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1. 外观设计

USD551447S1 Golf ball container 有权
标题翻译：高尔夫球容器
公开(公告)号：USD551447S1
公开(公告)日：2007-09-25
申请号：US29222805
申请日：2005-02-04
申请人： Kaoru Ogawa
设计人： Kaoru Ogawa

2. 发明申请

US20060172404A1 Methods of screening for compounds that inhibit the biosynthesis of gpi in malaria parasites 失效
标题翻译：筛选抑制疟疾寄生虫中gpi生物合成的化合物的方法
公开(公告)号：US20060172404A1
公开(公告)日：2006-08-03
申请号：US10535928
申请日：2003-11-21
申请人： Katsura Hata , Kaoru Ogawa , Itaru Tsukada , Kazutaka Nakamoto , Koji Sagane , Keigo Tanaka , Kappei Tsukahara , Toshihiro Horii
发明人： Katsura Hata , Kaoru Ogawa , Itaru Tsukada , Kazutaka Nakamoto , Koji Sagane , Keigo Tanaka , Kappei Tsukahara , Toshihiro Horii
IPC分类号： C07H21/04 , C12N9/10 , C12N1/10 , A61K31/44 , A61K31/47 , C12N15/74
CPC分类号： G01N33/573 , C07K14/445 , C12N9/1029 , C12Q1/18 , C12Q1/48 , G01N2333/37 , G01N2333/445 , G01N2500/04 , G01N2500/10
摘要： The present inventors succeeded in isolating GWT1 (PfGWT1), which is one of the enzymes involved in GPI biosynthesis in the malaria parasite P. falciparum. In addition, the inventors revealed that degenerate mutant DNAs, with a lower AT content than the DNA encoding the PfGWT1 protein, can complement the phenotype of GWT1-deficient yeast. Based on the findings, the present invention provides the GWT1 protein of malaria parasites and the use of the protein in methods of screening for antimalarial drugs. The present invention also provides degenerate mutant DNAs encoding proteins involved in GPI biosynthesis, and which have a lower AT content than the original DNAs. The present invention also provides methods of screening for antimalarial drugs which use the degenerate mutant DNAs.
摘要翻译：本发明人成功地分离了在疟原虫恶性疟原虫中参与GPI生物合成的酶之一的GWT1（PfGWT1）。此外，本发明人发现，具有比编码PfGWT1蛋白质的DNA低的AT含量的简并突变DNA可以补充GWT1缺陷型酵母的表型。基于这些发现，本发明提供了疟疾寄生虫的GWT1蛋白和该蛋白在筛选抗疟疾药物的方法中的应用。本发明还提供了编码参与GPI生物合成的蛋白质的简并突变DNA，其具有比原始DNA低的AT含量。本发明还提供筛选使用简并突变DNA的抗疟疾药物的方法。

3. 发明申请

US20070207153A1 Therapeutic Agents For Inner Ear Disorders Containing An Il-6 Antagonist As An Active Ingredient 失效
标题翻译：含有作为活性成分的Il-6拮抗剂的内耳疾病的治疗剂
公开(公告)号：US20070207153A1
公开(公告)日：2007-09-06
申请号：US10593776
申请日：2005-03-24
申请人： Masato Fujioka , Hirotaka Okano , Kaoru Ogawa , Hideyuki Okano , Sho Kanzaki
发明人： Masato Fujioka , Hirotaka Okano , Kaoru Ogawa , Hideyuki Okano , Sho Kanzaki
IPC分类号： A61K39/395 , C07K16/28 , C07K16/24
CPC分类号： C07K16/2866 , A61K2039/505
摘要： A therapeutic and/or preventive agent for inner ear disorders comprising an IL-6 antagonist, preferably an anti-IL-6R antibody, as an active ingredient.
摘要翻译：包含IL-6拮抗剂，优选抗IL-6R抗体的内耳疾病的治疗和/或预防剂作为活性成分。

4. 发明申请

US20070070468A1 COLOR ADJUSTING APPARATUS, DISPLAY APPARATUS, PRINTING APPARATUS, IMAGE PROCESSING APPARATUS, COLOR ADJUSTMENT METHOD, GUI DISPLAY METHOD, AND PROGRAM 有权
标题翻译：彩色调节装置，显示装置，印刷装置，图像处理装置，颜色调整方法，GUI显示方法和程序
公开(公告)号：US20070070468A1
公开(公告)日：2007-03-29
申请号：US11535120
申请日：2006-09-26
申请人： Kaoru Ogawa
发明人： Kaoru Ogawa
IPC分类号： G03F3/08
CPC分类号： H04N1/6075
摘要： A color adjusting apparatus includes a first storage unit for storing information indicating a hue (color phase) range arbitrarily designated in a hue space, a second storage unit for storing an adjustment value for adjusting a degree of color shift in the hue range, and a color conversion unit for performing expansion processing or compression processing on a color component of input image data, the color component being associated with the hue range, in accordance with the degree of color shift determined by the adjustment value.
摘要翻译：颜色调节装置包括：第一存储单元，用于存储指示在色调空间中任意指定的色调（色相）范围的信息;第二存储单元，用于存储用于调整色调范围中的色移程度的调整值;以及颜色转换单元，用于根据由调整值确定的颜色偏移程度，对输入图像数据的颜色分量执行扩展处理或压缩处理，颜色分量与色调范围相关联。

5. 发明授权

US06986990B1 Pollen allergy-related gene 513 失效
标题翻译：花粉过敏相关基因513
公开(公告)号：US06986990B1
公开(公告)日：2006-01-17
申请号：US10019832
申请日：2000-04-26
申请人： Takeshi Nagasu , Yuji Sugita , Tomoko Fujishima , Tadahiro Oshida , Masaya Obayashi , Shigemichi Gunji , Izumi Obayashi , Yukiho Imai , Nei Yoshida , Kaoru Ogawa , Keiko Matsui
发明人： Takeshi Nagasu , Yuji Sugita , Tomoko Fujishima , Tadahiro Oshida , Masaya Obayashi , Shigemichi Gunji , Izumi Obayashi , Yukiho Imai , Nei Yoshida , Kaoru Ogawa , Keiko Matsui
IPC分类号： C12Q1/66
CPC分类号： C07K14/47
摘要： T cells from multiple subjects who showed different cedar pollen specific IgE titers were prepared before and after cedar pollen dispersal, and differential display analysis was performed to screen for pollen antigen responsive genes. As a result, a novel gene was successfully isolated whose expression is significantly higher in subjects with high cedar pollen specific IgE titer. The inventors have found that it is possible to use this gene to test for an allergic disease and to screen for candidate compounds for therapeutic drugs for an allergic disease.
摘要翻译：在雪松花粉散布前后制备了显示不同雪松花粉特异性IgE滴度的多个受试者的T细胞，进行差异显示分析筛选花粉抗原应答基因。结果，成功地分离出一种新型基因，其表达在具有高雪松花粉特异性IgE滴度的受试者中显着更高。发明人已经发现，可以使用该基因来测试过敏性疾病并筛选用于过敏性疾病的治疗药物的候选化合物。

6. 发明授权

US08376640B2 Printing media feeding apparatus, printing apparatus provided with the feeding apparatus, printing media feeding speed control method and computer program 失效
标题翻译：印刷介质进给装置，设有进给装置的打印装置，打印介质进给速度控制方法和计算机程序
公开(公告)号：US08376640B2
公开(公告)日：2013-02-19
申请号：US11203395
申请日：2005-08-12
申请人： Kaoru Ogawa
发明人： Kaoru Ogawa
IPC分类号： B41J11/00 , B41J11/42 , B41J2/32
CPC分类号： G03G15/6529 , B41J11/42 , B41J13/103 , G03G2215/00645 , G03G2215/00746
摘要： The present invention prevents density irregularity from appearing in a print result and to thereby improve image quality by controlling a motor so that the rotational speed of a drive shaft that feeds printing media is constant. The present invention provides a printing media feeding apparatus including a feeding section that includes a motor, a drive transmission mechanism which transmits a driving force of the motor, and a drive shaft to which the driving force is transmitted by the drive transmission mechanism. The drive shaft is rotated to feed the printing medium. A detection section is provided having at least a portion secured to the drive shaft and the detection section determines the rotational speed of the drive shaft and a controller controls the motor based on an input from the detection section so that the rotational speed the of the drive shaft is constant.
摘要翻译：本发明防止了在打印结果中出现浓度不均匀性，从而通过控制马达使得馈送打印介质的驱动轴的旋转速度恒定而提高图像质量。本发明提供了一种打印介质进给装置，包括：馈送部分，其包括马达，传递马达的驱动力的驱动传递机构和由驱动传动机构传递驱动力的驱动轴。驱动轴旋转以供给打印介质。检测部具有至少一部分固定在驱动轴上，检测部确定驱动轴的转速，控制器根据来自检测部的输入来控制马达，使得驱动部的转速轴是恒定的。

7. 发明授权

US08252294B2 Methods of screening for compounds that inhibit the biosynthesis of GPI in malaria parasites 失效
标题翻译：筛选疟原虫抑制GPI生物合成的化合物的方法
公开(公告)号：US08252294B2
公开(公告)日：2012-08-28
申请号：US13040970
申请日：2011-03-04
申请人： Katsura Hata , Kaoru Ogawa , Itaru Tsukada , Kazutaka Nakamoto , Koji Sagane , Keigo Tanaka , Kappei Tsukahara , Toshihiro Horii
发明人： Katsura Hata , Kaoru Ogawa , Itaru Tsukada , Kazutaka Nakamoto , Koji Sagane , Keigo Tanaka , Kappei Tsukahara , Toshihiro Horii
IPC分类号： A61A39/015 , C07K12/00 , C07H21/04
CPC分类号： G01N33/573 , C07K14/445 , C12N9/1029 , C12Q1/18 , C12Q1/48 , G01N2333/37 , G01N2333/445 , G01N2500/04 , G01N2500/10
摘要： The present inventors succeeded in isolating GWT1 (PfGWT1), which is one of the enzymes involved in GPI biosynthesis in the malaria parasite P. falciparum. In addition, the inventors revealed that degenerate mutant DNAs, with a lower AT content than the DNA encoding the PfGWT1 protein, can complement the phenotype of GWT1-deficient yeast. Based on the findings, the present invention provides the GWT1 protein of malaria parasites and the use of the protein in methods of screening for antimalarial drugs. The present invention also provides degenerate mutant DNAs encoding proteins involved in GPI biosynthesis, and which have a lower AT content than the original DNAs. The present invention also provides methods of screening for antimalarial drugs which use the degenerate mutant DNAs.
摘要翻译：本发明人成功地分离了在疟原虫恶性疟原虫中参与GPI生物合成的酶之一的GWT1（PfGWT1）。此外，本发明人发现，与编码PfGWT1蛋白的DNA相比，AT含量低的退化突变体DNA可以补充GWT1缺陷型酵母的表型。基于这些发现，本发明提供了疟疾寄生虫的GWT1蛋白和该蛋白在筛选抗疟疾药物的方法中的应用。本发明还提供了编码参与GPI生物合成的蛋白质的简并突变DNA，其具有比原始DNA低的AT含量。本发明还提供筛选使用简并突变DNA的抗疟疾药物的方法。

8. 发明授权

US07381788B2 Method for continuous production of polyamide 有权
标题翻译：连续生产聚酰胺的方法
公开(公告)号：US07381788B2
公开(公告)日：2008-06-03
申请号：US10525740
申请日：2003-08-27
申请人： Yasuhito Tsujii , Gaku Maruyama , Kaoru Ogawa , Yoshinori Takada , Kazuhisa Koishi , Kenta Susuki
发明人： Yasuhito Tsujii , Gaku Maruyama , Kaoru Ogawa , Yoshinori Takada , Kazuhisa Koishi , Kenta Susuki
IPC分类号： C08G69/00 , C08G69/28 , B29C47/76
CPC分类号： C08G69/04 , C08G69/28
摘要： Provided is a continuous production method of a polyamide with stabilized polymerization degree and good quality, particularly an aromatic-containing polyamide. A continuous production method of a polyamide, comprising (a) a raw material preparation step of individually melting a diamine and a dicarboxylic acid, or producing a salt of amine and carboxylic acid in water, (b) a raw material introduction step of continuously introducing the prepared raw materials into a tubular reaction apparatus, (c) an amidation step of passing the introduced raw materials through the tubular reaction apparatus, thereby effecting amidation to obtain a reaction mixture containing an amidated product and a condensed water, (d) an initial polymerization step of introducing the reaction mixture into a continuous reaction apparatus capable of separation and removal of water, and elevating the polymerization degree while separating and removing water at a temperature higher than the melting point of the finally obtained polyamide to obtain a polyamide prepolymer, and (e) a final polymerization step of introducing the polyamide prepolymer into a continuous reaction apparatus capable of separation and removal of water, and further elevating the polymerization degree at a temperature higher than the melting point of the finally obtained polyamide to obtain a polyamide adjusted to a desired relative viscosity [RV].
摘要翻译：提供了具有稳定的聚合度和良好质量的聚酰胺的连续制备方法，特别是含芳族聚酰胺。一种聚酰胺的连续制造方法，其特征在于，包括：（a）将二胺和二羧酸单独熔融或在水中生成胺和羧酸盐的原料制备工序，（b）原料引入工序，所制备的原料进入管状反应装置，（c）使引入的原料通过管状反应装置的酰胺化步骤，从而进行酰胺化以获得含有酰胺化产物和冷凝水的反应混合物，（d）初始将反应混合物引入能够分离和除去水的连续反应装置的聚合步骤，并且在高于最终获得的聚酰胺的熔点的温度下分离和除去水以提高聚合度以获得聚酰胺预聚物，以及（e）将聚酰胺预聚物引入连续反应ap的最终聚合步骤能够分离和除去水，并且在高于最终获得的聚酰胺的熔点的温度下进一步提高聚合度，以获得调节至所需相对粘度[RV]的聚酰胺。

9. 发明授权

US07148011B2 Method of testing for allergic diseases 失效
标题翻译：过敏性疾病检测方法
公开(公告)号：US07148011B2
公开(公告)日：2006-12-12
申请号：US10380254
申请日：2001-09-21
申请人： Yuji Sugita , Ryoichi Hashida , Kaoru Ogawa , Tomoko Fujishima , Takeshi Nagasu , Gozoh Tsujimoto , Eiki Takahashi
发明人： Yuji Sugita , Ryoichi Hashida , Kaoru Ogawa , Tomoko Fujishima , Takeshi Nagasu , Gozoh Tsujimoto , Eiki Takahashi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/47 , C12Q2600/158
摘要： The differential display method was used to search for a gene whose expression level in eosinophils collected from patients with atopic dermatitis differs in the exacerbation stage and in the remission stage. As a result, gene “2090-05” showing a significant increase in expression in eosinophils of patients in the remission stage was isolated. This gene is usable in testing for an allergic disease and screening for a candidate compound for a therapeutic agent therefor an allergic disease.
摘要翻译：差异显示法用于寻找在特应性皮炎患者中收集的嗜酸性粒细胞的表达水平在恶化阶段和缓解期不同的基因。结果，分离出在缓解期患者嗜酸性粒细胞中表达显着增加的基因“2090-05”。该基因可用于测试过敏性疾病并筛选用于治疗剂的候选化合物用于过敏性疾病。

10. 外观设计

USD517313S1 Clip marker 有权
标题翻译：剪辑标记
公开(公告)号：USD517313S1
公开(公告)日：2006-03-21
申请号：US29223520
申请日：2005-02-16
申请人： Kaoru Ogawa
设计人： Kaoru Ogawa

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