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1. 发明授权

US07232460B2 Nanodevices, microdevices and sensors on in-vivo structures and method for the same 失效
标题翻译：纳米器件，微型器件和传感器的体内结构及方法相同
公开(公告)号：US07232460B2
公开(公告)日：2007-06-19
申请号：US10132555
申请日：2002-04-25
申请人： Julian Van Erlach , Arlen L. Olsen , Jeffrey M. Smith , Laura B. Smith , Gerald E. Bender , Audra L. Stinchcomb , Denis P. Donnelly , James E. Peterson , Roger D. Whitmer , Gerald F. Dudding , Mark D. Scott
发明人： Julian Van Erlach , Arlen L. Olsen , Jeffrey M. Smith , Laura B. Smith , Gerald E. Bender , Audra L. Stinchcomb , Denis P. Donnelly , James E. Peterson , Roger D. Whitmer , Gerald F. Dudding , Mark D. Scott
IPC分类号： A61F2/06 , A61B5/00
CPC分类号： A61F2/82 , A61B5/0031 , A61B5/0084 , A61B5/02007 , A61B5/0215 , A61B5/05 , A61B5/0538 , A61B5/07 , A61B5/14546 , A61B5/1459 , A61B5/411 , A61B5/4839 , A61B5/6862 , A61B5/6876 , A61B2562/0285 , A61N1/05
摘要： An in-vivo method and apparatus is disclosed that comprises at least one sensor for determining changes in a human's an animal's body and reporting said changes outside the body. The sensor may be embedded in a sheath. The apparatus may be used to monitor chemical or physical changes in the body fluids. Alternatively, the apparatus may be used to monitor and regulate chemical or physical levels in humans and animals.
摘要翻译：公开了一种体内方法和装置，其包括至少一个传感器，用于确定人类动物体内的变化并报告身体外部的变化。传感器可以嵌入护套中。该装置可用于监测体液中的化学或物理变化。或者，该装置可用于监测和调节人和动物中的化学或物理水平。

2. 发明授权

US5908624A Antigenic modulation of cells 失效
标题翻译：细胞的抗原调节
公开(公告)号：US5908624A
公开(公告)日：1999-06-01
申请号：US671452
申请日：1996-06-27
申请人： Mark D. Scott , John W. Eaton
发明人： Mark D. Scott , John W. Eaton
IPC分类号： A61K35/12 , A61K35/18 , A61K39/00 , C12N5/078 , A61K35/39 , C12N5/00
CPC分类号： C12N5/0644 , A61K35/18 , A61K39/001 , A61K47/48215 , A61K47/48776 , C12N5/0641 , A61K2035/124
摘要： The present invention is directed to a non-immunogenic cellular composition comprising: a cell having a cell surface and antigenic determinants on the cell surface; a linker molecule covalently attached to the cell surface; and a non-immunogenic compound (e.g., polyethylene glycol or derivative thereof) covalently attached to the linker molecule. In one embodiment, the linker molecule is covalently attached directly to the antigenic determinant on the cell surface. In an alternate embodiment, the linker molecule may be covalently attached to a non-antigenic site on the cell surface, but will camouflage the antigenic determinant on the cell surface by virtue of the long chain length of the non-immunogenic compound. Various uses of the resulting non-immunogenic cell are also provided, including a method of decreasing phagocytosis of a cell, a method of decreasing an adverse reaction to a transfusion, a method of decreasing rejection of a transplanted cell, tissue or organ, and a method of decreasing antibody-induced aggregation of cells.
摘要翻译：本发明涉及非免疫原性细胞组合物，其包含：在细胞表面上具有细胞表面和抗原决定簇的细胞; 共价连接到细胞表面的连接分子; 和共价连接到连接分子的非免疫原性化合物（例如聚乙二醇或其衍生物）。在一个实施方案中，连接体分子与细胞表面上的抗原决定簇直接共价连接。在替代实施方案中，连接体分子可以共价连接到细胞表面上的非抗原性位点，但是将通过非免疫原性化合物的长链长度伪装细胞表面上的抗原决定簇。还提供了所得非免疫原性细胞的各种用途，包括减少细胞吞噬作用的方法，减少输血不良反应的方法，减少移植的细胞，组织或器官的排斥反应的方法和减少抗体诱导的细胞聚集的方法。

3. 发明申请

US20070274945A1 High molecular weight chelation structure 失效
标题翻译：高分子量螯合结构
公开(公告)号：US20070274945A1
公开(公告)日：2007-11-29
申请号：US11441359
申请日：2006-05-25
申请人： Mark D. Scott , Jayachandran N. Kizhakkedathu
发明人： Mark D. Scott , Jayachandran N. Kizhakkedathu
IPC分类号： A61K31/785 , C08G63/91 , C08G63/48
CPC分类号： A61K31/785 , A61K47/58 , A61K47/60 , Y02A50/411
摘要： A chelation structure and method of forming and using the chelation structure. The chelation structure has a backbone that includes a linear sequence of monomeric backbone units, at least one polymer side chain, and at least one chelator side chain. The side chains are each covalently coupled to the backbone at one of the monomeric backbone units by a bond that is independently biodegradable or non-biodegradable. The chelation structure is synthesized by Radical Addition Fragmentation Transfer (RAFT), Atom Transfer Radical Polymerization (ATRP), or Free Radical Polymerization (FRP). The chelation structure, individually or in combination with a shuttle chelator, may be introduced into a mammal to bind an amount of a substance in a mammal, the substance being at least one of a metal and heme. The chelation structure has a log stability constant exceeding that of the shuttle chelator for binding the substance within cells of the mammal.
摘要翻译：一种螯合结构和形成和使用螯合结构的方法。螯合结构具有主链，其包括单体主链单元，至少一个聚合物侧链和至少一个螯合剂侧链的线性序列。侧链通过单独的可生物降解或不可生物降解的键共价偶联到单体主链单元之一的骨架上。螯合结构通过自由基加成转移（RAFT），原子转移自由基聚合（ATRP）或自由基聚合（FRP）合成。螯合结构单独地或与穿梭螯合剂组合可以引入到哺乳动物中以结合一定量的哺乳动物物质，该物质是金属和血红素中的至少一种。螯合结构的对数稳定性常数超过用于结合哺乳动物细胞内的物质的穿梭螯合剂的对数稳定性。

4. 发明授权

US06816464B1 Method, system, and computer program product for route quality checking and management 有权
标题翻译：方法，系统和计算机程序产品，用于路由质量检查和管理
公开(公告)号：US06816464B1
公开(公告)日：2004-11-09
申请号：US09660920
申请日：2000-09-13
申请人： Mark D. Scott , Anita T. Cheng
发明人： Mark D. Scott , Anita T. Cheng
IPC分类号： H04L1226
CPC分类号： H04L41/142 , H04L41/22 , H04L41/5009 , H04L43/0829 , H04L43/0852 , H04L43/087 , H04L43/50 , H04L45/70
摘要： A method, system and computer program product for route checking and management is described herein. In a voice over internet protocol environment, the invention allows for the testing of routes among various gateways. In one embodiment, gateways include routing managers for checking and storing route information. The method of the invention includes checking candidate routes for the level of quality, location and cost levels. Further, users can prioritize routes based on these criteria.
摘要翻译：本文描述了用于路由检查和管理的方法，系统和计算机程序产品。在互联网语音协议环境中，本发明允许测试各种网关之间的路由。在一个实施例中，网关包括用于检查和存储路由信息的路由管理器。本发明的方法包括检查候选路线的质量水平，位置和成本水平。此外，用户可以根据这些标准对路由进行优先级排序。

5. 发明授权

US08007784B1 Antigenic modulation of cells 有权
标题翻译：细胞的抗原调节
公开(公告)号：US08007784B1
公开(公告)日：2011-08-30
申请号：US09323765
申请日：1999-06-01
申请人： Mark D. Scott , John W. Eaton
发明人： Mark D. Scott , John W. Eaton
IPC分类号： A61K35/12 , A61K35/39 , C12N5/00
CPC分类号： A61K35/44 , A61K35/17 , A61K35/30 , A61K35/36 , A61K35/39 , A61K35/407 , A61K39/001 , A61K47/60 , A61K47/6901 , A61K2039/515 , C12N5/0006 , C12N5/0641 , C12N5/0644
摘要： The present invention is directed to a non-immunogenic cellular composition comprising: a cell having a cell surface and antigenic determinants on the cell surface; an optional linker molecule covalently attached to the cell surface; and a hydrophilic, biocompatible, non-immunogenicity providing compound or polymer (e.g., polyethylene glycol or a derivative thereof) covalently attached to the linker molecule or directly to the cell. In one embodiment, the linker molecule is covalently attached directly to the antigenic determinant on the cell surface. In an alternate embodiment, the linker molecule may be covalently attached to a non-antigenic site on the cell surface, but will camouflage the antigenic determinant on the cell surface. Various uses of the resulting non-immunogenic cell are also provided, including a method of decreasing phagocytosis of a cell, a method of decreasing an adverse reaction to a transfusion, a method of decreasing rejection of a transplanted cell, tissue or organ, and a method of decreasing antibody-induced aggregation of cells.
摘要翻译：本发明涉及非免疫原性细胞组合物，其包含：在细胞表面上具有细胞表面和抗原决定簇的细胞; 共价连接到细胞表面的任选的接头分子; 和亲水性，生物相容性，非免疫原性提供的化合物或聚合物（例如，聚乙二醇或其衍生物）共价连接到连接分子或直接连接至细胞。在一个实施方案中，连接体分子与细胞表面上的抗原决定簇直接共价连接。在替代实施方案中，连接体分子可共价连接到细胞表面上的非抗原性位点，但会伪装细胞表面上的抗原决定簇。还提供了所得非免疫原性细胞的各种用途，包括减少细胞吞噬作用的方法，减少输血不良反应的方法，减少移植的细胞，组织或器官的排斥反应的方法和减少抗体诱导的细胞聚集的方法。

6. 发明授权

US07964339B2 Cold storage of modified platelets 有权
标题翻译：改良血小板的冷藏
公开(公告)号：US07964339B2
公开(公告)日：2011-06-21
申请号：US11673287
申请日：2007-02-09
申请人： Mark D. Scott , Elisabeth Maurer
发明人： Mark D. Scott , Elisabeth Maurer
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0215 , A61K35/19 , A61K47/6901
摘要： A method for storing and using platelets and an associated platelet structure. At least one modified platelet is formed. Each modified platelet includes a platelet and at least one polymerated chemical. Each polymerated chemical includes a polymer covalently bonded directly to the platelet or includes the polymer and a linker molecule such that the linker molecule is covalently bonded to the platelet and the polymer is covalently attached to the linker molecule. The polymer of each polymerated chemical of each modified platelet is polyethylene glycol (PEG) or a PEG derivative. Forming each modified platelet does not include modifying the platelet membrane of each platelet with a glycan-modifying agent. The at least one modified platelet is stored in a temperature range below 20° C. for at least one hour. After being stored, the at least one modified platelet may be introduced into a mammal.
摘要翻译：一种用于储存和使用血小板和相关血小板结构的方法。至少形成一个改良的血小板。每个改性的血小板包括血小板和至少一种聚合化学品。每种聚合化学品包括直接共价键合到血小板上的聚合物，或包括聚合物和连接分子，使得连接体分子与血小板共价结合，并且聚合物共价连接到连接分子上。每个改性血小板的每种聚合化学品的聚合物是聚乙二醇（PEG）或PEG衍生物。形成每个修饰的血小板不包括用聚糖修饰剂修饰每个血小板的血小板膜。将至少一种修饰的血小板在低于20℃的温度范围内储存至少1小时。储存后，可将至少一种改良的血小板引入哺乳动物。

7. 发明申请

US20080193430A1 COLD STORAGE OF MODIFIED PLATELETS 有权
标题翻译：改装板冷库
公开(公告)号：US20080193430A1
公开(公告)日：2008-08-14
申请号：US11673287
申请日：2007-02-09
申请人： Mark D. Scott , Elisabeth Maurer
发明人： Mark D. Scott , Elisabeth Maurer
IPC分类号： A01N63/00 , A01N1/02
CPC分类号： A01N1/02 , A01N1/0215 , A61K35/19 , A61K47/6901
摘要： A method for storing and using platelets and an associated platelet structure. At least one modified platelet is formed. Each modified platelet includes a platelet and at least one polymerated chemical. Each polymerated chemical includes a polymer covalently bonded directly to the platelet or includes the polymer and a linker molecule such that the linker molecule is covalently bonded to the platelet and the polymer is covalently attached to the linker molecule. The polymer of each polymerated chemical of each modified platelet is polyethylene glycol (PEG) or a PEG derivative. Forming each modified platelet does not include modifying the platelet membrane of each platelet with a glycan-modifying agent. The at least one modified platelet is stored in a temperature range below 20° C. for at least one hour. After being stored, the at least one modified platelet may be introduced into a mammal.
摘要翻译：一种用于储存和使用血小板和相关血小板结构的方法。至少形成一个改良的血小板。每个改性的血小板包括血小板和至少一种聚合化学品。每种聚合化学品包括直接共价键合到血小板上的聚合物，或包括聚合物和连接分子，使得连接体分子与血小板共价结合，并且聚合物共价连接到连接分子上。每个改性血小板的每种聚合化学品的聚合物是聚乙二醇（PEG）或PEG衍生物。形成每个修饰的血小板不包括用聚糖修饰剂修饰每个血小板的血小板膜。将至少一种修饰的血小板在低于20℃的温度范围内储存至少1小时。储存后，可将至少一种改良的血小板引入哺乳动物。

8. 发明授权

US06524586B2 Enhancement of oligomeric viral immunogenicity 有权
公开(公告)号：US06524586B2
公开(公告)日：2003-02-25
申请号：US09861340
申请日：2001-05-18
申请人： Mark D. Scott
发明人： Mark D. Scott
IPC分类号： A61K3912
CPC分类号： C12N7/00 , A61K39/12 , A61K39/385 , A61K39/39 , A61K2039/6093 , C12N2710/22034 , C12N2710/22045 , C12N2710/22051
摘要： A method and structure for forming a viral-physiological structure. A naked virus having a capsid is provided. A linker molecule having a covalently attached polymer is covalently bonded to the capsid to form a polymer-protected virus. An immunogenicity of the polymer-protected virus with respect to an animal exceeds an immunogenicity of the naked virus with respect to the animal.

9. 发明授权

US08454934B2 High molecular weight chelation structure 失效
标题翻译：高分子量螯合结构
公开(公告)号：US08454934B2
公开(公告)日：2013-06-04
申请号：US11441359
申请日：2006-05-25
申请人： Mark D. Scott , Jayachandran N. Kizhakkedathu
发明人： Mark D. Scott , Jayachandran N. Kizhakkedathu
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K31/785 , A61K47/58 , A61K47/60 , Y02A50/411
摘要： A chelation structure and method of forming and using the chelation structure. The chelation structure has a backbone that includes a linear sequence of monomeric backbone units, at least one polymer side chain, and at least one chelator side chain. The side chains are each covalently coupled to the backbone at one of the monomeric backbone units by a bond that is independently biodegradable or non-biodegradable. The chelation structure is synthesized by Radical Addition Fragmentation Transfer (RAFT), Atom Transfer Radical Polymerization (ATRP), or Free Radical Polymerization (FRP). The chelation structure, individually or in combination with a shuttle chelator, may be introduced into a mammal to bind an amount of a substance in a mammal, the substance being at least one of a metal and heme. The chelation structure has a log stability constant exceeding that of the shuttle chelator for binding the substance within cells of the mammal.
摘要翻译：一种螯合结构和形成和使用螯合结构的方法。螯合结构具有主链，其包括单体主链单元，至少一个聚合物侧链和至少一个螯合剂侧链的线性序列。侧链通过单独的可生物降解或不可生物降解的键共价偶联到单体主链单元之一的骨架上。螯合结构通过自由基加成转移（RAFT），原子转移自由基聚合（ATRP）或自由基聚合（FRP）合成。螯合结构单独地或与穿梭螯合剂组合可以引入到哺乳动物中以结合一定量的哺乳动物物质，该物质是金属和血红素中的至少一种。螯合结构的对数稳定性常数超过用于结合哺乳动物细胞内的物质的穿梭螯合剂的对数稳定性。

10. 发明授权

US08067151B2 Cold storage of pegylated platelets at about or below 0° C. 有权
标题翻译：聚乙二醇化血小板在约0℃或低于0℃的冷藏
公开(公告)号：US08067151B2
公开(公告)日：2011-11-29
申请号：US12172284
申请日：2008-07-14
申请人： Elisabeth Maurer , Mark D. Scott , Nobu Kitamura
发明人： Elisabeth Maurer , Mark D. Scott , Nobu Kitamura
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0221 , A61K35/19 , A61K47/6901 , Y02A50/385
摘要： A method for storing and using platelets and an associated platelet structure. At least one modified platelet is formed. Each modified platelet includes a platelet and at least one polymerated chemical. Each polymerated chemical includes a polymer covalently bonded directly to the platelet or includes the polymer and a linker molecule such that the linker molecule is covalently bonded to the platelet and the polymer is covalently attached to the linker molecule. The polymer of each polymerated chemical of each modified platelet is polyethylene glycol (PEG) or a PEG derivative. Forming each modified platelet does not include modifying the platelet membrane of each platelet with a glycan-modifying agent. The at least one modified platelet is stored in a temperature range below 0° C. After being stored, the at least one modified platelet may be introduced into a subject to treat a condition related to a reduced platelet function.
摘要翻译：一种用于储存和使用血小板和相关血小板结构的方法。至少形成一个改良的血小板。每个改性的血小板包括血小板和至少一种聚合化学品。每种聚合化学品包括直接共价键合到血小板上的聚合物，或包括聚合物和连接分子，使得连接体分子与血小板共价结合，并且聚合物共价连接到连接体分子上。每个改性血小板的每种聚合化学品的聚合物是聚乙二醇（PEG）或PEG衍生物。形成每个修饰的血小板不包括用聚糖修饰剂修饰每个血小板的血小板膜。将至少一种改良的血小板储存在低于0℃的温度范围内。储存后，可将至少一种改良的血小板引入受试者以治疗与减少的血小板功能相关的病症。

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