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1. 发明授权

US07812030B2 Methods, compositions, and kits for organ protection during systemic anticancer therapy 有权
公开(公告)号：US07812030B2
公开(公告)日：2010-10-12
申请号：US12071648
申请日：2008-02-25
申请人： John P. Ford
发明人： John P. Ford
IPC分类号： A61K31/505
CPC分类号： A61K31/513 , A61K31/00 , A61K31/337 , A61K31/505 , A61K31/555 , A61K31/704 , A61K31/7072 , A61K2300/00
摘要： Methods, compositions, and kits are presented for local tissue protection during systemic administration of anticancer therapeutic agents.

2. 发明授权

US08258147B2 Compositions and methods for treating and preventing dermatoses 有权
标题翻译：用于治疗和预防皮肤病的组合物和方法
公开(公告)号：US08258147B2
公开(公告)日：2012-09-04
申请号：US12893692
申请日：2010-09-29
申请人： John P. Ford
发明人： John P. Ford
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： A61K31/513 , A61K9/006 , A61K9/06 , A61K31/00 , A61K31/337 , A61K31/505 , A61K31/555 , A61K31/704 , A61K31/7072 , A61K2300/00
摘要： The invention encompasses protectant agents including uracil or a metabolite thereof that effectively prevent and/or treat the cutaneous toxicities and dermatological side-effects associated with chemotherapeutic agents. Additionally, and surprisingly compositions including uracil or a metabolite thereof are effective for treating or preventing various dermatoses.
摘要翻译：本发明包括有效预防和/或治疗与化学治疗剂相关的皮肤毒性和皮肤病学副作用的包括尿嘧啶或其代谢物的保护剂。此外，令人惊奇的是包含尿嘧啶或其代谢物的组合物对于治疗或预防各种皮肤病是有效的。

3. 发明授权

US4794075A Method for locating and purifying DNA containing single base mismatches 失效
标题翻译：用于定位和纯化含有单碱基错配的DNA的方法
公开(公告)号：US4794075A
公开(公告)日：1988-12-27
申请号：US770841
申请日：1985-08-29
申请人： John P. Ford , David F. Novack , Nancy J. Casna
发明人： John P. Ford , David F. Novack , Nancy J. Casna
IPC分类号： C12N15/09 , C07H21/04 , C12Q1/68 , G01N27/447 , G01N33/50 , G01N33/48
CPC分类号： G01N27/447 , C12Q1/6827 , Y10S435/803
摘要： A method for distinguishing fragments of DNA which contain single base mismatches from their perfectly paired homologues is disclosed. Single stranded regions within a duplex fragment are modified with carbodiimide, which reacts with unpaired guanine (G) and thymine (T) residues in DNA. Linear duplex DNA molecules do not react, while DNA molecules with single base mismatches react quantitatively with carbodiimide. Following reaction with carbodiimide, the DNA molecules are fractionated on high percentage polyacrylamide gels such that modified and unmodified fragments can be clearly distinguished. Application of this technique in order to located and purify DNA sequence differences responsible for phenotype variation and inherited disease is disclosed.
摘要翻译：公开了从完全配对的同系物区分含有单碱基错配的DNA片段的方法。在双链体片段内的单链区域被碳二亚胺修饰，其与DNA中的不配对鸟嘌呤（G）和胸腺嘧啶（T）残基反应。线性双链DNA分子不反应，而具有单碱基错配的DNA分子与碳二亚胺定量反应。在与碳二亚胺反应后，DNA分子在高百分比聚丙烯酰胺凝胶上分馏，使得可以明确区分修饰和未修饰的片段。公开了该技术的应用以定位和纯化负责表型变异和遗传性疾病的DNA序列差异。

4. 发明授权

US4775745A Diazonium compounds useful as components for nucleic acid probes 失效
标题翻译：可用作核酸探针成分的重氮化合物
公开(公告)号：US4775745A
公开(公告)日：1988-10-04
申请号：US939370
申请日：1986-12-08
申请人： John P. Ford , Bernard F. Erlanger , C. William Blewett
发明人： John P. Ford , Bernard F. Erlanger , C. William Blewett
IPC分类号： C12Q1/68 , C07C113/00 , C07C113/04
CPC分类号： C12Q1/6827 , C12Q1/6816 , Y10S436/804 , Y10S436/828
摘要： This invention relates to a diazonium compound of the formula: ##STR1## wherein Z is selected from the group consisting of biotin, an antigen, an antibody, a photoreactive group, a fluorescent group and heavy metal-containing compounds;X is an alkylene group containing up to 18 carbon atoms in the principle chain and a total of up to 24 carbon atoms or a substituted alkylene group containing up to 18 carbon atoms in the principle chain with substituents selected from the group consisting of solubility-enhancing groups and cleavable --S--S-- containing moieties;Ar is an unsubstituted or substituted aryl or heteroaryl; andY is an anion and n is an integer from 1-3.Such compounds are useful as components for nucleic acid probes.
摘要翻译：本发明涉及下式的重氮化合物：其中Z选自生物素，抗原，抗体，光反应性基团，荧光基团和含重金属的化合物; X是在原则链中含有至多18个碳原子的亚烷基，在原理链中含有至多24个碳原子或含有至多18个碳原子的取代的亚烷基，所述取代基选自溶解度增强基团和可切割的含-SS的部分; Ar是未取代或取代的芳基或杂芳基; Y为阴离子，n为1-3的整数。这些化合物可用作核酸探针的组分。

5. 发明申请

US20120244211A1 Compositions And Methods For Treatment Of The Side-Effects Associated With Administration Of Cancer Chemotherapeutic Agents 有权
标题翻译：用于治疗与癌症化疗药物相关的副作用的组合物和方法
公开(公告)号：US20120244211A1
公开(公告)日：2012-09-27
申请号：US13446328
申请日：2012-04-13
申请人： John P. Ford
发明人： John P. Ford
IPC分类号： A61K31/52 , A61K9/127 , A61P1/00 , C07D473/34
CPC分类号： A61K9/127 , A61K31/513 , A61K31/7072 , A61K31/7076 , A61K45/06 , A61K2300/00
摘要： A composition and method for the treatment of the side-effects associated with the administration of cancer chemotherapeutic agents involves the oral ingestion of a slow release capsule containing adenine and orotate. The administration of a protein pump inhibitor decreases systemic absorption of orotate and the administration of allopurinol decreases the formation of 2,8-dihydroxy adenine from adenine. In an alternative embodiment, cationic liposomes contain purine/pyrimidine precursors. The cationic liposomes bind to the cells lining the mucosa of the intestinal tract and then the contents of the cationic liposome are then taken up in the interior of the cells to prevent the metabolism of the cancer treatment drug 5-FU into a toxic species.
摘要翻译：用于治疗与癌症化学治疗剂的给药相关的副作用的组合物和方法涉及口服摄取含有腺嘌呤和乳清酸的缓释胶囊。蛋白质泵抑制剂的施用降低乳清酸的全身吸收，并且施用别嘌呤醇降低腺嘌呤形成2,8-二羟基腺嘌呤。在另一个实施方案中，阳离子脂质体含有嘌呤/嘧啶前体。阳离子脂质体结合到肠道粘膜上的细胞，然后将阳离子脂质体的内容物吸收到细胞内部，以防止癌症治疗药物5-FU的代谢成为毒性物质。

6. 发明申请

US20120105471A1 Systems and Methods for Data Aggregation and Prioritization 有权
标题翻译：数据汇总和优先排序的系统和方法
公开(公告)号：US20120105471A1
公开(公告)日：2012-05-03
申请号：US13345939
申请日：2012-01-09
申请人： John P. Ford , Liying Huang
发明人： John P. Ford , Liying Huang
IPC分类号： G09G5/00
CPC分类号： G06F19/3487 , G06F3/04817 , G06F3/0482 , G06F17/30994 , G06F19/00 , G16H15/00
摘要： Computer-enabled systems and methods aggregate data related to a particular subject or field and present the data in a simplified display. The data is divided into predetermined categories, which are graphically displayed in a predetermined arrangement. Systems and methods differentiate and visually display critical data abnormalities separately from non-critical data. The systems and methods enable an observer to identify the critical deviations or anomalies of data with respect to a predetermined base line by an intuitive visual display of all of the data from any sized data universe on a single screen. The data is indexed at multiple display levels such as a stack of one patient's data, a stack of all patient data for the universe of patients of a single practitioner, or a group of practitioners of any size. A portion of the display preferably may be selected and expanded to show only that portion in greater detail.
摘要翻译：计算机启用的系统和方法聚合与特定主题或字段相关的数据，并以简化的显示呈现数据。数据被分成预定的类别，其以预定的布置图形地显示。系统和方法与非关键数据分开区分并可视地显示关键数据异常。系统和方法使得观察者能够通过在单个屏幕上来自任何尺寸的数据空间的所有数据的直观可视显示来识别数据相对于预定基线的关键偏差或异常。数据以多个显示级别进行索引，例如一个患者数据的堆叠，单个从业者的患者的全部患者数据的堆叠或任何大小的一组从业者。优选地，可以选择和扩展显示器的一部分，以更详细地仅显示该部分。

7. 发明授权

US07816366B2 Compositions and methods for treating and preventing dermatoses 有权
标题翻译：用于治疗和预防皮肤病的组合物和方法
公开(公告)号：US07816366B2
公开(公告)日：2010-10-19
申请号：US12114602
申请日：2008-05-02
申请人： John P. Ford
发明人： John P. Ford
IPC分类号： A61K31/505 , A01N43/54
CPC分类号： A61K31/513 , A61K9/006 , A61K9/06 , A61K31/00 , A61K31/337 , A61K31/505 , A61K31/555 , A61K31/704 , A61K31/7072 , A61K2300/00
摘要： The invention encompasses protectant agents including uracil or a metabolite thereof that effectively prevent and/or treat the cutaneous toxicities and dermatological side-effects associated with chemotherapeutic agents. Additionally, and surprisingly compositions including uracil or a metabolite thereof are effective for treating or preventing various dermatoses.
摘要翻译：本发明包括有效预防和/或治疗与化学治疗剂相关的皮肤毒性和皮肤病学副作用的包括尿嘧啶或其代谢物的保护剂。此外，令人惊奇的是包含尿嘧啶或其代谢物的组合物对于治疗或预防各种皮肤病是有效的。

8. 发明申请

US20100203140A1 METHODS, COMPOSITIONS, AND KITS FOR ORGAN PROTECTION DURING SYSTEMIC ANTICANCER THERAPY 审中-公开
标题翻译：系统反应治疗期间组织保护的方法，组合物和试剂盒
公开(公告)号：US20100203140A1
公开(公告)日：2010-08-12
申请号：US12683293
申请日：2010-01-06
申请人： John P. Ford
发明人： John P. Ford
IPC分类号： A61K9/107 , A61K31/513
CPC分类号： A61K31/513 , A61K31/00 , A61K31/337 , A61K31/505 , A61K31/555 , A61K31/704 , A61K31/7072 , A61K2300/00
摘要： Methods, compositions, and kits are presented for local tissue protection during systemic administration of anticancer therapeutic agents.
摘要翻译：在抗癌治疗剂的全身给药期间，提供了用于局部组织保护的方法，组合物和试剂盒。

9. 发明申请

US20090232884A1 Composition and method for treatment of the side-effects associated with administration of cancer chemotherapeutic agents 审中-公开
标题翻译：用于治疗与癌症化学治疗剂的给药相关的副作用的组合物和方法
公开(公告)号：US20090232884A1
公开(公告)日：2009-09-17
申请号：US12381474
申请日：2009-03-12
申请人： John P. Ford
发明人： John P. Ford
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K31/513 , A61K31/7072 , A61K31/7076 , A61K2300/00
摘要： A composition and method for the treatment of the side-effects associated with the administration of cancer chemotherapeutic agents involves the oral ingestion of cationic liposomes containing the substrates orotate, UMP and AMP. The cationic liposomes bind to the cells lining the mucosa of the intestinal tract and then the contents of the cationic liposome are then taken up in the interior of the cells to prevent the metabolism or anabolism of the cancer treatment drug 5-FU into a toxic species.
摘要翻译：用于治疗与癌症化学治疗剂的给药相关的副作用的组合物和方法涉及口服摄取含有底物乳清酸，UMP和AMP的阳离子脂质体。阳离子脂质体结合到肠道粘膜上的细胞，然后将阳离子脂质体的内容物吸收在细胞内部，以防止癌症治疗药物5-FU的代谢或合成代谢成为毒性物质。

10. 发明授权

US4750982A Process and apparatus for purifying and concentrating DNA from crude mixtures containing DNA 失效
标题翻译：用于从含有DNA的粗混合物中纯化和浓缩DNA的方法和装置
公开(公告)号：US4750982A
公开(公告)日：1988-06-14
申请号：US878822
申请日：1986-06-26
申请人： Graham J. Tomblin , Karen B. Wexler , John P. Ford , Stuart G. Fischer
发明人： Graham J. Tomblin , Karen B. Wexler , John P. Ford , Stuart G. Fischer
IPC分类号： B01D57/02 , G01N27/447 , G01N27/26
CPC分类号： G01N27/447 , B01D57/02
摘要： A process and apparatus for purifying and concentrating DNA, which has relatively high molecular weight, from test samples containing DNA, for example from human whole blood samples; the collected DNA is of usable volume and concentration, and is of such purity as to permit conventional restriction by a number of enzymes without the need for further purification. The apparatus consists essentially of an agarose gel disc, typically 5 mm. thick by 31 mm. in diameter, immersed in an electrophoresis buffer solution and supported between two 8 micrometer polycarbonate filters in an electric field. Further, the method involves the loading of a suitably treated sample such as blood lysate onto the top face of the agarose gel disc and then applying an electric field. Of the constituent parts of the treated blood, the DNA molecules are the largest with regard to molecular weight. Consequently, their passage through the agarose gel disc, under the force of the electric field, is impeded. All other constituent parts of the treated blood pass relatively rapidly through the disc and are removed, being swept away by flow of the buffer solution. The DNA is then eluted and collected, in concentrated form by application of the electric field, while the normal flow of buffer solution between the bottom of the gel matrix and a collection chamber is prevented.
摘要翻译：用于从含有DNA的测试样品中纯化和浓缩具有相对较高分子量的DNA的方法和装置，例如来自人全血样品; 所收集的DNA具有可用的体积和浓度，并且具有如下纯度：允许常规的许多酶的限制，而不需要进一步纯化。该装置基本上由通常为5mm的琼脂糖凝胶盘组成。厚31毫米。浸入电泳缓冲溶液中，并在电场下支撑在两个8微米的聚碳酸酯过滤器之间。此外，该方法包括将适当处理的样品如血液裂解物加载到琼脂糖凝胶盘的顶面上，然后施加电场。在处理血液的组成部分中，DNA分子在分子量方面是最大的。因此，它们在电场的作用下通过琼脂糖凝胶盘被阻止。经处理的血液的所有其他组成部分相对快速地通过椎间盘，并被除去，被缓冲溶液的流动扫除。然后通过施加电场以浓缩形式洗脱和收集DNA，同时防止凝胶基质的底部和收集室之间的缓冲溶液的正常流动。

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