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1. 发明授权

US07738953B2 Method and device for preventing plaque formation in coronary arteries 失效
标题翻译：用于预防冠状动脉斑块形成的方法和装置
公开(公告)号：US07738953B2
公开(公告)日：2010-06-15
申请号：US11203756
申请日：2005-08-15
申请人： Qingsheng Zhu , Avram Scheiner , Julio C. Spinelli
发明人： Qingsheng Zhu , Avram Scheiner , Julio C. Spinelli
IPC分类号： A61N1/36
CPC分类号： A61N1/326 , A61N1/0587
摘要： A method and device for preventing plaque build-up in a coronary artery includes providing an electrical field generating device, and generating an electrical field in the coronary artery to prevent plaque build-up in the coronary artery. The method further includes sensing the heart rhythm and generating the electrical field after a depolarization wave in the heart. The electrical field is generated by circuitry, in one embodiment implanted circuitry, connected to leads which are epicardially or intracardially positioned on the heart.
摘要翻译：用于防止冠状动脉斑块积聚的方法和装置包括提供电场产生装置，并且在冠状动脉中产生电场以防止冠状动脉中的斑块积聚。该方法还包括感测心脏节律并在心脏中去极化波之后产生电场。电场由电路产生，在一个实施例中，植入电路连接到心外膜或心内置于心脏上的引线。

2. 发明申请

US20080221635A1 IMPLANTABLE CARDIAC RHYTHM MANAGEMENT SYSTEM HAVING MULTIPLE THERAPY MODALITIES 有权
标题翻译：具有多种治疗方式的可持续心脏健康管理系统
公开(公告)号：US20080221635A1
公开(公告)日：2008-09-11
申请号：US12048144
申请日：2008-03-13
申请人： Julio C. Spinelli , Qingsheng Zhu , Bruce H. Kenknight , Yinghong Yu , Jiang Ding
发明人： Julio C. Spinelli , Qingsheng Zhu , Bruce H. Kenknight , Yinghong Yu , Jiang Ding
IPC分类号： A61N1/365
CPC分类号： A61N1/3627
摘要： A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.
摘要翻译：一种用于提供多种治疗方式的心律管理系统。例如，该系统可以包括用于提供心脏再同步治疗的心脏再同步治疗模块和用于提供心动过缓治疗的起搏器模块，以及耦合到心脏再同步治疗模块和心动过缓模块的选择器模块。选择器模块可以从包括心脏再同步治疗模块和起搏器模块的多个操作模式中选择操作模式。可以使用各种手动和自动方法来选择操作模式。此外，还可以包括回归管理系统以帮助心律管理系统在系统中断的情况下恢复。

3. 发明授权

US07177681B2 Cardiac rhythm management system for edema 有权
公开(公告)号：US07177681B2
公开(公告)日：2007-02-13
申请号：US10411795
申请日：2003-04-11
申请人： Qingsheng Zhu , Julio C. Spinelli
发明人： Qingsheng Zhu , Julio C. Spinelli
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3684
摘要： A cardiac rhythm management system detects edema. In response to an episode of detected edema, it initiates or adjusts a cardiac resynchronization therapy and/or a cardiac contractility modulation (CCM) therapy.

4. 发明授权

US06980851B2 Method and apparatus for determining changes in heart failure status 失效
标题翻译：用于确定心力衰竭状态变化的方法和装置
公开(公告)号：US06980851B2
公开(公告)日：2005-12-27
申请号：US10001223
申请日：2001-11-15
申请人： Qingsheng Zhu , Julio C. Spinelli , Bruce H. KenKnight , Jay A. Warren
发明人： Qingsheng Zhu , Julio C. Spinelli , Bruce H. KenKnight , Jay A. Warren
IPC分类号： A61N1/362 , A61N1/365 , A61B5/0402
CPC分类号： A61N1/3627 , A61N1/36585
摘要： A method for operating a cardiac rhythm management device in which a clinical state vector is computed as a combination of a plurality of parameters related to a patient's heart failure status and compared to a previously computed clinical state vector to determine a clinical trajectory indicative of changes in the patient's heart failure status. Such detected changes in status can be used both as a clinical tool to evaluate treatment and to automatically adjust the operation of the device.
摘要翻译：一种用于操作心律管理装置的方法，其中临床状态矢量被计算为与患者心力衰竭状态相关的多个参数的组合，并且与先前计算的临床状态向量进行比较，以确定指示变化的临床轨迹患者的心力衰竭状态。这种检测到的状态变化可以用作临床工具来评估治疗并自动调整装置的操作。

5. 发明授权

US06915163B2 Apparatus and method for testing and adjusting a bipolar stimulation configuration 有权
公开(公告)号：US06915163B2
公开(公告)日：2005-07-05
申请号：US10634202
申请日：2003-08-05
申请人： Julio C. Spinelli , Qingsheng Zhu
发明人： Julio C. Spinelli , Qingsheng Zhu
IPC分类号： A61N1/362 , A61N1/37 , A61N1/365
CPC分类号： A61N1/3627 , A61N1/371
摘要： A system and method for measuring the capture threshold of a bipolar lead in order to determine an appropriate value for the stimulus pulse energy to be used with the lead by a cardiac rhythm management device. An appropriate bipolar stimulating configuration can also be determined. The method is particularly useful in testing bipolar leads used to excite the left ventricle such as when delivering cardiac resynchronization therapy.

6. 发明授权

US06909916B2 Cardiac rhythm management system with arrhythmia classification and electrode selection 有权
公开(公告)号：US06909916B2
公开(公告)日：2005-06-21
申请号：US10027800
申请日：2001-12-20
申请人： Julio C. Spinelli , Qingsheng Zhu , Jeffrey E. Stahmann , Andrew P. Kramer
发明人： Julio C. Spinelli , Qingsheng Zhu , Jeffrey E. Stahmann , Andrew P. Kramer
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/3684
摘要： A system, method, or device classifies an arrhythmia according to the temporal order in which a depolarization wave associated with a particular heart contraction is received at a plurality of electrodes. One or more antiarrhythmia therapies is mapped to each arrhythmia classification. When a particularly classified arrhythmia is detected, the correspondingly mapped therapy list is selected and an appropriate antiarrhythmia therapy delivered. In one example, the particular therapy delivered in response to an arrhythmia depends at least in part on its historical success in treating arrhythmias of that classification.

7. 发明授权

US08532771B2 Maximum pacing rate limiter system 失效
标题翻译：最大起搏速率限制系统
公开(公告)号：US08532771B2
公开(公告)日：2013-09-10
申请号：US13115825
申请日：2011-05-25
申请人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio C. Spinelli
发明人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio C. Spinelli
IPC分类号： A61N1/365
CPC分类号： A61N1/365
摘要： A maximum pacing rate limiter for use in adaptive rate pacing in conjunction with a cardiac rhythm management system for a heart. The maximum pacing rate limiter may function to measure an interval, termed the ERT interval, between a paced ventricular evoked response and a T-wave. The maximum pacing rate limiter may further function to maintain the ERT interval at less than a certain percentage of the total cardiac cycle. In one disclosed embodiment, a maximum pacing rate limiter calculates an ERT rate based on the detected paced ventricular evoked response and the T-wave, and the pacing rate limiter module further communicates the minimum of the ERT rate and an adaptive-rate sensor indicated rate to a pacemaker.
摘要翻译：与心脏心律管理系统结合使用的适应性起搏速度的最大起搏速率限制器。最大起搏速率限制器可以用于测量在起搏心室诱发反应和T波之间的称为ERT间期的间隔。最大起搏速率限制器可进一步起作用以将ERT间期维持在小于总心律周期的一定百分比。在一个公开的实施例中，最大起搏速率限制器基于检测到的起搏心室诱发反应和T波计算ERT率，并且起搏速率限制器模块进一步传达最小ERT率和自适应速率传感器指示率到起搏器。

8. 发明授权

US08498703B2 Method and system for treatment of neurocardiogenic syncope 有权
公开(公告)号：US08498703B2
公开(公告)日：2013-07-30
申请号：US13235599
申请日：2011-09-19
申请人： Julio C. Spinelli , Qingsheng Zhu
发明人： Julio C. Spinelli , Qingsheng Zhu
IPC分类号： A61N1/16
CPC分类号： A61N1/3627 , A61N1/36564
摘要： A method and apparatus for treating or preventing neurocardiogenic syncope is disclosed. Upon detection of bradycardia or a drop in blood pressure indicating the onset of syncope, electrostimulation pulses are delivered during the heart's refractory period. The pulses are non-excitatory but increase myocardial contractility and thereby increase cardiac output.

9. 发明授权

US08024040B2 Method and system for treatment of neurocardiogenic syncope 有权
标题翻译：治疗神经心源性晕厥的方法和系统
公开(公告)号：US08024040B2
公开(公告)日：2011-09-20
申请号：US10862831
申请日：2004-06-07
申请人： Julio C. Spinelli , Qingsheng Zhu
发明人： Julio C. Spinelli , Qingsheng Zhu
IPC分类号： A61N1/16
CPC分类号： A61N1/3627 , A61N1/36564
摘要： A method and apparatus for treating or preventing neurocardiogenic syncope is disclosed. Upon detection of bradycardia or a drop in blood pressure indicating the onset of syncope, electrostimulation pulses are delivered during the heart's refractory period. The pulses are non-excitatory but increase myocardial contractility and thereby increase cardiac output.
摘要翻译：公开了用于治疗或预防神经心源性晕厥的方法和装置。一旦检测到心动过缓或血压下降，表明晕厥发作，电刺激脉搏在心脏不应期期间输送。脉冲是非兴奋性的，但增加心肌收缩力，从而增加心输出量。

10. 发明授权

US07970471B2 Capture verification for cardiac resynchronization pacing optimization 有权
标题翻译：捕获心脏再同步起搏优化的验证
公开(公告)号：US07970471B2
公开(公告)日：2011-06-28
申请号：US11776699
申请日：2007-07-12
申请人： Qingsheng Zhu , Julio C. Spinelli , Jiang Ding , Yinghong Yu
发明人： Qingsheng Zhu , Julio C. Spinelli , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/18
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3688 , A61N1/371
摘要： A system and method for automatically selecting among a plurality of pacing modes based upon capture detection. Patients suffering from heart failure may be optimally treated with different resynchronization pacing modes or configurations. By detecting whether capture is being achieved by a particular configuration or mode, a device is able to automatically switch to one that is both optimal in treating the patient and is successful in capturing the heart with pacing pulses.
摘要翻译：一种用于基于捕获检测在多个起搏模式之间自动选择的系统和方法。患有心力衰竭的患者可以用不同的再同步起搏模式或配置进行最佳治疗。通过检测是否通过特定配置或模式实现捕获，设备能够自动切换到在治疗患者时是最佳的并且成功地用起搏脉冲捕获心脏。

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