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1. 发明申请

US20130241553A1 METHOD OF CHARACTERIZING 有权
标题翻译：表征方法
公开(公告)号：US20130241553A1
公开(公告)日：2013-09-19
申请号：US13882293
申请日：2011-10-26
申请人： Johan Van Den Brink , Ingmar Graesslin , Sascha Krueger , Steffen Weiss , Peter Vernickel
发明人： Johan Van Den Brink , Ingmar Graesslin , Sascha Krueger , Steffen Weiss , Peter Vernickel
IPC分类号： G01R33/36 , G01R33/44
CPC分类号： G01R33/36 , G01R33/246 , G01R33/44 , G01R33/5612 , G01R33/583
摘要： The invention relates to a method of characterizing the RF transmit chain of a magnetic resonance imaging scanner (1) using a local transmit/receive coil system (204; 210), comprising a first local NMR probe and a first local magnetic resonance coil, the first NMR probe being spatially located in immediate neighborhood to the first coil, a local receive coil system (206; 208), comprising a second local NMR probe and a second local magnetic resonance coil, the second NMR probe being spatially located in immediate neighborhood to the second coil, wherein the transmit chain comprises an external MR coil (9; 11; 12; 13), the method comprising: determining with the first magnetic resonance coil, a first MR signal phase evolution of the local RF transmit field generated by MR excitation of the first probe using the first magnetic resonance coil by measuring the RF response of the first probe upon said excitation, determining with the second magnetic resonance coil a second MR signal phase evolution of the local RF transmit field generated by MR excitation of the second probe using the external MR coil (9; 11; 12; 13) by measuring the RF response of the second probe upon said excitation, calculating a phase offset between the first and second MR signal phase evolution.
摘要翻译：本发明涉及一种使用本地发射/接收线圈系统（204; 210）来表征磁共振成像扫描仪（1）的RF发射链的方法，该系统包括第一局部NMR探针和第一局部磁共振线圈，空间上位于第一线圈周围的第一NMR探针，包括第二局部NMR探针和第二局部磁共振线圈的局部接收线圈系统（206; 208），所述第二NMR探针在空间上位于紧邻附近所述第二线圈，其中所述发射链包括外部MR线圈（9; 11; 12; 13），所述方法包括：利用所述第一磁共振线圈确定由MR产生的所述本地RF发射场的第一MR信号相位演变通过在所述激发时测量第一探针的RF响应，使用第一磁共振线圈激发第一探针，用第二磁共振线圈确定第二MR信号相位ev 使用外部MR线圈（9; 9）对第二探针的MR激发产生的局部RF发射场的清零。 11; 12; 13）通过在所述激励时测量第二探针的RF响应，计算第一和第二MR信号相位演变之间的相位偏移。

2. 发明授权

US09575146B2 Method of characterizing 有权
标题翻译：表征方法
公开(公告)号：US09575146B2
公开(公告)日：2017-02-21
申请号：US13882293
申请日：2011-10-26
申请人： Johan Van Den Brink , Ingmar Graesslin , Sascha Krueger , Steffen Weiss , Peter Vernickel
发明人： Johan Van Den Brink , Ingmar Graesslin , Sascha Krueger , Steffen Weiss , Peter Vernickel
IPC分类号： G01R33/36 , G01R33/24 , G01R33/44 , G01R33/561 , G01R33/58
CPC分类号： G01R33/36 , G01R33/246 , G01R33/44 , G01R33/5612 , G01R33/583
摘要： The invention relates to a method of characterizing the RF transmit chain of a magnetic resonance imaging scanner (1) using a local transmit/receive coil system (204; 210), comprising a first local NMR probe and a first local magnetic resonance coil, the first NMR probe being spatially located in immediate neighborhood to the first coil, a local receive coil system (206; 208), comprising a second local NMR probe and a second local magnetic resonance coil, the second NMR probe being spatially located in immediate neighborhood to the second coil, wherein the transmit chain comprises an external MR coil (9; 11; 12; 13), the method comprising: determining with the first magnetic resonance coil, a first MR signal phase evolution of the local RF transmit field generated by MR excitation of the first probe using the first magnetic resonance coil by measuring the RF response of the first probe upon said excitation, determining with the second magnetic resonance coil a second MR signal phase evolution of the local RF transmit field generated by MR excitation of the second probe using the external MR coil (9; 11; 12; 13) by measuring the RF response of the second probe upon said excitation, calculating a phase offset between the first and second MR signal phase evolution.
摘要翻译：本发明涉及一种使用本地发射/接收线圈系统（204; 210）来表征磁共振成像扫描仪（1）的RF发射链的方法，该系统包括第一局部NMR探针和第一局部磁共振线圈，空间上位于第一线圈周围的第一NMR探针，包括第二局部NMR探针和第二局部磁共振线圈的局部接收线圈系统（206; 208），所述第二NMR探针在空间上位于紧邻附近所述第二线圈，其中所述发射链包括外部MR线圈（9; 11; 12; 13），所述方法包括：利用所述第一磁共振线圈确定由MR产生的所述本地RF发射场的第一MR信号相位演变通过在所述激发时测量第一探针的RF响应，使用第一磁共振线圈激发第一探针，用第二磁共振线圈确定第二MR信号相位ev 使用外部MR线圈（9; 9）对第二探针的MR激发产生的局部RF发射场的清零。 11; 12; 13）通过在所述激励时测量第二探针的RF响应，计算第一和第二MR信号相位演变之间的相位偏移。

3. 发明申请

US20070055135A1 Diagnostic imaging system with user interface 审中-公开
标题翻译：具有用户界面的诊断成像系统
公开(公告)号：US20070055135A1
公开(公告)日：2007-03-08
申请号：US10595471
申请日：2004-10-21
申请人： Frank Benschop , Rudolf Springorum , Johan Van Den Brink , Johannes Buurman , Hans Tuithof , Romhild Hoogeveen
发明人： Frank Benschop , Rudolf Springorum , Johan Van Den Brink , Johannes Buurman , Hans Tuithof , Romhild Hoogeveen
IPC分类号： A61B5/05
CPC分类号： G01R33/546 , G01R33/543
摘要： A diagnostic imaging system (1), in particular a magnetic resonance imaging system. The diagnostic imaging system comprises control system (2) to control the execution of operational items by the diagnostic imaging system. A user interface (3) is coupled to the control system, the user interface including a scheduler module which forms an ordered selection of operational items. The operational items are executed on the basis of the ordered selection. The ordered selection concerns the order, timing and conditions to be fulfilled to execute the operational items. Notably, in an magnetic resonance imaging system the actual acquisition concerns the execution of acquisition pulse sequences to receive magnetic resonance signals which is carried out for the planned geometry, the preferred embodiment comprises a patient support that can be moved among various positions which is used in a multi-station examination.
摘要翻译：诊断成像系统（1），特别是磁共振成像系统。诊断成像系统包括控制系统（2），用于控制由诊断成像系统执行的操作项目。用户界面（3）耦合到控制系统，用户界面包括形成操作项目的有序选择的调度器模块。操作项目是根据有序选择执行的。有序的选择涉及要执行操作项目的顺序，时间和条件。值得注意的是，在磁共振成像系统中，实际采集涉及采集脉冲序列的执行以接收为计划几何进行的磁共振信号，优选实施例包括可在各种位置之间移动的患者支架，多站考试。

4. 发明申请

US20050119554A1 T1-weighted multiecho magnetic resonance imaging 失效
标题翻译： T1加权多环磁共振成像
公开(公告)号：US20050119554A1
公开(公告)日：2005-06-02
申请号：US10510853
申请日：2003-03-27
申请人： Hans Jenniskens , Johan Van Den Brink
发明人： Hans Jenniskens , Johan Van Den Brink
IPC分类号： G01R33/48 , A61B5/055 , G01R33/561 , A61B5/05
CPC分类号： G01R33/5615 , G01R33/5613
摘要： The invention relates to a method for magnetic resonance imaging of at least a portion of a body placed in a stationary and substantially homogeneous main magnetic field. The body is subjected to a sequence of RF and magnetic field gradient pulses during an interval TSE, thereby generating a plurality of spin echo signals, which are measured and processed for reconstruction of an image. Thereafter, during an interval TDRV, an additional spin echo is generated by subjecting the body to at least one further refocusing RF pulse and/or magnetic field gradient pulse, and a RF drive pulse (βX) is irradiated at the time of this additional spin echo. In order to provide a fast and reliable method for T1-weighted imaging, which gives a high T1 contrast and also a sufficient signal-to-noise ratio, the phase of the RF drive pulse (βX) is selected such that nuclear magnetization at the time of the additional spin echo is transformed into negative longitudinal magnetization. The sequence is repeated beginning with another sequence of RF and magnetic field gradient pulses after a recovery period TREC.
摘要翻译：本发明涉及一种用于对置于静止和基本均匀的主磁场中的身体的至少一部分进行磁共振成像的方法。在间隔TSE期间，身体受到RF和磁场梯度脉冲序列的影响，从而产生多个自旋回波信号，这些信号被测量和处理以重建图像。此后，在间隔TDRV期间，通过使身体进行至少一个进一步的再聚焦RF脉冲和/或磁场梯度脉冲来产生附加的自旋回波，并且在该附加旋转时照射RF驱动脉冲（βX）回声。为了提供一种提供高T 1对比度并且具有足够的信噪比的T 1 - 1加权成像的快速可靠的方法，该相位选择RF驱动脉冲（βX），使得额外自旋回波时的核磁化转变为负的纵向磁化强度。在恢复期TREC之后，序列以另一个RF和磁场梯度脉冲序列重复开始。

5. 发明申请

US20060241897A1 Fibre tracking magnetic resonance imaging 失效
标题翻译：光纤跟踪磁共振成像
公开(公告)号：US20060241897A1
公开(公告)日：2006-10-26
申请号：US10554354
申请日：2004-04-22
申请人： Frank Hoogenraad , Arianne Margarethe Van Muiswinkel , Ronaldus Holthuizen , Johan Van Den Brink
发明人： Frank Hoogenraad , Arianne Margarethe Van Muiswinkel , Ronaldus Holthuizen , Johan Van Den Brink
IPC分类号： G06F15/00
CPC分类号： G01R33/56341 , G01R33/4806
摘要： A method of deriving a directional structure from an object dataset is proposed. The object dataset assigns local directions to positions in a multidimensional geometrical space. For example the local directions concern local flow directions in a diffusion tensor magnetic resonance image at least one ‘region of interest’ is selected on the basis of spatial functional information, such as an fMRI image, time correlation of an fMRI image series with a functional paradigm or an anatomical image. These ‘region of interest’ are employed to initialize a fibre tracking to derive the directional structure that represents the nervous fibre system.
摘要翻译：提出了从对象数据集导出定向结构的方法。对象数据集将本地方向分配给多维几何空间中的位置。例如，局部方向涉及扩散张量磁共振图像中的局部流动方向，基于空间功能信息来选择至少一个“感兴趣区域”，例如fMRI图像，fMRI图像序列与功能性的时间相关性范式或解剖图像。这些“感兴趣的区域”用于初始化光纤跟踪以导出代表神经纤维系统的定向结构。

6. 发明申请

US20060145696A1 Moving table mri with subsampling 失效
标题翻译：移动表mri与子采样
公开(公告)号：US20060145696A1
公开(公告)日：2006-07-06
申请号：US10547196
申请日：2004-02-18
申请人： Miha Fuderer , Paul Harvey , Johan Van Den Brink
发明人： Miha Fuderer , Paul Harvey , Johan Van Den Brink
IPC分类号： G01V3/00
CPC分类号： G01R33/56375 , G01R33/5611
摘要： A novel magnetic resonance imaging method is described, for forming an image of an object from a plurality of signals sampled in a restricted homogeneity region of a main magnet field of a magnetic resonance imaging apparatus. A patient disposed on a table is moved continuously through the bore of the main magnet and spins in a predetermined area of the patient are excited by an excitation pulse from a transmitter antenna, such that an image is formed over a region exceeding largely the restricted region. Data is undersampled in the restricted region by means off at least one receiver antenna in a plurality of receive situations being defined as a block of measurements contiguous in time having preserved magnetisation and presaturation conditions within the excited area of the patient. Fold-over artefacts due to said undersampling are unfolded by means of the known sensitivity pattern of the receiver antenna and/or the properties of selected factors determining said receive situations.
摘要翻译：描述了一种新颖的磁共振成像方法，用于从在磁共振成像装置的主磁场的受限同质区域中采样的多个信号形成物体的图像。设置在桌子上的患者连续移动通过主磁体的孔并且在患者的预定区域中的旋转被来自发射器天线的激励脉冲激发，使得在超过大部分限制区域的区域上形成图像。通过在多个接收情况中的至少一个接收机天线被限定为在时间上相邻的测量块，其在患者的激动区域内保持了磁化和预饱和状态，因此在受限区域中数据被欠采样。由于所述欠采样引起的折叠伪影通过接收机天线的已知灵敏度图案和/或确定所述接收情况的选定因素的特性而展开。

7. 发明申请

US20060006867A1 Magnetic resonance imaging apparatus and method 失效
标题翻译：磁共振成像装置及方法
公开(公告)号：US20060006867A1
公开(公告)日：2006-01-12
申请号：US10518983
申请日：2003-06-11
申请人： Johan Van Den Brink
发明人： Johan Van Den Brink
IPC分类号： G01V3/00
CPC分类号： G01R33/3621 , G01R33/5611
摘要： The present invention relates to a magnetic resonance imaging apparatus comprising an RF coil system comprising M RF coils (11-18) for detecting RF signals from a region of interest, M being an integer larger than 2, and N receiver channels (C1-C4) for receiving and processing the detected RF signals, N being an integer larger than 1 and smaller than M. According to the invention at least two RF coils (12, 16; 14, 18) are combined for reception of RF signals of said RF coils with a single receiver channel, wherein said at least two RF coils are selected so as to provide maximum spatially varying coil sensitivities along the principal axis for coil sensitivity encoding. The proposed MRI apparatus provides an optimal solution enabling it to be used with the SENSE method. The general idea is to have as much individuality as possible along the preferred or actual sense reduction direction and to feature as much spatial distinctness as possible along the axes of primary clinical interest.
摘要翻译：本发明涉及一种包括RF线圈系统的磁共振成像设备，该RF线圈系统包括用于检测来自感兴趣区域的RF信号的M个RF线圈（M-M为大于2的整数），以及N个接收器通道（C1- C 4），用于接收和处理所检测的RF信号，N是大于1且小于M的整数。根据本发明，至少两个RF线圈（12,16; 14,18）被组合用于接收RF信号所述RF线圈具有单个接收器通道，其中所述至少两个RF线圈被选择为沿着所述主轴提供最大空间变化的线圈灵敏度以用于线圈灵敏度编码。所提出的MRI装置提供了使其能够与SENSE方法一起使用的最佳解决方案。一般想法是沿着优选或实际的感官减少方向具有尽可能多的个性，并且沿着主要的临床兴趣的轴线具有尽可能多的空间独特性。

8. 发明申请

US20050036944A1 Diffusion-weighted parallel imaging with navigator-signal-based phase correction 审中-公开
标题翻译：基于导航信号的相位校正的扩散加权并行成像
公开(公告)号：US20050036944A1
公开(公告)日：2005-02-17
申请号：US10498634
申请日：2002-12-02
申请人： Johan Van Den Brink , Miha Fuderer
发明人： Johan Van Den Brink , Miha Fuderer
IPC分类号： G01R33/48 , A61B5/055 , G01R33/3415 , G01R33/561 , A61K49/00
CPC分类号： G01R33/3415 , G01R33/5611
摘要： A magnetic resonance imaging method for forming an image of an object from a plurality of signals acquired by an array of multiple receiver antennae, wherein spins are excitated in a part of the object. MR signals are measured along a predetermined trajectory containing a plurality of lines in k-space by application of a read gradient and other gradients. Further, a navigator gradient is applied for the measurement of navigator MR signals and an additional gradient is applied in order to achieve diffusion sensitivity of the MR signal, wherein phase corrections are determined from phases and moduli of the navigator MR signals so as to correct the measured MR signals. An image of the part of the object is determined from the corrected MR signals. The corrected phase is determined from the weighted phase difference between a reference navigator signal for each antenna and the actual navigator MR signal of said antenna.
摘要翻译：一种磁共振成像方法，用于从由多个接收器天线的阵列获取的多个信号中形成物体的图像，其中在物体的一部分中激发自旋。通过应用读取梯度和其他梯度，沿着包含k空间中的多条线的预定轨迹测量MR信号。此外，导航仪梯度被应用于导航器MR信号的测量，并且应用附加梯度以实现MR信号的扩散灵敏度，其中相位校正是从导航器MR信号的相位和模数确定的，以便校正测量MR信号。从校正的MR信号确定对象的一部分的图像。根据每个天线的参考导航器信号与所述天线的实际导航器MR信号之间的加权相位差来确定校正的相位。

9. 发明申请

US20070164738A1 Magnetic resonance imaging at several rf frequencies 有权
标题翻译：磁共振成像在几个频率
公开(公告)号：US20070164738A1
公开(公告)日：2007-07-19
申请号：US11568280
申请日：2005-04-22
申请人： Frank Hoogenraad , Johan Van Den Brink
发明人： Frank Hoogenraad , Johan Van Den Brink
IPC分类号： G01V3/00
CPC分类号： G01R33/4828 , G01R33/287
摘要： A magnetic resonance imaging system comprises a receiver system to acquire magnetic resonance signals. A control system controls the receiver system to reform an acquisition sequence to acquire the magnetic resonance signals in several acquisition segments. Respective groups of acquisition segments involve acquisition of magnetic resonance signals in different RF-receiver frequency bands. In the respective groups of acquisition segments, magnetic resonance signals are acquired from different nuclei having different gyromagnetic ratios. According to the invention, reconstruction of different types of information carried by the respective nuclei is made possible. For example, imaging of the anatomy of a patient to be examined is performed on the basis of proton magnetic resonance imaging. Imaging of a targeted contrast agent is achieved on the basis of 19F magnetic resonance imaging. Localisation of a invasive device, such as a catheter, is also performed on the basis of e.g. 19F magnetic resonance imaging.
摘要翻译：磁共振成像系统包括用于获取磁共振信号的接收器系统。控制系统控制接收机系统改造采集序列以获取几个采集段中的磁共振信号。获取段的各组涉及在不同的RF接收机频带中获取磁共振信号。在相应的采集段组中，从具有不同回旋磁比的不同核获取磁共振信号。根据本发明，由各个核承载的不同类型的信息的重构成为可能。例如，基于质子磁共振成像进行被检查患者的解剖结构的成像。靶向造影剂的成像基于^{19F磁共振成像来实现。侵入性装置（例如导管）的定位也基于例如导管进行。磁共振成像。}

10. 发明申请

US20060279282A1 System and method for magnetic resonance imaging 失效
标题翻译：磁共振成像系统和方法
公开(公告)号：US20060279282A1
公开(公告)日：2006-12-14
申请号：US10595273
申请日：2004-10-01
申请人： Johan Van Den Brink
发明人： Johan Van Den Brink
IPC分类号： G01V3/00
CPC分类号： G01R33/56 , G01R33/62
摘要： The invention relates to a system and method for magnetic resonance imaging. In order to achieve high resolution imaging a magnetic resonance imaging system and method is proposed, wherein magnetic resonance signals using a first resonance frequency are used for a central portion of k-space and magnetic resonance signals using a second resonance frequency are used for a peripheral portion of k-space. In a preferred embodiment of the invention non-proton magnetic resonance signals are used for the central portion of the k-space and proton magnetic resonance signals are used for the periphery of k-space. Accordingly, the reconstructed magnetic resonance image shows contrast relating to the non-proton nuclei and fine resolution dominated by the protons. Hence, the invention can especially provide a solution for the limited time available for the acquisition of non-proton magnetic resonance signals.
摘要翻译：本发明涉及一种用于磁共振成像的系统和方法。为了实现高分辨率成像，提出了一种磁共振成像系统和方法，其中使用第一共振频率的磁共振信号用于k空间的中心部分，并且使用第二共振频率的磁共振信号用于外围设备 k空间的一部分。在本发明的优选实施例中，非质子磁共振信号用于k空间的中心部分，质子磁共振信号用于k空间的周边。因此，重建的磁共振图像显示与非质子核相关的对比度和由质子所主导的精细分辨率。因此，本发明可以特别提供用于获取非质子磁共振信号的有限时间的解决方案。

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