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1. 发明授权

US08554487B2 Method and apparatus for analyzing genotype data 有权
标题翻译：分析基因型数据的方法和装置
公开(公告)号：US08554487B2
公开(公告)日：2013-10-08
申请号：US11326164
申请日：2006-01-04
申请人： Ki-eun Kim , Kyung-Hee Park , Jung-joo Hwang , Jae-Heup Kim , Yeon-Su Lee , Kyusang Lee
发明人： Ki-eun Kim , Kyung-Hee Park , Jung-joo Hwang , Jae-Heup Kim , Yeon-Su Lee , Kyusang Lee
IPC分类号： G01N33/50
CPC分类号： G06F19/18 , G06F19/26
摘要： Provided are a method and apparatus for analyzing genotype data plotted in a two-dimensional space. The method includes: connecting points representing the genotype data to a predetermined point to form straight lines and obtaining angles between adjacent straight lines; extracting the two largest angles from the obtained angles; and analyzing the plotted genotype data using three groups of the genotype data separated by the two extracted largest angles. According to the present invention, when the experimental results of classifying genotype are to be analyzed, the two largest angles from the angles obtained by connecting straight lines between points representing each of the genotype data and a predetermined point plotted in a two-dimensional space are detected, and three data regions separated by the detected two largest angles are used to analyze the genotype data. Thus, a large amount of the experimental data for classifying the genotype can be analyzed rapidly and conveniently.
摘要翻译：提供了用于分析绘制在二维空间中的基因型数据的方法和装置。该方法包括：将表示基因型数据的点连接到预定点以形成直线并获得相邻直线之间的角度; 从所获得的角度提取两个最大角度; 并使用由两个提取的最大角度分离的三组基因型数据分析绘制的基因型数据。根据本发明，当分析基因型分类的实验结果时，通过连接表示各基因型数据的点和在二维空间中绘制的预定点之间的直线连接获得的角度的两个最大角度为检测到的三个数据区域被检测到的两个最大角度分开，以分析基因型数据。因此，可以快速方便地分析大量用于分类基因型的实验数据。

2. 发明申请

US20060252059A1 Method and apparatus for analyzing genotype data 有权
公开(公告)号：US20060252059A1
公开(公告)日：2006-11-09
申请号：US11326164
申请日：2006-01-04
申请人： Ki-eun Kim , Kyung-Hee Park , Jung-joo Hwang , Jae-Heup Kim , Yeon-Su Lee , Kyusang Lee
发明人： Ki-eun Kim , Kyung-Hee Park , Jung-joo Hwang , Jae-Heup Kim , Yeon-Su Lee , Kyusang Lee
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G06F19/18 , G06F19/26
摘要： Provided are a method and apparatus for analyzing genotype data plotted in a two-dimensional space. The method includes: connecting points representing the genotype data to a predetermined point to form straight lines and obtaining angles between adjacent straight lines; extracting the two largest angles from the obtained angles; and analyzing the plotted genotype data using three groups of the genotype data separated by the two extracted largest angles. According to the present invention, when the experimental results of classifying genotype are to be analyzed, the two largest angles from the angles obtained by connecting straight lines between points representing each of the genotype data and a predetermined point plotted in a two-dimensional space are detected, and three data regions separated by the detected two largest angles are used to analyze the genotype data. Thus, a large amount of the experimental data for classifying the genotype can be analyzed rapidly and conveniently.

3. 发明申请

US20070048751A1 Method of diagnosing type II diabetes mellitus using multilocus marker, polynucleotide including marker associated with type II diabetes mellitus, and microarray and diagnostic kit including the polynucleotide 审中-公开
标题翻译：使用多位点标记物诊断II型糖尿病的方法，包括与II型糖尿病相关的标记的多核苷酸，以及包括该多核苷酸的微阵列和诊断试剂盒
公开(公告)号：US20070048751A1
公开(公告)日：2007-03-01
申请号：US11352174
申请日：2006-02-10
申请人： Jae-Heup Kim , Seung-Hak Choi , Yun-Sun Nam , Yeon-Su Lee , Jung-joo Hwang , Kyusang Lee
发明人： Jae-Heup Kim , Seung-Hak Choi , Yun-Sun Nam , Yeon-Su Lee , Jung-joo Hwang , Kyusang Lee
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Provided are a polynucleotide including a marker associated with type II diabetes mellitus and a method of diagnosing type II diabetes mellitus in an individual, which includes determining a nucleotide of a polymorphic site of at least one polynucleotide of Table 1 in the specification.
摘要翻译：提供了包含与II型糖尿病相关的标志物的多核苷酸和个体中诊断II型糖尿病的方法，其包括确定说明书中表1的至少一种多核苷酸的多态性位点的核苷酸。

4. 发明授权

US07833710B2 Polynucleotide associated with breast cancer comprising single nucleotide polymorphism, microarray and diagnostic kit comprising the same and method for diagnosing breast cancer using the same 有权
标题翻译：与包含单核苷酸多态性的乳腺癌相关的多核苷酸，包含相同的微阵列和诊断试剂盒以及使用该多核苷酸诊断乳腺癌的方法
公开(公告)号：US07833710B2
公开(公告)日：2010-11-16
申请号：US11329299
申请日：2006-01-10
申请人： Yeon-Su Lee , Kyung-Hee Park , Jae-Heup Kim , Kyusang Lee , Yeon-a Park , Ji-Young Cho , Ok-ryul Song , Tae-jin Ahn , Ok-kyoung Son
发明人： Yeon-Su Lee , Kyung-Hee Park , Jae-Heup Kim , Kyusang Lee , Yeon-a Park , Ji-Young Cho , Ok-ryul Song , Tae-jin Ahn , Ok-kyoung Son
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Provided is a polynucleotide for diagnosis or treatment of breast cancer, including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID No: 1 to SEQ ID No: 5 and comprising a nucleotide at 101st position of the nucleotide sequence, or a complementary polynucleotide thereof.
摘要翻译：提供了用于诊断或治疗乳腺癌的多核苷酸，包括选自SEQ ID No：1至SEQ ID No：5的核苷酸序列的核苷酸序列的至少10个连续核苷酸，并且包含第101位的核苷酸核苷酸序列或其互补多核苷酸。

5. 发明申请

US20060183139A1 Polynucleotide associated with breast cancer comprising single nucleotide polymorphism, microarray and diagnostic kit comprising the same and method for diagnosing breast cancer using the same 有权
标题翻译：与包含单核苷酸多态性的乳腺癌相关的多核苷酸，包含相同的微阵列和诊断试剂盒以及使用该多核苷酸诊断乳腺癌的方法
公开(公告)号：US20060183139A1
公开(公告)日：2006-08-17
申请号：US11329299
申请日：2006-01-10
申请人： Yeon-Su Lee , Kyung-Hee Park , Jae-Heup Kim , Kyusang Lee , Yeon-a Park , Ji-Young Cho , Ok-ryul Song , Tae-jin Ahn , Ok-kyoung Son
发明人： Yeon-Su Lee , Kyung-Hee Park , Jae-Heup Kim , Kyusang Lee , Yeon-a Park , Ji-Young Cho , Ok-ryul Song , Tae-jin Ahn , Ok-kyoung Son
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Provided is a polynucleotide for diagnosis or treatment of breast cancer, including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID No: 1 to SEQ ID No: 5 and comprising a nucleotide at 101st position of the nucleotide sequence, or a complementary polynucleotide thereof.
摘要翻译：提供了用于诊断或治疗乳腺癌的多核苷酸，包括选自SEQ ID No：1至SEQ ID No：5的核苷酸序列并且包含101

6. 发明申请

US20060089811A1 Method of detecting contamination and method of determining detection threshold in genotyping experiment 审中-公开
标题翻译：检测污染物的方法和确定基因分型实验检测阈值的方法
公开(公告)号：US20060089811A1
公开(公告)日：2006-04-27
申请号：US11128736
申请日：2005-05-13
申请人： Kyusang Lee , Kyung-hee Park , Kyoung-a Kim , Ok-ryul Song
发明人： Kyusang Lee , Kyung-hee Park , Kyoung-a Kim , Ok-ryul Song
IPC分类号： G06F19/00
CPC分类号： G16B40/00 , G16B20/00
摘要： A method of detecting a contamination event by using a blank well and a replicate well occurring during a high-throughput screening is provided. In the method, a logistic regression equation for detecting a contamination in a genotyping experiment is determined, and a BWE (blank well error), an IRF (intraplate replicate failure) and an HWE (Hardy-Weinberg equilibrium) occurring in a blank well and a replicate well of a well plate during the genotyping experiment are checked. The contamination is detected based on a result value of the logistic regression equation, which is calculated by using the BWE, the IRF and the HWE as input variables of the logistic regression equation. Thus, the contamination can be precisely measured by the quantitative indexes without any qualitative analysis.
摘要翻译：提供了一种通过使用空白孔和在高通量筛选期间发生的重复井来检测污染事件的方法。在该方法中，确定用于检测基因分型实验中的污染的逻辑回归方程，并且在空白井中发生BWE（空白井误差），IRF（板内复制失败）和HWE（Hardy-Weinberg平衡）在基因分型实验期间检查孔板的重复孔。基于逻辑回归方程的结果值检测污染物，通过使用BWE，IRF和HWE作为逻辑回归方程的输入变量计算。因此，可以通过定量指标精确测量污染物，无需任何定性分析。

7. 发明申请

US20130043214A1 SACRIFICIAL ETCH PROTECTION LAYERS FOR REUSE OF WAFERS AFTER EPITAXIAL LIFT OFF 审中-公开
标题翻译：外部提升关闭后的重复使用的防腐蚀层
公开(公告)号：US20130043214A1
公开(公告)日：2013-02-21
申请号：US13536267
申请日：2012-06-28
申请人： Stephen R. Forrest , Jeramy Zimmerman , Kyusang Lee
发明人： Stephen R. Forrest , Jeramy Zimmerman , Kyusang Lee
IPC分类号： B32B15/04 , B44C1/22
CPC分类号： H01L31/1896 , Y02E10/50 , Y10T428/31678
摘要： There is disclosed a growth structure comprising a growth substrate, a sacrificial layer, a buffer layer, at least three substrate protective layers, at least one epilayer, at least one contact, and a metal or alloy-coated host substrate. In one embodiment, the device further comprises at least three device structure protecting layers. The sacrificial layer may be positioned between the growth substrate and the at least one epilayer, wherein the at least three substrate protective layers are positioned between the growth substrate and the sacrificial layer, and the at least three device structure protecting layers are positioned between the sacrificial layer and the epilayer. There is also disclosed a method of preserving the integrity of a growth substrate by releasing the cell structure by etching the sacrificial layer and the protective layers.
摘要翻译：公开了一种生长结构，其包括生长衬底，牺牲层，缓冲层，至少三个衬底保护层，至少一个外延层，至少一个接触层，以及涂覆有金属或合金的主体衬底。在一个实施例中，该装置还包括至少三个装置结构保护层。牺牲层可以位于生长衬底和至少一个外延层之间，其中至少三个衬底保护层位于生长衬底和牺牲层之间，并且至少三个器件结构保护层位于牺牲层之间层和外延层。还公开了通过蚀刻牺牲层和保护层来释放细胞结构来保持生长基质的完整性的方法。

8. 发明授权

US08378385B2 Methods of preparing flexible photovoltaic devices using epitaxial liftoff, and preserving the integrity of growth substrates used in epitaxial growth 有权
公开(公告)号：US08378385B2
公开(公告)日：2013-02-19
申请号：US12878261
申请日：2010-09-09
申请人： Stephen R. Forrest , Jeramy Zimmerman , Kyusang Lee , Kuen-Ting Shiu
发明人： Stephen R. Forrest , Jeramy Zimmerman , Kyusang Lee , Kuen-Ting Shiu
IPC分类号： H01L29/06 , H01L21/302 , H01L31/0352
CPC分类号： H01L31/1892 , H01L21/7813 , H01L31/0735 , H01L31/1852 , H01L31/1896 , Y02E10/544
摘要： There is disclosed methods of making photosensitive devices, such as flexible photovoltaic (PV) devices, through the use of epitaxial liftoff. Also described herein are methods of preparing flexible PV devices comprising a structure having a growth substrate, wherein the selective etching of protective layers yields a smooth growth substrate that us suitable for reuse.

9. 发明申请

US20110186910A1 METHODS OF PREPARING FLEXIBLE PHOTOVOLTAIC DEVICES USING EPITAXIAL LIFTOFF, AND PRESERVING THE INTEGRITY OF GROWTH SUBSTRATES USED IN EPITAXIAL GROWTH 有权
标题翻译：使用外延起绒制备柔性光伏器件的方法，并保持外延生长中使用的生长基质的一致性
公开(公告)号：US20110186910A1
公开(公告)日：2011-08-04
申请号：US12878261
申请日：2010-09-09
申请人： Stephen R. Forrest , Jeramy Zimmerman , Kyusang Lee , Kuen-Ting Shiu
发明人： Stephen R. Forrest , Jeramy Zimmerman , Kyusang Lee , Kuen-Ting Shiu
IPC分类号： H01L29/06 , H01L21/302 , H01L31/0352
CPC分类号： H01L31/1892 , H01L21/7813 , H01L31/0735 , H01L31/1852 , H01L31/1896 , Y02E10/544
摘要： There is disclosed methods of making photosensitive devices, such as flexible photovoltaic (PV) devices, through the use of epitaxial liftoff. Also described herein are methods of preparing flexible PV devices comprising a structure having a growth substrate, wherein the selective etching of protective layers yields a smooth growth substrate that us suitable for reuse.
摘要翻译：公开了通过使用外延剥离来制造诸如柔性光伏（PV）器件的光敏器件的方法。本文还描述了制备包含具有生长衬底的结构的柔性PV器件的方法，其中保护层的选择性蚀刻产生了适合于再利用的平滑生长衬底。

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