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    • 4. 发明授权
    • Fiber unbalanced Mach-Zehnder interferometers with flat-top spectral response for application in wavelength division multiplexers
    • 光纤不平衡马赫 - 曾德干涉仪,具有平顶光谱响应,适用于波分复用器
    • US06263128B1
    • 2001-07-17
    • US09324238
    • 1999-06-02
    • Chi-Hung Huang
    • Chi-Hung Huang
    • G02B628
    • G02B6/29352G02B6/29319G02B6/29358G02B6/2938
    • According to the present invention, a multi-window wavelength division multiplexer (MWDM) is coupled to a correcting filter characterized by a shallow modulation depth and a channel separation smaller than the MWDM. A correcting filter is coupled to an input of the MWDM or to each of the two outputs of the MWDM. By changing the modulation depth and/or channel separation of the correcting filter(s), the spectral response of the filter can be adjusted to produce a more uniform gain (i.e., a “flat-top” spectral response) across wavelengths of passbands within the MWDM. In one embodiment, the correcting filter is an unbalanced Mach-Zehnder interferometer formed with two fused-fiber couplers having non-equal splitting ratios. In other embodiments, the correcting filter is a Fabry-Perot interferometer having a low end-face reflectivity.
    • 根据本发明,多窗口波分多路复用器(MWDM)耦合到校正滤波器,其特征在于浅调制深度和小于MWDM的信道分离。 校正滤波器耦合到MWDM的输入或MWDM的两个输出中的每一个。 通过改变校正滤波器的调制深度和/或信道间隔,可以调整滤波器的频谱响应,以在多个通带波长内产生更均匀的增益(即,“平顶”频谱响应) MWDM。 在一个实施例中,校正滤波器是由具有不相等分离比的两个熔接光纤耦合器形成的不平衡马赫 - 曾德干涉仪。 在其他实施例中,校正滤波器是具有低端面反射率的法布里 - 珀罗干涉仪。
    • 6. 发明申请
    • SYNTHESIS AND ANTICANCER ACTIVITY OF ARYL AND HETEROARYL-QUINOLIN DERIVATIVES
    • 芳基和喹啉衍生物的合成和反应活性
    • US20120015908A1
    • 2012-01-19
    • US13181978
    • 2011-07-13
    • Sheng-Chu KuoKuo-Hsiung LeeLi-Jiau HuangLi-Chen ChouTian-Shung WuTzong-Der WayJing-Gung ChungJai-Sing YangChi-Hung HuangMeng-Tung Tsai
    • Sheng-Chu KuoKuo-Hsiung LeeLi-Jiau HuangLi-Chen ChouTian-Shung WuTzong-Der WayJing-Gung ChungJai-Sing YangChi-Hung HuangMeng-Tung Tsai
    • A61K31/675A61K31/47C07D491/056A61K31/4741C07F9/60A61P35/00A61K31/5377C07D405/14A61K31/4709C07D413/10C07D401/10C07D215/233C07D413/14
    • C07D493/04C07D215/22C07D215/233C07D215/38C07D401/04C07F9/60C07F9/65583C07F9/6561
    • A compound of Formula I is disclosed as follows: or a pharmaceutically acceptable salt, prodrug, solvate, or metabolite thereof, wherein R is hydrogen, P(═O)(OH)2, P(═O)(O(C1-C18)alkylene(C6-C20)aryl)2, P(═O)(OH)(OM), P(═O)(OM)2, P═O(O2M), S(═O)(OH)2, S(═O)(O(C1-C18)alkylene(C6-C20)aryl)2, S(═O)(OH)(OM), S(═O)(OM)2; M is a monovalent or divalent metal ion, or alkylammonium ion; W is (C6-C20)aryl, (C6-C20)heteroaryl, (C1-C18)alkyl(C6-C20)aryl, (C1-C18)alkyl(C6-C20)heteroaryl, hydroxy(C6-C20)aryl, hydroxy(C6-C20)heteroaryl, (C1-C18)alkoxy(C6-C20)aryl, (C1-C18)alkoxy(C6-C20)heteroaryl, (C1-C18)alkylenedioxy(C6-C20)aryl, (C1-C18)alkylenedioxy(C6-C20)heteroaryl, halo(C6-C20)aryl, halo(C6-C20)heteroaryl, (C1-C18)alkylamino(C6-C20)aryl, (C1-C18)alkylamino(C6-C20)heteroaryl, (C1-C18)cycloalkylamino(C6-C20)aryl, or (C1-C18)cycloalkylamino(C6-C20)heteroaryl, and their OR8 substutes; R5 is (C1-C18alkoxy, hydrogen, hydroxyl, O—(C1-C18)alkyl(C6-C20)aryl, halo or OR8, or R5 and R6 are (C1-C18)dioxy provided that R7 is hydrogen; R6 is hydroxyl, O—(C1-C18)alkyl(C6-C20)aryl, halo or ORR, (C1-C18)alkoxy, (C1-C18)alkylamino, or (C1-C18)cycloalkylamino, or R6 and R7 are (C1-C18)dioxy provided that R5 is hydrogen; R7 is hydrogen, halo or OR8, hydroxyl, or O—(C1-C18)alkyl(C6-C20)aryl; and R8 is P(═O)(OH)2, P(═O)(O(C1-C18)alkyl(C6-C20)aryl)2, P(═O)(OH)(OM), or P(═O)(OM)2, P═O(O2M).
    • 式I的化合物公开如下:或其药学上可接受的盐,前药,溶剂合物或代谢物,其中R是氢,P(= O)(OH)2,P(= O)(O(C 1 -C 18) )亚烷基(C 6 -C 20)芳基)2,P(= O)(OH)(OM),P(= O)(OM)2,P = O(O 2 M) S(ΟO)(O(C1-C18)亚烷基(C6-C20)芳基)2,S(═0)(OH)(OM),S(ΟO)(OM) M是一价或二价金属离子或烷基铵离子; W是(C 6 -C 20)芳基,(C 6 -C 20)杂芳基,(C 1 -C 18)烷基(C 6 -C 20)芳基,(C 1 -C 18)烷基(C 6 -C 20) 羟基(C 6 -C 20)杂芳基,(C 1 -C 18)烷氧基(C 6 -C 20)芳基,(C 1 -C 18)烷氧基(C 6 -C 20)杂芳基,(C 1 -C 18)亚烷基二氧基 C 1 -C 20烷基氨基(C 6 -C 20)芳基,(C 1 -C 20)芳基,(C 1 -C 20)芳基, 杂芳基,(C1-C18)环烷基氨基(C6-C20)芳基或(C1-C18)环烷基氨基(C6-C20)杂芳基及其OR8分子; R5是(C1-C18烷氧基,氢,羟基,O-(C1-C18)烷基(C6-C20)芳基,卤素或OR8或R5和R6是(C1-C18)二氧基,条件是R7是氢; R6是羟基 ,(C 1 -C 18)烷基(C 6 -C 20)芳基,卤素或ORR,(C 1 -C 18)烷氧基,(C 1 -C 18)烷基氨基或(C 1 -C 18)环烷基氨基或R 6和R 7为 其中R 5为氢,R 7为氢,卤素或OR 8,羟基或O-(C 1 -C 18)烷基(C 6 -C 20)芳基; R 8为P(= O)(OH)2,P (O)(O(C1-C18)烷基(C6-C20)芳基)2,P(= O)(OH)(OM)或P(= O)(OM)2,P = O(O2M)。
    • 7. 发明授权
    • Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives
    • 芳基和杂芳基 - 喹啉衍生物的合成和抗癌活性
    • US08524740B2
    • 2013-09-03
    • US13181978
    • 2011-07-13
    • Sheng-Chu KuoKuo-Hsiung LeeLi-Jiau HuangLi-Chen ChouTian-Shung WuTzong-Der WayJing-Gung ChungJai-Sing YangChi-Hung HuangMeng-Tung Tsai
    • Sheng-Chu KuoKuo-Hsiung LeeLi-Jiau HuangLi-Chen ChouTian-Shung WuTzong-Der WayJing-Gung ChungJai-Sing YangChi-Hung HuangMeng-Tung Tsai
    • A61K31/04C07D215/04
    • C07D493/04C07D215/22C07D215/233C07D215/38C07D401/04C07F9/60C07F9/65583C07F9/6561
    • A compound of Formula I is disclosed as follows: or a pharmaceutically acceptable salt, prodrug, solvate, or metabolite thereof, wherein R is hydrogen, P(═O)(OH)2, P(═O)(O(C1-C18)alkylene(C6-C20)aryl)2, P(═O)(OH)(OM), P(═O)(OM)2, P═O(O2M), S(═O)(OH)2, S(═O)(O(C1-C18)alkylene(C6-C20)aryl)2, S(═O)(OH)(OM), S(═O)(OM)2; M is a monovalent or divalent metal ion, or alkylammonium ion; W is (C6-C20)aryl, (C6-C20)heteroaryl, (C1-C18)alkyl(C6-C20)aryl, (C1-C18)alkyl(C6-C20)heteroaryl, hydroxy(C6-C20)aryl, hydroxy(C6-C20)heteroaryl, (C1-C18)alkoxy(C6-C20)aryl, (C1-C18)alkoxy(C6-C20)heteroaryl, (C1-C18)alkylenedioxy(C6-C20)aryl, (C1-C18)alkylenedioxy(C6-C20)heteroaryl, halo(C6-C20)aryl, halo(C6-C20)heteroaryl, (C1-C18)alkylamino(C6-C20)aryl, (C1-C18)alkylamino(C6-C20)heteroaryl, (C1-C18)cycloalkylamino(C6-C20)aryl, or (C1-C18)cycloalkylamino(C6-C20)heteroaryl, and their OR8 substutes; R5 is (C1-C18alkoxy, hydrogen, hydroxyl, O—(C1-C18)alkyl(C6-C20)aryl, halo or OR8, or R5 and R6 are (C1-C18)dioxy provided that R7 is hydrogen; R6 is hydroxyl, O—(C1-C18)alkyl(C6-C20)aryl, halo or OR8, (C1-C18)alkoxy, (C1-C18)alkylamino, or (C1-C18)cycloalkylamino, or R6 and R7 are (C1-C18)dioxy provided that R5 is hydrogen; R7 is hydrogen, halo or OR8, hydroxyl, or O—(C1-C18)alkyl(C6-C20)aryl; and R8 is P(═O)(OH)2, P(═O)(O(C1-C18)alkyl(C6-C20)aryl)2, P(═O)(OH)(OM), or P(═O)(OM)2, P═O(O2M).
    • 式I化合物公开如下:或其药学上可接受的盐,前药,溶剂合物或代谢物,其中R是氢,P(= O)(OH)2,P(= O)(O(C 1 -C 18) )亚烷基(C 6 -C 20)芳基)2,P(= O)(OH)(OM),P(= O)(OM)2,P = O(O 2 M) S(= O)(O(C1-C18)亚烷基(C6-C20)芳基)2,S(= O)(OH)(OM),S(= O)(OM) M是一价或二价金属离子或烷基铵离子; W是(C 6 -C 20)芳基,(C 6 -C 20)杂芳基,(C 1 -C 18)烷基(C 6 -C 20)芳基,(C 1 -C 18)烷基(C 6 -C 20) 羟基(C 6 -C 20)杂芳基,(C 1 -C 18)烷氧基(C 6 -C 20)芳基,(C 1 -C 18)烷氧基(C 6 -C 20)杂芳基,(C 1 -C 18)亚烷基二氧基 C 1 -C 20烷基氨基(C 6 -C 20)芳基,(C 1 -C 20)芳基,(C 1 -C 20)芳基, 杂芳基,(C1-C18)环烷基氨基(C6-C20)芳基或(C1-C18)环烷基氨基(C6-C20)杂芳基及其OR8分子; R5是(C1-C18烷氧基,氢,羟基,O-(C1-C18)烷基(C6-C20)芳基,卤素或OR8或R5和R6是(C1-C18)二氧基,条件是R7是氢; R6是羟基 ,(C 1 -C 18)烷基(C 6 -C 20)芳基,卤素或OR 8,(C 1 -C 18)烷氧基,(C 1 -C 18)烷基氨基或(C 1 -C 18)环烷基氨基或R 6和R 7为 (C 1 -C 18)烷基(C 6 -C 20)芳基; R 8为P(= O)(OH)2,P(= O) = O)(O(C 1 -C 18)烷基(C 6 -C 20)芳基)2,P(= O)(OH)(OM)或P(= O)(OM)2,P = O(O 2 M)。