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1. 发明授权

US08515686B2 Detection and quantification of polypeptides using mass spectrometry 失效
标题翻译：使用质谱法检测和定量多肽
公开(公告)号：US08515686B2
公开(公告)日：2013-08-20
申请号：US11922690
申请日：2007-12-18
申请人： Keith Ashman , Matthew McKay , James Sherman , Mark Molloy
发明人： Keith Ashman , Matthew McKay , James Sherman , Mark Molloy
IPC分类号： G01N31/00
CPC分类号： G01N33/6848 , H01J49/0036 , H01J49/26
摘要： The invention relates to the detection and quantification of polypeptides using mass spectrometry. Specifically, the invention provides a method for testing whether a target polypeptide is present in a sample of a set of polypeptides, a method for deriving a value for distinguishing polypeptides of a set of polypeptides from each other, a database containing values for distinguishing each polypeptide of a set of polypeptides from each other, and an apparatus for configuring a mass scan of a mass spectrometer to test whether a target polypeptide of a set of polypeptides is present in a sample of the set.
摘要翻译：本发明涉及使用质谱法检测和定量多肽。具体地说，本发明提供了一种用于检测目标多肽是否存在于一组多肽的样品中的方法，用于导出一组多肽彼此区分多肽的值的方法，包含用于区分每种多肽的值的数据库的一组多肽，以及用于配置质谱仪的质量扫描以测试一组多肽的靶多肽是否存在于该组的样品中的装置。

2. 发明申请

US20100299081A1 Detection and Quantification of Polypeptides Using Mass Spectrometry 失效
标题翻译：使用质谱法检测和定量多肽
公开(公告)号：US20100299081A1
公开(公告)日：2010-11-25
申请号：US11922690
申请日：2007-12-18
申请人： Keith Ashman , Matthew McKay , Jamie Sherman , Mark Molloy
发明人： Keith Ashman , Matthew McKay , Jamie Sherman , Mark Molloy
IPC分类号： G06F19/00 , H01J49/26
CPC分类号： G01N33/6848 , H01J49/0036 , H01J49/26
摘要： The invention relates to the detection and quantification of polypeptides using mass spectrometry. Specifically, the invention provides a method for testing whether a target polypeptide is present in a sample of a set of polypeptides, a method for deriving a value for distinguishing polypeptides of a set of polypeptides from each other, a database containing values for distinguishing each polypeptide of a set of polypeptides from each other, and an apparatus for configuring a mass scan of a mass spectrometer to test whether a target polypeptide of a set of polypeptides is present in a sample of the set.
摘要翻译：本发明涉及使用质谱法检测和定量多肽。具体地说，本发明提供了一种用于检测目标多肽是否存在于一组多肽的样品中的方法，用于导出一组多肽彼此区分多肽的值的方法，包含用于区分每种多肽的值的数据库的一组多肽，以及用于配置质谱仪的质量扫描以测试一组多肽的靶多肽是否存在于该组的样品中的装置。

3. 发明授权

US06558522B1 Apparatus for electrophoresis 有权
标题翻译：电泳仪
公开(公告)号：US06558522B1
公开(公告)日：2003-05-06
申请号：US09582260
申请日：2000-09-14
申请人： Keith Leslie Williams , Mark Molloy , Andrew Arthur Gooley , Nicolle Hannah Packer , Ben Herbert , Bradley Walsh , George Fernwood , David Garfin
发明人： Keith Leslie Williams , Mark Molloy , Andrew Arthur Gooley , Nicolle Hannah Packer , Ben Herbert , Bradley Walsh , George Fernwood , David Garfin
IPC分类号： B01D5702
CPC分类号： B01D57/02 , G01N27/44704 , G01N27/44782
摘要： An electrophoresis apparatus for the simultaneous electrophoretic separation of a plurality of component mixtures using a disposable tray having a plurality of parallel troughs shaped to retain an elongate strip of isoelectric focusing medium and sufficient liquid to immerse the elongate strip. A frame is provided to retain the tray in a horizontal position using a pair of rotatably mounted support members moving between an open and closed position. Support members are also connected to a plurality of electrodes aligned with each of the troughs so that the electrodes are positioned clear of the troughs in the open position and positioned in the troughs when in the closed position.
摘要翻译：一种用于使用一次性盘的同时电泳分离多个组分混合物的电泳装置，所述一次性盘具有多个平行槽，所述多个平行槽被成形为保持等电聚焦介质的细长带和足够的液体以浸入细长条。提供了一个框架，以使用一对可旋转地安装的支撑构件在打开和关闭位置之间移动来将托盘保持在水平位置。支撑构件还连接到与每个槽对准的多个电极，使得电极在处于关闭位置时被定位成远离槽并且位于槽中。

4. 发明申请

US20060190388A1 Synthetic continuous double auctions 有权
标题翻译：合成连续双拍
公开(公告)号：US20060190388A1
公开(公告)日：2006-08-24
申请号：US11343929
申请日：2006-01-31
申请人： Mark Molloy
发明人： Mark Molloy
IPC分类号： G06Q40/00
CPC分类号： G06Q30/08 , G06Q30/0633 , G06Q40/00 , G06Q40/04
摘要： Methods, systems and data structures are described for conducting synthetic continuous double auctions. A method includes participating in a synthetic continuous double auction having contingent bidding on a plurality of heterogeneous item auctions. A composite reverse auction, defined by a bid set including a first contingent bid on a first of the plurality of heterogeneous item auctions and a second contingent bid on a second of the plurality of heterogeneous item auctions, is ended when i) the first contingent bid from the bid set is recognized as a winning bid and substantially simultaneously ii) the second contingent bid from the bid set is withdrawn as a remaining bid. The bid set is visible to at least one member selected from the group of a) at least one first seller associated with the first of the plurality of heterogeneous item auctions, b) at least one second seller associated with the second of the plurality of heterogeneous item auctions, and c) buyers bidding on the first of the plurality of heterogeneous item auctions or the second of the plurality of heterogeneous item auctions.
摘要翻译：描述了用于进行合成连续双拍的方法，系统和数据结构。一种方法包括参与在多个异类项目拍卖上具有或有出价的合成连续双重拍卖。由包括对所述多个异类项目拍卖中的第一个异类项目拍卖的第一偶然出价和对所述多个异类项目拍卖中的第二种异类项目拍卖的第二偶然投标的投标集合定义的复合反向拍卖在i）所述第一偶然投标从投标中被确认为中标，并且基本上同时进行ii）投标组的第二个或有出价作为剩余投标撤回。所述出价集对于至少一个选自以下组的成员是可见的：a）与所述多个异类项目拍卖中的第一个拍卖相关联的至少一个第一卖家，b）与所述多个异质项目拍卖中的第二个相关联的至少一个第二卖家项目拍卖，以及c）买方投标于多个异质项目拍卖中的第一个或多个异类项目拍卖中的第二个。

5. 发明申请

US20060190390A1 Compound buy-sell auctions 审中-公开
标题翻译：复合买卖拍卖
公开(公告)号：US20060190390A1
公开(公告)日：2006-08-24
申请号：US11344598
申请日：2006-01-31
申请人： Mark Molloy
发明人： Mark Molloy
IPC分类号： G06Q40/00
CPC分类号： G06Q30/08 , G06Q40/04
摘要： Methods, systems and data structures are described for conducting buy-sell auctions. A method includes participating in a compound buy-sell auction having contingent bidding on a plurality of heterogeneous items substantially simultaneously contingent on selling one or more other items in another auction. A composite reverse auction, defined by a bid set including a first contingent bid on a first of the plurality of heterogeneous item auctions and a second contingent bid on a second of the plurality of heterogeneous item auctions, is ended when i) the first contingent bid from the bid set is recognized as a winning bid and substantially simultaneously ii) the second contingent bid from the bid set is withdrawn as a remaining bid.
摘要翻译：描述进行买卖拍卖的方法，系统和数据结构。一种方法包括参与在多个异构项目上进行或有竞标的复合买卖拍卖，其基本上同时涉及在另一拍卖中出售一个或多个其他项目。由包括对所述多个异类项目拍卖中的第一个异类项目拍卖的第一偶然出价以及所述多个异类项目拍卖中的第二种异类项目拍卖的第二偶然投标的投标集定义的复合反向拍卖在i）从投标中被确认为中标，并且基本上同时进行ii）投标组的第二个或有出价作为剩余投标撤回。

6. 发明申请

US20060190389A1 Compound buy-buy auctions 审中-公开
标题翻译：复合买入拍卖
公开(公告)号：US20060190389A1
公开(公告)日：2006-08-24
申请号：US11343945
申请日：2006-01-31
申请人： Mark Molloy
发明人： Mark Molloy
IPC分类号： G06Q40/00
CPC分类号： G06Q30/08 , G06Q40/04
摘要： Methods, systems and data structures are described for conducting buy-buy auctions. A method includes participating in a compound buy-buy auction having contingent bidding on a plurality of heterogeneous items substantially simultaneously contingent on buying one or more other items in another auction. A composite reverse auction, defined by a bid set including a first contingent bid on a first of the plurality of heterogeneous item auctions and a second contingent bid on a second of the plurality of heterogeneous item auctions, is ended when i) the first contingent bid from the bid set is recognized as a winning bid and substantially simultaneously ii) the second contingent bid from the bid set is withdrawn as a remaining bid.
摘要翻译：描述了采购买卖拍卖的方法，系统和数据结构。一种方法包括参与在多个异质项目上进行或有竞标的复合购买拍卖，其基本上同时取决于在另一拍卖中购买一个或多个其他项目。由包括对所述多个异类项目拍卖中的第一个异类项目拍卖的第一偶然出价以及所述多个异类项目拍卖中的第二种异类项目拍卖的第二偶然投标的投标集定义的复合反向拍卖在i）从投标中被确认为中标，并且基本上同时进行ii）投标组的第二个或有出价作为剩余投标撤回。

7. 发明申请

US20060190387A1 Normalized synthetic continuous double auctions 审中-公开
标题翻译：规范化合成连续双拍
公开(公告)号：US20060190387A1
公开(公告)日：2006-08-24
申请号：US11343928
申请日：2006-01-31
申请人： Mark Molloy
发明人： Mark Molloy
IPC分类号： G06Q40/00
CPC分类号： G06Q30/08 , G06Q40/04
摘要： Methods, systems and data structures are described for conducting normalized synthetic continuous double auctions. A method includes participating in a normalized auction having contingent bidding on a plurality of heterogeneous item auctions. Contingent bidding includes price normalization as a function of at least one attribute. A composite reverse auction, defined by a bid set including a first contingent bid on a first of the plurality of heterogeneous item auctions and a second contingent bid on a second of the plurality of heterogeneous item auctions, is ended when i) the first contingent bid from the bid set is recognized as a winning bid and substantially simultaneously ii) the second contingent bid from the bid set is withdrawn as a remaining bid.
摘要翻译：描述了用于进行标准化合成连续双拍的方法，系统和数据结构。一种方法包括参与在多个异质项目拍卖上具有或有出价的标准化拍卖。或有投标将价格归一化作为至少一个属性的函数。由包括对所述多个异类项目拍卖中的第一个异类项目拍卖的第一偶然出价以及所述多个异类项目拍卖中的第二种异类项目拍卖的第二偶然投标的投标集定义的复合反向拍卖在i）从投标中被确认为中标，并且基本上同时进行ii）投标组的第二个或有出价作为剩余投标撤回。

8. 发明申请

US20050124011A1 Diagnosis of disease using tears 审中-公开
标题翻译：使用眼泪诊断疾病
公开(公告)号：US20050124011A1
公开(公告)日：2005-06-09
申请号：US10896868
申请日：2004-07-23
申请人： Carol Morris , Mark Willcox , Shirley Bolis , Bradley Walsh , Ben Herbert , Mark Molloy , Andrew Gooley , Keith Williams
发明人： Carol Morris , Mark Willcox , Shirley Bolis , Bradley Walsh , Ben Herbert , Mark Molloy , Andrew Gooley , Keith Williams
IPC分类号： C07K14/47 , G01N33/574 , G01N33/53
CPC分类号： C07K14/47 , G01N33/57415 , G01N33/57434 , G01N33/57488
摘要： A method of screening or detecting non-ocular disease in an animal, the method comprising the steps of: (a) obtaining a tear sample from the animal; (b) separating biomolecules present in the tear sample; and (c) detecting for the presence or absence of one or more biomolecules such that the presence or absence of the one or more biomolecules being an indicator or marker of a disease state in the animal.
摘要翻译：一种在动物中筛选或检测非眼部疾病的方法，所述方法包括以下步骤：（a）从动物获得泪液样品; （b）分离存在于泪液样品中的生物分子; 和（c）检测一种或多种生物分子的存在或不存在，使得一种或多种生物分子的存在或不存在是动物中疾病状态的指示剂或标志物。

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