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1. 发明授权

US08554487B2 Method and apparatus for analyzing genotype data 有权
标题翻译：分析基因型数据的方法和装置
公开(公告)号：US08554487B2
公开(公告)日：2013-10-08
申请号：US11326164
申请日：2006-01-04
申请人： Ki-eun Kim , Kyung-Hee Park , Jung-joo Hwang , Jae-Heup Kim , Yeon-Su Lee , Kyusang Lee
发明人： Ki-eun Kim , Kyung-Hee Park , Jung-joo Hwang , Jae-Heup Kim , Yeon-Su Lee , Kyusang Lee
IPC分类号： G01N33/50
CPC分类号： G06F19/18 , G06F19/26
摘要： Provided are a method and apparatus for analyzing genotype data plotted in a two-dimensional space. The method includes: connecting points representing the genotype data to a predetermined point to form straight lines and obtaining angles between adjacent straight lines; extracting the two largest angles from the obtained angles; and analyzing the plotted genotype data using three groups of the genotype data separated by the two extracted largest angles. According to the present invention, when the experimental results of classifying genotype are to be analyzed, the two largest angles from the angles obtained by connecting straight lines between points representing each of the genotype data and a predetermined point plotted in a two-dimensional space are detected, and three data regions separated by the detected two largest angles are used to analyze the genotype data. Thus, a large amount of the experimental data for classifying the genotype can be analyzed rapidly and conveniently.
摘要翻译：提供了用于分析绘制在二维空间中的基因型数据的方法和装置。该方法包括：将表示基因型数据的点连接到预定点以形成直线并获得相邻直线之间的角度; 从所获得的角度提取两个最大角度; 并使用由两个提取的最大角度分离的三组基因型数据分析绘制的基因型数据。根据本发明，当分析基因型分类的实验结果时，通过连接表示各基因型数据的点和在二维空间中绘制的预定点之间的直线连接获得的角度的两个最大角度为检测到的三个数据区域被检测到的两个最大角度分开，以分析基因型数据。因此，可以快速方便地分析大量用于分类基因型的实验数据。

2. 发明申请

US20060252059A1 Method and apparatus for analyzing genotype data 有权
公开(公告)号：US20060252059A1
公开(公告)日：2006-11-09
申请号：US11326164
申请日：2006-01-04
申请人： Ki-eun Kim , Kyung-Hee Park , Jung-joo Hwang , Jae-Heup Kim , Yeon-Su Lee , Kyusang Lee
发明人： Ki-eun Kim , Kyung-Hee Park , Jung-joo Hwang , Jae-Heup Kim , Yeon-Su Lee , Kyusang Lee
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G06F19/18 , G06F19/26
摘要： Provided are a method and apparatus for analyzing genotype data plotted in a two-dimensional space. The method includes: connecting points representing the genotype data to a predetermined point to form straight lines and obtaining angles between adjacent straight lines; extracting the two largest angles from the obtained angles; and analyzing the plotted genotype data using three groups of the genotype data separated by the two extracted largest angles. According to the present invention, when the experimental results of classifying genotype are to be analyzed, the two largest angles from the angles obtained by connecting straight lines between points representing each of the genotype data and a predetermined point plotted in a two-dimensional space are detected, and three data regions separated by the detected two largest angles are used to analyze the genotype data. Thus, a large amount of the experimental data for classifying the genotype can be analyzed rapidly and conveniently.

3. 发明授权

US07635559B2 Polynucleotide associated with a type II diabetes mellitus comprising single nucleotide polymorphism, microarray and diagnostic kit comprising the same and method for analyzing polynucleotide using the same 有权
标题翻译：与包含单核苷酸多态性的II型糖尿病相关的多核苷酸，包含该多核苷酸的微阵列和诊断试剂盒以及使用其分析多核苷酸的方法
公开(公告)号：US07635559B2
公开(公告)日：2009-12-22
申请号：US10546685
申请日：2004-12-24
申请人： Kyu-Sang Lee , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Ok-Kyoung Son , Ji-Young Cho , Yeon-A Park , Sung-Woo Hong , Jung-Joo Hwang , Hyo-Jeong Jeon
发明人： Kyu-Sang Lee , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Ok-Kyoung Son , Ji-Young Cho , Yeon-A Park , Sung-Woo Hong , Jung-Joo Hwang , Hyo-Jeong Jeon
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q2600/156
摘要： Provided is a polynucleotide for diagnosis or treatment of type II diabetes mellitus, including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID NOS: 1-80 and including a nucleotide at position 101 of the nucleotide sequence, or a complementary polynucleotide thereof.
摘要翻译：提供了用于诊断或治疗II型糖尿病的多核苷酸，包括选自SEQ ID NO：1-80的核苷酸序列的核苷酸序列的至少10个连续核苷酸，并且包含核苷酸的位置101的核苷酸序列或其互补多核苷酸。

4. 发明申请

US20060216712A1 Polynucleotide associated with a type II diabetes mellitus comprising single nucleotide polymorphism, microarray and diagnostic kit comprising the same and method for analyzing polynucleotide using the same 有权
公开(公告)号：US20060216712A1
公开(公告)日：2006-09-28
申请号：US10546685
申请日：2004-12-24
申请人： Kyu-Sang Lee , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Ok-Kyoung Son , Ji-Young Cho , Yeon-A Park , Sung-Woo Hong , Jung-Joo Hwang , Hyo-Jeong Jeon
发明人： Kyu-Sang Lee , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Ok-Kyoung Son , Ji-Young Cho , Yeon-A Park , Sung-Woo Hong , Jung-Joo Hwang , Hyo-Jeong Jeon
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q2600/156
摘要： Provided is a polynucleotide for diagnosis or treatment of type II diabetes mellitus, including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID NOS: 1-80 and including a nucleotide at position 101 of the nucleotide sequence, or a complementary polynucleotide thereof.

5. 发明申请

US20060183139A1 Polynucleotide associated with breast cancer comprising single nucleotide polymorphism, microarray and diagnostic kit comprising the same and method for diagnosing breast cancer using the same 有权
标题翻译：与包含单核苷酸多态性的乳腺癌相关的多核苷酸，包含相同的微阵列和诊断试剂盒以及使用该多核苷酸诊断乳腺癌的方法
公开(公告)号：US20060183139A1
公开(公告)日：2006-08-17
申请号：US11329299
申请日：2006-01-10
申请人： Yeon-Su Lee , Kyung-Hee Park , Jae-Heup Kim , Kyusang Lee , Yeon-a Park , Ji-Young Cho , Ok-ryul Song , Tae-jin Ahn , Ok-kyoung Son
发明人： Yeon-Su Lee , Kyung-Hee Park , Jae-Heup Kim , Kyusang Lee , Yeon-a Park , Ji-Young Cho , Ok-ryul Song , Tae-jin Ahn , Ok-kyoung Son
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Provided is a polynucleotide for diagnosis or treatment of breast cancer, including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID No: 1 to SEQ ID No: 5 and comprising a nucleotide at 101st position of the nucleotide sequence, or a complementary polynucleotide thereof.
摘要翻译：提供了用于诊断或治疗乳腺癌的多核苷酸，包括选自SEQ ID No：1至SEQ ID No：5的核苷酸序列并且包含101

6. 发明申请

US20100203503A1 GENETIC POLYMORPHISMS ASSOCIATED WITH MYOCARDIAL INFARCTION AND USES THEREOF 审中-公开
标题翻译：与心肌梗塞相关的遗传多态性及其用途
公开(公告)号：US20100203503A1
公开(公告)日：2010-08-12
申请号：US11993549
申请日：2006-05-17
申请人： Byung-Chul Kim , Kyung-Hee Park , Tae-Jin Ahn , Kyu-Sang Lee , Jae-Heup Kim , Ki-Eun Kim , Yeon-Su Lee
发明人： Byung-Chul Kim , Kyung-Hee Park , Tae-Jin Ahn , Kyu-Sang Lee , Jae-Heup Kim , Ki-Eun Kim , Yeon-Su Lee
IPC分类号： C12Q1/68 , G01N33/53 , C12N5/02 , G01N33/566 , C40B30/04 , C40B40/06 , C40B40/10 , C07K14/435 , C07K16/18 , C07H21/04
CPC分类号： C07K14/4702 , C12N15/113 , C12N2310/11 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： A genetic polymorphism associated with myocardial infarction is provided. More particularly, provided are a polynucleotide including a single nucleotide polymorphism (SNP) or a haplotype associated with myocardial infarction, a polynucleotide hybridized with the polynucleotide, a polypeptide encoded by one of the polynucleotides, an antibody bound to the polypeptide, a microarray and a kit including one of the polynucleotides, a myocardial infarction diagnosis method, a SNP detecting method and a method of screening pharmaceutical compositions for myocardial infarction.
摘要翻译：提供与心肌梗死相关的遗传多态性。更具体地，提供了包括单核苷酸多态性（SNP）或与心肌梗死相关的单元型的多核苷酸，与多核苷酸杂交的多核苷酸，由多核苷酸之一编码的多肽，与多肽结合的抗体，微阵列和包括多核苷酸之一，心肌梗塞诊断方法，SNP检测方法和筛选用于心肌梗塞的药物组合物的方法。

7. 发明申请

US20060257913A1 Genetic polymorphisms associated with myocardial infarction and uses thereof 审中-公开
标题翻译：与心肌梗塞相关的遗传多态性及其用途
公开(公告)号：US20060257913A1
公开(公告)日：2006-11-16
申请号：US11430939
申请日：2006-05-10
申请人： Byung-chul Kim , Yeon-Su Lee , Min-sun Kim , Ok-kyoung Son , Moon-sue Lee , Ki-eun Kim , Ok-ryul Song , Hyo-jeong Jeon , Kyung-Hee Park , Tae-jin Ahn , Jae-Heup Kim
发明人： Byung-chul Kim , Yeon-Su Lee , Min-sun Kim , Ok-kyoung Son , Moon-sue Lee , Ki-eun Kim , Ok-ryul Song , Hyo-jeong Jeon , Kyung-Hee Park , Tae-jin Ahn , Jae-Heup Kim
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C07K14/47
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： A genetic polymorphism associated with myocardial infarction is provided. More particularly, provided are a polynucleotide including a single nucleotide polymorphism (SNP) associated with myocardial infarction, a polynucleotide hybridized with the polynucleotide, a polypeptide encoded by one of the polynucleotides, an antibody bound to the polypeptide, a microarray and a kit including one of the polynucleotides, a myocardial infarction diagnosis method, a SNP detecting method and a method of screening pharmaceutical compositions for myocardial infarction.
摘要翻译：提供与心肌梗死相关的遗传多态性。更具体地，提供了包括与心肌梗死相关的单核苷酸多态性（SNP），与多核苷酸杂交的多核苷酸，由多核苷酸之一编码的多肽，与多肽结合的抗体，微阵列和包含一个的多核苷酸，心肌梗死诊断方法，SNP检测方法和筛选用于心肌梗塞的药物组合物的方法。

8. 发明授权

US07833710B2 Polynucleotide associated with breast cancer comprising single nucleotide polymorphism, microarray and diagnostic kit comprising the same and method for diagnosing breast cancer using the same 有权
标题翻译：与包含单核苷酸多态性的乳腺癌相关的多核苷酸，包含相同的微阵列和诊断试剂盒以及使用该多核苷酸诊断乳腺癌的方法
公开(公告)号：US07833710B2
公开(公告)日：2010-11-16
申请号：US11329299
申请日：2006-01-10
申请人： Yeon-Su Lee , Kyung-Hee Park , Jae-Heup Kim , Kyusang Lee , Yeon-a Park , Ji-Young Cho , Ok-ryul Song , Tae-jin Ahn , Ok-kyoung Son
发明人： Yeon-Su Lee , Kyung-Hee Park , Jae-Heup Kim , Kyusang Lee , Yeon-a Park , Ji-Young Cho , Ok-ryul Song , Tae-jin Ahn , Ok-kyoung Son
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Provided is a polynucleotide for diagnosis or treatment of breast cancer, including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID No: 1 to SEQ ID No: 5 and comprising a nucleotide at 101st position of the nucleotide sequence, or a complementary polynucleotide thereof.
摘要翻译：提供了用于诊断或治疗乳腺癌的多核苷酸，包括选自SEQ ID No：1至SEQ ID No：5的核苷酸序列的核苷酸序列的至少10个连续核苷酸，并且包含第101位的核苷酸核苷酸序列或其互补多核苷酸。

9. 发明申请

US20070128602A1 Polynucleotide associated with a colon cancer comprising single nucleotide poylmorphism, microarray and diagnostic kit comprising the same and method for diagnosing a colon cancer using the polynucleotide 有权
标题翻译：与包含单核苷酸多态性的结肠癌相关的多核苷酸，微阵列和包含其的诊断试剂盒和使用多核苷酸诊断结肠癌的方法
公开(公告)号：US20070128602A1
公开(公告)日：2007-06-07
申请号：US10549661
申请日：2005-02-19
申请人： Kyung-Hee Park , Kyu-Sang Lee , Yeon-Su Lee , Jae-Heup Kim , Yeon-A Park , Ji-Young Cho , Ok-Kyoung Son , Byung-Chul Kim , Min-Sun Kim
发明人： Kyung-Hee Park , Kyu-Sang Lee , Yeon-Su Lee , Jae-Heup Kim , Yeon-A Park , Ji-Young Cho , Ok-Kyoung Son , Byung-Chul Kim , Min-Sun Kim
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： Provided is a polynucleotide including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID NOS: 1-12 and including a nucleotide at position 101 of the nucleotide sequence, or a complementary polynucleotide thereof.
摘要翻译：提供了包含选自SEQ ID NO：1-12的核苷酸序列并且包含核苷酸序列的101位的核苷酸的核苷酸序列的至少10个连续核苷酸或其互补多核苷酸的多核苷酸。

10. 发明申请

US20060263815A1 Multiple SNP for diagnosing cardiovascular disease, microarray and kit comprising the same, and method of diagnosing cardiovascular disease using the same 有权
标题翻译：用于诊断心血管疾病的多重SNP，包含该SNP的微阵列和试剂盒以及使用该SNP诊断心血管疾病的方法
公开(公告)号：US20060263815A1
公开(公告)日：2006-11-23
申请号：US11435662
申请日：2006-05-17
申请人： Seung-Hak Choi , Yun-sun Nam , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Hyo-jeong Jeon , Ok-ryul Song , Tae-jin Ahn , Kyu-sang Lee
发明人： Seung-Hak Choi , Yun-sun Nam , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Hyo-jeong Jeon , Ok-ryul Song , Tae-jin Ahn , Kyu-sang Lee
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： A multiple single nucleotide polymorphism (multi-SNP) marker for cardiovascular disease diagnosis and a method of diagnosing cardiovascular disease are provided. Also, sets of polynucleotides, a microarray, and a kit including the microarray are provided.
摘要翻译：提供了用于心血管疾病诊断的多重单核苷酸多态性（多SNP）标记物和诊断心血管疾病的方法。此外，提供了多组核苷酸，微阵列和包含微阵列的试剂盒。

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