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1. 发明授权

US06757735B2 Method for distributing multiple description streams on servers in fixed and mobile streaming media systems 有权
标题翻译：在固定和移动流媒体系统的服务器上分发多个描述流的方法
公开(公告)号：US06757735B2
公开(公告)日：2004-06-29
申请号：US09898643
申请日：2001-07-03
申请人： John G. Apostolopulos , Sujoy Basu , Gene Cheung , Raj Kumar , Sumit Roy , Bo Shen , Wai-Tian Tan , Susie J. Wee , Tina Wong
发明人： John G. Apostolopulos , Sujoy Basu , Gene Cheung , Raj Kumar , Sumit Roy , Bo Shen , Wai-Tian Tan , Susie J. Wee , Tina Wong
IPC分类号： G06F1516
CPC分类号： H04N7/17336 , G21C3/332 , G21C3/34 , G21Y2002/302 , H04L29/06027 , H04L65/607 , H04L67/04 , H04N21/222 , H04N21/234327 , H04N21/41407 , H04N21/6131 , H04W28/14 , Y02E30/40
摘要： A method and system for streaming media data to a fixed client and/or a mobile client. In one method embodiment, the present invention recites encoding media data to be streamed to a client into a first multiple description bitstream and into a second multiple description bitstream. The present method then determines the appropriate plurality of servers from a network of servers onto which the first and second multiple description bitstreams should be distributed. The present embodiment then recites distributing the first and second multiple description bitstreams to the appropriate plurality of servers positioned at intermediate nodes throughout a network such that a client is provided with access to the media data via a plurality of transmission paths. The present method is also well suited to redistribution of multiple description bitstreams to servers based upon time-varying demand, client movement, and the like.
摘要翻译：一种用于将媒体数据流传输到固定客户端和/或移动客户端的方法和系统。在一个方法实施例中，本发明将要流式传输到客户端的编码媒体数据描述为第一多重描述比特流并转换成第二多描述比特流。本方法然后从应该分发第一和第二多个描述比特流的服务器网络中确定适当的多个服务器。本实施例然后将第一和第二多个描述比特流分发到位于整个网络中的中间节点处的适当的多个服务器，从而经由多个传输路径向客户端提供对媒体数据的访问。本方法还非常适合于基于时变需求，客户端移动等将多个描述比特流重新分配给服务器。

2. 发明授权

US06996618B2 Method for handling off multiple description streaming media sessions between servers in fixed and mobile streaming media systems 有权
标题翻译：用于处理固定和移动流媒体系统中的服务器之间的多描述流媒体会话的方法
公开(公告)号：US06996618B2
公开(公告)日：2006-02-07
申请号：US09898807
申请日：2001-07-03
申请人： John G. Apostolopoulos , Sujoy Basu , Gene Cheung , Rajendra Kumar , Sumit Roy , Wai-tan Tan , Susie J. Wee , Tina Wong , Bo Shen
发明人： John G. Apostolopoulos , Sujoy Basu , Gene Cheung , Rajendra Kumar , Sumit Roy , Wai-tan Tan , Susie J. Wee , Tina Wong , Bo Shen
IPC分类号： G06F15/16
CPC分类号： H04W36/12 , H04L67/04 , H04L67/14 , H04L69/329
摘要： A method for handing off to a second server, in either a fixed or mobile streaming media system, a multiple description streaming session between a first server and either a fixed or mobile client. In one embodiment, the present invention recites selecting a second server to receive a handoff of a multiple description streaming media session between the first server and the client. In this embodiment, the multiple description streaming media session is comprised of a first multiple description bitstream and a second multiple description bitstream. The present embodiment further recites receiving at the second server, the second multiple description bitstream for streaming to the client. This embodiment further recites sending the second multiple description bitstream from the second server to the client.
摘要翻译：一种在固定或移动流媒体系统中切换到第二服务器的方法，在第一服务器和固定或移动客户端之间的多描述流会话。在一个实施例中，本发明阐述了选择第二服务器以接收第一服务器和客户端之间的多描述流媒体会话的切换。在该实施例中，多描述流媒体会话由第一多重描述比特流和第二多个描述比特流组成。本实施例进一步在第二服务器处接收第二多个描述比特流，以便流式传送到客户端。该实施例进一步叙述将第二多重描述比特流从第二服务器发送到客户端。

3. 发明授权

US06941378B2 Method for assigning a streaming media session to a server in fixed and mobile streaming media systems 有权
标题翻译：将流媒体会话分配给固定和移动流媒体系统中的服务器的方法
公开(公告)号：US06941378B2
公开(公告)日：2005-09-06
申请号：US09898800
申请日：2001-07-03
申请人： John G. Apostolopoulos , Sujoy Basu , Gene Cheung , Rajendra Kumar , Sumit Roy , Wai-tan Tan , Susie J. Wee , Tina Wong , Bo Shen
发明人： John G. Apostolopoulos , Sujoy Basu , Gene Cheung , Rajendra Kumar , Sumit Roy , Wai-tan Tan , Susie J. Wee , Tina Wong , Bo Shen
IPC分类号： H04L12/56 , H04L29/06 , H04L29/08 , H04L29/14 , G06F15/16 , G06F15/173
CPC分类号： H04L65/4084 , H04L29/06027 , H04L65/607 , H04L69/329 , H04L69/40 , H04N21/23103 , H04N21/234327 , H04N21/234381 , H04N21/2662 , H04N21/41407 , H04W4/00 , H04W88/08
摘要： A method for assigning servers to provide multiple description bitstreams to a mobile client (in a mobile client environment) or to a fixed client (in a fixed client environment). In one embodiment, the present invention, upon receiving a request from a mobile client to have media data streamed thereto, analyzes a plurality of servers to determine a first candidate server for providing a first multiple description bitstream to the base station along a first path. The present method also determines a second candidate server for providing a second multiple description bitstream to the base station along a second path. The present method then sends a request to the first candidate server to provide the first multiple description bitstream to a mobile client through a base station along the first path, and also sends a request to the second candidate server to provide the second multiple description bitstream to the mobile client through the same base station along a second path. In another embodiment, there are two separate paths from two separate servers to two separate base stations and then from each base station there is a separate path to the mobile client. In still another embodiment, there are two paths from a single server to two separate base stations and then from each base station there is a separate path to the mobile client. In one fixed client embodiment, the present invention is able to assign a plurality of servers to provide a plurality of MD bitstreams to the fixed client.
摘要翻译：一种用于分配服务器以向移动客户端（在移动客户端环境中）或固定客户端（在固定客户端环境中）提供多个描述比特流的方法。在一个实施例中，本发明在从移动客户端接收到流媒体数据流的请求时分析多个服务器以确定第一候选服务器，用于沿着第一路径向基站提供第一多个描述比特流。本方法还确定用于沿着第二路径向基站提供第二多描述比特流的第二候选服务器。本方法然后向第一候选服务器发送请求，以通过沿着第一路径的基站向移动客户端提供第一多个描述比特流，并且还向第二候选服务器发送请求以将第二多个描述比特流提供给移动客户端通过相同的基站沿着第二条路径。在另一个实施例中，存在从两个分离的服务器到两个单独的基站的两个单独的路径，然后从每个基站到达移动客户端的单独的路径。在另一个实施例中，存在从单个服务器到两个单独基站的两条路径，然后从每个基站到达移动客户端的单独路径。在一个固定客户端实施例中，本发明能够分配多个服务器以向固定客户端提供多个MD比特流。

4. 发明授权

US07200402B2 Method for handing off streaming media sessions between wireless base stations in a mobile streaming media system 有权
标题翻译：用于在移动流媒体系统中的无线基站之间切换流媒体会话的方法
公开(公告)号：US07200402B2
公开(公告)日：2007-04-03
申请号：US09898572
申请日：2001-07-03
申请人： John G. Apostolopoulos , Sujoy Basu , Gene Cheung , Rajendra Kumar , Sumit Roy , Wai-tan Tan , Susie J. Wee , Tina Wong , Bo Shen
发明人： John G. Apostolopoulos , Sujoy Basu , Gene Cheung , Rajendra Kumar , Sumit Roy , Wai-tan Tan , Susie J. Wee , Tina Wong , Bo Shen
IPC分类号： H04Q7/20
CPC分类号： H04W36/18 , H04B7/022 , H04L25/4919 , H04W36/08
摘要： A method for performing a soft-handoff in a mobile streaming media system, and a method for performing a hard-handoff in a mobile streaming media system are is disclosed. In the soft-handoff embodiment, the present invention detects that a channel quality between a mobile client and a first base station remains above a drop threshold and that a channel quality between the mobile client and a second base station increases from below to above an add threshold. The present embodiment then sends a first multiple description bitstream from the first base station to the mobile client and sends a complementary second multiple description bitstream from the second base station to the mobile client. This method thereby provides improved utilization of wireless bandwidth during soft-handoffs, in contrast to conventional systems where the same bitstream is transmitted from each base station. In both the cases of soft-handoffs and hard-handoffs, when a mobile client enters a cell whose base station has no free capacity, the base station may prevent call dropping by reducing the number of descriptions being served to the existing clients and thereby providing capacity (at least one description) for the new client. These methods provide improved utilization of wireless bandwidth during soft-handoffs, and reduced probability of service disruption during both soft-handoffs and hard-handoffs.
摘要翻译：公开了一种用于在移动流媒体系统中执行软切换的方法，以及用于在移动流媒体系统中执行硬切换的方法。在软切换实施例中，本发明检测到移动客户端与第一基站之间的信道质量保持高于丢弃阈值，并且移动客户端与第二基站之间的信道质量从下至上增加阈。本实施例然后将第一多个描述比特流从第一基站发送到移动客户端，并将互补的第二多个描述比特流从第二基站发送到移动客户端。因此，与从每个基站发送相同比特流的常规系统相比，该方法从而提供了在软切换期间无线带宽的改进的利用。在软切换和硬切换的情况下，当移动客户端进入其基站没有可用容量的小区时，基站可以通过减少向现有客户端提供的描述的数量来防止呼叫丢弃，从而提供新客户端的容量（至少一个描述）。这些方法在软切换期间提供了无线带宽的改进的利用，并且在软切换和硬切换期间降低了服务中断的概率。

5. 发明授权

US07451205B2 Multimedia stream pre-fetching and redistribution in servers to accommodate mobile clients 有权
标题翻译：服务器中的多媒体流预取和重新分配，以适应移动客户端
公开(公告)号：US07451205B2
公开(公告)日：2008-11-11
申请号：US09969474
申请日：2001-10-01
申请人： Gene Cheung , Tina Wong , Susie J. Wee
发明人： Gene Cheung , Tina Wong , Susie J. Wee
IPC分类号： G06F15/173 , G06F15/16
CPC分类号： H04L65/607 , G01S5/0009 , H04L29/06 , H04L29/06027 , H04L67/18 , H04W4/00 , H04W40/00 , H04W64/00
摘要： A method and system for streaming media data to a mobile client device. Using information such as the previous locations of the mobile client device, a prediction is made of a future location of the client device. A server servicing the predicted location, such as the server closest to the predicted location, is identified. This server is informed of the impending arrival of the mobile device into the area serviced by the server. The server can thus obtain ahead of time the media stream needed for the client, so that the data are available to the client without disruption when the client moves to the predicted location. To account for uncertainty in the prediction, the data can also be directed to other servers that can service the predicted location.
摘要翻译：一种用于将媒体数据流传输到移动客户端设备的方法和系统。使用诸如移动客户端设备的先前位置的信息，预测客户端设备的未来位置。识别服务于预测位置的服务器，例如最接近预测位置的服务器。该服务器被通知移动设备即将到达服务器所服务的区域。因此，服务器可以提前获得客户端所需的媒体流，以便当客户端移动到预测位置时，数据可供客户端使用，而不会中断。为了解决预测中的不确定性，数据也可以指向可以服务于预测位置的其他服务器。

6. 发明申请

US20130211314A1 GLAUCOMA VALVE, A CASING FOR CONTAINING A GLAUCOMA VALVE, AND A GLAUCOMA DRAINAGE DEVICE COMPRISING THE VALVE AND/OR THE CASING 审中-公开
标题翻译： GLAUCOMA阀，包含GLAUCOMA阀的壳体和包含阀门和/或壳体的GLAUCOMA排水装置
公开(公告)号：US20130211314A1
公开(公告)日：2013-08-15
申请号：US13816631
申请日：2011-08-12
申请人： Subramanian Venkatraman , Lei Shang , Yin Chiang Freddy Boey , Tina Wong
发明人： Subramanian Venkatraman , Lei Shang , Yin Chiang Freddy Boey , Tina Wong
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61F2210/0004
摘要： Various embodiments of the invention relate to a glaucoma valve, a casing for containing a glaucoma valve and a glaucoma drainage device comprising the glaucoma valve and/or the casing. The valve includes a flow channel having an inlet and an outlet and a valve member connected to the outlet of the flow channel. The valve member may be formed from a degradable polymer or a combination of degradable polymer and non-degradable polymer. Various embodiments of the invention relate to a glaucoma valve, the valve having a first flow channel. The interior of the first flow channel may be coated with a degradable polymer, such that in use, the polymer degrades to allow a greater flow of fluid through the flow channel. In some embodiments, the valve includes a second flow channel, which may be arranged in parallel to the first flow channel. The first flow channel may be completely sealed with the polymer such that in use, the polymer degrades to allow fluid to flow through the first flow channel. Various embodiments relate to a casing for containing a glaucoma valve. The casing may be formed from a degradable polymer, such as a biodegradable polymer.
摘要翻译：本发明的各种实施方案涉及青光眼瓣膜，用于容纳青光眼瓣膜的外壳和包括青光眼瓣膜和/或外壳的青光眼引流装置。阀包括具有入口和出口的流动通道和连接到流动通道的出口的阀构件。阀构件可以由可降解聚合物或可降解聚合物和不可降解聚合物的组合形成。本发明的各种实施例涉及青光眼瓣膜，该瓣膜具有第一流动通道。第一流动通道的内部可涂覆有可降解的聚合物，使得在使用中，聚合物降解以允许流体流过流动通道。在一些实施例中，阀包括可以与第一流动通道平行布置的第二流动通道。第一流动通道可以用聚合物完全密封，使得在使用中，聚合物降解以允许流体流过第一流动通道。各种实施方式涉及用于容纳青光眼阀的外壳。外壳可以由可降解的聚合物形成，例如可生物降解的聚合物。

7. 发明授权

US10548769B2 Glaucoma valve, a casing for containing a glaucoma valve, and a glaucoma drainage device comprising the valve and/or the casing 有权
公开(公告)号：US10548769B2
公开(公告)日：2020-02-04
申请号：US13816631
申请日：2011-08-12
申请人： Subramanian Venkatraman , Lei Shang , Yin Chiang Freddy Boey , Tina Wong
发明人： Subramanian Venkatraman , Lei Shang , Yin Chiang Freddy Boey , Tina Wong
IPC分类号： A61F9/007
摘要： Provided is a glaucoma valve, a casing for containing a glaucoma valve and a glaucoma drainage device including the glaucoma valve and/or the casing. The valve includes a flow channel having an inlet and an outlet and a valve member connected to the outlet of the flow channel. The valve member may be formed from a degradable polymer or a combination of degradable polymer and non-degradable polymer. The valve may have a first flow channel, the interior of which may be coated with a degradable polymer, such that in use, the polymer degrades to allow a greater flow of fluid through the flow channel. The valve may include a second flow channel, which may be arranged in parallel to the first flow channel. The casing may be formed from a degradable polymer, such as a biodegradable polymer.

8. 发明申请

US20130209538A1 BIODEGRADABLE OCULAR IMPLANT 审中-公开
标题翻译：可生物降解的OCULAR IMPLANT
公开(公告)号：US20130209538A1
公开(公告)日：2013-08-15
申请号：US13816637
申请日：2011-08-12
申请人： Subramanian Venkatraman , Yin Chiang Freddy Boey , Tina Wong , Jodhbh Metha
发明人： Subramanian Venkatraman , Yin Chiang Freddy Boey , Tina Wong , Jodhbh Metha
IPC分类号： A61L31/14 , A61L31/12 , B05D5/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/1647 , A61K31/19 , A61K31/5575 , A61K31/573 , A61K47/34 , A61L27/18 , A61L27/54 , A61L27/58 , A61L31/125 , A61L31/148 , A61L2430/16 , B05D5/00 , B29C39/02 , B29C39/025 , B29D11/023 , B29K2067/04 , B29K2067/046 , B29K2105/0035 , B29K2105/0073 , B29K2995/0056 , B29K2995/006 , C08L67/04 , C08L69/005
摘要： The present invention relates to a biodegradable ocular implant for sustained drug delivery, comprising a first layer comprising a first biodegradable polymer, wherein the first layer contains a drug dispersed or dissolved therein. A multi-layered biodegradable ocular implant is also disclosed.
摘要翻译：本发明涉及用于持续药物递送的可生物降解的眼部植入物，其包含第一层，其包含第一可生物降解聚合物，其中第一层含有分散或溶解于其中的药物。还公开了一种多层可生物降解的眼部植入物。

9. 发明申请

US20130216606A1 LIPOSOMAL FORMULATION FOR OCULAR DRUG DELIVERY 审中-公开
标题翻译：用于药物输送的药物制剂
公开(公告)号：US20130216606A1
公开(公告)日：2013-08-22
申请号：US13816640
申请日：2011-08-12
申请人： Subramanian Venkatraman , Jayaganesh V. Natarajan , Tina Wong , Yin Chiang Freddy Boey
发明人： Subramanian Venkatraman , Jayaganesh V. Natarajan , Tina Wong , Yin Chiang Freddy Boey
IPC分类号： A61K9/127 , A61K31/215
CPC分类号： A61K9/127 , A61K9/0048 , A61K31/215 , A61K31/5575
摘要： The present invention is directed to a liposomal formulation for ocular drug delivery comprising (i) liposomes comprising at least one lipid bilayer, and (ii) a prostaglandin drug and/or a prostaglandin derivative associated in the liposomes, wherein the liposomes have a mean diameter of less than 2μπι. The present invention is also directed to a pharmaceutical comprising the liposomal formulation and a method of producing the liposomal formulation for ocular drug delivery. Additionally, the present invention is directed to a method of treating or preventing an ocular disease, comprising administering the liposomal formulation or the pharmaceutical composition to a subject in need thereof.
摘要翻译：本发明涉及一种用于眼药物递送的脂质体制剂，其包含（i）包含至少一种脂质双层的脂质体，和（ii）在脂质体中相关的前列腺素药物和/或前列腺素衍生物，其中所述脂质体具有平均直径小于2mupiiota。本发明还涉及包含脂质体制剂和生产用于眼药物递送的脂质体制剂的方法的药物。另外，本发明涉及治疗或预防眼部疾病的方法，包括将脂质体制剂或药物组合物施用于有需要的受试者。

10. 发明申请

US20120244077A1 METHODS AND COMPOSITIONS FOR MAINTENANCE OF A FUNCTIONAL WOUND 审中-公开
标题翻译：功能维护的方法和组成
公开(公告)号：US20120244077A1
公开(公告)日：2012-09-27
申请号：US13501077
申请日：2010-10-08
申请人： Tina Wong , Li-Fong Seet
发明人： Tina Wong , Li-Fong Seet
IPC分类号： A61K31/713 , A61K33/00 , A61K39/395 , A61K49/00 , C07H21/02 , A61P27/06 , A61K9/48 , A61K9/00 , G01N33/573 , C12Q1/02 , A61P27/02 , A61K38/02 , A61K9/127
CPC分类号： A61K31/7105 , A61K38/00 , A61K49/0008 , C12N15/113 , C12N2310/14 , G01N33/5088
摘要： The present invention relates to methods and compositions for the modulation of wound healing and/or the production of extracellular membrane components by modulating the activity and/or amount of secreted protein acidic and rich in cysteine (SPARC) protein. The invention further provides methods for identifying compounds useful in the above-mentioned methods and compositions.
摘要翻译：本发明涉及通过调节酸性和富含半胱氨酸（SPARC）蛋白质的分泌蛋白质的活性和/或量来调节伤口愈合和/或产生细胞外膜组分的方法和组合物。本发明还提供用于鉴定可用于上述方法和组合物的化合物的方法。

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