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1. 发明授权

US11417037B2 Visualization tools for digital PCR data 有权
公开(公告)号：US11417037B2
公开(公告)日：2022-08-16
申请号：US16937634
申请日：2020-07-24
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Harrison Leong , Nivedita Sumi Majumdar , Jeffrey A. Marks , Theodore E. Straub , Ryan J. Talbot , Kevin S. Bodner , David Hoard
IPC分类号： G06T11/20 , G16B45/00
摘要： A method for generating a data visualization is provided. The method includes displaying a representation of a portion of detected data from a substrate to a user. The method further includes generating a data quality value for the portion of detected data and displaying, along with the representation of the portion of detected data, an indication of data quality value for the portion of detected data. The method further includes selecting, by the user, a quality value threshold, and displaying an adjusted indication of data quality value for the portion of detected data meeting the quality value threshold.

2. 发明申请

US20160321398A1 Systems and Methods for the Analysis of Protein Melt Curve Data 审中-公开
标题翻译：蛋白质熔解曲线数据分析系统与方法
公开(公告)号：US20160321398A1
公开(公告)日：2016-11-03
申请号：US15144369
申请日：2016-05-02
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Nivedita Sumi Majumdar , Harrison Leong , Ruoyun Wu
IPC分类号： G06F19/26 , G06F3/0482 , G06F3/0484 , G06T11/20
CPC分类号： G16B45/00 , G06F3/0482 , G06F3/04847 , G06T11/206 , G06T2200/24 , G16B40/00
摘要： The present teachings relate to embodiments of systems and methods for the analysis of melt curve data for a plurality of samples. According to various embodiments, a melting temperature (Tm) may be determined across a range of different types of protein melt curve data, having variability over a plurality of analytical attributes in order to accommodate the complexity of protein melt curve data. The combination of a plurality of samples, coupled with the complexity of the data gives rise for a need to process the data in a manner that readily facilitates end-user to analysis of the data. Various embodiments of an interactive graphical user interface (GUI) according to the present teachings provide for rapid and sequential changes that may be made by an end user to displayed protein melt curve data to allow such analysis.
摘要翻译：本教导涉及用于分析多个样品的熔体曲线数据的系统和方法的实施例。根据各种实施方案，可以在不同类型的蛋白质熔融曲线数据的范围内确定熔解温度（Tm），其具有多个分析属性的变异性，以适应蛋白质熔融曲线数据的复杂性。多个样本的组合以及数据的复杂性导致需要以容易促进最终用户分析数据的方式处理数据。根据本发明的交互式图形用户界面（GUI）的各种实施例提供了可以由终端用户进行快速和顺序改变以显示蛋白质熔解曲线数据以允许这种分析。

3. 发明授权

US10984888B2 Methods and systems for a digital PCR experiment designer 有权
公开(公告)号：US10984888B2
公开(公告)日：2021-04-20
申请号：US14428312
申请日：2013-09-13
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Nivedita Sumi Majumdar , Thomas Wessel , David C. Woo , Marcin Sikora , Gordon A. Janaway , Shweta Raizada , Joanna Lankester , Jeffrey A. Marks , Daniel Wessel
IPC分类号： G16B25/00 , G16B40/00 , C12Q1/686
摘要： A computer-implemented method for designing a digital PCR (dPCR) experiment is provided. The method includes receiving, from a user, a selection of optimization type. The optimization type may be maximizing the dynamic range, minimizing the number of substrates including reaction sites needed for the experiment, determining a dilution factor, or determining the lower limit of detection, for example. The method further includes receiving, from the user, a precision measure for an experiment, and a minimum concentration of a target in a reaction site for the experiment. The method also includes determining a set of dPCR experiment design factors for the experiment based on the optimization type. The set of dPCR experiment design factors is then displayed to the user.

4. 发明授权

US10930373B2 Methods and systems for knowledge discovery using biological data 有权
公开(公告)号：US10930373B2
公开(公告)日：2021-02-23
申请号：US15128859
申请日：2015-03-24
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Nivedita Sumi Majumdar , Harrison Leong , Shakila Pothini , David Hoard , Christopher Fong , Pratik Simon Soares , Salil Kumar , Thomas Wessel , Manjula Aliminati , Levente Egry
IPC分类号： G16B50/00 , G16B30/00 , G16B45/00 , G06F16/904 , G06F16/951
摘要： A system for analyzing biological data, comprising: a storage configured to store a plurality of data files containing biological data obtained from a plurality of devices; a server configured to: host a plurality of applications, each configured to be implemented on the server and to provide analysis, manipulation, comparison, visualization, or a combination thereof, of the biological data included in the data files, wherein the plurality of applications allow a user to analyze different data files related to the same sample and compare the results of the analysis.

5. 外观设计

USD839276S1 Display screen with transitional graphical user interface 有权
公开(公告)号：USD839276S1
公开(公告)日：2019-01-29
申请号：US29574943
申请日：2016-08-19
申请人： LIFE TECHNOLOGIES CORPORATION
设计人： Nivedita Sumi Majumdar , Abhishek Saseendran , Apuroop Kalapala , Jayashree Srivastava , Brian Ho , Patricia Hegerich , Marion Laig

6. 发明申请

US20180330047A1 SYSTEMS AND METHODS FOR THE ANALYSIS OF PROXIMITY BINDING ASSAY DATA 审中-公开
公开(公告)号：US20180330047A1
公开(公告)日：2018-11-15
申请号：US15967501
申请日：2018-04-30
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Harrison Leong , Nivedita Sumi Majumdar , Elana E Swartzman
IPC分类号： G06F19/18 , G06F19/24
CPC分类号： G06F19/18 , G06F19/24
摘要： A proximity binding assay (PBA) is performed on at least one test sample, at least one reference sample, a background sample, and one or more calibration samples using a thermal cycler instrument. Ct values are determined for at least one set of test sample data and at least one set of reference sample data. Background corrected Ct values are calculated using a corresponding value in a background sample data set. A linear range is determined for the background corrected Ct values as a function of sample quantity. A linear regression line is calculated for each linear range. One or more parameter values of an exponential model (EM) fold change formula are estimated from the one or more sets of calibration sample data. A target protein quantity and associated confidence interval are calculated using the linear regression lines and the EM fold change formula.

7. 发明申请

US20160275149A1 Methods and Systems for Visualizing Data Quality 审中-公开
标题翻译：数据质量可视化方法与系统
公开(公告)号：US20160275149A1
公开(公告)日：2016-09-22
申请号：US14392323
申请日：2014-06-27
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Nivedita Sumi Majumdar , Harrison Leong , Theodore E. Straub , David Hoard
IPC分类号： G06F17/30
CPC分类号： G06F16/24575 , G06F16/248 , G16B45/00
摘要： A method for generating a data visualization is provided. The method includes receiving a plurality of data points related to fluorescent emissions values from a plurality of reaction sites. The fluorescent emission values include information for a first type of dye and a second type of dye. The method further includes displaying a first portion of the plurality of data points related to the first type of dye in a representation of location of the plurality of reaction sites, and displaying a second portion of the plurality of data points related to the second type of dye in the representation. The method further includes displaying the first portion of the plurality of data points in a scatter plot display. The scatter plot shows fluorescent values related to the first dye on the y-axis and fluorescent values related to the second dye on the x-axis. The method includes displaying the second portion of the plurality of data points in the scatter plot display.
摘要翻译：提供了一种用于生成数据可视化的方法。该方法包括从多个反应位点接收与荧光发射值有关的多个数据点。荧光发射值包括第一类染料和第二类染料的信息。该方法还包括在多个反应位置的位置的表示中显示与第一类型的染料相关的多个数据点的第一部分，以及显示与第二类型的染色相关的多个数据点的第二部分染料代表。该方法还包括在散点图显示中显示多个数据点的第一部分。散点图显示与y轴上的第一染料相关的荧光值和与x轴上的第二染料相关的荧光值。该方法包括在散点图显示中显示多个数据点的第二部分。

8. 发明授权

US10726589B2 Visualization tools for digital PCR data 有权
公开(公告)号：US10726589B2
公开(公告)日：2020-07-28
申请号：US14441500
申请日：2013-11-07
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Harrison Leong , Nivedita Sumi Majumdar , Jeffrey A. Marks , Theodore E. Straub , Ryan J. Talbot , Kevin S. Bodner , David Hoard
IPC分类号： G06T11/20 , G16B45/00
摘要： A method for generating a data visualization is provided. The method includes displaying a representation of a portion of detected data from a substrate to a user. The method further includes generating a data quality value for the portion of detected data and displaying, along with the representation of the portion of detected data, an indication of data quality value for the portion of detected data. The method further includes selecting, by the user, a quality value threshold, and displaying an adjusted indication of data quality value for the portion of detected data meeting the quality value threshold.

9. 发明申请

US20160312274A1 METHODS AND SYSTEMS FOR VOLUME VARIATION MODELING IN DIGITAL PCR 审中-公开
标题翻译：数字PCR中体积变异建模的方法与系统
公开(公告)号：US20160312274A1
公开(公告)日：2016-10-27
申请号：US15136774
申请日：2016-04-22
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Nivedita Sumi Majumdar , Swapnonil Banerjee
IPC分类号： C12Q1/68 , G06F17/18
CPC分类号： C12Q1/6851 , G06F17/18 , G16B40/00
摘要： A method for performing digital polymerase chain reaction (dPCR) is provided. The method includes partitioning a biological sample volume including a plurality of target nucleic acids into a plurality of partitions, where at least one partition includes at least one target nucleic acid. The method further includes determining a model for volume variation of the plurality of partitions and determining a number of partitions including at least one target nucleic acid. The method includes generating a concentration of target nucleic acids in the biological sample based on the model for volume variation and the fraction of partitions including at least one target nucleic acid.
摘要翻译：提供了一种进行数字聚合酶链反应（dPCR）的方法。该方法包括将包括多个靶核酸的生物样品体积分成多个分区，其中至少一个分区包含至少一个靶核酸。该方法还包括确定多个分区的体积变化的模型并确定包括至少一个靶核酸的分割数。该方法包括基于用于体积变化的模型和包括至少一种靶核酸的分配部分产生生物样品中靶核酸的浓度。

10. 发明申请

US20150278437A1 Methods and Systems for a Digital PCR Experiment Designer 审中-公开
标题翻译：数字PCR实验设计器的方法和系统
公开(公告)号：US20150278437A1
公开(公告)日：2015-10-01
申请号：US14428312
申请日：2013-09-13
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Nivedita Sumi Majumdar , Thomas Wessel , David C. Woo , Marcin Sikora , Gordon A. Janaway , Shweta Raizada , Joanna Lankester , Jeffrey A. Marks , Daniel Wessel
IPC分类号： G06F19/20 , C12Q1/68
CPC分类号： G16B25/00 , C12Q1/686 , G16B40/00
摘要： A computer-implemented method for designing a digital PCR (dPCR) experiment is provided. The method includes receiving, from a user, a selection of optimization type. The optimization type may be maximizing the dynamic range, minimizing the number of substrates including reaction sites needed for the experiment, determining a dilution factor, or determining the lower limit of detection, for example. The method further includes receiving, from the user, a precision measure for an experiment, and a minimum concentration of a target in a reaction site for the experiment. The method also includes determining a set of dPCR experiment design factors for the experiment based on the optimization type. The set of dPCR experiment design factors is then displayed to the user.
摘要翻译：提供了一种用于设计数字PCR（dPCR）实验的计算机实现方法。该方法包括从用户接收优化类型的选择。优化类型可以使动态范围最大化，例如最小化包括实验所需的反应位点，确定稀释因子或确定检测下限的底物数量。该方法还包括从用户接收实验的精确度量，以及用于实验的反应部位中靶的最小浓度。该方法还包括基于优化类型确定实验的一组dPCR实验设计因子。然后将该组dPCR实验设计因子显示给用户。

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