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1. 发明授权

US08075907B2 Polymethylmethacrylate revision bone cement 有权
标题翻译：聚甲基丙烯酸甲酯修复骨水泥
公开(公告)号：US08075907B2
公开(公告)日：2011-12-13
申请号：US12017499
申请日：2008-01-22
申请人： Klaus-Dieter Kühn , Sebastian Vogt , Hubert Büchner
发明人： Klaus-Dieter Kühn , Sebastian Vogt , Hubert Büchner
IPC分类号： A61F2/28
CPC分类号： A61L24/0015 , A61L24/06 , A61L27/16 , A61L27/54 , A61L2300/406 , A61L2300/45 , A61L2300/622 , A61L2430/02 , C08L33/12
摘要： The invention relates to a PMMA revision bone cement having powder and liquid component, in which the powder component contains two or more granular antibiotics whose grain size distribution is equal in that the main screening fraction each of the individual antibiotics is in the same grain size range, in particular in the range of 100-250 μm or 150-250 μm.
摘要翻译：本发明涉及具有粉末和液体组分的PMMA修复骨水泥，其中粉末组分含有两种或更多种粒度分布相等的粒状抗生素，因为各个抗生素的主要筛选部分具有相同的粒度范围，特别是在100-250μm或150-250μm的范围内。

2. 发明授权

US08092824B2 Antibiotic coating of implants 有权
标题翻译：植入物的抗生素涂层
公开(公告)号：US08092824B2
公开(公告)日：2012-01-10
申请号：US11335323
申请日：2006-01-19
申请人： Klaus-Dieter Kühn , Sebastian Vogt , Matthias Schnabelrauch
发明人： Klaus-Dieter Kühn , Sebastian Vogt , Matthias Schnabelrauch
IPC分类号： A61F2/02
CPC分类号： A61L27/54 , A61L27/28 , A61L2300/404 , A61L2300/606
摘要： An antibiotic coating of implants is described, which is characterized in that the coating comprises at least one saturated, organic, hydrophobic, low molecular matrix former whose melting point is in the temperature range of 45° C. to 100° C., in which a low molecular, hydrophobic additive is dissolved and that an antibiotic/antibiotics is/are suspended in the mixture of matrix former and additive and/or in which an antibiotic/antibiotics miscible with a mixture of matrix former and additive is/are dissolved.
摘要翻译：描述了植入物的抗生素涂层，其特征在于该涂层包含至少一种饱和的，有机的，疏水的，低分子量的基质，其熔点在45℃至100℃的温度范围内，其中溶解低分子疏水性添加剂，并且将抗生素/抗生素悬浮在基质前体和添加剂的混合物中，和/或其中溶解有与基质前体和添加剂的混合物混溶的抗生素/抗生素。

3. 发明授权

US07358232B2 Method for the antibiotic coating of bodies with interconnecting microcavities as well as coated bodies and their usage 有权
标题翻译：具有互连微腔以及涂层体的物体的抗生素涂层方法及其用途
公开(公告)号：US07358232B2
公开(公告)日：2008-04-15
申请号：US10174682
申请日：2002-06-19
申请人： Sebastian Vogt , Matthias Schnabelrauch , Klaus-Dieter Kühn
发明人： Sebastian Vogt , Matthias Schnabelrauch , Klaus-Dieter Kühn
IPC分类号： A61K31/70 , C07H15/02
CPC分类号： A61K9/0024
摘要： The invention relates to a method for the antibiotic coating of bodies with interconnecting microcavities as well as bodies coated this way and their usage. The invented method is characterized in that in the microcavities of non-metallic bodies an aqueous solution 1, which contains at least one easily water-soluble antibiotic component from the groups of the aminoglycoside antibiotics, the tetracycline antibiotics, the lincosamide antibiotics and the 4-quinolone antibiotics, and an aqueous solution 2, which contains at least one easily water-soluble amphiphilic component from the groups of the alkyl sulfates, alkyl sulfonates, alkylaryl sulfates, dialkylaryl sulfates, alkylaryl sulfonates, dialkylaryl sulfonates, cycloalkyl sulfates, cycloalkyl sulfonates, alkylcycloalkyl sulfates, are introduced, wherein between the introduction of solutions 1 and 2 the water is basically removed through vaporization and/or evaporation, and whereby from the components of solutions 1 and 2 in the microcavities a deposit is formed, which is sparingly soluble in water.
摘要翻译：本发明涉及一种用于具有互连微腔的物体的抗生素包被的方法以及这种方式涂覆的物体及其用途。本发明的方法的特征在于，在非金属体的微腔中，含有来自氨基糖苷类抗生素组的至少一种容易水溶性抗生素成分的水溶液1，四环素抗生素，林可素类抗生素和4- 喹诺酮抗生素和水溶液2，其含有至少一种容易水溶性的两亲成分，分别为烷基硫酸盐，烷基磺酸盐，烷基芳基硫酸盐，二烷基芳基硫酸盐，烷基芳基磺酸盐，二烷基芳基磺酸盐，环烷基硫酸盐，环烷基磺酸盐，烷基环烷基硫酸盐，其中在引入溶液1和2之间基本上通过蒸发和/或蒸发除去水，并且由此在微腔中的溶液1和2的组分中形成沉积物，其沉积物微溶于水。

4. 发明授权

US06913764B2 Antibiotic(s) preparation with retarding active ingredient release 失效
标题翻译：具有延缓活性成分释放的抗生素制剂
公开(公告)号：US06913764B2
公开(公告)日：2005-07-05
申请号：US10100839
申请日：2002-03-19
申请人： Sebastian Vogt , Matthias Schnabelrauch , Klaus-Dieter Kühn
发明人： Sebastian Vogt , Matthias Schnabelrauch , Klaus-Dieter Kühn
IPC分类号： A61K9/00 , A61K9/10 , A61K9/14 , A61K9/20 , A61K9/22 , A61K9/70 , A61K31/00 , A61K31/70 , A61K31/7036 , A61K31/726 , A61K45/06 , A61K45/08 , A61K47/02 , A61K47/14 , A61K47/16 , A61K47/20 , A61K47/24 , A61L27/54 , A61L31/16 , A61K2/02
CPC分类号： A61K31/7036 , A61K9/0024 , A61K9/2013 , A61K31/00 , A61L27/54 , A61L2300/406 , A61L2300/602 , A61L2300/802
摘要： The present invention concerns an antibiotic/antibiotics preparation for resorbable and non-resorbable implants for human and veterinary medicine, for the treatment of local microbial infections in hard and soft tissue. The invented antibiotic/antibiotics preparation is a mixture consisting of at least one amphiphilic component of a representative of the alkyl sulfates, aryl sulfates, alkylaryl sulfates, cycloalkyl sulfates, alkylcycloalkyl sulfates, alkyl sulfamates, cycloalkyl sulfamates, alkylcycloalkyl sulfamates, aryl sulfamates, alkylaryl sulfamates, alkyl sulfonates, fatty acid-2-sulfonates, aryl sulfonates, alkylaryl sulfonates, cycloalkyl sulfonates, alkylcycloalkyl sulfonates, alkyl disulfates, cycloalkyl disulfates, alkyl disulfonates, cycloalkyl disulfonates, aryl disulfonates, alkylaryl disulfonates, aryl trisulfonates and alkylaryl trisulfonates as well as at least one antibiotic component from the group of aminoglycoside antibiotics, lincosamide antibiotics, 4-quinolone antibiotics and tetracycline antibiotics, and if need be at least one anhydrous organic auxiliary component and if need be at least one inorganic auxiliary component and if need be at least one biologically active component. The antibiotic/antibiotics preparation of the invention has a retarding active ingredient release.
摘要翻译：本发明涉及用于人和兽医药物的可再吸收和不可吸收植入物的抗生素/抗生素制剂，用于治疗硬组织和软组织中的局部微生物感染。本发明的抗生素/抗生素制剂是由至少一种代表烷基硫酸盐，芳基硫酸盐，烷基芳基硫酸盐，环烷基硫酸盐，烷基环烷基硫酸盐，氨基磺酸烷基酯，环烷基磺酸盐，烷基环烷基氨基磺酸盐，芳基亚磺酸盐，烷基芳基亚磺酸盐烷基磺酸盐，脂肪酸-2-磺酸盐，芳基磺酸盐，烷基芳基磺酸盐，环烷基磺酸盐，烷基环烷基磺酸盐，烷基二硫酸盐，环烷基二硫酸盐，烷基二磺酸盐，环烷基二磺酸盐，芳基二磺酸盐，烷基芳基二磺酸盐，芳基三磺酸盐和烷基芳基三磺酸盐以及至少一种来自氨基糖苷类抗生素的抗生素成分，林可素类抗生素，4-喹诺酮类抗生素和四环素抗生素，如果需要至少一种无机有机辅助成分，如果需要至少一种无机辅助成分，如果需要至少一种生物活性成分 ent。本发明的抗生素/抗生素制剂具有缓释活性成分释放。

5. 发明授权

US09078959B2 Coating method and coating device 有权
标题翻译：涂布方法和涂布装置
公开(公告)号：US09078959B2
公开(公告)日：2015-07-14
申请号：US13330936
申请日：2011-12-20
申请人： Sebastian Vogt , Klaus-Dieter Kühn
发明人： Sebastian Vogt , Klaus-Dieter Kühn
IPC分类号： B05C11/00 , A61L31/16 , A61L27/30 , A61L27/32 , A61L27/54 , A61L31/08
CPC分类号： A61L31/16 , A61L27/306 , A61L27/32 , A61L27/54 , A61L31/086 , A61L31/088 , A61L2300/60 , A61L2430/24
摘要： A device for coating at least regions of a medical implant includes an elastically deformable transfer means having a liquid that contains at least one pharmaceutically active substance. The liquid can be transferred to the medical implant when the transfer means is contacted with a surface of the medical implant.
摘要翻译：用于涂覆医疗植入物的至少区域的装置包括具有含有至少一种药物活性物质的液体的可弹性变形的转移装置。当转移装置与医用植入物的表面接触时，可将液体转移到医疗植入物。

6. 发明授权

US07923019B2 Antibiotic/s containing bone substitute material with sustained active substance release 有权
标题翻译：含有持久活性物质释放的骨替代材料的抗生素
公开(公告)号：US07923019B2
公开(公告)日：2011-04-12
申请号：US11294001
申请日：2005-12-05
申请人： Klaus-Dieter Kühn , Sebastian Vogt
发明人： Klaus-Dieter Kühn , Sebastian Vogt
IPC分类号： A61K33/42 , A61F2/00
CPC分类号： A61L27/025 , A61L27/54 , A61L2300/404 , A61L2300/406 , A61L2430/02
摘要： Antibiotic/s containing bone substitute material is described which is characterized in that it is composed of a compacted mixture of granules of calcium sulfate dihydrate, calcium carbonate and at least one representative of the aminoglycoside antibiotics, lincosamide antibiotics, glycopeptide antibiotics, macrolide antibiotics, ketolide antibiotics, the nitroimidazoles, the fluorochinolone antibiotics and the oxazolidinone antibiotics, the steroid antibiotics, the antiseptic agents and the fungicidal/fungistatic antibiotics which are partly or entirely sheathed with a layer of glycerol tripalmitate and/or glycerol tristearate and/or glycerol trilaurate and/or 1-hexadecyl alcohol which connects the granules with each other.
摘要翻译：描述了含有抗生素的骨替代材料，其特征在于其由硫酸钙二水合物，碳酸钙和至少一种氨基糖苷类抗生素代谢物的压实混合物，氯胺素抗生素，糖肽抗生素，大环内酯类抗生素，酮内酯抗生素，硝基咪唑，氟喹诺酮抗生素和恶唑烷酮抗生素，类固醇抗生素，防腐剂和杀真菌/抑菌抗生素，其部分或全部用三层棕榈酸甘油酯和/或甘油三硬脂酸酯和/或甘油三月桂酸酯和/ 或将该颗粒彼此连接的1-十六烷基醇。

7. 发明授权

US07858109B2 Implant material 有权
标题翻译：植入材料
公开(公告)号：US07858109B2
公开(公告)日：2010-12-28
申请号：US11675127
申请日：2007-02-15
申请人： Klaus-Dieter Kühn , Sebastian Vogt
发明人： Klaus-Dieter Kühn , Sebastian Vogt
IPC分类号： A61F2/00 , A61K31/70 , A61K38/16 , A61K31/496
CPC分类号： A61K9/0024 , A61K9/2072 , A61K9/70 , A61K31/7036 , A61L27/54 , A61L2300/406
摘要： Form bodies, which can be rotationally-symmetrical or irregularly-shaped, consist of at least one member of the group of the antibiotic salts, gentamicin myristate, gentamicin palmitate, gentamicin stearate, tobramycin myristate, tobramycin palmitate, tobramycin stearate, amikacin myristate, amikacin palmitate, amikacin stearate, vancomycin palmitate, vancomycin stearate, ramoplanin palmitate, ramoplanin stearate, levofloxacin palmitate, levofloxacin stearate, ofloxacin palmitate, ofloxacin stearate, moxifloxacin palmitate, moxifloxacin stearate, clindamycin palmitate, and clindamycin stearate. A medical device for implantation, in which the form bodies are arranged on a biodegradable filament at a distance of 1 mm to 25 mm as well as a method for the manufacture of the medical device and the use of the form bodies or the medical device to treat chronic osteomyelitis are described.
摘要翻译：可以旋转对称或不规则形状的成形体由至少一种抗生素盐，庆大霉素，肉豆蔻酸庆大霉素，庆大霉素棕榈酸酯，肉豆蔻酸庆大霉素，妥布霉素棕榈酸酯，妥布霉素棕榈酸酯，肉豆蔻酸阿米卡星，阿米卡星棕榈酸盐，阿米卡星硬脂酸盐，万古霉素棕榈酸酯，拉莫洛维林棕榈酸酯，拉莫洛宁硬脂酸酯，左氧氟沙星棕榈酸酯，左氧氟沙星硬脂酸酯，氧氟沙星棕榈酸酯，氧氟沙星硬脂酸酯，莫西沙星棕榈酸酯，莫西沙星硬脂酸酯，克林霉素棕榈酸酯和克林霉素硬脂酸酯。一种用于植入的医疗装置，其中，所述成形体以1mm至25mm的距离布置在生物可降解的长丝上，以及用于制造所述医疗装置的方法以及所述成形体或所述医疗装置的使用描述治疗慢性骨髓炎。

8. 发明授权

US07655706B2 Polymethylmethacrylate bone cement 有权
标题翻译：聚甲基丙烯酸甲酯骨水泥
公开(公告)号：US07655706B2
公开(公告)日：2010-02-02
申请号：US11447807
申请日：2006-06-06
申请人： Klaus-Dieter Kühn , Sebastian Vogt
发明人： Klaus-Dieter Kühn , Sebastian Vogt
IPC分类号： A61F2/28
CPC分类号： A61L27/50 , A61L24/001 , A61L24/06 , A61L27/16 , A61L2430/02 , C08L33/12
摘要： A polymethylmethacrylate bone cement with a liquid monomer component and a solid component contains in the monomer liquid, for example, 0.001-1.00 mass percent of a dye or dye mixture that is insoluble or poorly soluble in methacrylic acid methylester and, for example, 0.001-2.00 mass percent of a synthetically produced, protein-free, hydrophobic, low molecular or oligomeric solubilizer for the dye or dye mixture. The solubilizer preferably is liquid or pasty at room temperature. The monomer liquid is translucent at room temperature. Preferably, 0.001-1.00 mass percent of a dye or dye mixture that is insoluble or poorly soluble in methacrylic acid methylester and, preferably, 0.001-2.00 mass percent of a synthetically produced, protein-free, hydrophobic, low molecular or oligomeric solubilizer that is liquid or pasty at room temperature are homogeneously dissolved in the polymethacrylate or polymethylacrylate of the powder component.
摘要翻译：具有液体单体组分和固体组分的聚甲基丙烯酸甲酯骨粘固剂在单体液体中含有例如0.001-1.00质量％的不溶于或难溶于甲基丙烯酸甲酯的染料或染料混合物，例如，用于染料或染料混合物的合成产生的无蛋白质，疏水性，低分子或低聚增溶剂的2.00质量％。增溶剂在室温下优选为液体或糊状。单体液体在室温下是半透明的。优选0.001〜1.00质量％的不溶于或难溶于甲基丙烯酸甲酯的染料或染料混合物，优选0.001-2.00质量％的合成产生的无蛋白质，疏水性，低分子或低聚物的增溶剂，其为液体或糊状物均匀地溶解在粉末组分的聚甲基丙烯酸酯或聚甲基丙烯酸甲酯中。

9. 发明授权

US06942877B2 Method for producing antibiotic composites 失效
标题翻译：生产抗生素复合材料的方法
公开(公告)号：US06942877B2
公开(公告)日：2005-09-13
申请号：US10100843
申请日：2002-03-19
申请人： Sebastian Vogt , Matthias Schnabelrauch , Klaus-Dieter Kühn
发明人： Sebastian Vogt , Matthias Schnabelrauch , Klaus-Dieter Kühn
IPC分类号： A61K9/06 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/22 , A61K31/00 , A61K31/65 , A61K31/7036 , A61K31/7056 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , A61P31/00 , A61P31/04 , B01J2/22 , B01J2/28 , A61F13/00 , A61F2/00 , A61K9/50
CPC分类号： A61K31/7036 , A61K9/2009 , A61K31/00
摘要： A method for producing antibiotic composites is described, which is characterized in that a salt, which can be subjected to plastic deformation and which consists of at least one cationic component of a protonated antibiotics base from the groups of aminoglycoside antibiotics, the lincosamide antibiotics and the tetracycline antibiotics and of at least one anionic components from the group of organic sulfates and/or organic sulfonates and/or fatty acid esters, is used as a binding agent for the fixation of inorganic composite components and/or possibly organic composite components and possibly for the molding of the composites while adding water, especially through pressing, extrusion, rolling, calendering and grinding processes.
摘要翻译：描述了一种生产抗生素复合材料的方法，其特征在于可以进行塑性变形的盐，其由至少一种由氨基糖苷类抗生素组成的质子化抗生素碱的阳离子组分，氯胺素抗生素和使用四环素抗生素和来自有机硫酸盐和/或有机磺酸盐和/或脂肪酸酯基团的至少一种阴离子组分作为固定无机复合组分和/或可能的有机复合组分的粘合剂，并且可能用于同时加入水，特别是通过压制，挤出，轧制，压延和研磨加工而成型。

10. 发明授权

US07264825B2 Pharmaceutical preparation with retarding active ingredient release, method for its production and its use 有权
标题翻译：具有延缓活性成分释放的药物制剂，其制备方法及其用途
公开(公告)号：US07264825B2
公开(公告)日：2007-09-04
申请号：US10600557
申请日：2003-06-20
申请人： Sebastian Vogt , Matthias Schnabelrauch , Klaus-Dieter Kühn
发明人： Sebastian Vogt , Matthias Schnabelrauch , Klaus-Dieter Kühn
IPC分类号： A61J9/14
CPC分类号： A61K9/0024 , A61K9/2009 , A61K9/204 , A61K38/14 , A61K45/06 , A61K2300/00
摘要： The invention describes pharmaceutical preparations with retarding active ingredient release, which consist of mixtures of powdery teicoplanin and at least one powdery, water soluble salt form of gentamicin, clindamycin, kanamycin, amikacin, tobramycin, vancomycin, moxifloxacin and ciprofloxacin and an inorganic and/or organic adjuvant. The pharmaceutical preparations are used as permanent or as temporary implants in the form of tablets, molded bodies, fibers and granules.
摘要翻译：本发明描述了具有延迟活性成分释放的药物制剂，其由替考拉宁粉末与至少一种粉末状水溶性盐形式的庆大霉素，克林霉素，卡那霉素，阿米卡星，妥布霉素，万古霉素，莫西沙星和环丙沙星以及无机和/或有机佐剂。药物制剂用作片剂，成型体，纤维和颗粒形式的永久或临时植入物。

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