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1. 发明授权

US08163746B2 Azolecarboxamide derivative 失效
标题翻译：偶氮甲酰胺衍生物
公开(公告)号：US08163746B2
公开(公告)日：2012-04-24
申请号：US12297275
申请日：2007-04-19
申请人： Keizo Sugasawa , Kenichi Kawaguchi , Takaho Matsuzawa , Ryushi Seo , Hironori Harada , Akira Suga , Tomoaki Abe , Hidenori Azami , Shunichiro Matsumoto , Takashi Shin , Masayuki Tanahashi , Toru Watanabe
发明人： Keizo Sugasawa , Kenichi Kawaguchi , Takaho Matsuzawa , Ryushi Seo , Hironori Harada , Akira Suga , Tomoaki Abe , Hidenori Azami , Shunichiro Matsumoto , Takashi Shin , Masayuki Tanahashi , Toru Watanabe
IPC分类号： A61K31/5355 , A61K31/496 , A61K31/451 , A61K31/4535 , A61K31/426 , C07D413/14 , C07D211/32 , C07D211/46 , C07D277/24
CPC分类号： C07D277/56 , C07D263/34 , C07D263/48 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/08
摘要： Provided is an agent for treating or preventing urinary frequency, urinary urgency and urinary, incontinence which are associated with overactive bladder, a lower urinary tract disease such as interstitial cystitis and chronic prostatitis accompanied by lower urinary tract pain, and various diseases accompanied by pain. A novel azolecarboxamide derivative in which an azole ring such as thioazole or oxazole is bonded to a benzene ring, pyridine ring or pyrimidine ring through carboxamide was confirmed to have a potent trkA receptor-inhibitory activity and found to be an agent for treating or preventing lower urinary tract disease and various diseases accompanied by pain, which is excellent in efficacy and safety, and thus the present invention was accomplished.
摘要翻译：提供治疗或预防与膀胱过度活动相关的尿频，尿急和尿失禁的药物，诸如间质性膀胱炎的下尿路疾病和伴有下尿路疼痛的慢性前列腺炎以及伴有疼痛的各种疾病。通过甲酰胺将唑环或吡唑环或吡啶环或吡啶环与吡唑或恶唑等唑类结合的新型偶氮甲酰胺衍生物被证实具有强的trkA受体抑制活性，被发现是用于治疗或预防较低泌尿道疾病，伴有疼痛的各种疾病，其功效和安全性优异，从而完成了本发明。

2. 发明申请

US20090286766A1 AZOLECARBOXAMIDE DERIVATIVE 失效
公开(公告)号：US20090286766A1
公开(公告)日：2009-11-19
申请号：US12297275
申请日：2007-04-19
申请人： Keizo Sugasawa , Kenichi Kawaguchi , Takaho Matsuzawa , Ryushi Seo , Hironori Harada , Akira Suga , Tomoaki Abe , Hidenori Azami , Shunichiro Matsumoto , Takashi Shin , Masayuki Tanahashi , Toru Watanabe
发明人： Keizo Sugasawa , Kenichi Kawaguchi , Takaho Matsuzawa , Ryushi Seo , Hironori Harada , Akira Suga , Tomoaki Abe , Hidenori Azami , Shunichiro Matsumoto , Takashi Shin , Masayuki Tanahashi , Toru Watanabe
IPC分类号： A61K31/496 , C07D417/12 , C07D487/04 , C07D417/14 , C07D413/12 , C07D413/14 , A61K31/454 , A61K31/5377 , A61K31/551 , A61K31/55 , A61K31/541 , A61P13/00
CPC分类号： C07D277/56 , C07D263/34 , C07D263/48 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/08
摘要： Provided is an agent for treating or preventing urinary frequency, urinary urgency and urinary, incontinence which are associated with overactive bladder, a lower urinary tract disease such as interstitial cystitis and chronic prostatitis accompanied by lower urinary tract pain, and various diseases accompanied by pain. A novel azolecarboxamide derivative in which an azole ring such as thioazole or oxazole is bonded to a benzene ring, pyridine ring or pyrimidine ring through carboxamide was confirmed to have a potent trkA receptor-inhibitory activity and found to be an agent for treating or preventing lower urinary tract disease and various diseases accompanied by pain, which is excellent in efficacy and safety, and thus the present invention was accomplished.
摘要翻译：本发明提供一种治疗或预防尿频，尿急，尿失禁，与膀胱过度活动，下尿路疾病如间质性膀胱炎和伴有下尿路疼痛的慢性前列腺炎以及伴有疼痛的各种疾病相关的尿失禁。通过甲酰胺将唑环或吡唑环或吡啶环或吡啶环与吡唑或恶唑等唑类结合的新型偶氮甲酰胺衍生物被证实具有强的trkA受体抑制活性，被发现是用于治疗或预防较低泌尿道疾病，伴有疼痛的各种疾病，其功效和安全性优异，从而完成了本发明。

3. 发明授权

US08304547B2 Azolecarboxamide compound or salt thereof 有权
标题翻译：偶氮甲酰胺化合物或其盐
公开(公告)号：US08304547B2
公开(公告)日：2012-11-06
申请号：US12739433
申请日：2008-10-23
申请人： Keizo Sugasawa , Kenichi Kawaguchi , Takaho Nomura , Shunichiro Matsumoto , Takashi Shin , Hidenori Azami , Tomoaki Abe , Akira Suga , Ryushi Seo , Masayuki Tanahashi , Toru Watanabe
发明人： Keizo Sugasawa , Kenichi Kawaguchi , Takaho Nomura , Shunichiro Matsumoto , Takashi Shin , Hidenori Azami , Tomoaki Abe , Akira Suga , Ryushi Seo , Masayuki Tanahashi , Toru Watanabe
IPC分类号： C07D211/68 , C07D221/20 , C07D491/20 , C07D413/14 , C07D239/09 , A61K31/535 , A61K31/505 , A61K31/44 , A61K31/445
CPC分类号： C07D263/34 , C07D263/48 , C07D277/20 , C07D277/56 , C07D401/14 , C07D403/12 , C07D407/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/08 , C07D491/107 , C07D491/113 , C07D491/20 , C07D495/04 , C07D498/10
摘要： [Object] To provide a therapeutic and/or prophylactic agent for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis, and the like, and various diseases accompanied by pain, based on an excellent trkA receptor inhibitory action.[Means for Solution] A novel azolecarboxamide compound in which a thiazole ring or an oxazole ring is bonded to a benzene ring, a pyridine ring, a pyridazine ring, a thiophene ring, a pyrazole ring or a pyrrole ring through carboxamide, or a salt thereof is confirmed to have a potent trkA receptor inhibitory activity, and found to be capable of being used as a therapeutic and/or prophylactic agent which is excellent in efficacy and safety for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis, and the like, and various diseases accompanied by pain, thereby completing the present invention.
摘要翻译：本发明提供一种用于与各种下尿路疾病（包括膀胱过度活动症，伴有下尿路疼痛，诸如间质性膀胱炎等）的各种下尿路疾病相关的尿频，尿急和尿失禁的治疗和/或预防剂，慢性前列腺炎等，以及伴有疼痛的各种疾病，基于优异的trkA受体抑制作用。 [解决方案]通过甲酰胺或其盐将噻唑环或恶唑环与苯环，吡啶环，哒嗪环，噻吩环，吡唑环或吡咯环结合的新型偶氮甲酰胺化合物被证实具有强的trkA受体抑制活性，发现能够用作治疗和/或预防剂，其对于尿频，尿急和与各种下尿路相关的尿失禁的功效和安全性优异包括膀胱活动过度，伴有尿路下下尿路疼痛的下尿路疾病，如间质性膀胱炎，慢性前列腺炎等多种疾病，伴有疼痛的各种疾病，从而完成本发明。

4. 发明申请

US20100249088A1 AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF 有权
标题翻译： AZOLECARBOXAMIDE化合物或其盐
公开(公告)号：US20100249088A1
公开(公告)日：2010-09-30
申请号：US12739433
申请日：2008-10-23
申请人： Keizo Sugasawa , Kenichi Kawaguchi , Takaho Nomura , Shunichiro Matsumoto , Takashi Shin , Hidenori Azami , Tomoaki Abe , Akira Suga , Ryushi Seo , Masayuki Tanahashi , Toru Watanabe
发明人： Keizo Sugasawa , Kenichi Kawaguchi , Takaho Nomura , Shunichiro Matsumoto , Takashi Shin , Hidenori Azami , Tomoaki Abe , Akira Suga , Ryushi Seo , Masayuki Tanahashi , Toru Watanabe
IPC分类号： A61K31/4545 , C07D413/14 , C07D417/14 , A61P13/02 , A61P13/10 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/397 , A61P13/00 , A61P13/08
CPC分类号： C07D263/34 , C07D263/48 , C07D277/20 , C07D277/56 , C07D401/14 , C07D403/12 , C07D407/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/08 , C07D491/107 , C07D491/113 , C07D491/20 , C07D495/04 , C07D498/10
摘要： [Object] To provide a therapeutic and/or prophylactic agent for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis, and the like, and various diseases accompanied by pain, based on an excellent trkA receptor inhibitory action.[Means for Solution] A novel azolecarboxamide compound in which a thiazole ring or an oxazole ring is bonded to a benzene ring, a pyridine ring, a pyridazine ring, a thiophene ring, a pyrazole ring or a pyrrole ring through carboxamide, or a salt thereof is confirmed to have a potent trkA receptor inhibitory activity, and found to be capable of being used as a therapeutic and/or prophylactic agent which is excellent in efficacy and safety for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis, and the like, and various diseases accompanied by pain, thereby completing the present invention.
摘要翻译：本发明提供一种用于与各种下尿路疾病（包括膀胱过度活动症，伴有下尿路疼痛，诸如间质性膀胱炎等）的各种下尿路疾病相关的尿频，尿急和尿失禁的治疗和/或预防剂，慢性前列腺炎等，以及伴有疼痛的各种疾病，基于优异的trkA受体抑制作用。 [解决方案]通过甲酰胺或其盐将噻唑环或恶唑环与苯环，吡啶环，哒嗪环，噻吩环，吡唑环或吡咯环结合的新型偶氮甲酰胺化合物被证实具有强的trkA受体抑制活性，发现能够用作治疗和/或预防剂，其对于尿频，尿急和与各种下尿路相关的尿失禁的功效和安全性优异包括膀胱活动过度，伴有尿路下下尿路疼痛的下尿路疾病，如间质性膀胱炎，慢性前列腺炎等多种疾病，伴有疼痛的各种疾病，从而完成本发明。

5. 发明授权

US06958339B2 Pyrazole derivative 失效
标题翻译：吡唑衍生物
公开(公告)号：US06958339B2
公开(公告)日：2005-10-25
申请号：US09773736
申请日：2001-02-02
申请人： Hirokazu Kubota , Yasuhiro Yonetoku , Keizo Sugasawa , Masashi Funatsu , Souichirou Kawazoe , Akira Toyoshima , Jun Ishikawa , Makoto Takeuchi
发明人： Hirokazu Kubota , Yasuhiro Yonetoku , Keizo Sugasawa , Masashi Funatsu , Souichirou Kawazoe , Akira Toyoshima , Jun Ishikawa , Makoto Takeuchi
IPC分类号： A61K31/4155 , A61K31/416 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/538 , C07D231/12 , C07D231/14 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/02 , C07D417/02 , C07D417/04 , C07D417/12 , C07D417/14 , C07D521/00 , A61K31/415
CPC分类号： C07D231/12 , C07D231/14 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention is directed to drugs, in particular, pyrazole derivatives represented by the following general formula (I) which have a calcium release-activated calcium channel inhibitory effect and medicinal compositions, in particular, calcium release-activated calcium channel inhibitors containing the above compounds as the active ingredient, wherein each substituent is defined in the specification. The present invention also relates to a pharmaceutical composition containing an effective amount of the compound of formula (I) and a pharmaceutically effective carrier.The present invention further relates to methods of treatment of diseases associated with calcium release-activated calcium channels, diseases associated with IL-2 production, and methods of treatment of allergic, inflammatory or auto-immune diseases.
摘要翻译：本发明涉及具有钙释放激活的钙通道抑制作用的药物，特别是由以下通式（I）表示的吡唑衍生物，特别是含有上述的钙释放激活的钙通道抑制剂的药物组合物化合物作为活性成分，其中每个取代基在说明书中定义。本发明还涉及含有有效量的式（I）化合物和药学有效载体的药物组合物。本发明还涉及治疗与钙释放激活的钙通道有关的疾病，与IL-2产生有关的疾病，以及治疗过敏性，炎性或自身免疫性疾病的方法。

6. 发明申请

US20050153977A1 2-Acylaminothiazole derivative or salt thereof 有权
标题翻译： 2-酰基氨基噻唑衍生物或其盐
公开(公告)号：US20050153977A1
公开(公告)日：2005-07-14
申请号：US10500964
申请日：2003-01-15
申请人： Keizo Sugasawa , Susumu Watanuki , Yuji Koga , Hiroshi Nagata , Kazuyoshi Obitsu , Ryutaro Wakayama , Fukushi Hirayama , Ken-ichi Suzuki
发明人： Keizo Sugasawa , Susumu Watanuki , Yuji Koga , Hiroshi Nagata , Kazuyoshi Obitsu , Ryutaro Wakayama , Fukushi Hirayama , Ken-ichi Suzuki
IPC分类号： A61K31/426 , A61K31/427 , A61K31/439 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/695 , A61P7/00 , A61P43/00 , C07D277/44 , C07D277/46 , C07D417/04 , C07D417/12 , C07D417/14 , C07D453/02
CPC分类号： C07D417/14 , A61K31/426 , A61K31/427 , A61K31/439 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/695 , C07D277/46 , C07D417/04 , C07D417/12 , C07D453/02
摘要： A 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl-Ba/F3 cells and an activity of increasing platelets based on the effect of promoting the formation of megakaryocytic colonies. A compound or a pharmaceutically acceptable salt thereof useful in treating thrombocytopenia.
摘要翻译：基于促进巨核细胞集落形成的效果，具有对人c-mpl-Ba / F3细胞增殖的优异效果的2-酰基氨基噻唑衍生物或其药学上可接受的盐和增加血小板的活性。用于治疗血小板减少症的化合物或其药学上可接受的盐。

7. 发明授权

US07504417B2 Substituted benzene derivatives or salts thereof 有权
标题翻译：取代的苯衍生物或其盐
公开(公告)号：US07504417B2
公开(公告)日：2009-03-17
申请号：US10399625
申请日：2001-11-21
申请人： Tsukasa Ishihara , Fukushi Hirayama , Keizo Sugasawa , Yuji Koga , Takeshi Kadokura , Takeshi Shigenaga
发明人： Tsukasa Ishihara , Fukushi Hirayama , Keizo Sugasawa , Yuji Koga , Takeshi Kadokura , Takeshi Shigenaga
IPC分类号： A61K31/445 , C07D211/68 , C07D211/80 , C07D213/02
CPC分类号： C07D401/12 , C07D211/26 , C07D401/14 , C07H15/203 , C07H15/26
摘要： There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents for diseases induced by thrombosis or embolism. Effective ingredients are the compounds such as 4′-bromo-2′-[(5-chloro-2-pyridyl)carbamoyl]-6′-β-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide, 2′-(2-acetamido-2-deoxy-β-D-glucopyranosyloxy)-4′-bromo-6′-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide, etc. or salts thereof.
摘要翻译：提供了基于活化凝血因子X的抑制具有抗凝血作用的化合物，并且可用作血栓形成或栓塞引起的疾病的抗凝剂或预防/治疗剂。有效成分是诸如4'-溴-2' - [（5-氯-2-吡啶基）氨基甲酰基] -6'-β-D-吡喃半乳糖氧基-1-异丙基哌啶-4-甲酰苯胺，2' - （2 - 乙酰氨基-2-脱氧-β-D-吡喃葡萄糖基氧基）-4'-溴-6' - [（5-氯-2-吡啶基）氨基甲酰基] -1-异丙基哌啶-4-甲酰苯胺等或其盐。

8. 发明授权

US07285554B2 Pyrazole derivative 失效
标题翻译：吡唑衍生物
公开(公告)号：US07285554B2
公开(公告)日：2007-10-23
申请号：US11399379
申请日：2006-04-07
申请人： Hirokazu Kubota , Yasuhiro Yonetoku , Keizo Sugasawa , Masashi Funatsu , Souichirou Kawazoe , Akira Toyoshima , Yoshinori Okamoto , Jun Ishikawa , Makoto Takeuchi
发明人： Hirokazu Kubota , Yasuhiro Yonetoku , Keizo Sugasawa , Masashi Funatsu , Souichirou Kawazoe , Akira Toyoshima , Yoshinori Okamoto , Jun Ishikawa , Makoto Takeuchi
IPC分类号： C07D231/12 , A61K31/415
CPC分类号： C07D231/12 , C07D231/14 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Drugs, in particular, pyrazole derivatives represented by the following general formula (I) which have a calcium release-activated calcium channel inhibitory effect and medicinal compositions, in particular, calcium release-activated calcium channel inhibitors containing the above compounds as the active ingredient, (in the formula, each symbol has the following meaning: D: pyrazolyl which may have 1 to 3 substituents selected from the group consisting of -Alk, -lower alkenyl, -lower alkynyl, -halogeno-lower alkyl, -Alk-cycloalkyl, -Alk-O-Alk, -cycloalkyl, —O-Alk, —COOH, —COO-Alk and -Hal, n: 0 or 1, B: phenylene, a nitrogen-containing, divalent, saturated ring group, or a monocyclic, divalent heteroaromatic ring group which may be substituted with Alk, X: —NR1—CR2R3—, —CR2R3—NR1—, —NR1—SO2—, —SO2—NR1— or —CR4═CR5—, and A: benzene ring which may have one or more substituents; mono-, di- or tricyclic fused heteroaryl which may have one or more substituents; cycloalkyl which may have one or more substituents; a nitrogen-containing, saturated ring group which may have one or more substituents; lower alkenyl which may have one or more substituents; lower alkynyl which may have one or more substituents; or Alk which may have one or more substituents).
摘要翻译：药物，特别是具有钙释放激活的钙通道抑制作用的以下通式（I）表示的吡唑衍生物和药物组合物，特别是含有上述化合物作为活性成分的钙释放激活的钙通道抑制剂，（式中，每个符号具有以下含义：D：吡唑基，其可以具有1〜3个选自-Alk， - 低级烯基， - 低级炔基， - 卤代 - 低级烷基，-Al-环烷基， -Alk-O-Alk， - 环烷基，-O-Alk，-COOH，-COO-Alk和-Hal，n：0或1，B：亚苯基，含氮二价饱和环基或单环可以被Alk取代的二价杂芳族环基团，X：-NR 1 -CR 2，R 3，...， 2，-NR 3 -NR 1 - ， - NR 1 -SO 2 - ， - SO 2 - ， - SO 2 或者-CR 4 -CR 5 - ，以及可以具有的A：苯环一个o 更多取代基; 可以具有一个或多个取代基的单 - ，二 - 或三环稠合杂芳基; 可以具有一个或多个取代基的环烷基; 可具有一个或多个取代基的含氮饱和环基; 可以具有一个或多个取代基的低级烯基; 可以具有一个或多个取代基的低级炔基; 或Alk，其可以具有一个或多个取代基）。

9. 发明申请

US20100041668A1 Compositions and methods for treating thrombocytopenia 审中-公开
标题翻译：治疗血小板减少症的组合物和方法
公开(公告)号：US20100041668A1
公开(公告)日：2010-02-18
申请号：US12583359
申请日：2009-08-19
申请人： Ken-Ichi Suzuki , Keizo Sugasawa
发明人： Ken-Ichi Suzuki , Keizo Sugasawa
IPC分类号： A61K31/496 , A61P7/00
CPC分类号： A61K45/06 , A61K31/496 , A61K2300/00
摘要： The present invention in certain embodiments is directed to a pharmaceutical dosage form comprising a therapeutically effective amount of a first agent that agonizes a human TPO receptor by binding to the rhTPO binding site of the human TPO receptor; and a therapeutically effective amount of a second agent that agonizes the human TPO receptor by binding to a binding site of the human TPO receptor distinct from the rhTPO binding site.
摘要翻译：本发明在某些实施方案中涉及药物剂型，其包含治疗有效量的通过结合人TPO受体的rhTPO结合位点而激动人类TPO受体的第一药剂; 和治疗有效量的通过结合不同于rhTPO结合位点的人TPO受体的结合位点来激动人类TPO受体的第二药剂。

10. 发明授权

US07307074B2 Diazepan derivatives or salts thereof 有权
标题翻译：二氮杂环庚烷衍生物或其盐
公开(公告)号：US07307074B2
公开(公告)日：2007-12-11
申请号：US10656129
申请日：2003-09-08
申请人： Fukushi Hirayama , Hiroyuki Koshio , Tsukasa Ishihara , Norio Seki , Shunichiro Hachiya , Keizo Sugasawa , Ryota Shiraki , Yuji Koga , Yuzo Matsumoto , Takeshi Shigenaga , Souichirou Kawazoe
发明人： Fukushi Hirayama , Hiroyuki Koshio , Tsukasa Ishihara , Norio Seki , Shunichiro Hachiya , Keizo Sugasawa , Ryota Shiraki , Yuji Koga , Yuzo Matsumoto , Takeshi Shigenaga , Souichirou Kawazoe
IPC分类号： A61P7/02 , A61K31/55 , C07D223/04 , C07D401/00
CPC分类号： C07D401/04 , A61K31/551 , C07D243/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04
摘要： To provide a compound which has an anticoagulation action based upon inhibition of activated blood coagulation factor X and is useful as an anticoagulant or an agent for prevention and treatment of diseases caused by thrombus or embolus. A diazepan derivative such as 4-[(3-carbamimidoylphenylamino)methyl]-3-[4-(4-methyl-1,4-diazepan-1-yl)benzoylamino]benzoic acid and 3-hydroxy-4′-methoxy-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzanilide or a salt thereof is an effective ingredient.
摘要翻译：提供具有基于活化凝血因子X的抑制的抗凝作用的化合物，并且可用作抗凝血剂或用于预防和治疗由血栓或栓塞引起的疾病的药剂。二氮杂环丁烷衍生物如4 - [（3-氨甲酰氨基）甲基] -3- [4-（4-甲基-1,4-二氮杂环庚烷-1-基）苯甲酰基氨基]苯甲酸和3-羟基-4'-甲氧基 - 2 - {[4-（4-甲基-1,4-二氮杂环庚烷-1-基）苯甲酰基]氨基} -N-苯甲酰苯胺或其盐是有效成分。

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