权
标题翻译：用于在动物体内植入一排放射性种子和非放射性隔离物的装置
公开(公告)号：US20050177020A1
公开(公告)日：2005-08-11
申请号：US10674356
申请日：2003-10-01
申请人： Johann Kindlein , Arie Visscher , Ulrike Lutz , Jeroen Schuurman , Mark Adam
发明人： Johann Kindlein , Arie Visscher , Ulrike Lutz , Jeroen Schuurman , Mark Adam
IPC分类号： G21K1/00 , A61M36/00 , A61M36/04 , A61M36/12 , A61N5/10 , A61N5/00
CPC分类号： A61N5/1007 , A61N2005/1011 , A61N2005/1023
摘要： The invention relates to a device for implanting at least one row of X radioactive seeds and Y non-radioactive spacers with Xε[1, 2, . . . ] and Yε[0, 1, . . . ] in a desired configuration to a desired location in an animal body for effecting radiation therapy of cancerous tissue in said body, said device comprising: at least one elongated hollow needle with an open distal end to be inserted towards said desired location in the body and with a proximal end to be connected to a seed loading apparatus; and at least one pushing element for implanting during retraction of the elongated hollow needle said row of radioactive seeds and non-radioactive spacers from said seed loading apparatus through said hollow needle towards said location. The prior art rows of seeds/spacers have the disadvantage, that after insertion into the body or near to the tissue to be irradiated no physical relation between the inserted seeds and spacers exists other than through the tissue of the body, thus affecting the radiation treatment to be performed. Therefore in order to avoid mutual displacement of the seeds/spacers after insertion of the row into the body due to movements of the patient the device according to the invention further comprises at least one tube-shaped element with at least one open end to be inserted through said hollow needle towards said desired location; and at least one tube-shaped sleeve member with an open distal and open proximal end for inserting said tube-shaped element through said hollow needle towards said desired location, wherein said tube-shaped element serves to accommodate said row of radioactive seeds and non-radioactive spacers.
摘要翻译：本发明涉及用Xepsilon [1,2]注入至少一行X放射性种子和Y型非放射性间隔物的装置。。。 ]和Yepsilon [0,1]。。。 ]以期望的配置到动物体内的所需位置，用于对所述体内的癌组织进行放射治疗，所述装置包括：至少一个细长的中空针头，其具有敞开的远端，以朝向身体中的所述期望位置插入;以及其近端连接到种子装载装置; 以及至少一个推动元件，用于在所述细长中空针将所述放射性种子排和非放射性间隔物从所述种子装载装置通过所述中空针向所述位置缩回时进行植入。现有技术的种子/隔离物排的缺点在于，在插入体内或靠近要照射的组织之后，插入的种子和间隔物之间不存在物理关系，而不是通过身体的组织而存在，从而影响放射治疗被执行。因此，为了避免由于患者的移动而将排插入体内的种子/间隔物的相互移位，根据本发明的装置还包括至少一个具有至少一个开放端插入的管状元件通过所述中空针朝向所述所需位置; 以及至少一个管形套筒构件，其具有开放的远侧和近端近端，用于将所述管状元件穿过所述中空针头朝向所述期望位置插入，其中所述管状元件用于容纳所述一排放射性种子，放射性隔片。

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