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1. 发明申请

US20180311407A1 METHOD FOR MANUFACTURING BONE IMPLANTS AND BONE IMPLANT 审中-公开
公开(公告)号：US20180311407A1
公开(公告)日：2018-11-01
申请号：US15571825
申请日：2016-05-05
申请人： INSTYTUT WYSOKICH CISNIEN POLSKIEJ AKADEMII NAUK
发明人： WOJCIECH SWIESZKOWSKI , TADEUSZ CHUDOBA , SYLWIA KUSNIERUK , ALEKSANDRA KEDZIERSKA , BARTOSZ WOZNIAK , JULIA ROGOWSKA-TYLMAN , DARIUSZ SMOLEN , ELZBIETA PIETRZYKOWSKA , WITOLD LOJKOWSKI , JACEK WOJNAROWICZ , AHARON GEDANKEN , JANIS LOCS , VITA ZALITE , MARA PILMANE , ILZE SALMA
IPC分类号： A61L27/32 , A61L27/56 , A61L27/10 , A61L27/14 , A61L27/12
CPC分类号： A61L27/32 , A61L27/56 , A61L31/086 , A61L2400/12 , A61L2420/02 , A61L2430/02
摘要： The method of making an implant consists on coating of a supporting structure (1) with synthetic hydroxyapatite by immersing the supporting structure (1) in a suspension (3) and triggering of a cavitation in a portion of the suspension (3) being in contact with the supporting structure (1). The suspension (3) is formed by a liquid external phase, advantageously water, and internal phase, i.e. particles of synthetic hydroxyapatite having an average particle size not exceeding 100 nm and containing structural water in an amount from 2 to 6% by weight. The implant is coated with the above described hydroxyapatite subjected to cavitation and a thickness of 50 nm to 1000 nm, advantageously 50 nm to 300 nm.

2. 发明申请

US20180243803A1 SHELF-LIFE-IMPROVED NANOSTRUCTURED IMPLANT SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20180243803A1
公开(公告)日：2018-08-30
申请号：US15907149
申请日：2018-02-27
申请人： Nanovation Partners LLC
发明人： Sungho Jin , Daniel F. Justin
IPC分类号： B08B7/00 , B08B11/00 , B08B3/04 , A61L2/10 , A61L2/14 , A61L31/08 , A61L31/16
CPC分类号： B08B7/0057 , A61B90/70 , A61L2/10 , A61L2/14 , A61L27/06 , A61L27/50 , A61L31/086 , A61L31/088 , A61L31/16 , A61L2202/24 , A61L2300/406 , A61L2300/412 , A61L2400/12 , A61L2400/18 , B08B3/041 , B08B7/0071 , B08B11/00 , B08B17/065 , B82Y5/00 , B82Y40/00
摘要： Methods and treatments for removing contaminants from nanotube surfaces covering a medical device are disclosed herein. These methods and treatments include commencing exposure of a nanotube surface to at least one condition that at least partially removes the contaminants including: ultraviolet light, elevated temperature, plasma, and/or combinations thereof. These methods and treatments may also include orienting the nanotube surface relative to the at least one condition in order to enhance removal of the contaminants by the at least one condition. Exposure of the nanotube surface to the at least one condition may be ceased after the contaminants are at least partially removed from the nanotube surface.

3. 发明申请

US20170173213A1 POLARIZED HYDROXYAPATITE FILMS AND METHODS OF MAKING AND USING SAME 审中-公开
公开(公告)号：US20170173213A1
公开(公告)日：2017-06-22
申请号：US15124401
申请日：2015-03-10
申请人： University of Rochester
发明人： Matthew YATES , Keith SAVINO , Paul GABRYS , Cong FU
IPC分类号： A61L27/32 , A61L31/08 , A61K33/42 , C25D9/04 , A61L31/16 , A61K33/38 , C25D3/46 , A61L27/30 , A61L27/54
CPC分类号： A61L27/32 , A61K33/38 , A61K33/42 , A61L27/30 , A61L27/306 , A61L27/54 , A61L31/086 , A61L31/088 , A61L31/16 , A61L2300/404 , A61L2400/12 , A61L2400/18 , A61L2420/02 , A61L2430/02 , C25D3/46 , C25D9/04
摘要： Polarized hydroxyapatite films disposed on a substrate. The films have a residual polarization of at least 5 mC/cm2. Also provided are methods of making and using polarized hydroxyapatite. The films can be used as coatings of medical devices, such as, for example, medical implants.

4. 发明授权

US09592206B2 Methods of using water-soluble inorganic compounds for implants 有权
标题翻译：使用水溶性无机化合物作为植入物的方法
公开(公告)号：US09592206B2
公开(公告)日：2017-03-14
申请号：US14168975
申请日：2014-01-30
申请人： AMxTek LLC
发明人： James A Walls
IPC分类号： A61F2/02 , A61K9/70 , A61K33/38 , A61K33/42 , A61L24/00 , A61L31/12 , A61L31/14 , A61L31/16 , A61L27/42 , A61L27/44 , A61F2/30 , A61F2/46 , A61L27/10 , A61B17/60 , A61B17/86 , A61F2/44
CPC分类号： A61L31/086 , A61B17/60 , A61B17/8625 , A61B17/866 , A61F2/28 , A61F2/32 , A61F2/4455 , A61F2/4644 , A61F2002/30013 , A61F2002/30032 , A61F2002/30034 , A61F2002/30036 , A61F2002/30677 , A61F2002/3068 , A61F2310/00329 , A61F2310/00359 , A61F2310/00928 , A61K9/70 , A61K33/38 , A61K33/42 , A61L24/0036 , A61L24/0042 , A61L24/0063 , A61L24/0068 , A61L24/0084 , A61L24/0089 , A61L27/10 , A61L27/425 , A61L27/427 , A61L27/446 , A61L31/022 , A61L31/082 , A61L31/123 , A61L31/124 , A61L31/127 , A61L31/128 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2400/18 , A61L2420/04 , A61L2430/02 , A61L2430/10 , A61L2430/34
摘要： A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.
摘要翻译：通过选择至少一种具有所需粒径和溶解度的水溶性无机材料，并将水溶性无机材料与至少一种难溶于水或可生物降解的基质材料。将基质材料与水溶性无机材料混合后，在组织附近放置在患者体内，使得水溶性无机材料以预定的速率溶解，以在基质材料中产生生物上希望的空隙，骨中的骨骼或其他组织然后可以生长。

5. 发明申请

US20160144080A1 PEO COATING ON MG SCREWS 有权
标题翻译： PEO涂层在MG螺丝上
公开(公告)号：US20160144080A1
公开(公告)日：2016-05-26
申请号：US15010583
申请日：2016-01-29
申请人： AAP IMPLANTATE AG
发明人： Elvira DINGELDEIN , Cyrille GASQUERES , Amir ELIEZER , Marco WOLFSTADTER , Lydia HEIMANN
IPC分类号： A61L31/08 , C25D11/02 , A61L31/02 , C25D11/30
CPC分类号： A61L31/086 , A61L31/022 , A61L31/148 , A61L2400/18 , A61L2420/02 , C25D11/024 , C25D11/026 , C25D11/30
摘要： The present invention relates generally to a bio-degradable implant based on magnesium having a reduced corrosion rate and to a method for the production of such an implant. It is a a method for treating a surface of a bio-degradable metallic implant comprising the following steps: providing a dispersed system comprising a colloid-dispersed apatite and adding an apatite powder to the dispersed system, subjecting an implant to the dispersed system such that a surface of the implant which is to be treated is immersed in the dispersed system wherein the implant comprises a magnesium based alloy, applying an AC voltage difference between the implant as a first electrode and a second electrode positioned in the dispersed system for generating a plasma electrolytic oxidation on the immersed surface of the implant so that the immersed surface is converted to an oxide film which is at least partially covered by apatites formed by the colloid-dispersed apatite and the apatite powder. The evolution of corrosion induced hydrogen gas evolution is decreased and osseointegration is improved.
摘要翻译：本发明一般涉及具有降低的腐蚀速率的基于镁的生物可降解植入物和用于生产这种植入物的方法。它是用于处理生物可降解金属植入物的表面的方法，包括以下步骤：提供包含胶体分散的磷灰石并将磷灰石粉末加入到分散体系中的分散体系，使植入物经受分散体系，使得将待处理的植入物的表面浸入分散体系中，其中植入物包括镁基合金，在作为第一电极的植入物和位于分散系统中的第二电极之间施加AC电压差以产生等离子体电解质在植入物的浸渍表面上氧化，使得浸入的表面转化为至少部分被由胶体分散的磷灰石和磷灰石粉末形成的磷灰石覆盖的氧化膜。腐蚀诱导氢气演化的演化减少，骨整体提高。

6. 发明授权

US09155646B2 Composite stent with bioremovable ceramic flakes 有权
标题翻译：具有生物可降解陶瓷片的复合支架
公开(公告)号：US09155646B2
公开(公告)日：2015-10-13
申请号：US11380572
申请日：2006-04-27
申请人： James R. Johnson
发明人： James R. Johnson
IPC分类号： A61F2/06 , A61F2/92 , A61L31/08 , A61L31/12 , A61L31/14
CPC分类号： A61F2/86 , A61F2/92 , A61F2210/0076 , A61L31/086 , A61L31/126 , A61L31/127 , A61L31/128 , A61L31/148 , C08L67/04
摘要： A biodegradable and/or bioabsorbable composite stent includes a bioabsorbable ceramic material dispersed and embedded in a biodegradable polymeric material. The bioabsorbable ceramic material is made of flakes that have a thin, flat shape. In one embodiment, the composite stent comprises a body of one or more layers of polymer alone coupled to layers of polymer in which the ceramic flakes are dispersed and embedded and the composite is coiled to form the stent.
摘要翻译：可生物降解和/或生物可吸收的复合支架包括分散并嵌入可生物降解的聚合物材料中的生物可吸收陶瓷材料。生物可吸收陶瓷材料由薄片形状的薄片制成。在一个实施方案中，复合支架包括单独一个或多个聚合物层的主体，其与聚合物层相耦合，其中陶瓷片被分散和嵌入，并且复合材料被卷绕以形成支架。

7. 发明申请

US20150209484A1 BONE CONNECTION MATERIAL 审中-公开
公开(公告)号：US20150209484A1
公开(公告)日：2015-07-30
申请号：US14164258
申请日：2014-01-27
申请人： Luke Lu , Toshihiro Tokizawa , Kuan-Yu Lu , I-Ching Lu
发明人： Luke Lu , Toshihiro Tokizawa , Kuan-Yu Lu , I-Ching Lu
IPC分类号： A61L31/08 , A61L31/10 , A61L31/02 , A61B17/86 , A61L31/04
CPC分类号： A61B17/68 , A61B17/7002 , A61B17/80 , A61B17/866 , A61B17/869 , A61F2/28 , A61L31/026 , A61L31/028 , A61L31/044 , A61L31/086 , A61L31/10 , A61L31/16 , A61L2430/02
摘要： The present invention provides a bone connection material that includes an internal layer. The internal layer is formed by braiding a plurality of filaments. The internal layer that is formed by braiding filaments is resistant to lateral shearing forces and may provide flexibility so as to achieve wide applications. Further, the present invention overcomes the drawback of the conventionally used metallic materials that are rigid and inelastic and also overcomes the problem of polylactic acid material of being brittle. Thus, the bone formed according to the present invention is close to a natural bone and is more suitable for uses in portions where frequent movements are made and scaffolds of stem cells.

8. 发明申请

US20140335142A1 METHOD OF SURFACE TREATMENT OF AN IMPLANT, AN IMPLANT TREATED BY SAID METHOD AND AN ELECTROLYTE SOLUTION FOR USE IN SAID METHOD 审中-公开
标题翻译：植入物的表面处理方法，通过方法处理的植入物和电解质溶液在使用方法中的方法
公开(公告)号：US20140335142A1
公开(公告)日：2014-11-13
申请号：US13260875
申请日：2009-04-02
申请人： Martina Frischherz , Vinzenz Max Frauchiger
发明人： Martina Frischherz , Vinzenz Max Frauchiger
IPC分类号： C25D9/08 , A61L31/16 , A61L31/08
CPC分类号： C25D9/08 , A61L27/32 , A61L27/54 , A61L31/086 , A61L31/088 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2300/802 , A61L2400/18 , A61L2420/02 , A61L2420/06 , C25D9/04
摘要： A method of surface treatment of at least part of an electro-conductive surface of an implant, in particular an orthopaedic or a dental implant is described which permits the simultaneous, electrochemical deposition of a therapeutic agent and a calcium phosphate coating in a combined single-step deposition process. The method involves the preparation of an electrolyte solution containing calcium and phosphorus ions and a therapeutic agent, preferably in combination with a complexing agent such that the resulting complex has a net positive charge. This electrolyte solution is then used in an electrochemical deposition process to produce a calcium phosphate coating incorporating the therapeutic agent on the electro-conductive surface of the implant Preferably, the therapeutic agent comprises metal ions, for example silver ions, and the complexing agent comprises an ammine complex. Also provided are an implant treated by the described method and an electrolyte solution for use in the described method.
摘要翻译：描述了一种对植入物，特别是整形外科或牙科植入物的导电表面的至少一部分进行表面处理的方法，该方法允许将治疗剂和磷酸钙涂层同时，步骤沉积工艺。该方法包括制备含有钙和磷离子的电解质溶液和治疗剂，优选与络合剂组合，使得所得复合物具有净正电荷。然后将该电解质溶液用于电化学沉积工艺中以在植入物的导电表面上产生掺入治疗剂的磷酸钙涂层。优选地，治疗剂包括金属离子，例如银离子，并且络合剂包括氨基复合物还提供了通过所述方法处理的植入物和用于所述方法的电解质溶液。

9. 发明申请

US20140147487A1 Methods of Using Water-Soluble Inorganic Compounds for Implants 有权
标题翻译：使用水溶性无机化合物作为植入物的方法
公开(公告)号：US20140147487A1
公开(公告)日：2014-05-29
申请号：US14168975
申请日：2014-01-30
申请人： AMxTek LLC
发明人： James A. Walls
IPC分类号： A61K9/70 , A61K33/42
CPC分类号： A61L31/086 , A61B17/60 , A61B17/8625 , A61B17/866 , A61F2/28 , A61F2/32 , A61F2/4455 , A61F2/4644 , A61F2002/30013 , A61F2002/30032 , A61F2002/30034 , A61F2002/30036 , A61F2002/30677 , A61F2002/3068 , A61F2310/00329 , A61F2310/00359 , A61F2310/00928 , A61K9/70 , A61K33/38 , A61K33/42 , A61L24/0036 , A61L24/0042 , A61L24/0063 , A61L24/0068 , A61L24/0084 , A61L24/0089 , A61L27/10 , A61L27/425 , A61L27/427 , A61L27/446 , A61L31/022 , A61L31/082 , A61L31/123 , A61L31/124 , A61L31/127 , A61L31/128 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2400/18 , A61L2420/04 , A61L2430/02 , A61L2430/10 , A61L2430/34
摘要： A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.
摘要翻译：通过选择至少一种具有所需粒径和溶解度的水溶性无机材料，并将水溶性无机材料与至少一种难溶于水或可生物降解的基质材料。将基质材料与水溶性无机材料混合后，在组织附近放置在患者体内，使得水溶性无机材料以预定的速率溶解，以在基质材料中产生生物上希望的空隙，骨中的骨骼或其他组织然后可以生长。

10. 发明授权

US08337936B2 Implant and method for manufacturing same 有权
标题翻译：种植体及其制造方法
公开(公告)号：US08337936B2
公开(公告)日：2012-12-25
申请号：US12564282
申请日：2009-09-22
申请人： Ullrich Bayer , Jan Schettler , Guenter Ewert
发明人： Ullrich Bayer , Jan Schettler , Guenter Ewert
IPC分类号： B05D3/10 , C25D5/18 , C25D11/18 , C25D11/02 , C25D9/06
CPC分类号： A61L31/022 , A61L31/086
摘要： The present invention proposes a method for manufacturing an implant, in particular an intraluminal endoprosthesis, having a body such that the body has metallic material. To control the degradation in a desired time window, e.g., between four weeks and six months, the following production method is performed: a) preparing the body of the implant, and b) plasma-chemical treatment of at least a portion of the surface of the body in an aqueous solution by applying a plasma-generating electric alternating voltage to the body (5) of the implant, said voltage having a frequency of at least approximately 1 kHz, to create a first layer. The invention also relates to an implant obtainable by such a method.
摘要翻译：本发明提出了一种用于制造植入物，特别是腔内内用假体的方法，其具有主体使得身体具有金属材料。为了控制期望时间窗口（例如四周至六个月）之间的降解，执行以下生产方法：a）准备植入物的主体，以及b）等离子体化学处理表面的至少一部分通过向植入物的本体（5）施加等离子体产生的电交流电压，所述电压在水溶液中，所述电压具有至少约1kHz的频率，以产生第一层。本发明还涉及通过这种方法可获得的植入物。

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