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1. 发明授权

US09572982B2 Techniques for placing medical leads for electrical stimulation of nerve tissue 有权
标题翻译：放置用于电刺激神经组织的医疗线的技术
公开(公告)号：US09572982B2
公开(公告)日：2017-02-21
申请号：US12433766
申请日：2009-04-30
申请人： John E. Burnes , Kenneth C. Gardeski , Ruth N. Klepfer , Patrick E. Macaulay , Mary M. Morris , Avram Scheiner
发明人： John E. Burnes , Kenneth C. Gardeski , Ruth N. Klepfer , Patrick E. Macaulay , Mary M. Morris , Avram Scheiner
IPC分类号： A61B19/00 , A61N1/36 , A61N1/05 , A61M25/09
CPC分类号： A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
摘要： This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient.
摘要翻译：本公开涉及用于在患者体内靠近神经组织布置医疗引线和电刺激和/或感测电极的额外的，内部的和经血管内的医疗引线放置技术。

2. 发明授权

US09026206B2 Therapy system including cardiac rhythm therapy and neurostimulation capabilities 有权
标题翻译：治疗系统包括心律治疗和神经刺激能力
公开(公告)号：US09026206B2
公开(公告)日：2015-05-05
申请号：US12610160
申请日：2009-10-30
申请人： Paul G. Krause , Avram Scheiner
发明人： Paul G. Krause , Avram Scheiner
IPC分类号： A61N1/362 , A61N1/36 , A61N1/365
CPC分类号： A61N1/36114 , A61N1/36514 , A61N1/36521
摘要： An implantable medical system that includes a cardiac therapy module and a neurostimulation therapy module may identify when neurostimulation electrodes have migrated toward a patient's heart. In some examples, the system may determine whether the neurostimulation electrodes have migrated toward the patient's heart based on a physiological response to an electrical signal delivered to the patient via the neurostimulation electrodes. In addition, in some examples, the system may determine whether the neurostimulation electrodes have migrated toward the patient's heart based on an electrical cardiac signal sensed via the neurostimulation electrodes.
摘要翻译：包括心脏治疗模块和神经刺激治疗模块的可植入医疗系统可以识别神经刺激电极何时向患者的心脏移动。在一些示例中，系统可以基于对通过神经刺激电极递送给患者的电信号的生理反应来确定神经刺激电极是否已经向患者的心脏迁移。此外，在一些示例中，系统可以基于经由神经刺激电极感测的电心脏信号来确定神经刺激电极是否已经向患者的心脏迁移。

3. 发明授权

US08660638B2 Syncope logbook and method of using same 有权
标题翻译：晕厥日志及其使用方法
公开(公告)号：US08660638B2
公开(公告)日：2014-02-25
申请号：US12616536
申请日：2009-11-11
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Jesse W. Hartley , Avram Scheiner
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Jesse W. Hartley , Avram Scheiner
IPC分类号： A61B5/0402
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/02405 , A61B5/0402 , A61B5/0476 , A61B5/11 , A61B5/1116 , A61B5/145 , A61B5/14532 , A61B5/14546 , A61N1/362 , A61N1/37247 , G06F19/00 , G06F19/3418 , G06F19/3481 , G16H40/63
摘要： Methods and systems are directed to acquiring and organizing information associated with at least one syncope event. A syncope event may be a suspected syncope event, a verified syncope event or a syncope event that is suspected and verified. Automated processes are used to collect information associated with at least one syncope event and organize the information as a syncope log entry. At least one of acquiring the information and organizing the information is performed at least in part implantably.
摘要翻译：方法和系统旨在获取和组织与至少一个晕厥事件相关联的信息。晕厥事件可能是疑似晕厥事件，经过验证的晕厥事件或怀疑和验证的晕厥事件。自动进程用于收集与至少一个晕厥事件相关的信息，并将该信息组织为晕厥日志条目。至少部分地可植入地执行获取信息和组织信息中的至少一个。

4. 发明授权

US08634921B2 Implantable and rechargeable neural stimulator 有权
标题翻译：可植入和可充电的神经刺激器
公开(公告)号：US08634921B2
公开(公告)日：2014-01-21
申请号：US13402196
申请日：2012-02-22
申请人： Abhi V. Chavan , Anthony V. Caparso , Avram Scheiner
发明人： Abhi V. Chavan , Anthony V. Caparso , Avram Scheiner
IPC分类号： A61N1/05
CPC分类号： A61N1/36117 , A61N1/3605 , A61N1/36071 , A61N1/36135 , A61N1/37205 , A61N1/37217 , A61N1/37288 , A61N1/3787
摘要： One aspect of the present subject matter relates to an implantable medical device. An embodiment of the device comprises a rechargeable power supply adapted to be recharged through an ultrasound signal, a neural stimulator connected to the rechargeable power supply, and a controller connected to the rechargeable power supply. The neural stimulator is adapted to generate a neural stimulation signal for delivery to a neural stimulation target through an electrode. The controller is further connected to the neural stimulator to control the neural stimulator according to a neural stimulation protocol. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及可植入医疗装置。该装置的实施例包括适于通过超声信号再充电的可再充电电源，连接到可再充电电源的神经刺激器和连接到可再充电电源的控制器。神经刺激器适于产生用于通过电极递送到神经刺激靶的神经刺激信号。控制器进一步连接到神经刺激器，以根据神经刺激方案来控制神经刺激器。本文提供了其他方面。

5. 发明授权

US08583235B2 Cardiac rhythm management system and method 有权
公开(公告)号：US08583235B2
公开(公告)日：2013-11-12
申请号：US13494785
申请日：2012-06-12
申请人： Qingsheng Zhu , Avram Scheiner
发明人： Qingsheng Zhu , Avram Scheiner
IPC分类号： A61N1/00
CPC分类号： A61N1/3712
摘要： A system and method for cardiac rhythm management, which includes an electrode system having at least one electrode and control circuitry coupled to the electrode system from which a first cardiac signal is sensed. The control circuitry includes a pulse circuit to produce electrical pulses at a first value to be delivered to the electrode system in a first cardiac region. At least one cardiac signal is sensed from a second cardiac region, where the cardiac signal includes indications of cardiac depolarizations from the second cardiac region which occurs in direct reaction to the electrical pulses delivered to the first cardiac region. The first value of the electrical pulses are then modified by a pulse adjustment circuit when a cardiac depolarization which occurs in direct reaction to the electrical pulse delivered to the first cardiac region is detected from the second cardiac region.

6. 发明授权

US08532793B2 Techniques for placing medical leads for electrical stimulation of nerve tissue 有权
标题翻译：放置用于电刺激神经组织的医疗线的技术
公开(公告)号：US08532793B2
公开(公告)日：2013-09-10
申请号：US12433809
申请日：2009-04-30
申请人： Mary M. Morris , Avram Scheiner , Ruth N. Klepfer , John E. Burnes
发明人： Mary M. Morris , Avram Scheiner , Ruth N. Klepfer , John E. Burnes
IPC分类号： A61N1/00
CPC分类号： A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
摘要： This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient.
摘要翻译：本公开涉及用于在患者体内靠近神经组织布置医疗引线和电刺激和/或感测电极的额外的，内部的和经血管内的医疗引线放置技术。

7. 发明授权

US08473076B2 Lead for stimulating the baroreceptors in the pulmonary artery 有权
标题翻译：用于刺激肺动脉中的压力感受器的铅
公开(公告)号：US08473076B2
公开(公告)日：2013-06-25
申请号：US13225769
申请日：2011-09-06
申请人： Imad Libbus , Ronald W. Heil, Jr. , Avram Scheiner
发明人： Imad Libbus , Ronald W. Heil, Jr. , Avram Scheiner
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/0476 , A61N1/05 , A61N1/056 , A61N1/057 , A61N1/36117
摘要： An apparatus includes a flexible lead body extending from a proximal end to a distal end, an expandable electrode coupled proximate the distal end, the expandable electrode having an expanded diameter dimensioned to abut a wall of a pulmonary artery, and an implantable pulse generator electrically coupled to the expandable electrode. The expandable electrode includes a plurality of electrode zones. The plurality of zones can be tested to determine which zone delivers the best baroreflex response. At least one of the electrode zones can be selected to deliver a stimulation signal based on the testing. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.
摘要翻译：一种装置包括从近端延伸到远端的柔性引线主体，靠近远端连接的可扩张电极，所述可扩张电极具有尺寸设计成邻接肺动脉壁的扩张直径，以及电耦合的可植入脉冲发生器到可膨胀电极。可膨胀电极包括多个电极区。可以测试多个区域以确定哪个区域提供最佳的压力反射响应。可以选择至少一个电极区域以基于测试传递刺激信号。可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。

8. 发明授权

US08204594B2 Cardiac rhythm management system and method 有权
标题翻译：心律管理系统及方法
公开(公告)号：US08204594B2
公开(公告)日：2012-06-19
申请号：US12974837
申请日：2010-12-21
申请人： Qingsheng Zhu , Avram Scheiner
发明人： Qingsheng Zhu , Avram Scheiner
IPC分类号： A61N1/00
CPC分类号： A61N1/3712
摘要： A system and method for cardiac rhythm management, which includes an electrode system having at least one electrode and control circuitry coupled to the electrode system from which a first cardiac signal is sensed. The control circuitry includes a pulse circuit to produce electrical pulses at a first value to be delivered to the electrode system in a first cardiac region. At least one cardiac signal is sensed from a second cardiac region, where the cardiac signal includes indications of cardiac depolarizations from the second cardiac region which occurs in direct reaction to the electrical pulses delivered to the first cardiac region. The first value of the electrical pulses are then modified by a pulse adjustment circuit when a cardiac depolarization which occurs in direct reaction to the electrical pulse delivered to the first cardiac region is detected from the second cardiac region.
摘要翻译：一种用于心律管理的系统和方法，其包括具有耦合到所述电极系统的至少一个电极和控制电路的电极系统，从所述电极系统感测到第一心脏信号。控制电路包括脉冲电路，以在第一心脏区域产生将被传送到电极系统的第一值的电脉冲。从第二心脏区域感测至少一个心脏信号，其中心脏信号包括来自第二心脏区域的心脏去极化的指示，其发生在与递送至第一心脏区域的电脉冲直接反应中。当从第二心脏区域检测到与传送到第一心脏区域的电脉冲直接反应发生的心脏去极化时，脉冲调节电路修改电脉冲的第一值。

9. 发明授权

US08126560B2 Stimulation lead for stimulating the baroreceptors in the pulmonary artery 有权
标题翻译：刺激肺动脉压力感受器的刺激
公开(公告)号：US08126560B2
公开(公告)日：2012-02-28
申请号：US10746852
申请日：2003-12-24
申请人： Avram Scheiner , Ronald W. Heil, Jr. , Peter T. Kelley
发明人： Avram Scheiner , Ronald W. Heil, Jr. , Peter T. Kelley
IPC分类号： A61N1/18 , A61N1/362
CPC分类号： A61N1/057 , A61N1/36117
摘要： An apparatus includes a flexible lead body extending from a proximal end to a distal end, the distal end having a biased portion having an outer diameter dimensioned to abut a wall of a pulmonary artery, an electrode coupled proximate the distal end, and an implantable pulse generator electrically coupled to the electrode. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.
摘要翻译：一种装置包括从近端延伸到远端的柔性引线体，所述远端具有偏压部分，所述偏压部分的外径尺寸设计成邻接肺动脉壁，邻近远端连接的电极和可植入脉冲发电机电耦合到电极。可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。

10. 发明授权

US07738970B2 Medical electrical lead employing load bearing sleeve 失效
标题翻译：医用电线使用承载套
公开(公告)号：US07738970B2
公开(公告)日：2010-06-15
申请号：US11643224
申请日：2006-12-21
申请人： Randy Westlund , Mohan Krishnan , Avram Scheiner
发明人： Randy Westlund , Mohan Krishnan , Avram Scheiner
IPC分类号： A61N1/02
CPC分类号： A61N1/056 , A61N2001/0578 , A61N2001/0585
摘要： A medical electrical lead employs a load bearing sleeve arrangement. A medical electrical lead includes an outer sleeve, having proximal and distal ends, and is formed of a first material. At least one electrical conductor is situated within the outer sleeve and extends between the proximal and distal ends of the outer sleeve. At least one electrode is electrically coupled to the electrical conductor. A load bearing sleeve extends between the proximal and distal ends of the outer sleeve. The load bearing sleeve is formed of a second material different from the first material. The load bearing sleeve offers resistance to axial loading forces applied to the lead. The load bearing sleeve can be coextensive with the outer sleeve or extend along at least the majority of the length of the outer sleeve.
摘要翻译：医用电线使用承载套筒装置。医用电线包括具有近端和远端的外套，并由第一材料形成。至少一个电导体位于外套筒内并且在外套筒的近端和远端之间延伸。至少一个电极电耦合到电导体。承载套筒在外套筒的近端和远端之间延伸。承载套筒由不同于第一材料的第二材料形成。承载套筒提供抵抗施加到引线的轴向载荷力。承载套筒可以与外套筒共同延伸或者沿外套筒的至少大部分长度延伸。

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