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1. 发明授权

US07588916B2 T1R taste receptors and genes encoding same 有权
标题翻译： T1R味觉受体和编码相同的基因
公开(公告)号：US07588916B2
公开(公告)日：2009-09-15
申请号：US11745857
申请日：2007-05-08
申请人： Jon Elliott Adler , Xiaondong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya
发明人： Jon Elliott Adler , Xiaondong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya
IPC分类号： C12N15/12 , C07K14/705
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00 , C12Q1/6883 , G01N33/5041 , G01N33/6872 , G01N33/74 , G01N2333/726 , G06F19/12
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
摘要翻译：描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。具体地说，描述了活跃于味觉信号传导中的T1R G蛋白偶联受体以及编码相同基因的cDNA，以及用于分离这些基因并用于分离和表达此类受体的方法。还描述了用于表示哺乳动物中特定味觉刺激的味觉感知的方法，以及用于产生哺乳动物中引发预定味觉的新颖分子或分子组合的方法，以及用于模拟一种或多种口味的方法。此外，还公开了哺乳动物刺激或阻止味觉的方法。

2. 发明授权

US07790848B2 T1R3 receptor binding assays for identification of T1R3 modulatory compounds 有权
标题翻译：用于鉴定T1R3调节化合物的T1R3受体结合测定
公开(公告)号：US07790848B2
公开(公告)日：2010-09-07
申请号：US11798576
申请日：2007-05-15
申请人： Jon Elliott Adler , Sergey Zozulya , Xiaondong Li , Shawn O'Connell , Lena Staszewski
发明人： Jon Elliott Adler , Sergey Zozulya , Xiaondong Li , Shawn O'Connell , Lena Staszewski
IPC分类号： C07K14/705 , G01N33/566
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
摘要翻译：描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。具体地说，描述了活跃于味觉信号传导中的T1R G蛋白偶联受体以及编码相同基因的cDNA，以及用于分离这些基因并用于分离和表达此类受体的方法。还描述了用于表示哺乳动物中特定促味剂的味觉的方法，以及用于产生在哺乳动物中引发预定味觉的新颖分子或分子组合的方法，以及用于模拟一种或多种口味的方法。此外，还公开了哺乳动物刺激或阻止味觉的方法。

3. 发明授权

US07927823B2 Assays using chimeric T1R3 taste receptor polypeptides 有权
标题翻译：使用嵌合T1R3味觉受体多肽进行测定
公开(公告)号：US07927823B2
公开(公告)日：2011-04-19
申请号：US12766121
申请日：2010-04-23
申请人： Jon Elliott Adler , Sergey Zozulya , Xiaodong Li , Shawn O'Connell , Lena Staszewski
发明人： Jon Elliott Adler , Sergey Zozulya , Xiaodong Li , Shawn O'Connell , Lena Staszewski
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
摘要翻译：描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。具体地说，描述了活跃于味觉信号传导中的T1R G蛋白偶联受体以及编码相同基因的cDNA，以及用于分离这些基因并用于分离和表达此类受体的方法。还描述了用于表示哺乳动物中特定促味剂的味觉的方法，以及用于产生在哺乳动物中引发预定味觉的新颖分子或分子组合的方法，以及用于模拟一种或多种口味的方法。此外，还公开了哺乳动物刺激或阻止味觉的方法。

4. 发明授权

US07705121B2 Chimeric human T1R3 taste receptor polypeptides and compositions containing same 有权
标题翻译：嵌合人类T1R3味觉受体多肽和含有它们的组合物
公开(公告)号：US07705121B2
公开(公告)日：2010-04-27
申请号：US11797155
申请日：2007-05-01
申请人： Jon Elliott Adler , Sergey Zozulya , Xiadong Li , Shawn O'Connell , Lena Staszewski
发明人： Jon Elliott Adler , Sergey Zozulya , Xiadong Li , Shawn O'Connell , Lena Staszewski
IPC分类号： C07K14/705 , C07K19/00 , C12N15/62
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
摘要翻译：描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。具体地说，描述了活跃于味觉信号传导中的T1R G蛋白偶联受体以及编码相同基因的cDNA，以及用于分离这些基因并用于分离和表达此类受体的方法。还描述了用于表示哺乳动物中特定促味剂的味觉的方法，以及用于产生在哺乳动物中引发预定味觉的新颖分子或分子组合的方法，以及用于模拟一种或多种口味的方法。此外，还公开了哺乳动物刺激或阻止味觉的方法。

5. 发明授权

US08314224B2 T1R taste receptors and genes encoding same 有权
标题翻译： T1R味觉受体和编码相同的基因
公开(公告)号：US08314224B2
公开(公告)日：2012-11-20
申请号：US13023836
申请日：2011-02-09
申请人： Jon Elliott Adler , Sergey Zozulya , Xiaodong Li , Shawn O'Connell , Lena Staszewski
发明人： Jon Elliott Adler , Sergey Zozulya , Xiaodong Li , Shawn O'Connell , Lena Staszewski
IPC分类号： C12N15/12 , C07K14/705
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
摘要翻译：描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。具体地说，描述了活跃于味觉信号传导中的T1R G蛋白偶联受体以及编码相同基因的cDNA，以及用于分离这些基因并用于分离和表达此类受体的方法。还描述了用于表示哺乳动物中特定促味剂的味觉的方法，以及用于产生在哺乳动物中引发预定味觉的新颖分子或分子组合的方法，以及用于模拟一种或多种口味的方法。此外，还公开了哺乳动物刺激或阻止味觉的方法。

6. 发明申请

US20090053730A1 CHIMERIC HUMAN T1R1 TASTE RECEPTOR POLYPEPTIDES AND COMPOSITIONS CONTAINING SAME 有权
标题翻译： CHIMERIC人类T1R1脂肪受体多肽及其组合物
公开(公告)号：US20090053730A1
公开(公告)日：2009-02-26
申请号：US11877835
申请日：2007-10-24
申请人： Jon Elliott Adler , Sergey Zozulya , Xiaodong Li , Shawn O'Connell , Lena Staszewski
发明人： Jon Elliott Adler , Sergey Zozulya , Xiaodong Li , Shawn O'Connell , Lena Staszewski
IPC分类号： G01N33/53 , C07K14/435
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
摘要翻译：描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。具体地说，描述了活跃于味觉信号传导中的T1R G蛋白偶联受体以及编码相同基因的cDNA，以及用于分离这些基因并用于分离和表达此类受体的方法。还描述了用于表示哺乳动物中特定促味剂的味觉的方法，以及用于产生在哺乳动物中引发预定味觉的新颖分子或分子组合的方法，以及用于模拟一种或多种口味的方法。此外，还公开了哺乳动物刺激或阻止味觉的方法。

7. 发明授权

US08759015B2 Methods of screening T1R1/T1R3 receptors for compounds that modulate umami taste signaling 有权
标题翻译：筛选调节鲜味信号的化合物的T1R1 / T1R3受体的方法
公开(公告)号：US08759015B2
公开(公告)日：2014-06-24
申请号：US13549833
申请日：2012-07-16
申请人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
发明人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/5041 , A01K2217/05 , C07K14/705 , C07K2319/00 , C12Q1/6876 , C12Q2600/124 , C12Q2600/158 , G01N33/5008 , G01N33/566 , G01N2333/4719 , G01N2333/705 , G01N2333/726 , G01N2500/04
摘要： The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Finally, the invention relates to the discovery that some compounds, e.g., lactisole, inhibit both the activities of human T1R2/T1R3 and T1R1/T1R3 receptors, and accordingly the sweet and umami taste, suggesting that these receptors may be the only sweet and umami receptors.
摘要翻译：本发明涉及T1R受体组装形成功能性味觉受体的发现。特别地，已经发现，T1R1和T1R3的共表达导致对鲜味刺激（包括谷氨酸钠）起反应的味觉感受器。此外，已经发现，T1R2和T1R3受体的共表达导致对包括天然存在的和人造甜味剂的甜味刺激有反应的味觉受体。最后，本发明涉及一些发现，一些化合物，例如乳酸，抑制人T1R2 / T1R3和T1R1 / T1R3受体的活性，因此抑制甜味和鲜味，这表明这些受体可能是唯一的甜味和鲜味受体。

8. 发明授权

US08436143B2 T1R taste receptors and genes encoding same 有权
公开(公告)号：US08436143B2
公开(公告)日：2013-05-07
申请号：US13288322
申请日：2011-11-03
申请人： Jon Elliot Adler , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya
发明人： Jon Elliot Adler , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya
IPC分类号： C07K14/705 , C07K19/00
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00 , C12Q1/6883 , G01N33/5041 , G01N33/6872 , G01N33/74 , G01N2333/726 , G06F19/12
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

9. 发明授权

US08323912B2 Methods of screening heteromeric T1R2/T1R3 receptors which modulate sweet taste signaling 有权
标题翻译：筛选调节甜味信号的异源性T1R2 / T1R3受体的方法
公开(公告)号：US08323912B2
公开(公告)日：2012-12-04
申请号：US13023502
申请日：2011-02-08
申请人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
发明人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
IPC分类号： G01N33/567 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： G01N33/5008 , C12N2503/00 , C12N2510/00 , C40B30/04 , G01N33/6872 , G01N2333/726 , G01N2500/10
摘要： The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners.Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.Finally, the invention relates to the discovery that some compounds, e.g., lactisole, inhibit both the activities of human T1R2/T1R3 and T1R1/T1R3 receptors, and accordingly the sweet and umami taste, suggesting that these receptors may be the only sweet and umami receptors.
摘要翻译：本发明涉及T1R受体组装形成功能性味觉受体的发现。特别地，已经发现，T1R1和T1R3的共表达导致对鲜味刺激（包括谷氨酸钠）起反应的味觉感受器。此外，已经发现，T1R2和T1R3受体的共表达导致对包括天然存在的和人造甜味剂的甜味刺激有反应的味觉受体。本发明还涉及在测定中使用包含T1R1 / T1R3和T1R2 / T1R3的异低聚味觉感受器来鉴定分别响应于鲜味刺激和甜味刺激的化合物。此外，本发明涉及稳定或瞬时共表达T1R1和T1R3的组合的细胞系的组成; 或T1R2和T1R3; 在组成型或诱导性条件下。还提供了在基于细胞的测定中使用这些细胞系以鉴定鲜味和甜味调节化合物，特别是通过使用荧光成像检测受体活性的高通量筛选测定。最后，本发明涉及一些发现，一些化合物，例如乳酸，抑制人T1R2 / T1R3和T1R1 / T1R3受体的活性，因此抑制甜味和鲜味，这表明这些受体可能是唯一的甜味和鲜味受体。

10. 发明申请

US20120164664A1 T1R TASTE RECEPTORS AND GENES ENCODING SAME 有权
标题翻译： T1R TASTE受体和编码它们的基因
公开(公告)号：US20120164664A1
公开(公告)日：2012-06-28
申请号：US13288322
申请日：2011-11-03
申请人： Jon Elliot Adler , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya
发明人： Jon Elliot Adler , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya
IPC分类号： G01N33/566 , C07K14/705 , C12N1/19 , C12N5/10 , C12N1/21 , C12N15/12 , C12N15/63
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00 , C12Q1/6883 , G01N33/5041 , G01N33/6872 , G01N33/74 , G01N2333/726 , G06F19/12
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
摘要翻译：描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。具体地说，描述了活跃于味觉信号传导中的T1R G蛋白偶联受体以及编码相同基因的cDNA，以及用于分离这些基因并用于分离和表达此类受体的方法。还描述了用于表示哺乳动物中特定味觉刺激的味觉感知的方法，以及用于产生哺乳动物中引发预定味觉的新颖分子或分子组合的方法，以及用于模拟一种或多种口味的方法。此外，还公开了哺乳动物刺激或阻止味觉的方法。

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