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1. 发明授权

US11549909B2 Elution and detection 有权
公开(公告)号：US11549909B2
公开(公告)日：2023-01-10
申请号：US16325600
申请日：2017-08-15
申请人： GREYSCAN PTY LTD
发明人： Graham William Lyford , Michael Smith , Alistair Stuart Webb , Adam John Cusick , Leigh Ryan , Ian Emil Sohn
IPC分类号： G01N27/447 , G01N27/453 , B01D57/02 , G01N27/06 , B01L3/00 , B01D15/42 , G01N1/40 , G01N1/28
摘要： An elution apparatus and a detection apparatus are described. The elution apparatus includes: a sample trap for trapping a sample; and one or more pumps and/or valves to move a liquid eluent and a liquid eluate, wherein the eluate includes an extracted portion of the sample that is extracted by the eluent. The detection apparatus includes: a capillary having a low-voltage (LV) end portion to receive a sample; and a conductivity detector coupled to a high-voltage (HV) end portion of the capillary to generate signals based on conductivity of a monitored portion of the capillary in the HV end portion, wherein the conductivity detector is electrically isolated from the LV end portion.

2. 发明申请

US20220314042A1 Personal Air Filter Utilizing Mechanical, Chemical and Electrostatic Filter Media 有权
公开(公告)号：US20220314042A1
公开(公告)日：2022-10-06
申请号：US17712393
申请日：2022-04-04
申请人： Philter Labs Incorporated
发明人： John Grimm , Andrew Lammoureux
IPC分类号： A62B23/02 , B01D39/12 , B01D46/00 , B01D57/02 , B01D53/00 , B01D53/86 , B01D39/20
摘要： As an accessory to smoke or vaporizer devices or integrated into same, or to accompany smokers in general, a personal air filter comprising multiple filter mediums and technologies, and various combinations thereof, including mechanical, chemical and electrostatic principles, is disclosed. The different mediums and components are sequentially incorporated into a compact unit that can fit easily into a user's bag, purse or pocket. Importantly, harmful organic compounds are targeted as well as nanoparticles. An additional feature is that the filter device is easily disassembled to replace and/or reuse inner and outer components.

3. 发明授权

US11167247B2 Length-based separation of carbon nanotubes 有权
公开(公告)号：US11167247B2
公开(公告)日：2021-11-09
申请号：US15897781
申请日：2018-02-15
申请人： NANOLC-12, LLC
发明人： Zahra Borzooeian , Mohammad E. Taslim
IPC分类号： B01D57/02 , C01B32/172 , B82Y40/00 , B82Y30/00
摘要： Disclosed are methods for separating carbon nanotubes on the basis of a specified parameter, such as length. The methods include labelling of the carbon nanotubes with a biological moiety, followed by SDS-PAGE and staining, to separate the carbon nanotubes on the basis of length and/or characterize their length. In some embodiments, egg-white lysozyme, conjugated covalently onto single-walled carbon nanotubes surfaces using carbodiimide method, followed by SDS-PAGE and visualization of the single-walled nanotubes using silver staining, provides high resolution characterization of length of the single-walled carbon nanotubes. This high precision, inexpensive, rapid and simple separation method obviates the need for centrifugation, additional chemical analyses, and expensive spectroscopic techniques such as Raman spectroscopy to visualize carbon nanotube bands. The disclosed methods find utility in quality-control in the manufacture of carbon nanotubes of specific lengths.

4. 发明授权

US11033859B2 Methods for electroelution of biomolecules 有权
公开(公告)号：US11033859B2
公开(公告)日：2021-06-15
申请号：US16012147
申请日：2018-06-19
申请人： Global Life Sciences Solutions Operations UK Ltd
发明人： Christopher Michael Puleo , John Richard Nelson , Patrick McCoy Spooner , Ralf Lenigk , Nicole Lea Wood , Li Zhu , Craig Patrick Galligan
IPC分类号： B01D57/02 , C12N15/10
摘要： A method of eluting biomolecules, such as nucleic acids from a biological sample by electroelution is provided. An example of a method includes various steps, such as loading the biological sample to a device comprising a housing, at least two conductive redox polymer electrodes operationally coupled to the housing and a biomolecule impermeable layer disposed on at least one of the electrodes. The loading of sample is followed by initiating an electrical connection to generate an electric field strength sufficient to elute biomolecules from the biological sample; and eluting the biomolecules from the biological sample.

5. 发明申请

US20210101115A1 OBJECT TRAPPING DEVICE AND OBJECT TRAPPING DEVICE UNIT 有权
公开(公告)号：US20210101115A1
公开(公告)日：2021-04-08
申请号：US16500089
申请日：2018-03-23
申请人： SHARP KABUSHIKI KAISHA , The University of Tokyo
发明人： KUNIHIKO IIZUKA , TAKESHI MITSUNAKA , YOSHIHISA FUJIMOTO , TERUO FUJII , SOO-HYEON KIM
IPC分类号： B01D57/02 , G01N27/447 , B03C5/02 , C12M1/00
摘要： An object trapping device enables efficiently trapping a plurality of objects in a specific combination. Each of a first electrode pair (13), a second electrode pair (14), and a third electrode pair (15) in an electrode pair group (3) is applied with an individual AC voltage and traps an object by dielectrophoresis generated in accordance with the AC voltage that is applied.

6. 发明授权

US10946346B2 Sperm separation by electrophoresis 有权
公开(公告)号：US10946346B2
公开(公告)日：2021-03-16
申请号：US16343680
申请日：2017-10-20
申请人： Memphasys Limited
发明人： Xing Feng Zhao , Hani Nur
IPC分类号： B01D61/42 , B01D71/38 , C12N5/076 , B01D57/02
摘要： The present invention relates to the separation of sperm. In particular, the present invention relates to the use of polyvinyl alcohol membranes in the electrophoretic separation of sperm.

7. 发明申请

US20210032695A1 SELECTIVE MODIFICATION OF POLYMER SUBUNITS TO IMPROVE NANOPORE-BASED ANALYSIS 有权
公开(公告)号：US20210032695A1
公开(公告)日：2021-02-04
申请号：US17028784
申请日：2020-09-22
申请人： University of Washington through its Center for Commercialization , Illumina, Inc.
发明人： Jens H. Gundlach , Andrew Laszlo , Ian Derrington , Jeffrey G. Mandell
IPC分类号： C12Q1/6869 , B01D57/02
摘要： The present disclosure provides method and systems for improving nanopore-based analyses of polymers. The disclosure provides methods for selectively modifying one or more monomeric subunit(s) of a kind a pre-analyte polymer that results polymer analyte with a modified subunit. The polymer analyte produces a detectable signal in a nanopore-based system. The detectable signal, and/or its deviation from a reference signal, indicates the location of the modified subunit in the polymer analyte and, thus, permits the identification of the subunit at that location in the original pre-analyte polymer.

8. 发明授权

US10830508B2 Ionic air cooling device 有权
公开(公告)号：US10830508B2
公开(公告)日：2020-11-10
申请号：US15853956
申请日：2017-12-25
申请人： David John Tanner
发明人： David John Tanner
IPC分类号： F25B30/06 , B01D57/02 , F25B13/00 , H01M8/22 , F24F5/00
摘要： An ionic air cooling device that uses a salinity differential heat engine having a heat pump as the primary heat source is provided. The devices uses a closed loop thermodynamic cycle which produces a high thermodynamic efficiency in heat to energy conversion with a low temperature differential between the high and low sides, in addition to a net ambient temperature cooling effect by directly or indirectly converting ambient temperature/environmental low grade heat to electricity or potential kinetic energy or mechanical work.

9. 发明授权

US10768141B2 Isoelectric focusing arrays and methods of use thereof 有权
公开(公告)号：US10768141B2
公开(公告)日：2020-09-08
申请号：US15749039
申请日：2016-09-08
申请人： The Regents of the University of California
发明人： Amy E. Herr , Augusto M. Tentori , Kevin A. Yamauchi
IPC分类号： G01N27/447 , B01D57/02
摘要： Isoelectric focusing devices configured for multiplex separation of sample components of interest in a polymeric separation medium are provided. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays.

10. 发明授权

US10711265B2 Electrophoresis assisted method for purifying a target nucleic acid using a delayed elution approach 有权
公开(公告)号：US10711265B2
公开(公告)日：2020-07-14
申请号：US15576353
申请日：2016-06-01
申请人： Qiagen GmbH
发明人： Thorsten Singer , Sarah Fakih
IPC分类号： G01N27/447 , C12N15/10 , B01D15/20 , B01D15/42 , B01D57/02
摘要： Provided is inter alia to an electrophoresis assisted method for purifying a target nucleic acid from a nucleic acid containing sample, comprising (a) binding the target nucleic acid to a solid phase; (b) placing the solid phase with the bound target nucleic acid into a loading chamber of a device, wherein the device comprises a passage which comprises the loading chamber, optionally a liquid permeable separation matrix adjacent to the loading chamber, and a liquid permeable collection matrix and wherein the solid phase with the bound target nucleic acid is present in the loading chamber in a liquid medium comprising at least one water-miscible organic solvent and wherein the target nucleic acid remains bound to the solid phase in said liquid medium; (c) generating an electric field between a cathode and an anode and using a running solution that conducts the electric current, wherein the running solution dilutes the liquid medium comprised in the loading chamber resulting in elution of the bound target nucleic acid, and wherein the eluted target nucleic acid migrates according to its charge in the electric field and is retained by the collection matrix; (d) collecting the purified target nucleic acid. The method is particularly suitable for isolating RNA. The liquid medium delays elution of the RNA from the solid phase, thereby preventing a degradation of the RNA by e.g. RNases.

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