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1. 发明申请

US20120201788A1 METHODS AND COMPOSITIONS FOR CELL THERAPY 审中-公开
标题翻译：细胞治疗方法与组合物
公开(公告)号：US20120201788A1
公开(公告)日：2012-08-09
申请号：US13339614
申请日：2011-12-29
申请人： Jose Cibelli , Tanja Dominko
发明人： Jose Cibelli , Tanja Dominko
IPC分类号： A61K35/12 , A61P25/16 , A61P25/28 , A61P25/00
CPC分类号： A01K67/0271 , A01K2217/05 , A61K35/12 , A61K48/00 , C12N15/873 , C12N2517/02 , C12N2517/04
摘要： Improved methods of cell therapy are provided using cells and tissues that are histocompatible with a human or non-human transplant recipient. The cells and tissues for transplant produced by the present invention exhibit a youthful state and can be committed to specific cell lineages to better infiltrate and proliferate at a desired target, e.g., a tissue, or organ in need of cell replacement therapy. For providing cells and tissues for transplant to a non-human mammal, the cells and tissues can be isolated from a gastrulating embryo produced by same-species nuclear transfer.
摘要翻译：使用与人或非人类移植受体组织相容的细胞和组织提供改进的细胞治疗方法。本发明生产的用于移植的细胞和组织表现出年轻状态，并且可以致力于特定的细胞谱系，以在期望的靶，例如需要细胞替代疗法的组织或器官中更好地渗透和增殖。为了提供用于移植到非人哺乳动物的细胞和组织，细胞和组织可以从通过相同种类的核转移产生的诱导胚胎中分离出来。

2. 发明申请

US20090136464A1 Methods and compositions for cell therapy 审中-公开
标题翻译：细胞治疗方法和组成
公开(公告)号：US20090136464A1
公开(公告)日：2009-05-28
申请号：US12218045
申请日：2008-07-09
申请人： Jose Cibelli , Tanja Dominko
发明人： Jose Cibelli , Tanja Dominko
IPC分类号： A61K35/12 , A61P43/00
CPC分类号： A01K67/0271 , A01K2217/05 , A61K35/12 , A61K48/00 , C12N15/873 , C12N2517/02 , C12N2517/04
摘要： Improved methods of cell therapy are provided using cells and tissues that are histocompatible with a human or non-human transplant recipient. The cells and tissues for transplant produced by the present invention exhibit a youthful state and can be committed to specific cell lineages to better infiltrate and proliferate at a desired target, e.g., a tissue, or organ in need of cell replacement therapy. For providing cells and tissues for transplant to a non-human mammal, the cells and tissues can be isolated from a gastrulating embryo produced by same-species nuclear transfer. Histocompatible cells and tissues for transplant to a human can be isolated from a gastrulating embryo that (i) is genetically modified to be in capable of developing beyond an early stage, or (ii) is produced by cross-species nuclear transfer between a human nuclear donor cell and an enucleated recipient cell, e.g., an oocyte, of a non-human mammal, or (iii) is produced by androgenesis or gynogenesis, or from pluripotent stem cells generated from such an embryo. Methods for producing histocompatible cells and tissues for transplant to a human can also be used to produce such cells or tissues for transplant to non-human mammals. The present invention also provides model embryonic systems having defined genetic makeup that are useful for developing and testing methods for cell and tissue therapy, and for studying genetic imprinting, reprogramming, rejuvenation, and other biochemical, metabolic, and physiological phenomena associated with embryogenesis.
摘要翻译：使用与人或非人类移植受体组织相容的细胞和组织提供改进的细胞治疗方法。本发明生产的用于移植的细胞和组织表现出年轻状态，并且可以致力于特定的细胞谱系，以在期望的靶，例如需要细胞替代疗法的组织或器官中更好地渗透和增殖。为了提供用于移植到非人哺乳动物的细胞和组织，细胞和组织可以从通过相同种类的核转移产生的诱导胚胎中分离出来。用于移植到人中的组织相容的细胞和组织可以从一个起胚胚胎中分离出来，（i）经过基因修饰以能够在早期阶段发育，或（ii）通过人类核之间的跨物种核转移产生供体细胞和去核的受体细胞，例如非人哺乳动物的卵母细胞，或（iii）通过雄激素或雌激素产生，或由这种胚胎产生的多能干细胞产生。用于生产用于移植到人中的组织相容性细胞和组织的方法也可以用于产生用于移植到非人哺乳动物的这种细胞或组织。本发明还提供具有确定的遗传构成的模型胚胎系统，其可用于细胞和组织治疗的开发和测试方法，以及用于研究与胚胎发生相关的遗传印记，重编程，复壮和其他生物化学，代谢和生理现象。

3. 发明申请

US20060083722A1 Methods and compositions for cell therapy 审中-公开
标题翻译：细胞治疗方法和组成
公开(公告)号：US20060083722A1
公开(公告)日：2006-04-20
申请号：US10484398
申请日：2002-01-25
申请人： Jose Cibelli , Tanja Dominko
发明人： Jose Cibelli , Tanja Dominko
IPC分类号： A61K48/00 , C12N5/08
CPC分类号： A01K67/0271 , A01K2217/05 , A61K35/12 , A61K48/00 , C12N15/873 , C12N2517/02 , C12N2517/04
摘要： Improved methods of cell therapy are provided using cells and tissues that are histocompatible with a human or non-human mammal transplant recipient. The cells and tissues for transplant produced by the present invention exhibit a youthful state and can be committed to specific cell lineages to better infiltrate and proliferate at a desired target, e.g., a tissue, or organ in need of cell replacement therapy. For providing cells and tissues for transplant to a non-human mammal, the cells and tissues can be isolated from a gastrulating embryo produced by same-species nuclear transfer. Histocompatible cells and tissues for transplant to a human can be isolated from a gastrulating embryo that (i) is genetically modified to be in capable of developing beyond and early stage, or (ii) is produced by cross-species nuclear transfer between a human nuclear donor cell and an enucleated recipient cell, e.g., an oocyte, of a non-human mammal, or (iii) is produced by androgenesis or gynogenesis, or from pluripotent stem cells generated from such an embryo. Methods for producing histocompatible cells and tissues for transplant to a human can also be used to produce such cells or tissues for transplant to non-human mammals. The present invention also provides model embryonic systems having defined genetic makeup that are useful for developing and testing methods for cell and tissue therapy, and for studying genetic imprinting, reprogramming, rejuvenation, and other biochemical, metabolic, and physiological phenomena associated with embryogenesis.
摘要翻译：使用与人或非人哺乳动物移植受体组织相容的细胞和组织提供改进的细胞治疗方法。本发明生产的用于移植的细胞和组织表现出年轻状态，并且可以致力于特定的细胞谱系，以在期望的靶，例如需要细胞替代疗法的组织或器官中更好地渗透和增殖。为了提供用于移植到非人哺乳动物的细胞和组织，细胞和组织可以从通过相同种类的核转移产生的诱导胚胎中分离出来。用于移植到人的组织相容的细胞和组织可以从一个起胚胚胎中分离出来，其中（i）经遗传修饰以能够发展到超前和早期阶段，或者（ii）是通过人类核之间的跨物种核转移产生的供体细胞和去核的受体细胞，例如非人哺乳动物的卵母细胞，或（iii）通过雄激素或雌激素产生，或由这种胚胎产生的多能干细胞产生。用于生产用于移植到人中的组织相容性细胞和组织的方法也可以用于产生用于移植到非人哺乳动物的这种细胞或组织。本发明还提供具有确定的遗传构成的模型胚胎系统，其可用于细胞和组织治疗的开发和测试方法，以及用于研究与胚胎发生相关的遗传印记，重编程，复壮和其他生物化学，代谢和生理现象。

4. 发明申请

US20080076176A1 De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies 审中-公开
标题翻译：体细胞的分化和再分化以及用于细胞治疗的细胞的产生
公开(公告)号：US20080076176A1
公开(公告)日：2008-03-27
申请号：US11842074
申请日：2007-08-20
申请人： Tanja Dominko , Raymond Page
发明人： Tanja Dominko , Raymond Page
IPC分类号： C12N5/00 , C12N5/08
CPC分类号： C12N5/0618 , C12N5/16 , C12N2500/25 , C12N2500/80 , C12N2500/90 , C12N2501/13 , C12N2502/13 , C12N2506/1307
摘要： The invention provides a method for effecting the de-differentiation of a somatic cell by culturing the cell in the absence of growth factors, cytokines, or other differentiation-inducing agents, and introducing components of cytoplasm of plutipotent cells into the somatic cell and allowing the cell to de-differentiate. The method can be used with somatic cells of any type, from any species of animal. The pluripotent cells may be oocytes, blastomeres, inner cell mass cells, embryonic stem cells, embryonic germ cells, embryos consisting of one or more cells, embryoid body (embryoid) cells, moruia-derived cells, teratoma (teratocarcinoma) cells, as well as multipotent partially differentiated embryonic stem cells taken from later in the embryonic development process. After being de-differentiated, the cell can be induced to re-differentiate into a different somatic cell type. A method for de-differentiating a somatic cell and inducing it to re-differentiate into a cell of neural lineage is disclosed.
摘要翻译：本发明提供了一种通过在不存在生长因子，细胞因子或其它分化诱导剂的情况下培养细胞来实现体细胞去分化的方法，并将多能细胞的细胞质成分引入体细胞，并允许细胞去分化。该方法可以与来自任何动物种类的任何类型的体细胞一起使用。多能细胞可以是卵母细胞，卵裂球细胞，内细胞大量细胞，胚胎干细胞，胚胎生殖细胞，由一种或多种细胞组成的胚胎，胚状体（胚状体）细胞，蚕源性细胞，畸胎瘤（畸胎癌）细胞，以及作为从胚胎发育过程后期获取的多能部分分化胚胎干细胞。在被分化后，可诱导细胞重新分化成不同的体细胞类型。公开了一种使体细胞去分化并诱导其重新分化成神经谱系的细胞的方法。

5. 发明申请

US20050210537A1 Pluripotent mammalian cells 审中-公开
标题翻译：多能哺乳动物细胞
公开(公告)号：US20050210537A1
公开(公告)日：2005-09-22
申请号：US11131703
申请日：2005-05-18
申请人： Tanja Dominko , Raymond Page , Alan Colman , Todd Vaught , Vivienne Marshall
发明人： Tanja Dominko , Raymond Page , Alan Colman , Todd Vaught , Vivienne Marshall
IPC分类号： A61K48/00 , C12N5/16 , C12N15/873 , A01K67/027 , C12N5/06 , C12N5/08
CPC分类号： C12N15/873 , A61K48/00 , C12N5/16 , C12N2506/04 , C12N2517/04 , C12N2517/10
摘要： The invention relates to a method of making pluripotent stem cells that does not involve the formation of early preimplantation embryos or fetal tissue. The method has general utility in the production of pluripotent stem cells from many mammalian species but has particular application in man where pluripotent stem cell production can be customized to particular human individual. The method involves the fusion of donor somatic or stem cells (or their karyoplasts) with cytoplasmic, membrane-delimited fragments of mammalian oocytes or zygotes. After the initial genomic reprogramming occurs, the cells can proliferate and thus multiply in vitro yielding a large number of autologous cells for cell therapy application. The result of this process is a cell population genomically identical to the somatic, differentiated cells derived from an individual patient. However, these cells are pluripotent in that upon application of specific growth factors, the cells are capable of differentiating into specific cell types as required by the sought clinical indication.
摘要翻译：本发明涉及一种制造不涉及早期植入前胚胎或胎儿组织的形成的多能干细胞的方法。该方法在许多哺乳动物物种的多能干细胞的生产中具有普遍的用途，但在人类中具有特殊应用，其中多能干细胞的生产可以根据具体的个体进行定制。该方法涉及供体体细胞或干细胞（或它们的核型）与哺乳动物卵母细胞或合子的细胞质膜分离的片段的融合。在初始基因组重编程发生后，细胞可以增殖并因此在体外繁殖产生大量用于细胞治疗应用的自体细胞。该过程的结果是与来自个体患者的体细胞分化细胞基因相同的细胞群体。然而，这些细胞是多能的，因为在应用特定生长因子时，细胞能够根据寻求的临床适应症的要求将其分化成特定的细胞类型。

6. 发明申请

US20110286978A1 Genetically Intact Induced Pluripotent Cells Or Transdifferentiated Cells And Methods For The Production Thereof 审中-公开
标题翻译：基因完整诱导多能细胞或转分化细胞及其生产方法
公开(公告)号：US20110286978A1
公开(公告)日：2011-11-24
申请号：US12787175
申请日：2010-05-25
申请人： Irina V. Klimanskaya , Shi-Jiang Lu , Robert Lanza , Michael D. West , Karen B. Chapman , Roy Geoffrey Sargent , Raymond Page , Tanja Dominko , Christopher Malcuit
发明人： Irina V. Klimanskaya , Shi-Jiang Lu , Robert Lanza , Michael D. West , Karen B. Chapman , Roy Geoffrey Sargent , Raymond Page , Tanja Dominko , Christopher Malcuit
IPC分类号： A61K35/12 , C12N5/00 , C12N15/01
CPC分类号： C12N5/0696 , C07K2319/10 , C07K2319/60 , C07K2319/71 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608
摘要： The present disclosure relates to methods for dedifferentiating and transdifferentiating recipient cells, preferably human somatic cells. These methods minimize the risk of undesired genome sequence alteration. These methods employ reprogramming factors, which may be used alone or in certain combinations with one another. These methods have application especially in the context of cell-based therapies, establishment of cell lines, and the production of genetically modified cells.
摘要翻译：本公开涉及用于去分化和转分化受体细胞，优选人体细胞的方法。这些方法使不希望的基因组序列改变的风险最小化。这些方法采用重编程因子，其可以单独使用或以某种组合使用。这些方法特别适用于基于细胞的疗法，细胞系的建立以及转基因细胞的生产。

7. 发明申请

US20100120079A1 Trans-Differentiation And Re-Differentiation Of Somatic Cells And Production Of Cells For Cell Therapies 审中-公开
标题翻译：体细胞细胞的转分化和再分化以及细胞治疗细胞的产生
公开(公告)号：US20100120079A1
公开(公告)日：2010-05-13
申请号：US12609439
申请日：2009-10-30
申请人： Raymond Page , Tanja Dominko , Christopher Malcuit
发明人： Raymond Page , Tanja Dominko , Christopher Malcuit
IPC分类号： C12N5/071 , C12N5/00 , C12Q1/02
CPC分类号： C12N5/0618 , A61K35/12 , C12N2501/70 , C12N2501/999 , C12N2506/1307
摘要： The invention provides a method for effecting the trans-differentiation of a somatic cell, i.e., the conversion of a somatic cell of one cell type into a somatic cell of a different cell type. The method is practiced by culturing a somatic cell in the presence of at least one agent selected from the group consisting of (a) cytoskeletal inhibitors and (b) inhibitors of acetylation, and (c) inhibitors of methylation, and also culturing the cell in the presence of agents or conditions that induce differentiation to a different cell type. The method is useful for producing histocompatible cells for cell therapy.
摘要翻译：本发明提供了一种用于实现体细胞的转分化的方法，即将一种细胞类型的体细胞转化成不同细胞类型的体细胞。所述方法是通过在至少一种选自（a）细胞骨架抑制剂和（b）乙酰化抑制剂）的药剂存在下培养体细胞来实施的，和（c）甲基化抑制剂，并且还将细胞培养诱导分化成不同细胞类型的药剂或病症的存在。该方法可用于生产用于细胞治疗的组织相容性细胞。

8. 发明授权

US08969290B2 Matrix scaffold with antimicrobial activity 有权
标题翻译：具有抗菌活性的基质支架
公开(公告)号：US08969290B2
公开(公告)日：2015-03-03
申请号：US13928245
申请日：2013-06-26
申请人： Marsha Rolle , Fioleda Prifti , Chris Malcuit , Terri Anne Camesano , Tanja Dominko , Denis Kole
发明人： Marsha Rolle , Fioleda Prifti , Chris Malcuit , Terri Anne Camesano , Tanja Dominko , Denis Kole
IPC分类号： A61L27/54 , C07K14/78 , C07K14/47 , C12N15/62
CPC分类号： A61L27/54 , A61L2300/404 , C07K14/4723 , C07K14/78 , C07K2319/00 , C12N15/62
摘要： The invention provides a scaffold of extracellular matrix polymers with recombinant chimeric peptides tethered thereto. The invention also provides recombinant chimeric peptides of antimicrobial peptides and extracellular matrix binding domains. The invention also provides methods for treating chronic wounds using the scaffold and/or recombinant chimeric peptides.
摘要翻译：本发明提供了具有与其连接的重组嵌合肽的细胞外基质聚合物的支架。本发明还提供抗微生物肽和细胞外基质结合结构域的重组嵌合肽。本发明还提供了使用支架和/或重组嵌合肽治疗慢性伤口的方法。

9. 发明申请

US20130095078A1 METHODS FOR REGENERATING SKELETAL MUSCLE 审中-公开
标题翻译：用于再生骨骼肌肉的方法
公开(公告)号：US20130095078A1
公开(公告)日：2013-04-18
申请号：US13634075
申请日：2011-03-11
申请人： Christopher Malcuit , Tanja Dominko , Raymond Lynn Page , George D. Pins , Jennifer Makridakis
发明人： Christopher Malcuit , Tanja Dominko , Raymond Lynn Page , George D. Pins , Jennifer Makridakis
IPC分类号： A61K38/39 , A61M37/00 , A61K35/12 , A61K35/34 , A61K35/44
CPC分类号： A61K38/39 , A61K35/33 , A61K35/34 , A61K35/44 , A61L27/225 , A61L27/24 , A61L27/38 , A61M37/00
摘要： An engineered muscle construct in the form of a braided collagen microthread scaffold is provided. The microthread scaffold can be used with or without cells as engineered skeletal muscle. The microthread scaffold can also be used to promote cell attachment and growth to deliver cells to a large muscle defect to stimulate muscle regeneration. Methods for making a muscle construct, seeding cells onto microthread scaffolds and treating muscle defects are also provided.
摘要翻译：提供了一种以编织胶原微结构支架形式的工程肌肉构造。微型支架可用于或不使用细胞作为工程骨骼肌。微观支架也可用于促进细胞附着和生长，以将细胞递送至大的肌肉缺陷以刺激肌肉再生。还提供了制备肌肉构造物，将细胞接种到微型支架上并治疗肌肉缺陷的方法。

10. 发明授权

US10449271B2 Matrix scaffold with antimicrobial activity 有权
公开(公告)号：US10449271B2
公开(公告)日：2019-10-22
申请号：US15943163
申请日：2018-04-02
申请人： Marsha Rolle , Fioleda Prifti , Christopher Malcuit , Terri Anne Camesano , Tanja Dominko , Denis Kole
发明人： Marsha Rolle , Fioleda Prifti , Christopher Malcuit , Terri Anne Camesano , Tanja Dominko , Denis Kole
IPC分类号： A61L27/54 , C07K14/78 , C07K14/47 , C12N15/62
摘要： The invention provides a scaffold of extracellular matrix polymers with recombinant chimeric peptides tethered thereto. The invention also provides recombinant chimeric peptides of antimicrobial peptides and extracellular matrix binding domains. The invention also provides methods for treating chronic wounds using the scaffold and/or recombinant chimeric peptides.

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