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1. 发明授权

US08657862B2 Light system for photodynamic diagnosis and/or therapy 失效
标题翻译：用于光动力学诊断和/或治疗的光系统
公开(公告)号：US08657862B2
公开(公告)日：2014-02-25
申请号：US11432014
申请日：2006-05-11
申请人： Klaus M. Irion , André Ehrhardt , Andreas Schmal
发明人： Klaus M. Irion , André Ehrhardt , Andreas Schmal
IPC分类号： A61N5/06
CPC分类号： G02B6/4298 , A61B5/0059 , A61N5/0601 , A61N5/062 , G02B6/4225 , G02B6/4226
摘要： A light system for medical photodynamic applications comprises an incoherent light source emitting a light with a power and a light guide which has a distal end and an entrance interface. The entrance interface and the light source have a position relative to one another and are able to be positioned relative to one another. The light system further comprises a luminous power meter for measuring a luminous power emitted at the distal end of the light guide, a motorized positioning unit for positioning the entrance interface and the light source relative to one another, and a control unit which controls the positioning unit as a function of the luminous power measured by the luminous power meter.
摘要翻译：用于医疗光动力学应用的光系统包括发射具有光焦度的光和具有远端和入射界面的光导的非相干光源。入口接口和光源具有相对于彼此的位置，并且能够相对于彼此定位。光系统还包括用于测量在光导的远端发射的发光功率的光功率计，用于相对于彼此定位入口界面和光源的电动定位单元，以及控制单元，其控制定位单位作为由发光度计测量的发光功率的函数。

2. 发明授权

US09585612B2 Multifunctional fluorescence diagnosis system 有权
标题翻译：多功能荧光诊断系统
公开(公告)号：US09585612B2
公开(公告)日：2017-03-07
申请号：US11361484
申请日：2006-02-24
申请人： Klaus M. Irion , André Ehrhardt , Reinhold Baumgartner , Herbert Stepp , Thomas Pongratz
发明人： Klaus M. Irion , André Ehrhardt , Reinhold Baumgartner , Herbert Stepp , Thomas Pongratz
IPC分类号： A61B6/00 , G01N21/64 , A61B5/00 , A61B1/00 , A61B1/04 , A61B1/06 , A61B1/307
CPC分类号： A61B5/413 , A61B1/00009 , A61B1/00186 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B1/307 , A61B5/0071 , A61B5/0084 , A61B5/721 , G01N21/6428 , G01N21/6456
摘要： A fluorescence diagnosis system has a viewing system at least one light source and a camera system. The at least one light source can be operated in three modes, a first generating white light, a second with a first fluorescence excitation light of a first excitation wavelength and a third in which a second fluorescence excitation light of a second excitation wavelength is generated producing a fluorescence image in the NIR range. The camera system is sensitive at least in the visible and the NIR range. The system further comprises an image processing system for converting the fluorescence image in the NIR range into a visible image.
摘要翻译：荧光诊断系统具有至少一个光源和相机系统的观察系统。所述至少一个光源可以以三种模式操作，第一产生白光，第二产生具有第一激发波长的第一荧光激发光，其中第三激发光产生第二激发波长的第二荧光激发光，产生产生 NIR范围内的荧光图像。至少在可见光和近红外范围内，相机系统是敏感的。该系统还包括用于将NIR范围内的荧光图像转换成可见图像的图像处理系统。

3. 发明授权

US06494826B1 Coupling for a mechanical a light-guiding and an image-guiding connection of an endoscope to a camera module 有权
标题翻译：将内窥镜的机械，导光和图像引导连接耦合到相机模块
公开(公告)号：US06494826B1
公开(公告)日：2002-12-17
申请号：US09418542
申请日：1999-10-14
申请人： David Chatenever , Klaus M. Irion , André Ehrhardt , Jürgen Rudischhauser , Daniel Mattsson-Boze
发明人： David Chatenever , Klaus M. Irion , André Ehrhardt , Jürgen Rudischhauser , Daniel Mattsson-Boze
IPC分类号： A61B104
CPC分类号： A61B1/00188 , A61B1/00195 , A61B1/042 , G02B23/2484 , G03B17/48
摘要： A coupling provides mechanical, light-guiding, and image-guiding connection of an endoscope to a camera module. It is proposed that a first cylindrical stem, in whose interior a proximal end segment of the light guiding system is received, project in the coupling direction from a coupling end of the endoscope. Also projecting from the coupling end in the coupling direction is a second approximately cylindrical stem whose length and diameter are greater than the length and diameter of the first stem, a proximal end segment of the image guiding system being received in the interior of the second stem. The second stem coacts with an interlock arranged on the camera module, for mechanical interlocking of the coupling. The first and second stems extend at a distance next to one another, and the coupling end of the camera module has receptacles, complementary to the two stems, into which the two stems penetrate. In the base, the receptacle into which the second stem enters is optically connected to the image sensing system of the camera module, and the receptacle into which the shorter first stem can be received has a light guide.
摘要翻译：联轴器提供内窥镜到相机模块的机械，导光和图像引导连接。提出在其内部容纳有导光系统的近端部分的第一圆柱形杆在从内窥镜的联接端沿联接方向突出。从联接端在耦合方向上突出的是第二近似圆柱形的杆，其长度和直径大于第一杆的长度和直径，图像引导系统的近端段被容纳在第二杆的内部。第二杆与布置在相机模块上的互锁件共同作用，用于联接器的机械互锁。第一和第二杆彼此相距一定距离延伸，并且相机模块的联接端具有与两个杆互补的插座，两个杆穿过该插座。在基座中，第二杆进入的插座光学地连接到相机模块的图像感测系统，并且可以容纳更短的第一杆的容座具有光导。

4. 发明授权

US08616894B2 Virtual operation simulator 有权
标题翻译：虚拟操作模拟器
公开(公告)号：US08616894B2
公开(公告)日：2013-12-31
申请号：US11232359
申请日：2005-09-21
申请人： André Ehrhardt , Klaus M. Irion , Björn Speiser
发明人： André Ehrhardt , Klaus M. Irion , Björn Speiser
IPC分类号： G09B23/28
CPC分类号： G09B23/285
摘要： The invention relates to a virtual OP simulator (10) for training for minimal-invasive operations, in particular for endourological interventions, having a simulation calculator unit (12), at least one instrument (40), at least one instrument input unit (30) for picking up the instrument (40), with the instrument input unit (30) allowing and recording movement of the instrument (40) in a predetermined number of degrees of freedom, and a force feedback unit (60) which is associated with the instrument input unit (30) and applies variable forces to the instrument (40) directly or indirectly via the instrument input unit (30). A monitoring control unit (20) is provided, which is connected to the simulation computer unit (12) and to the instrument input unit (30), with the monitoring control unit (20) having a first interface (24) which provides communication of parameters between the monitoring control unit (20) and the simulation computer unit (12) at a speed in the region of the video framing rate, and having a second interface (26) which provides communication of parameters with the instrument input unit (30) at a speed which is higher than, in particular a multiple of, the video framing rate, and with the instrument input unit (30) allowing at least four degrees of freedom, detecting movements of the instrument (40) within these degrees of freedom, supplying corresponding signals to the monitoring control unit (20) and receiving signals for the force feedback unit (60), at least some of which are generated by the simulation computer unit (12).
摘要翻译：本发明涉及一种用于训练最小侵入性操作的虚拟OP模拟器（10），特别是用于内科学干预，具有模拟计算器单元（12），至少一个仪器（40），至少一个仪器输入单元（30）），用于拾取所述仪器（40），所述仪器输入单元（30）允许和记录所述仪器（40）以预定数量的自由度的运动;以及力反馈单元（60），所述力反馈单元仪器输入单元（30），并通过仪器输入单元（30）直接或间接地向仪器（40）施加可变力。提供了一个监视控制单元（20），其连接到模拟计算机单元（12）和仪器输入单元（30），监视控制单元（20）具有第一接口（24）监视控制单元（20）和模拟计算机单元（12）之间的参数以视频成帧速率区域的速度，并且具有提供与仪器输入单元（30）的参数通信的第二接口（26）以高于视频成帧速率的速度，并且通过允许至少四个自由度的仪器输入单元（30）检测仪器（40）在这些自由度内的运动，向所述监视控制单元（20）提供相应的信号并且接收所述力反馈单元（60）的信号，所述力反馈单元（60）中的至少一些由所述模拟计算机单元（12）产生。

5. 发明授权

US06212425B1 Apparatus for photodynamic diagnosis 有权
标题翻译：光动力诊断装置
公开(公告)号：US06212425B1
公开(公告)日：2001-04-03
申请号：US09043850
申请日：1998-09-18
申请人： Klaus Irion , Reinhold Baumgartner , Herbert Stepp , André Ehrhardt , Karlheinz Strobl
发明人： Klaus Irion , Reinhold Baumgartner , Herbert Stepp , André Ehrhardt , Karlheinz Strobl
IPC分类号： A61B500
CPC分类号： G01N21/6486 , A61B1/00186 , A61B1/043 , A61B1/055 , A61B1/0638 , A61B1/0646 , A61B5/0071 , A61B5/0084 , G01N21/6456
摘要： A device for “in vivo” diagnosis by means of a photosensibilisator light-induced reaction or a reaction caused by intrinsic fluorescence in biological tissue, having an illumination system, which is provided with at least one light source having a lamp system which generates incoherent light in a wavelength range of at least 380 to 680 nm, a light delivering unit which directs the light of said illumination system at the therapy and/or to-be-diagnosed tissue area, and an imaging, image-recording and image-transmitting unit which images the light coming from said tissue area in a proximal image plane. The device is distinguished in that the net spectral transmittance in the light delivering unit and in the image-generating unit of the device are selected in such a manner that, on the one hand, practically no light with a wavelength of &lgr; from the range utilized for excitation, which by nature has relatively high intensity, “reaches” via the image-generating unit of the device into the proximal image plane, whereas light with a wavelength of &lgr; from the range in which fluorescence occurs can reach the proximal image plane only if it comes from the illuminated tissue are and not from the illumination system.
摘要翻译：一种用于通过光敏效应器光诱导反应或由生物组织中的固有荧光引起的反应进行的“体内”诊断的装置，具有照明系统，其具有至少一个具有产生不相干光的灯系统的光源在至少380至680nm的波长范围内，将所述照明系统的光引导到治疗和/或待诊断的组织区域的光输送单元，以及成像，图像记录和图像发送单元其在近端图像平面中对来自所述组织区域的光进行成像。该装置的特征在于，以这样的方式选择装置中的光输送单元和图像生成单元中的净光谱透射率，一方面实际上不具有从所使用的范围的羔羊波长的光对于本质上具有相对高强度的激发，通过装置的图像生成单元“到达”到近端图像平面中，而从发生荧光的范围的波长为lamb的光可以仅到达近端图像平面如果它来自照明组织而不是来自照明系统。

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