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1. 发明申请

US20190209631A1 Lipid Extract of Passiflora Seeds 审中-公开
公开(公告)号：US20190209631A1
公开(公告)日：2019-07-11
申请号：US16243491
申请日：2019-01-09
申请人： Laboratoires Expanscience
发明人： Sophie LECLERE-BIENFAIT , Stephanie BREDIF , Sebastien DEBROCK , Sebastien GARNIER
IPC分类号： A61K36/185 , C11B3/00 , A23D9/007 , C11B3/12 , A61K8/92 , A61K8/67 , A61K31/01 , A61K31/20 , A61K31/201 , A61K31/202 , A61K31/355 , A61K31/56 , A61K9/06 , A61K9/00 , A61Q19/06 , A61Q19/00 , A61K9/107 , A61K8/97 , A61Q19/08 , A61P17/02 , A23L33/105 , A61Q19/04 , C11B3/02 , A61K8/31 , A61K8/36 , A61K8/63
摘要： The invention relates to a lipid extract of the seeds of passion fruit, Passiflora incarnata and/or Passiflora edulis, preferably P. edulis, characterised in that said lipid extract is an oil of passion fruit seeds concentrated in its unsaponifiable fraction, containing between 3 wt. % and 100 wt. % of unsaponifiable matter in relation to the total weight of the extract. The invention also relates to a method for preparing such an extract and to a composition comprising said extract, especially for the use thereof in a dermatological or pharmaceutical composition or as a food.

2. 发明申请

US20220249446A1 Composition Comprising at Least One Oxazoline for Inhibiting the Growth of Malassezia Yeasts Involved in Cradle Cap, in Particular 有权
公开(公告)号：US20220249446A1
公开(公告)日：2022-08-11
申请号：US17624692
申请日：2020-07-13
申请人： Laboratoires Expanscience
发明人： Stephanie BREDIF , Sophie LECLERE-BIENFAIT , David DURANCET
IPC分类号： A61K31/421 , A61K47/44 , A61K47/14 , A61K47/36 , A61P31/10 , A61K8/49 , A61Q5/00 , A61Q17/00
摘要： The present invention relates to a composition comprising at least one oxazoline, such as OX100, for inhibiting the growth of Malassezia yeasts and/or for preventing and/or treating conditions caused by Malassezia yeasts, seborrheic dermatitis, cradle cap, Malassezia folliculitis, dandruff, Pityriasis versicolor or Pityriasis capitis. The present invention also relates to a composition comprising at least one oxazoline such as OX100, at least one compound such as malic acid diester and a vegetable oil oleodistillate and/or arabinogalactan, and to the use of same for preventing and/or treating, in particular, affections caused by Malassezia yeasts, seborrheic dermatitis, cradle cap, Malassezia folliculitis, dandruff, Pityriasis versicolor or Pityriasis capitis.

3. 发明申请

US20190242880A1 METHOD FOR EVALUATING THE EFFECTS OF DEHYDRATION ON CHILDREN'S SKIN 审中-公开
公开(公告)号：US20190242880A1
公开(公告)日：2019-08-08
申请号：US16062488
申请日：2016-12-16
申请人： Laboratoires Expanscience
发明人： Stephanie BREDIF , Caroline BAUDOUIN
IPC分类号： G01N33/50 , G01N33/68 , C12N5/071 , C12Q1/6883
CPC分类号： G01N33/5088 , C12N5/0698 , C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G01N33/6881
摘要： The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is dry. Such markers are particularly advantageous in that they allow the skin's response to dehydration to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of dehydration on children's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.

4. 发明申请

US20160326492A1 RECONSTITUTED NIPPLE SKIN MODEL 审中-公开
标题翻译：重建鼻孔皮肤模型
公开(公告)号：US20160326492A1
公开(公告)日：2016-11-10
申请号：US15110826
申请日：2015-01-12
申请人： LABORATOIRES EXPANSCIENCE
发明人： Stephanie BREDIF , Caroline BAUDOUIN , Philippe MSIKA , Marisa MELONI
IPC分类号： C12N5/071 , G01N33/50 , C07K14/78
CPC分类号： C12N5/0629 , C07K14/495 , C07K14/52 , C07K14/78 , C12N5/0698 , C12N9/0006 , C12N2533/54 , G01N33/5082 , G01N33/5088 , G01N2333/47 , G01N2333/495 , G01N2333/525 , G01N2333/7055 , G01N2333/904
摘要： A first subject of the invention is a skin model characterized in that it comprises keratinocytes capable of overexpressing filaggrin. A second subject of the invention is a method for evaluating the in vitro activity of a formulation or of at least one active agent on the healing of nipple skin and/or on the reduction of nipple skin inflammation, characterized in that said method comprises at least the following steps: a) bringing said active agent or said formulation into contact with a skin model comprising keratinocytes overexpressing filaggrin and also comprising a lesion; b) measuring the level of production of at least one biological marker in the nipple skin model of step a), characterized in that said biological marker can be chosen from lactate dehydrogenase (LDH), TNFα, filaggrin, TGFβ1 and β1 integrin; c) comparing the level of production of at least one biological marker obtained in step b) with a reference level of production; evaluating the efficacy of said active agent or of said formulation according to the comparison of step c).
摘要翻译：本发明的第一主题是皮肤模型，其特征在于其包含能够过表达丝聚蛋白的角质形成细胞。本发明的第二个主题是用于评估制剂或至少一种活性剂对乳头皮肤愈合和/或降低乳头皮肤炎症的体外活性的方法，其特征在于所述方法至少包括以下步骤：a）使所述活性剂或所述制剂与包含过表达丝聚蛋白并且还包含病变的角质形成细胞的皮肤模型接触; b）测量步骤a）的乳头皮肤模型中至少一种生物标志物的产生水平，其特征在于所述生物标志物可以选自乳酸脱氢酶（LDH），TNFα，丝聚蛋白，TGFβ1和β1整联蛋白; c）将步骤b）中获得的至少一种生物标志物的产量水平与参考生产水平进行比较; 根据步骤c）的比较评估所述活性剂或所述制剂的功效。

5. 发明申请

US20220071891A1 Extract of Chlamydomonas Acidophila, Method for Preparing Same and Cosmetic Compositions and Dermatological Compositions Comprising Same 有权
公开(公告)号：US20220071891A1
公开(公告)日：2022-03-10
申请号：US17416868
申请日：2019-12-30
申请人： Laboratoires Expanscience
发明人： Sophie LECLERE-BIENFAIT , Stephanie BREDIF
IPC分类号： A61K8/9722 , A61Q19/00
摘要： The invention relates to a peptide extract of the microalga Chlamydomonas acidophila, and to a method for the preparation thereof. The invention also relates to a composition, advantageously a cosmetic or dermatological composition, comprising such an extract. The invention also relates to such a composition or such an extract for use in the prevention or treatment of disorders or diseases affecting the skin, mucous membranes or skin appendages, for use in the prevention or treatment of vascular disorders, or else for use in the prevention or treatment of adipose tissue modifications. The invention finally relates to a cosmetic care process for the skin, the skin appendages or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which process consists in administering such a composition or such an extract.

6. 发明申请

US20200256853A1 Models of Reconstructed Sensitive Skin 审中-公开
公开(公告)号：US20200256853A1
公开(公告)日：2020-08-13
申请号：US16624087
申请日：2018-06-21
申请人： Laboratoires Expanscience
发明人： Gaelle BELLEMERE , Stephanie BREDIF , Gaetan BOYER , Caroline BAUDOUIN
IPC分类号： G01N33/50 , C12N5/071
摘要： The present invention relates to models of reconstructed sensitive skin reproducing the features of sensitive skin, as well as to processes for obtaining such models. The present invention further relates to in vitro processes for testing formulations or active ingredients for the prevention or treatment of sensitive skin.

7. 发明申请

US20190234939A1 Juvenile Atopic Dermatitis Models 审中-公开
公开(公告)号：US20190234939A1
公开(公告)日：2019-08-01
申请号：US16311378
申请日：2017-06-23
申请人： Laboratoires Expanscience
发明人： Caroline BAUDOUIN , Stephanie BREDIF
IPC分类号： G01N33/50 , C12N5/00 , C12N5/071
CPC分类号： G01N33/5064 , C12N5/0062 , C12N5/0629 , C12N2503/06 , C12N2513/00 , C12Q1/68 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5044 , G01N2500/02 , G01N2500/10 , G01N2800/202 , G01N2800/38
摘要： The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is affected by atopic dermatitis. Such markers are particularly advantageous in that they allow the skin's response to atopic dermatitis to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of atopic dermatitis on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.

8. 发明申请

US20160235794A1 LIPID EXTRACT OF PASSIFLORA SEEDS 审中-公开
标题翻译：大豆种子的脂肪提取物
公开(公告)号：US20160235794A1
公开(公告)日：2016-08-18
申请号：US15023893
申请日：2014-09-25
申请人： LABORATOIRES EXPANSCIENCE
发明人： Sophie LECLERE-BIENFAIT , Stephanie BREDIF , Sebastien DEBROCK , Sebastien GARNIER
IPC分类号： A61K36/185 , A61Q19/08 , A61Q19/00 , A61Q19/06 , A61Q19/04 , A61K9/00 , C11B3/12 , C11B3/00 , C11B3/02 , A61K31/20 , A61K8/36 , A61K31/201 , A61K31/202 , A61K31/355 , A61K8/67 , A61K31/56 , A61K8/63 , A61K31/01 , A61K8/31 , A61K8/92
CPC分类号： A61K36/185 , A23D9/007 , A23L33/105 , A23V2002/00 , A61K8/31 , A61K8/361 , A61K8/63 , A61K8/678 , A61K8/922 , A61K8/97 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K31/01 , A61K31/20 , A61K31/201 , A61K31/202 , A61K31/355 , A61K31/56 , A61K2236/55 , A61K2800/592 , A61K2800/80 , A61P17/02 , A61Q19/00 , A61Q19/004 , A61Q19/007 , A61Q19/04 , A61Q19/06 , A61Q19/08 , C11B3/001 , C11B3/006 , C11B3/02 , C11B3/12 , A61K2300/00
摘要： The invention relates to a lipid extract of the seeds of passion fruit, Passiflora incarnata and/or Passiflora edulis, preferably P. edulis, characterised in that said lipid extract is an oil of passion fruit seeds concentrated in its unsaponifiable fraction, containing between 3 wt. % and 100 wt. % of unsaponifiable matter in relation to the total weight of the extract. The invention also relates to a method for preparing such an extract and to a composition comprising said extract, especially for the use thereof in a dermatological or pharmaceutical composition or as a food.
摘要翻译：本发明涉及西番莲果实的种子的脂质提取物，和西番茄和/或西番莲，其特征在于，所述脂质提取物是浓缩在其不皂化部分中的含有3wt 。％和100wt。关于提取物总重量的不皂化物质的百分比。本发明还涉及制备这种提取物的方法和包含所述提取物的组合物，特别是用于皮肤病学或药物组合物或作为食物的组合物。

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